Fibroblast growth factor 2 exacerbates inflammation in adipocytes through NLRP3 inflammasome activation

Chronic inflammation in adipose tissue is the hallmark of obesity and a major risk factor for the development of obesity-induced insulin resistance. NLRP3 inflammasome regulates the maturation and secretion of pro-inflammatory cytokines, such as IL-1β and IL-18, and was recently discovered to be inv...

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Published in	Archives of pharmacal research Vol. 43; no. 12; pp. 1311 - 1324
Main Authors	ZhuGe, De-Li, Javaid, Hafiz Muhammad Ahmad, Sahar, Namood E., Zhao, Ying-Zheng, Huh, Joo Young
Format	Journal Article
Language	English
Published	Seoul Pharmaceutical Society of Korea 01.12.2020
Subjects	adipocytes adipokines adipose tissue epididymis exercise fibroblast growth factor 2 fibroblasts high fat diet inflammasomes inflammation insulin resistance interleukin-18 Medicine metabolism obesity Pharmacology/Toxicology Pharmacy Research Article risk factors secretion Adipocyte Obesity NLRP3 Inflammasome Metabolism FGF2
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ISSN	0253-6269 1976-3786 1976-3786
DOI	10.1007/s12272-020-01295-2

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Abstract	Chronic inflammation in adipose tissue is the hallmark of obesity and a major risk factor for the development of obesity-induced insulin resistance. NLRP3 inflammasome regulates the maturation and secretion of pro-inflammatory cytokines, such as IL-1β and IL-18, and was recently discovered to be involved in obesity-related metabolic diseases. Fibroblast growth factors (FGFs) such as FGF1, FGF10, and FGF21 are adipokines that regulate adipocyte development and metabolism, but reports on the effect of other FGFs on adipocytes are lacking. In the present study, the novel role of FGF2 in NLRP3 inflammasome activation was elucidated. Our results showed that FGF2 levels were increased during adipocyte differentiation and in the adipose tissue of high-fat diet (HFD)-induced obese mice. Recombinant FGF2 treatment upregulated inflammasome markers such as NLRP3, which was further exaggerated by TNF-ɑ treatment. Interestingly, β-Klotho, a co-receptor of FGF21, was significantly decreased by FGF2 treatment. Results from mice confirmed the positive correlation between FGF2 and NLRP3 expression in epididymal and subcutaneous adipose tissue, while exercise training effectively reversed HFD-induced NLRP3 expression as well as FGF2 levels in both adipose depots. Our results suggest that FGF2 is an adipokine that may exacerbate the inflammatory response in adipocytes through NLRP3 inflammasome activation.
AbstractList	Chronic inflammation in adipose tissue is the hallmark of obesity and a major risk factor for the development of obesity-induced insulin resistance. NLRP3 inflammasome regulates the maturation and secretion of pro-inflammatory cytokines, such as IL-1β and IL-18, and was recently discovered to be involved in obesity-related metabolic diseases. Fibroblast growth factors (FGFs) such as FGF1, FGF10, and FGF21 are adipokines that regulate adipocyte development and metabolism, but reports on the effect of other FGFs on adipocytes are lacking. In the present study, the novel role of FGF2 in NLRP3 inflammasome activation was elucidated. Our results showed that FGF2 levels were increased during adipocyte differentiation and in the adipose tissue of high-fat diet (HFD)-induced obese mice. Recombinant FGF2 treatment upregulated inflammasome markers such as NLRP3, which was further exaggerated by TNF-ɑ treatment. Interestingly, β-Klotho, a co-receptor of FGF21, was significantly decreased by FGF2 treatment. Results from mice confirmed the positive correlation between FGF2 and NLRP3 expression in epididymal and subcutaneous adipose tissue, while exercise training effectively reversed HFD-induced NLRP3 expression as well as FGF2 levels in both adipose depots. Our results suggest that FGF2 is an adipokine that may exacerbate the inflammatory response in adipocytes through NLRP3 inflammasome activation. Chronic inflammation in adipose tissue is the hallmark of obesity and a major risk factor for the development of obesity-induced insulin resistance. NLRP3 inflammasome regulates the maturation and secretion of pro-inflammatory cytokines, such as IL-1β and IL-18, and was recently discovered to be involved in obesity-related metabolic diseases. Fibroblast growth factors (FGFs) such as FGF1, FGF10, and FGF21 are adipokines that regulate adipocyte development and metabolism, but reports on the effect of other FGFs on adipocytes are lacking. In the present study, the novel role of FGF2 in NLRP3 inflammasome activation was elucidated. Our results showed that FGF2 levels were increased during adipocyte differentiation and in the adipose tissue of high-fat diet (HFD)-induced obese mice. Recombinant FGF2 treatment upregulated inflammasome markers such as NLRP3, which was further exaggerated by TNF-ɑ treatment. Interestingly, β-Klotho, a co-receptor of FGF21, was significantly decreased by FGF2 treatment. Results from mice confirmed the positive correlation between FGF2 and NLRP3 expression in epididymal and subcutaneous adipose tissue, while exercise training effectively reversed HFD-induced NLRP3 expression as well as FGF2 levels in both adipose depots. Our results suggest that FGF2 is an adipokine that may exacerbate the inflammatory response in adipocytes through NLRP3 inflammasome activation.Chronic inflammation in adipose tissue is the hallmark of obesity and a major risk factor for the development of obesity-induced insulin resistance. NLRP3 inflammasome regulates the maturation and secretion of pro-inflammatory cytokines, such as IL-1β and IL-18, and was recently discovered to be involved in obesity-related metabolic diseases. Fibroblast growth factors (FGFs) such as FGF1, FGF10, and FGF21 are adipokines that regulate adipocyte development and metabolism, but reports on the effect of other FGFs on adipocytes are lacking. In the present study, the novel role of FGF2 in NLRP3 inflammasome activation was elucidated. Our results showed that FGF2 levels were increased during adipocyte differentiation and in the adipose tissue of high-fat diet (HFD)-induced obese mice. Recombinant FGF2 treatment upregulated inflammasome markers such as NLRP3, which was further exaggerated by TNF-ɑ treatment. Interestingly, β-Klotho, a co-receptor of FGF21, was significantly decreased by FGF2 treatment. Results from mice confirmed the positive correlation between FGF2 and NLRP3 expression in epididymal and subcutaneous adipose tissue, while exercise training effectively reversed HFD-induced NLRP3 expression as well as FGF2 levels in both adipose depots. Our results suggest that FGF2 is an adipokine that may exacerbate the inflammatory response in adipocytes through NLRP3 inflammasome activation.
Author	ZhuGe, De-Li Zhao, Ying-Zheng Sahar, Namood E. Huh, Joo Young Javaid, Hafiz Muhammad Ahmad
Author_xml	– sequence: 1 givenname: De-Li surname: ZhuGe fullname: ZhuGe, De-Li organization: College of Pharmacy, Chonnam National University, College of Pharmacy, Wenzhou Medical University – sequence: 2 givenname: Hafiz Muhammad Ahmad surname: Javaid fullname: Javaid, Hafiz Muhammad Ahmad organization: College of Pharmacy, Chonnam National University – sequence: 3 givenname: Namood E. surname: Sahar fullname: Sahar, Namood E. organization: College of Pharmacy, Chonnam National University – sequence: 4 givenname: Ying-Zheng surname: Zhao fullname: Zhao, Ying-Zheng organization: College of Pharmacy, Wenzhou Medical University – sequence: 5 givenname: Joo Young orcidid: 0000-0002-2982-4420 surname: Huh fullname: Huh, Joo Young email: jooyhuh@jnu.ac.kr organization: College of Pharmacy, Chonnam National University
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Cites_doi	10.1016/j.cmet.2010.11.011 10.1042/cs20150622 10.1016/S0022-5347(01)63298-1 10.1111/febs.12161 10.1111/jpi.12414 10.1016/j.bbrc.2007.05.070 10.1073/pnas.95.3.1062 10.1016/j.cell.2007.12.040 10.1038/onc.2017.278 10.1007/s12272-017-0994-y 10.1007/s11154-014-9301-0 10.1016/j.mce.2011.10.018 10.1007/s13105-016-0468-6 10.1016/j.cmet.2019.10.006 10.1016/j.tem.2015.01.006 10.1016/j.celrep.2019.02.014 10.1016/j.metabol.2010.02.003 10.1074/jbc.M310500200 10.1080/21623945.2018.1445889 10.1186/gb-2001-2-3-reviews3005 10.1038/oby.2002.83 10.1016/s0140-6736(16)30054-x 10.3389/fendo.2014.00018 10.1210/jc.2004-1309 10.1016/j.cca.2019.08.005 10.1038/ki.2008.244 10.1038/ni.1831 10.1038/nrcardio.2009.55 10.1016/j.biomaterials.2017.06.012 10.1172/JCI26498 10.3390/ijms20133328 10.1007/s12272-013-0023-8 10.1038/nature05482 10.3389/fendo.2013.00071 10.1016/j.jnutbio.2016.11.015 10.1126/scitranslmed.aag0945 10.1684/ecn.2009.0155 10.1210/en.2012-1193 10.1161/01.ATV.0000244684.23499.bf 10.1038/srep19868 10.1007/s11892-014-0508-y 10.1210/jcem.81.12.8954057 10.1074/jbc.REV119.008907 10.4061/2010/218142 10.1079/pns2001110 10.1007/s12272-016-0827-4 10.1002/path.4420 10.1007/s12272-020-01274-7 10.1172/jci115984 10.1038/nrendo.2012.75 10.1194/jlr.M038638 10.1016/j.biocel.2011.07.009 10.1016/j.febslet.2004.10.020 10.1007/s10753-017-0718-y 10.1038/nature10759 10.1016/j.exer.2019.107775 10.1002/jcb.22452 10.2337/db12-0420 10.1210/en.2005-1529 10.1210/jc.2014-1437 10.1038/s41574-019-0176-8
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References	Choi, Jang, Choi, Ryoo, Park (CR7) 2016; 72 Zimering, Eng (CR61) 1996; 81 Diaz-Delfin, Hondares, Iglesias, Giralt, Caelles, Villarroya (CR9) 2012; 153 Stienstra, Joosten, Koenen, Van Tits, Van Diepen, Van Den Berg, Rensen, Voshol, Fantuzzi, Hijmans, Kersten, Muller, Van Den Berg, Van Rooijen, Wabitsch, Kullberg, Van Der Meer, Kanneganti, Tack, Netea (CR49) 2010; 12 Huh, Mougios, Kabasakalis, Fatouros, Siopi, Douroudos, Filippaios, Panagiotou, Park, Mantzoros (CR19) 2014; 99 Moncion, Lin, O’neill, Franceschi, Kripfgans, Putnam, Fabiilli (CR34) 2017; 140 Mydlo, Kral, Macchia (CR35) 1998; 159 Hao, Guo, Dong, Weng, Yan, Zhu, Chen, Chen, Yang (CR17) 2016; 6 Strowig, Henao-Mejia, Elinav, Flavell (CR51) 2012; 481 Zhou, Tardivel, Thorens, Choi, Tschopp (CR59) 2010; 11 Schäfer, Zentgraf, Zehe, Brügger, Bernhagen, Nickel (CR47) 2004; 279 Kwon, Pessin (CR30) 2013; 4 Gustafson, Hedjazifar, Gogg, Hammarstedt, Smith (CR16) 2015; 26 Strand, Herum, Rana, Skrbic, Askevold, Dahl, Vistnes, Hasic, Kvaløy, Sjaastad, Carlson, Tønnessen, Gullestad, Christensen, Lunde (CR50) 2013; 280 Fujii, Yonemitsu, Onimaru, Tanii, Nakano, Egashira, Takehara, Inoue, Hasegawa, Kuwano, Sueishi (CR11) 2006; 26 Benham, Chakraborty, Bullard, Bernard (CR1) 2018; 7 Chien, Huang, Tsai, Wang, Lin, Tang (CR5) 2016; 130 Okla, Zaher, Alfayez, Chung (CR39) 2018; 41 Rocha, Libby (CR46) 2009; 6 Dong, Santeford, Ban, Lee, Smith, Ornitz, Apte (CR10) 2019; 187 Neubauer, Fischbach, Bauer-Kreisel, Lieb, Hacker, Tessmar, Schulz, Goepferich, Blunk (CR37) 2004; 577 Teichert-Kuliszewska, Hamilton, Deitel, Roncari (CR54) 1992; 90 Strunz, Roggerio, Cruz, Pacanaro, Salemi, Benvenuti, Mansur, Irigoyen (CR52) 2017; 40 Su, Kong, Peng (CR53) 2019; 498 Keller, Rüegg, Werner, Beer (CR25) 2008; 132 Camell, Gunther, Lee, Goldberg, Spadaro, Youm, Bartke, Hubbard, Ikeno, Ruddle, Schultze, Dixit (CR3) 2019; 30 Pulgaron, Delamater (CR44) 2014; 14 Pham, Park (CR42) 2020 Klöting, Blüher (CR28) 2014; 15 Bluher (CR2) 2019; 15 Ohta, Itoh (CR38) 2014; 5 Zimering, Anderson, Ge, Moritz (CR60) 2011; 60 Kanda, Tateya, Tamori, Kotani, Hiasa, Kitazawa, Kitazawa, Miyachi, Maeda, Egashira, Kasuga (CR23) 2006; 116 Coppack (CR8) 2001; 60 Kawaguchi, Toriyama, Nicodemou-Lena, Inou, Torii, Kitagawa (CR24) 1998; 95 Sitia, Rubartelli (CR48) 2020; 295 Kühn, Willenberg, Schott, Papewalis, Stumpf, Flohé, Scherbaum, Schinner (CR29) 2012; 349 Giordano, Murano, Mondini, Perugini, Smorlesi, Severi, Barazzoni, Scherer, Cinti (CR14) 2013; 54 Huh (CR18) 2018; 41 Lee, Kim, Kim, Shong, Ku, Jo (CR31) 2013; 62 Kelley, Jeltema, Duan, He (CR26) 2019 Lee (CR32) 2013; 36 Razzaque (CR45) 2012; 8 Yu, Lee (CR55) 2016; 39 Presta, Andres, Leali, Dell'era, Ronca (CR43) 2009; 20 Yun, Won, Jeon, Lee, Kang, Jo, Jang, Shin, Kim (CR56) 2010; 1 (CR36) 2016; 387 Gabrielsson, Johansson, Jennische, Jernås, Itoh, Peltonen, Olbers, Lönn, Lönroth, Sjöström, Carlsson, Carlsson, Lönn (CR12) 2002; 10 Kahn, Hull, Utzschneider (CR21) 2006; 444 Zhang, Li, Fan, Wu, Zhao, Guan, Chien, Wang (CR57) 2008; 74 Liu, Gan, Xu, Luo, Ren, Wu, Sun (CR33) 2017; 63 Patel, Kumar, Eggo (CR41) 2005; 90 Zhang, Guan, Yang (CR58) 2010; 109 Geng, Liao, Jin, Huang, Triggle, Ding, Zhang, Huang, Lin, Xu (CR13) 2019; 26 Ornitz, Itoh (CR40) 2001; 2 Chakraborty, Benham, Bullard, Kearney, Hsia, Gibbon, Demireva, Lunt, Bernard (CR4) 2017; 36 Kihira, Yamano, Izawa-Ishizawa, Ishizawa, Ikeda, Tsuchiya, Tamaki, Tomita (CR27) 2011; 43 Incio, Ligibel, Mcmanus, Suboj, Jung (CR20) 2018; 10 Chihara, Rakugi, Ishikawa, Ikushima, Maekawa, Ohta, Kida, Ogihara (CR6) 2006; 147 Guan, Nie, He, Yang, Xiao, Wang, Huang, Zhang, Wang, Sharma, Liu, Zhao (CR15) 2014; 234 Kakudo, Shimotsuma, Kusumoto (CR22) 2007; 359 SW Coppack (1295_CR8) 2001; 60 A Moncion (1295_CR34) 2017; 140 JY Huh (1295_CR19) 2014; 99 T Zhang (1295_CR58) 2010; 109 Y Kihira (1295_CR27) 2011; 43 L Geng (1295_CR13) 2019; 26 M Bluher (1295_CR2) 2019; 15 Z Liu (1295_CR33) 2017; 63 B Gustafson (1295_CR16) 2015; 26 ME Strand (1295_CR50) 2013; 280 Ncd-Risc (1295_CR36) 2016; 387 X Su (1295_CR53) 2019; 498 M Okla (1295_CR39) 2018; 41 NG Patel (1295_CR41) 2005; 90 N Kawaguchi (1295_CR24) 1998; 95 MC Kühn (1295_CR29) 2012; 349 D Chakraborty (1295_CR4) 2017; 36 R Stienstra (1295_CR49) 2010; 12 SY Chien (1295_CR5) 2016; 130 Y Chihara (1295_CR6) 2006; 147 X Guan (1295_CR15) 2014; 234 MB Zimering (1295_CR60) 2011; 60 N Kelley (1295_CR26) 2019 J Lee (1295_CR32) 2013; 36 JY Huh (1295_CR18) 2018; 41 N Kakudo (1295_CR22) 2007; 359 M Presta (1295_CR43) 2009; 20 MS Razzaque (1295_CR45) 2012; 8 T Schäfer (1295_CR47) 2004; 279 Y Choi (1295_CR7) 2016; 72 J Diaz-Delfin (1295_CR9) 2012; 153 H Zhang (1295_CR57) 2008; 74 M Keller (1295_CR25) 2008; 132 MB Zimering (1295_CR61) 1996; 81 H Ohta (1295_CR38) 2014; 5 R Sitia (1295_CR48) 2020; 295 JW Yu (1295_CR55) 2016; 39 BG Gabrielsson (1295_CR12) 2002; 10 K Teichert-Kuliszewska (1295_CR54) 1992; 90 CD Camell (1295_CR3) 2019; 30 T Fujii (1295_CR11) 2006; 26 H Kanda (1295_CR23) 2006; 116 H Kwon (1295_CR30) 2013; 4 Z Dong (1295_CR10) 2019; 187 CMC Strunz (1295_CR52) 2017; 40 M Neubauer (1295_CR37) 2004; 577 ER Pulgaron (1295_CR44) 2014; 14 A Giordano (1295_CR14) 2013; 54 VZ Rocha (1295_CR46) 2009; 6 HM Lee (1295_CR31) 2013; 62 V Benham (1295_CR1) 2018; 7 JH Mydlo (1295_CR35) 1998; 159 RH Hao (1295_CR17) 2016; 6 SE Kahn (1295_CR21) 2006; 444 DM Ornitz (1295_CR40) 2001; 2 T Strowig (1295_CR51) 2012; 481 R Zhou (1295_CR59) 2010; 11 DV Pham (1295_CR42) 2020 YR Yun (1295_CR56) 2010; 1 J Incio (1295_CR20) 2018; 10 N Klöting (1295_CR28) 2014; 15
References_xml	– volume: 12 start-page: 593 year: 2010 end-page: 605 ident: CR49 article-title: The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity publication-title: Cell Metab doi: 10.1016/j.cmet.2010.11.011 – volume: 130 start-page: 667 year: 2016 end-page: 681 ident: CR5 article-title: Interleukin-1β induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes publication-title: Clin Sci (Lond) doi: 10.1042/cs20150622 – volume: 159 start-page: 2159 year: 1998 end-page: 2163 ident: CR35 article-title: Preliminary results comparing the recovery of basic fibroblast growth factor (FGF-2) in adipose tissue and benign and malignant renal tissue publication-title: J Urol doi: 10.1016/S0022-5347(01)63298-1 – volume: 280 start-page: 2228 year: 2013 end-page: 2247 ident: CR50 article-title: Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart publication-title: FEBS J doi: 10.1111/febs.12161 – volume: 63 start-page: e12414 year: 2017 ident: CR33 article-title: Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue publication-title: J Pineal Res doi: 10.1111/jpi.12414 – volume: 359 start-page: 239 year: 2007 end-page: 244 ident: CR22 article-title: Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2007.05.070 – volume: 95 start-page: 1062 year: 1998 end-page: 1066 ident: CR24 article-title: De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.95.3.1062 – volume: 132 start-page: 818 year: 2008 end-page: 831 ident: CR25 article-title: Active caspase-1 is a regulator of unconventional protein secretion publication-title: Cell doi: 10.1016/j.cell.2007.12.040 – volume: 36 start-page: 6668 year: 2017 end-page: 6679 ident: CR4 article-title: Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer publication-title: Oncogene doi: 10.1038/onc.2017.278 – volume: 41 start-page: 14 year: 2018 end-page: 29 ident: CR18 article-title: The role of exercise-induced myokines in regulating metabolism publication-title: Arch Pharm Res doi: 10.1007/s12272-017-0994-y – volume: 15 start-page: 277 year: 2014 end-page: 287 ident: CR28 article-title: Adipocyte dysfunction, inflammation and metabolic syndrome publication-title: Rev Endocr Metab Disord doi: 10.1007/s11154-014-9301-0 – volume: 349 start-page: 180 year: 2012 end-page: 188 ident: CR29 article-title: Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation publication-title: Mol Cell Endocrinol doi: 10.1016/j.mce.2011.10.018 – volume: 72 start-page: 157 year: 2016 end-page: 167 ident: CR7 article-title: Increased expression of FGF1-mediated signaling molecules in adipose tissue of obese mice publication-title: J Physiol Biochem doi: 10.1007/s13105-016-0468-6 – volume: 30 start-page: 1024 year: 2019 end-page: 1039 e1026 ident: CR3 article-title: Aging induces an Nlrp3 inflammasome-dependent expansion of adipose B cells that impairs metabolic homeostasis publication-title: Cell Metab doi: 10.1016/j.cmet.2019.10.006 – volume: 26 start-page: 193 year: 2015 end-page: 200 ident: CR16 article-title: Insulin resistance and impaired adipogenesis publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2015.01.006 – volume: 26 start-page: 2738 year: 2019 end-page: 2752 e2734 ident: CR13 article-title: Exercise alleviates obesity-induced metabolic dysfunction via enhancing FGF21 sensitivity in adipose tissues publication-title: Cell Rep doi: 10.1016/j.celrep.2019.02.014 – volume: 60 start-page: 284 year: 2011 end-page: 291 ident: CR60 article-title: Increased plasma basic fibroblast growth factor is associated with coronary heart disease in adult type 2 diabetes mellitus publication-title: Metabolism doi: 10.1016/j.metabol.2010.02.003 – volume: 279 start-page: 6244 year: 2004 end-page: 6251 ident: CR47 article-title: Unconventional secretion of fibroblast growth factor 2 is mediated by direct translocation across the plasma membrane of mammalian cells publication-title: J Biol Chem doi: 10.1074/jbc.M310500200 – volume: 7 start-page: 113 year: 2018 end-page: 120 ident: CR1 article-title: A role for FGF2 in visceral adiposity-associated mammary epithelial transformation publication-title: Adipocyte doi: 10.1080/21623945.2018.1445889 – volume: 2 start-page: Reviews3005 year: 2001 ident: CR40 article-title: Fibroblast growth factors publication-title: Genome Biol doi: 10.1186/gb-2001-2-3-reviews3005 – volume: 10 start-page: 608 year: 2002 end-page: 616 ident: CR12 article-title: Depot-specific expression of fibroblast growth factors in human adipose tissue publication-title: Obes Res doi: 10.1038/oby.2002.83 – volume: 387 start-page: 1377 year: 2016 end-page: 1396 ident: CR36 article-title: Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants publication-title: Lancet doi: 10.1016/s0140-6736(16)30054-x – volume: 5 start-page: 18 year: 2014 ident: CR38 article-title: Roles of FGFs as adipokines in adipose tissue development, remodeling, and metabolism publication-title: Front Endocrinol (Lausanne) doi: 10.3389/fendo.2014.00018 – volume: 90 start-page: 1226 year: 2005 end-page: 1232 ident: CR41 article-title: Essential role of fibroblast growth factor signaling in preadipoctye differentiation publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-1309 – volume: 498 start-page: 30 year: 2019 end-page: 37 ident: CR53 article-title: Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease publication-title: Clin Chim Acta doi: 10.1016/j.cca.2019.08.005 – volume: 74 start-page: 732 year: 2008 end-page: 739 ident: CR57 article-title: Klotho is a target gene of PPAR-gamma publication-title: Kidney Int doi: 10.1038/ki.2008.244 – volume: 11 start-page: 136 year: 2010 end-page: 140 ident: CR59 article-title: Thioredoxin-interacting protein links oxidative stress to inflammasome activation publication-title: Nat Immunol doi: 10.1038/ni.1831 – volume: 6 start-page: 399 year: 2009 end-page: 409 ident: CR46 article-title: Obesity, inflammation, and atherosclerosis publication-title: Nat Rev Cardiol doi: 10.1038/nrcardio.2009.55 – volume: 140 start-page: 26 year: 2017 end-page: 36 ident: CR34 article-title: Controlled release of basic fibroblast growth factor for angiogenesis using acoustically-responsive scaffolds publication-title: Biomaterials doi: 10.1016/j.biomaterials.2017.06.012 – volume: 116 start-page: 1494 year: 2006 end-page: 1505 ident: CR23 article-title: MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity publication-title: J Clin Investig doi: 10.1172/JCI26498 – year: 2019 ident: CR26 article-title: The NLRP3 inflammasome: an overview of mechanisms of activation and regulation publication-title: Int J Mol Sci doi: 10.3390/ijms20133328 – volume: 36 start-page: 208 year: 2013 end-page: 222 ident: CR32 article-title: Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes publication-title: Arch Pharm Res doi: 10.1007/s12272-013-0023-8 – volume: 444 start-page: 840 year: 2006 end-page: 846 ident: CR21 article-title: Mechanisms linking obesity to insulin resistance and type 2 diabetes publication-title: Nature doi: 10.1038/nature05482 – volume: 4 start-page: 71 year: 2013 ident: CR30 article-title: Adipokines mediate inflammation and insulin resistance publication-title: Front Endocrinol (Lausanne) doi: 10.3389/fendo.2013.00071 – volume: 40 start-page: 219 year: 2017 end-page: 227 ident: CR52 article-title: Down-regulation of fibroblast growth factor 2 and its co-receptors heparan sulfate proteoglycans by resveratrol underlies the improvement of cardiac dysfunction in experimental diabetes publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2016.11.015 – volume: 10 start-page: eaag0945 year: 2018 ident: CR20 article-title: Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aag0945 – volume: 20 start-page: 39 year: 2009 end-page: 50 ident: CR43 article-title: Inflammatory cells and chemokines sustain FGF2-induced angiogenesis publication-title: Eur Cytokine Netw doi: 10.1684/ecn.2009.0155 – volume: 153 start-page: 4238 year: 2012 end-page: 4245 ident: CR9 article-title: TNF-alpha represses beta-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway publication-title: Endocrinology doi: 10.1210/en.2012-1193 – volume: 26 start-page: 2483 year: 2006 end-page: 2489 ident: CR11 article-title: Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: critical role of the inflammatory/arteriogenic pathway publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000244684.23499.bf – volume: 6 start-page: 19868 year: 2016 ident: CR17 article-title: Associations of plasma FGF2 levels and polymorphisms in the FGF2 gene with obesity phenotypes in Han Chinese population publication-title: Sci Rep doi: 10.1038/srep19868 – volume: 14 start-page: 508 year: 2014 ident: CR44 article-title: Obesity and type 2 diabetes in children: epidemiology and treatment publication-title: Curr Diabetes Rep doi: 10.1007/s11892-014-0508-y – volume: 81 start-page: 4446 year: 1996 end-page: 4452 ident: CR61 article-title: Increased basic fibroblast growth factor-like substance in plasma from a subset of middle-aged or elderly male diabetic patients with microalbuminuria or proteinuria publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.81.12.8954057 – volume: 295 start-page: 7799 year: 2020 end-page: 7811 ident: CR48 article-title: Evolution, role in inflammation, and redox control of leaderless secretory proteins publication-title: J Biol Chem doi: 10.1074/jbc.REV119.008907 – volume: 1 start-page: 218142 year: 2010 ident: CR56 article-title: Fibroblast growth factors: biology, function, and application for tissue regeneration publication-title: J Tissue Eng doi: 10.4061/2010/218142 – volume: 60 start-page: 349 year: 2001 end-page: 356 ident: CR8 article-title: Pro-inflammatory cytokines and adipose tissue publication-title: Proc Nutr Soc doi: 10.1079/pns2001110 – volume: 39 start-page: 1503 year: 2016 end-page: 1518 ident: CR55 article-title: Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance publication-title: Arch Pharm Res doi: 10.1007/s12272-016-0827-4 – volume: 234 start-page: 560 year: 2014 end-page: 572 ident: CR15 article-title: Klotho suppresses renal tubulo-interstitial fibrosis by controlling basic fibroblast growth factor-2 signalling publication-title: J Pathol doi: 10.1002/path.4420 – year: 2020 ident: CR42 article-title: Recent insights on modulation of inflammasomes by adipokines: a critical event for the pathogenesis of obesity and metabolism-associated diseases publication-title: Arch Pharm Res doi: 10.1007/s12272-020-01274-7 – volume: 90 start-page: 1226 year: 1992 end-page: 1231 ident: CR54 article-title: Augmented production of heparin-binding mitogenic proteins by preadipocytes from massively obese persons publication-title: J Clin Investig doi: 10.1172/jci115984 – volume: 8 start-page: 579 year: 2012 end-page: 587 ident: CR45 article-title: The role of Klotho in energy metabolism publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2012.75 – volume: 54 start-page: 2423 year: 2013 end-page: 2436 ident: CR14 article-title: Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis publication-title: J Lipid Res doi: 10.1194/jlr.M038638 – volume: 43 start-page: 1602 year: 2011 end-page: 1611 ident: CR27 article-title: Basic fibroblast growth factor regulates glucose metabolism through glucose transporter 1 induced by hypoxia-inducible factor-1alpha in adipocytes publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2011.07.009 – volume: 577 start-page: 277 year: 2004 end-page: 283 ident: CR37 article-title: Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells publication-title: FEBS Lett doi: 10.1016/j.febslet.2004.10.020 – volume: 41 start-page: 626 year: 2018 end-page: 642 ident: CR39 article-title: Inhibitory effects of toll-like receptor 4, NLRP3 inflammasome, and interleukin-1beta on white adipocyte browning publication-title: Inflammation doi: 10.1007/s10753-017-0718-y – volume: 481 start-page: 278 year: 2012 end-page: 286 ident: CR51 article-title: Inflammasomes in health and disease publication-title: Nature doi: 10.1038/nature10759 – volume: 187 start-page: 107775 year: 2019 ident: CR10 article-title: FGF2-induced STAT3 activation regulates pathologic neovascularization publication-title: Exp Eye Res doi: 10.1016/j.exer.2019.107775 – volume: 109 start-page: 737 year: 2010 end-page: 746 ident: CR58 article-title: Keratinocyte growth factor promotes preadipocyte proliferation via an autocrine mechanism publication-title: J Cell Biochem doi: 10.1002/jcb.22452 – volume: 62 start-page: 194 year: 2013 end-page: 204 ident: CR31 article-title: Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes publication-title: Diabetes doi: 10.2337/db12-0420 – volume: 147 start-page: 3835 year: 2006 end-page: 3842 ident: CR6 article-title: Klotho protein promotes adipocyte differentiation publication-title: Endocrinology doi: 10.1210/en.2005-1529 – volume: 99 start-page: E2154 year: 2014 end-page: E2161 ident: CR19 article-title: Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-1437 – volume: 15 start-page: 288 year: 2019 end-page: 298 ident: CR2 article-title: Obesity: global epidemiology and pathogenesis publication-title: Nat Rev Endocrinol doi: 10.1038/s41574-019-0176-8 – year: 2019 ident: 1295_CR26 publication-title: Int J Mol Sci doi: 10.3390/ijms20133328 – volume: 90 start-page: 1226 year: 2005 ident: 1295_CR41 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-1309 – volume: 39 start-page: 1503 year: 2016 ident: 1295_CR55 publication-title: Arch Pharm Res doi: 10.1007/s12272-016-0827-4 – volume: 349 start-page: 180 year: 2012 ident: 1295_CR29 publication-title: Mol Cell Endocrinol doi: 10.1016/j.mce.2011.10.018 – volume: 10 start-page: eaag0945 year: 2018 ident: 1295_CR20 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aag0945 – volume: 14 start-page: 508 year: 2014 ident: 1295_CR44 publication-title: Curr Diabetes Rep doi: 10.1007/s11892-014-0508-y – volume: 41 start-page: 14 year: 2018 ident: 1295_CR18 publication-title: Arch Pharm Res doi: 10.1007/s12272-017-0994-y – volume: 26 start-page: 2738 year: 2019 ident: 1295_CR13 publication-title: Cell Rep doi: 10.1016/j.celrep.2019.02.014 – volume: 132 start-page: 818 year: 2008 ident: 1295_CR25 publication-title: Cell doi: 10.1016/j.cell.2007.12.040 – volume: 40 start-page: 219 year: 2017 ident: 1295_CR52 publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2016.11.015 – volume: 279 start-page: 6244 year: 2004 ident: 1295_CR47 publication-title: J Biol Chem doi: 10.1074/jbc.M310500200 – volume: 481 start-page: 278 year: 2012 ident: 1295_CR51 publication-title: Nature doi: 10.1038/nature10759 – volume: 95 start-page: 1062 year: 1998 ident: 1295_CR24 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.95.3.1062 – volume: 62 start-page: 194 year: 2013 ident: 1295_CR31 publication-title: Diabetes doi: 10.2337/db12-0420 – volume: 8 start-page: 579 year: 2012 ident: 1295_CR45 publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2012.75 – volume: 359 start-page: 239 year: 2007 ident: 1295_CR22 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2007.05.070 – volume: 41 start-page: 626 year: 2018 ident: 1295_CR39 publication-title: Inflammation doi: 10.1007/s10753-017-0718-y – volume: 43 start-page: 1602 year: 2011 ident: 1295_CR27 publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2011.07.009 – volume: 116 start-page: 1494 year: 2006 ident: 1295_CR23 publication-title: J Clin Investig doi: 10.1172/JCI26498 – volume: 577 start-page: 277 year: 2004 ident: 1295_CR37 publication-title: FEBS Lett doi: 10.1016/j.febslet.2004.10.020 – volume: 72 start-page: 157 year: 2016 ident: 1295_CR7 publication-title: J Physiol Biochem doi: 10.1007/s13105-016-0468-6 – volume: 63 start-page: e12414 year: 2017 ident: 1295_CR33 publication-title: J Pineal Res doi: 10.1111/jpi.12414 – volume: 30 start-page: 1024 year: 2019 ident: 1295_CR3 publication-title: Cell Metab doi: 10.1016/j.cmet.2019.10.006 – volume: 6 start-page: 399 year: 2009 ident: 1295_CR46 publication-title: Nat Rev Cardiol doi: 10.1038/nrcardio.2009.55 – volume: 147 start-page: 3835 year: 2006 ident: 1295_CR6 publication-title: Endocrinology doi: 10.1210/en.2005-1529 – volume: 5 start-page: 18 year: 2014 ident: 1295_CR38 publication-title: Front Endocrinol (Lausanne) doi: 10.3389/fendo.2014.00018 – volume: 498 start-page: 30 year: 2019 ident: 1295_CR53 publication-title: Clin Chim Acta doi: 10.1016/j.cca.2019.08.005 – volume: 1 start-page: 218142 year: 2010 ident: 1295_CR56 publication-title: J Tissue Eng doi: 10.4061/2010/218142 – volume: 11 start-page: 136 year: 2010 ident: 1295_CR59 publication-title: Nat Immunol doi: 10.1038/ni.1831 – volume: 159 start-page: 2159 year: 1998 ident: 1295_CR35 publication-title: J Urol doi: 10.1016/S0022-5347(01)63298-1 – volume: 15 start-page: 288 year: 2019 ident: 1295_CR2 publication-title: Nat Rev Endocrinol doi: 10.1038/s41574-019-0176-8 – volume: 10 start-page: 608 year: 2002 ident: 1295_CR12 publication-title: Obes Res doi: 10.1038/oby.2002.83 – volume: 295 start-page: 7799 year: 2020 ident: 1295_CR48 publication-title: J Biol Chem doi: 10.1074/jbc.REV119.008907 – year: 2020 ident: 1295_CR42 publication-title: Arch Pharm Res doi: 10.1007/s12272-020-01274-7 – volume: 153 start-page: 4238 year: 2012 ident: 1295_CR9 publication-title: Endocrinology doi: 10.1210/en.2012-1193 – volume: 99 start-page: E2154 year: 2014 ident: 1295_CR19 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2014-1437 – volume: 140 start-page: 26 year: 2017 ident: 1295_CR34 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2017.06.012 – volume: 26 start-page: 2483 year: 2006 ident: 1295_CR11 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000244684.23499.bf – volume: 20 start-page: 39 year: 2009 ident: 1295_CR43 publication-title: Eur Cytokine Netw doi: 10.1684/ecn.2009.0155 – volume: 12 start-page: 593 year: 2010 ident: 1295_CR49 publication-title: Cell Metab doi: 10.1016/j.cmet.2010.11.011 – volume: 444 start-page: 840 year: 2006 ident: 1295_CR21 publication-title: Nature doi: 10.1038/nature05482 – volume: 234 start-page: 560 year: 2014 ident: 1295_CR15 publication-title: J Pathol doi: 10.1002/path.4420 – volume: 130 start-page: 667 year: 2016 ident: 1295_CR5 publication-title: Clin Sci (Lond) doi: 10.1042/cs20150622 – volume: 36 start-page: 208 year: 2013 ident: 1295_CR32 publication-title: Arch Pharm Res doi: 10.1007/s12272-013-0023-8 – volume: 90 start-page: 1226 year: 1992 ident: 1295_CR54 publication-title: J Clin Investig doi: 10.1172/jci115984 – volume: 280 start-page: 2228 year: 2013 ident: 1295_CR50 publication-title: FEBS J doi: 10.1111/febs.12161 – volume: 187 start-page: 107775 year: 2019 ident: 1295_CR10 publication-title: Exp Eye Res doi: 10.1016/j.exer.2019.107775 – volume: 60 start-page: 349 year: 2001 ident: 1295_CR8 publication-title: Proc Nutr Soc doi: 10.1079/pns2001110 – volume: 54 start-page: 2423 year: 2013 ident: 1295_CR14 publication-title: J Lipid Res doi: 10.1194/jlr.M038638 – volume: 2 start-page: Reviews3005 year: 2001 ident: 1295_CR40 publication-title: Genome Biol doi: 10.1186/gb-2001-2-3-reviews3005 – volume: 60 start-page: 284 year: 2011 ident: 1295_CR60 publication-title: Metabolism doi: 10.1016/j.metabol.2010.02.003 – volume: 109 start-page: 737 year: 2010 ident: 1295_CR58 publication-title: J Cell Biochem doi: 10.1002/jcb.22452 – volume: 15 start-page: 277 year: 2014 ident: 1295_CR28 publication-title: Rev Endocr Metab Disord doi: 10.1007/s11154-014-9301-0 – volume: 26 start-page: 193 year: 2015 ident: 1295_CR16 publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2015.01.006 – volume: 81 start-page: 4446 year: 1996 ident: 1295_CR61 publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.81.12.8954057 – volume: 36 start-page: 6668 year: 2017 ident: 1295_CR4 publication-title: Oncogene doi: 10.1038/onc.2017.278 – volume: 6 start-page: 19868 year: 2016 ident: 1295_CR17 publication-title: Sci Rep doi: 10.1038/srep19868 – volume: 387 start-page: 1377 year: 2016 ident: 1295_CR36 publication-title: Lancet doi: 10.1016/s0140-6736(16)30054-x – volume: 7 start-page: 113 year: 2018 ident: 1295_CR1 publication-title: Adipocyte doi: 10.1080/21623945.2018.1445889 – volume: 4 start-page: 71 year: 2013 ident: 1295_CR30 publication-title: Front Endocrinol (Lausanne) doi: 10.3389/fendo.2013.00071 – volume: 74 start-page: 732 year: 2008 ident: 1295_CR57 publication-title: Kidney Int doi: 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Snippet	Chronic inflammation in adipose tissue is the hallmark of obesity and a major risk factor for the development of obesity-induced insulin resistance. NLRP3...
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SubjectTerms	adipocytes adipokines adipose tissue epididymis exercise fibroblast growth factor 2 fibroblasts high fat diet inflammasomes inflammation insulin resistance interleukin-18 Medicine metabolism obesity Pharmacology/Toxicology Pharmacy Research Article risk factors secretion
Title	Fibroblast growth factor 2 exacerbates inflammation in adipocytes through NLRP3 inflammasome activation
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