Diagnostic ability of salivary matrix metalloproteinase‐9 lateral flow test point‐of‐care test for periodontitis
Aim This cross‐sectional study aimed to examine the diagnostic ability of salivary matrix metalloproteinase (MMP)‐9 lateral flow test (LFT) point‐of‐care (POC) kit and develop an algorithm for diagnosis of periodontitis. Materials and Methods Through Seoul National Dental Hospital, 137 participants...
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| Published in | Journal of clinical periodontology Vol. 47; no. 11; pp. 1354 - 1361 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.11.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0303-6979 1600-051X 1600-051X |
| DOI | 10.1111/jcpe.13360 |
Cover
| Abstract | Aim
This cross‐sectional study aimed to examine the diagnostic ability of salivary matrix metalloproteinase (MMP)‐9 lateral flow test (LFT) point‐of‐care (POC) kit and develop an algorithm for diagnosis of periodontitis.
Materials and Methods
Through Seoul National Dental Hospital, 137 participants (46 LFT negatives, 91 LFT positives) were recruited. For salivary diagnostics, 150 μl of the unstimulated saliva was applied to LFT‐POC kit. To make a diagnosis of periodontitis, stage II‐IV in modified new international classification system was used. Covariates encompassing age, sex, smoking and obesity were evaluated through face‐to‐face interview. Enzyme‐linked immunosorbent assay was used for quantification of salivary MMP‐9. To develop a diagnostic algorithm, multivariable logistic regression analysis was used. Receiver operating characteristic curve was applied for evaluating diagnostic ability.
Results
Diagnostic ability of salivary MMP‐9 LFT‐POC test was 0.82 (sensitivity of 0.92, specificity of 0.72) in total participants. Diagnostic algorithm using POC test resulted in a response equation, that is algorithm score = −3.675 + 2.877*LFT + 0.034*age + 0.121*sex + 0.372*smoking + 0.192*obesity. Diagnostic ability of the algorithm was 0.88 (sensitivity of 0.92, specificity of 0.85) with cut‐off score of 0.589.
Conclusions
Salivary MMP‐9 LFT‐POC kit showed appropriate diagnostic ability for periodontitis and would be an efficient tool for screening of periodontitis. |
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| AbstractList | AimThis cross‐sectional study aimed to examine the diagnostic ability of salivary matrix metalloproteinase (MMP)‐9 lateral flow test (LFT) point‐of‐care (POC) kit and develop an algorithm for diagnosis of periodontitis.Materials and MethodsThrough Seoul National Dental Hospital, 137 participants (46 LFT negatives, 91 LFT positives) were recruited. For salivary diagnostics, 150 μl of the unstimulated saliva was applied to LFT‐POC kit. To make a diagnosis of periodontitis, stage II‐IV in modified new international classification system was used. Covariates encompassing age, sex, smoking and obesity were evaluated through face‐to‐face interview. Enzyme‐linked immunosorbent assay was used for quantification of salivary MMP‐9. To develop a diagnostic algorithm, multivariable logistic regression analysis was used. Receiver operating characteristic curve was applied for evaluating diagnostic ability.ResultsDiagnostic ability of salivary MMP‐9 LFT‐POC test was 0.82 (sensitivity of 0.92, specificity of 0.72) in total participants. Diagnostic algorithm using POC test resulted in a response equation, that is algorithm score = −3.675 + 2.877*LFT + 0.034*age + 0.121*sex + 0.372*smoking + 0.192*obesity. Diagnostic ability of the algorithm was 0.88 (sensitivity of 0.92, specificity of 0.85) with cut‐off score of 0.589.ConclusionsSalivary MMP‐9 LFT‐POC kit showed appropriate diagnostic ability for periodontitis and would be an efficient tool for screening of periodontitis. Aim This cross‐sectional study aimed to examine the diagnostic ability of salivary matrix metalloproteinase (MMP)‐9 lateral flow test (LFT) point‐of‐care (POC) kit and develop an algorithm for diagnosis of periodontitis. Materials and Methods Through Seoul National Dental Hospital, 137 participants (46 LFT negatives, 91 LFT positives) were recruited. For salivary diagnostics, 150 μl of the unstimulated saliva was applied to LFT‐POC kit. To make a diagnosis of periodontitis, stage II‐IV in modified new international classification system was used. Covariates encompassing age, sex, smoking and obesity were evaluated through face‐to‐face interview. Enzyme‐linked immunosorbent assay was used for quantification of salivary MMP‐9. To develop a diagnostic algorithm, multivariable logistic regression analysis was used. Receiver operating characteristic curve was applied for evaluating diagnostic ability. Results Diagnostic ability of salivary MMP‐9 LFT‐POC test was 0.82 (sensitivity of 0.92, specificity of 0.72) in total participants. Diagnostic algorithm using POC test resulted in a response equation, that is algorithm score = −3.675 + 2.877*LFT + 0.034*age + 0.121*sex + 0.372*smoking + 0.192*obesity. Diagnostic ability of the algorithm was 0.88 (sensitivity of 0.92, specificity of 0.85) with cut‐off score of 0.589. Conclusions Salivary MMP‐9 LFT‐POC kit showed appropriate diagnostic ability for periodontitis and would be an efficient tool for screening of periodontitis. This cross-sectional study aimed to examine the diagnostic ability of salivary matrix metalloproteinase (MMP)-9 lateral flow test (LFT) point-of-care (POC) kit and develop an algorithm for diagnosis of periodontitis. Through Seoul National Dental Hospital, 137 participants (46 LFT negatives, 91 LFT positives) were recruited. For salivary diagnostics, 150 μl of the unstimulated saliva was applied to LFT-POC kit. To make a diagnosis of periodontitis, stage II-IV in modified new international classification system was used. Covariates encompassing age, sex, smoking and obesity were evaluated through face-to-face interview. Enzyme-linked immunosorbent assay was used for quantification of salivary MMP-9. To develop a diagnostic algorithm, multivariable logistic regression analysis was used. Receiver operating characteristic curve was applied for evaluating diagnostic ability. Diagnostic ability of salivary MMP-9 LFT-POC test was 0.82 (sensitivity of 0.92, specificity of 0.72) in total participants. Diagnostic algorithm using POC test resulted in a response equation, that is algorithm score = -3.675 + 2.877*LFT + 0.034*age + 0.121*sex + 0.372*smoking + 0.192*obesity. Diagnostic ability of the algorithm was 0.88 (sensitivity of 0.92, specificity of 0.85) with cut-off score of 0.589. Salivary MMP-9 LFT-POC kit showed appropriate diagnostic ability for periodontitis and would be an efficient tool for screening of periodontitis. This cross-sectional study aimed to examine the diagnostic ability of salivary matrix metalloproteinase (MMP)-9 lateral flow test (LFT) point-of-care (POC) kit and develop an algorithm for diagnosis of periodontitis.AIMThis cross-sectional study aimed to examine the diagnostic ability of salivary matrix metalloproteinase (MMP)-9 lateral flow test (LFT) point-of-care (POC) kit and develop an algorithm for diagnosis of periodontitis.Through Seoul National Dental Hospital, 137 participants (46 LFT negatives, 91 LFT positives) were recruited. For salivary diagnostics, 150 μl of the unstimulated saliva was applied to LFT-POC kit. To make a diagnosis of periodontitis, stage II-IV in modified new international classification system was used. Covariates encompassing age, sex, smoking and obesity were evaluated through face-to-face interview. Enzyme-linked immunosorbent assay was used for quantification of salivary MMP-9. To develop a diagnostic algorithm, multivariable logistic regression analysis was used. Receiver operating characteristic curve was applied for evaluating diagnostic ability.MATERIALS AND METHODSThrough Seoul National Dental Hospital, 137 participants (46 LFT negatives, 91 LFT positives) were recruited. For salivary diagnostics, 150 μl of the unstimulated saliva was applied to LFT-POC kit. To make a diagnosis of periodontitis, stage II-IV in modified new international classification system was used. Covariates encompassing age, sex, smoking and obesity were evaluated through face-to-face interview. Enzyme-linked immunosorbent assay was used for quantification of salivary MMP-9. To develop a diagnostic algorithm, multivariable logistic regression analysis was used. Receiver operating characteristic curve was applied for evaluating diagnostic ability.Diagnostic ability of salivary MMP-9 LFT-POC test was 0.82 (sensitivity of 0.92, specificity of 0.72) in total participants. Diagnostic algorithm using POC test resulted in a response equation, that is algorithm score = -3.675 + 2.877*LFT + 0.034*age + 0.121*sex + 0.372*smoking + 0.192*obesity. Diagnostic ability of the algorithm was 0.88 (sensitivity of 0.92, specificity of 0.85) with cut-off score of 0.589.RESULTSDiagnostic ability of salivary MMP-9 LFT-POC test was 0.82 (sensitivity of 0.92, specificity of 0.72) in total participants. Diagnostic algorithm using POC test resulted in a response equation, that is algorithm score = -3.675 + 2.877*LFT + 0.034*age + 0.121*sex + 0.372*smoking + 0.192*obesity. Diagnostic ability of the algorithm was 0.88 (sensitivity of 0.92, specificity of 0.85) with cut-off score of 0.589.Salivary MMP-9 LFT-POC kit showed appropriate diagnostic ability for periodontitis and would be an efficient tool for screening of periodontitis.CONCLUSIONSSalivary MMP-9 LFT-POC kit showed appropriate diagnostic ability for periodontitis and would be an efficient tool for screening of periodontitis. |
| Author | Kim, ByungGee Kim, Hyun‐Duck Lee, Chang‐Soo Vu, Huong Cho, Hyun‐Jae Jeon, Sumin Jeong, Hee‐Jin Kim, SungTae Kim, DanHee Choi, Young‐Nim Jin Lee, Hyun |
| Author_xml | – sequence: 1 givenname: Hyun‐Duck orcidid: 0000-0003-3905-6952 surname: Kim fullname: Kim, Hyun‐Duck email: hyundkim@snu.ac.kr organization: Seoul National University – sequence: 2 givenname: Chang‐Soo surname: Lee fullname: Lee, Chang‐Soo organization: Chungnam National University – sequence: 3 givenname: Hyun‐Jae orcidid: 0000-0002-3079-8629 surname: Cho fullname: Cho, Hyun‐Jae organization: Seoul National University – sequence: 4 givenname: Sumin surname: Jeon fullname: Jeon, Sumin organization: Seoul National University – sequence: 5 givenname: Young‐Nim orcidid: 0000-0002-6496-5560 surname: Choi fullname: Choi, Young‐Nim organization: Seoul National University – sequence: 6 givenname: SungTae surname: Kim fullname: Kim, SungTae organization: Seoul National University Dental Hospital – sequence: 7 givenname: DanHee surname: Kim fullname: Kim, DanHee organization: Seoul National University – sequence: 8 givenname: Hyun surname: Jin Lee fullname: Jin Lee, Hyun organization: Seoul National University – sequence: 9 givenname: Huong surname: Vu fullname: Vu, Huong organization: Seoul National University – sequence: 10 givenname: Hee‐Jin surname: Jeong fullname: Jeong, Hee‐Jin organization: HongIk University – sequence: 11 givenname: ByungGee surname: Kim fullname: Kim, ByungGee organization: Seoul National University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32841379$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.14219/jada.archive.2006.0181 10.1007/s00784-017-2132-0 10.1016/S0140-6736(03)15268-3 10.1111/j.1600-0757.2008.00288.x 10.1177/003591576505800503 10.1177/154405910408300214 10.1038/nrdp.2017.38 10.1016/S0021-9258(19)50563-4 10.1046/j.0906-6713.2002.003421.x 10.1016/j.diagmicrobio.2019.114871 10.1155/2018/1306396 10.1161/01.RES.77.5.863 10.3390/diagnostics8040074 10.1038/sj.ebd.6401037 10.5051/jpis.2018.48.4.251 10.1111/jre.12392 10.1002/JPER.18-0006 10.1007/978-3-319-53737-5_5 10.1111/jcpe.12607 10.1038/nrdp.2017.69 10.1111/j.1601-0825.2004.01038.x 10.1902/jop.2014.140061 10.1074/jbc.270.11.6351 10.1111/odi.12521 10.1016/j.diagmicrobio.2019.05.006 10.1080/10409230290771546 |
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| References | 2004; 10 2004; 363 2017; 52 2018; 8 2002; 37 2018; 2018 2004; 83 2017; 3 2019; 95 1965; 58 2009; 50 1992; 267 2004; 34 1995; 77 2016; 43 2014; 15 2018 2014; 85 2018; 89 2006; 137 2018; 22 2018; 48 1995; 270 2016; 22 e_1_2_8_24_1 e_1_2_8_25_1 e_1_2_8_26_1 Shapiro S. D. (e_1_2_8_21_1) 1995; 270 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_22_1 e_1_2_8_23_1 WHO, E. C. (e_1_2_8_27_1) 2004; 363 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_15_1 e_1_2_8_16_1 Ogata Y. (e_1_2_8_14_1) 1992; 267 Hill A. B. (e_1_2_8_7_1) 1965; 58 e_1_2_8_10_1 e_1_2_8_11_1 e_1_2_8_12_1 |
| References_xml | – volume: 22 start-page: 681 issue: 7 year: 2016 end-page: 687 article-title: Rapid assessment of salivary MMP‐8 and periodontal disease using lateral flow immunoassay publication-title: Oral Diseases – volume: 8 start-page: 74 issue: 4 year: 2018 article-title: Point‐of‐Care/Chairside aMMP‐8 analytics of periodontal diseases’ activity and episodic progression publication-title: Diagnostics – volume: 50 start-page: 52 issue: 1 year: 2009 end-page: 64 article-title: Saliva as a diagnostic tool for periodontal disease: Current state and future directions publication-title: Periodontology 2000 – volume: 85 start-page: 1676 issue: 12 year: 2014 end-page: 1683 article-title: Validation of periodontitis screening model using sociodemographic, systemic, and molecular information in a korean population publication-title: Journal of Periodontology – volume: 89 start-page: S159 year: 2018 end-page: S172 article-title: Staging and grading of periodontitis: Framework and proposal of a new classification and case definition publication-title: Journal of Periodontology – volume: 2018 start-page: 1 year: 2018 end-page: 5 article-title: The ability of quantitative, specific, and sensitive point‐of‐care/chair‐side oral fluid immunotests for aMMP‐8 to detect periodontal and peri‐implant diseases publication-title: Disease Markers – volume: 3 start-page: 17038 year: 2017 article-title: Periodontal diseases publication-title: Nature Reviews Disease Primers – volume: 267 start-page: 3581 issue: 6 year: 1992 end-page: 3584 article-title: Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9 publication-title: Journal of Biological Chemistry – volume: 48 start-page: 251 issue: 4 year: 2018 end-page: 260 article-title: Association of chairside salivary aMMP‐8 findings with periodontal risk assessment parameters in patients receiving supportive periodontal therapy publication-title: Journal of Periodontal & Implant Science – volume: 95 start-page: 179 issue: 2 year: 2019 end-page: 184 article-title: Associations of chairside salivary aMMP‐8 findings with periodontal parameters, potentially periodontal pathogenic bacteria and selected blood parameters in systemically healthy adults publication-title: Diagnostic Microbiology and Infectious Disease – volume: 15 start-page: 70 issue: 3 year: 2014 end-page: 71 article-title: Review finds that severe periodontitis affects 11% of the world population publication-title: Evidence‐Based Dentistry – volume: 83 start-page: 156 issue: 2 year: 2004 end-page: 160 article-title: Periodontitis and systemic inflammation: Control of the local infection is associated with a reduction in serum inflammatory markers publication-title: Journal of Dental Research – volume: 34 start-page: 9 issue: 1 year: 2004 end-page: 21 article-title: Periodontal diagnoses and classification of periodontal diseases publication-title: Periodontology 2000 – volume: 43 start-page: 1032 issue: 12 year: 2016 end-page: 1040 article-title: Incipient periodontitis and salivary molecules among Korean adults: Association and screening ability publication-title: Journal of Clinical Periodontology – volume: 10 start-page: 311 issue: 6 year: 2004 end-page: 318 article-title: Matrix metalloproteinases (MMPs) in oral diseases publication-title: Oral Diseases – volume: 363 start-page: 157 issue: 9403 year: 2004 article-title: Appropriate body‐mass index for Asian populations and its implications for policy and intervention strategies publication-title: Lancet (London, England) – volume: 270 start-page: 6351 issue: 11 year: 1995 end-page: 6356 article-title: Activation of the 92‐kDa Gelatinase by Stromelysin and 4‐Aminophenylmercuric Acetate. Differential processing and stabilization of the carboxyl‐terminal domain by tissue inhibitor of metalloproteinases (TIMP) publication-title: Journal of Biological Chemistry – volume: 95 start-page: 114871 issue: 4 year: 2019 article-title: On the diagnostic discrimination ability of mouthrinse and salivary aMMP‐8 point‐of‐care testing regarding periodontal health and disease publication-title: Diagnostic Microbiology and Infectious Disease – volume: 22 start-page: 449 issue: 1 year: 2018 end-page: 460 article-title: aMMP‐8 in correlation to caries and periodontal condition in adolescents—results of the epidemiologic LIFE child study publication-title: Clinical Oral Investigations – start-page: 51 year: 2018 end-page: 57 – volume: 3 start-page: 1 issue: 1 year: 2017 article-title: A quantitative point‐of‐care test for periodontal and dental peri‐implant diseases publication-title: Nature Reviews Disease Primers – volume: 77 start-page: 863 issue: 5 year: 1995 end-page: 868 article-title: Matrix metalloproteinases and cardiovascular disease publication-title: Circulation Research – volume: 37 start-page: 375 issue: 6 year: 2002 end-page: 536 article-title: Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase‐9 (MMP‐9) publication-title: Critical Reviews in Biochemistry and Molecular Biology – volume: 137 start-page: 322 issue: 3 year: 2006 end-page: 329 article-title: Salivary biomarkers of existing periodontal disease: A cross‐sectional study publication-title: The Journal of the American Dental Association – volume: 58 start-page: 295 issue: 5 year: 1965 end-page: 300 article-title: The environment and disease: association or causation? publication-title: Journal of the Royal Society of Medicine – volume: 52 start-page: 277 issue: 2 year: 2017 end-page: 284 article-title: Evaluation of a novel point‐of‐care test for active matrix metalloproteinase‐8: Agreement between qualitative and quantitative measurements and relation to periodontal inflammation publication-title: Journal of Periodontal Research – ident: e_1_2_8_13_1 doi: 10.14219/jada.archive.2006.0181 – ident: e_1_2_8_20_1 doi: 10.1007/s00784-017-2132-0 – volume: 363 start-page: 157 issue: 9403 year: 2004 ident: e_1_2_8_27_1 article-title: Appropriate body‐mass index for Asian populations and its implications for policy and intervention strategies publication-title: Lancet (London, England) doi: 10.1016/S0140-6736(03)15268-3 – ident: e_1_2_8_6_1 doi: 10.1111/j.1600-0757.2008.00288.x – volume: 58 start-page: 295 issue: 5 year: 1965 ident: e_1_2_8_7_1 article-title: The environment and disease: association or causation? publication-title: Journal of the Royal Society of Medicine doi: 10.1177/003591576505800503 – ident: e_1_2_8_4_1 doi: 10.1177/154405910408300214 – ident: e_1_2_8_11_1 doi: 10.1038/nrdp.2017.38 – volume: 267 start-page: 3581 issue: 6 year: 1992 ident: e_1_2_8_14_1 article-title: Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9 publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(19)50563-4 – ident: e_1_2_8_3_1 doi: 10.1046/j.0906-6713.2002.003421.x – ident: e_1_2_8_15_1 doi: 10.1016/j.diagmicrobio.2019.114871 – ident: e_1_2_8_2_1 doi: 10.1155/2018/1306396 – ident: e_1_2_8_5_1 doi: 10.1161/01.RES.77.5.863 – ident: e_1_2_8_16_1 doi: 10.3390/diagnostics8040074 – ident: e_1_2_8_17_1 doi: 10.1038/sj.ebd.6401037 – ident: e_1_2_8_19_1 doi: 10.5051/jpis.2018.48.4.251 – ident: e_1_2_8_12_1 doi: 10.1111/jre.12392 – ident: e_1_2_8_25_1 doi: 10.1002/JPER.18-0006 – ident: e_1_2_8_23_1 doi: 10.1007/978-3-319-53737-5_5 – ident: e_1_2_8_9_1 doi: 10.1111/jcpe.12607 – ident: e_1_2_8_22_1 doi: 10.1038/nrdp.2017.69 – ident: e_1_2_8_24_1 doi: 10.1111/j.1601-0825.2004.01038.x – ident: e_1_2_8_10_1 doi: 10.1902/jop.2014.140061 – volume: 270 start-page: 6351 issue: 11 year: 1995 ident: e_1_2_8_21_1 article-title: Activation of the 92‐kDa Gelatinase by Stromelysin and 4‐Aminophenylmercuric Acetate. Differential processing and stabilization of the carboxyl‐terminal domain by tissue inhibitor of metalloproteinases (TIMP) publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.270.11.6351 – ident: e_1_2_8_8_1 doi: 10.1111/odi.12521 – ident: e_1_2_8_18_1 doi: 10.1016/j.diagmicrobio.2019.05.006 – ident: e_1_2_8_26_1 doi: 10.1080/10409230290771546 |
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| Title | Diagnostic ability of salivary matrix metalloproteinase‐9 lateral flow test point‐of‐care test for periodontitis |
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