Anti-obesity effects of agar ( Gelidium amansii )-derived oligosaccharides in high-fat diet-treated C57BL/6N mice due to differential regulations of lipogenesis and lipolysis
To investigate the effects of agar oligosaccharides (AO) on lipid metabolism, changes in obesity phenotypes and related molecular factors were evaluated in C57BL/6N mice fed a high-fat diet (HFD). When HFD-induced obese mice were fed AO, they lost weight. Also, fat accumulation in abdominal and live...
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| Published in | Bioscience, biotechnology, and biochemistry Vol. 86; no. 12; pp. 1648 - 1657 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
23.11.2022
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| Online Access | Get full text |
| ISSN | 1347-6947 1347-6947 |
| DOI | 10.1093/bbb/zbac159 |
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| Abstract | To investigate the effects of agar oligosaccharides (AO) on lipid metabolism, changes in obesity phenotypes and related molecular factors were evaluated in C57BL/6N mice fed a high-fat diet (HFD). When HFD-induced obese mice were fed AO, they lost weight. Also, fat accumulation in abdominal and liver tissues was lower in the AO groups than in the Vehicle group. Lipid droplet sizes in tissue sections were reduced by AO, and these observations were mirrored by serum lipid contents. To evaluate the effects of AO on lipid metabolism, lipogenesis and lipolysis-related factors were analyzed. The mRNA expressions of genes involved in lipogenesis, such as adipocyte-protein 2 (aP2) and fatty acid synthase (FAS), were reduced by AO administration, and the expressions of lipolysis-associated proteins, including perilipin, hormone-sensitive lipase (HSL), and fat triglyceride lipase (ATGL), were increased. Taken together, our results suggest that AO should be considered a valuable natural agent that inhibits obesity. |
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| AbstractList | To investigate the effects of agar oligosaccharides (AO) on lipid metabolism, changes in obesity phenotypes and related molecular factors were evaluated in C57BL/6N mice fed a high-fat diet (HFD). When HFD-induced obese mice were fed AO, they lost weight. Also, fat accumulation in abdominal and liver tissues was lower in the AO groups than in the Vehicle group. Lipid droplet sizes in tissue sections were reduced by AO, and these observations were mirrored by serum lipid contents. To evaluate the effects of AO on lipid metabolism, lipogenesis and lipolysis-related factors were analyzed. The mRNA expressions of genes involved in lipogenesis, such as adipocyte-protein 2 (aP2) and fatty acid synthase (FAS), were reduced by AO administration, and the expressions of lipolysis-associated proteins, including perilipin, hormone-sensitive lipase (HSL), and fat triglyceride lipase (ATGL), were increased. Taken together, our results suggest that AO should be considered a valuable natural agent that inhibits obesity.To investigate the effects of agar oligosaccharides (AO) on lipid metabolism, changes in obesity phenotypes and related molecular factors were evaluated in C57BL/6N mice fed a high-fat diet (HFD). When HFD-induced obese mice were fed AO, they lost weight. Also, fat accumulation in abdominal and liver tissues was lower in the AO groups than in the Vehicle group. Lipid droplet sizes in tissue sections were reduced by AO, and these observations were mirrored by serum lipid contents. To evaluate the effects of AO on lipid metabolism, lipogenesis and lipolysis-related factors were analyzed. The mRNA expressions of genes involved in lipogenesis, such as adipocyte-protein 2 (aP2) and fatty acid synthase (FAS), were reduced by AO administration, and the expressions of lipolysis-associated proteins, including perilipin, hormone-sensitive lipase (HSL), and fat triglyceride lipase (ATGL), were increased. Taken together, our results suggest that AO should be considered a valuable natural agent that inhibits obesity. To investigate the effects of agar oligosaccharides (AO) on lipid metabolism, changes in obesity phenotypes and related molecular factors were evaluated in C57BL/6N mice fed a high-fat diet (HFD). When HFD-induced obese mice were fed AO, they lost weight. Also, fat accumulation in abdominal and liver tissues was lower in the AO groups than in the Vehicle group. Lipid droplet sizes in tissue sections were reduced by AO, and these observations were mirrored by serum lipid contents. To evaluate the effects of AO on lipid metabolism, lipogenesis and lipolysis-related factors were analyzed. The mRNA expressions of genes involved in lipogenesis, such as adipocyte-protein 2 (aP2) and fatty acid synthase (FAS), were reduced by AO administration, and the expressions of lipolysis-associated proteins, including perilipin, hormone-sensitive lipase (HSL), and fat triglyceride lipase (ATGL), were increased. Taken together, our results suggest that AO should be considered a valuable natural agent that inhibits obesity. |
| Author | Hong, Jin Tae Jang, Miran Lee, Mi Rim Jung, Min Wook Jin, You Jeong Song, Hee Jin Roh, Yu Jeong Hwang, Dae Youn Kim, Ji Eun Seol, Ayun |
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| Cites_doi | 10.1042/BCJ20190468 10.1007/s00343-019-8145-6 10.3390/md17090540 10.1016/j.foodres.2021.110408 10.1016/j.carbpol.2017.01.078 10.1111/jfbc.12939 10.1016/j.carbpol.2021.118076 10.1016/j.foodhyd.2020.106220 10.3390/md16060198 10.1016/j.carbpol.2019.115482 10.1016/j.nut.2019.03.001 10.1006/meth.2001.1262 10.3390/molecules23102451 10.1016/j.jff.2022.105141 10.1371/journal.pone.0091106 10.1016/j.lfs.2021.120131 10.1152/ajpgi.00324.2015 10.1016/bs.apha.2019.10.002 10.3389/fendo.2020.563816 10.3746/pnf.2019.24.4.400 10.1002/mnfr.201900922 10.1146/annurev-food-032519-051743 10.3390/nu13020551 10.1016/j.jnutbio.2022.108998 10.1016/j.cmet.2010.02.003 10.3390/molecules25214995 10.1258/002367707779399518 10.3389/fmicb.2020.01352 10.1021/acs.jafc.9b06079 10.3402/fnr.v60.30428 10.1080/10408398.2020.1716207 10.3390/nu11091967 10.1016/j.fshw.2015.08.001 |
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