The Spectrum of IgG4-Related Disease in the Abdomen and Pelvis

IgG4-related disease was not recognized as a specific clinical entity until 2003 when extrapancreatic lesions were reported in patients with autoimmune pancreatitis. IgG4-related disease is characterized by elevated serum IgG4 levels and infiltration of the target organ by IgG4-positive plasma cells...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of roentgenology (1976) Vol. 201; no. 1; pp. 14 - 22
Main Authors Hedgire, Sandeep S., McDermott, Shaunagh, Borczuk, David, Elmi, Azadeh, Saini, Sanjay, Harisinghani, Mukesh G.
Format Journal Article
LanguageEnglish
Published United States 01.07.2013
Subjects
Autoimmune Diseases - blood
Autoimmune Diseases - diagnosis
Autoimmune Diseases - immunology
Diagnostic Imaging
Digestive System Diseases - blood
Digestive System Diseases - diagnosis
Digestive System Diseases - immunology
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Lymphatic Diseases - blood
Lymphatic Diseases - diagnosis
Lymphatic Diseases - immunology
Male
Male Urogenital Diseases - blood
Male Urogenital Diseases - diagnosis
Male Urogenital Diseases - immunology
Online AccessGet full text
ISSN0361-803X
1546-3141
1546-3141
DOI10.2214/AJR.12.9995

Cover

Abstract IgG4-related disease was not recognized as a specific clinical entity until 2003 when extrapancreatic lesions were reported in patients with autoimmune pancreatitis. IgG4-related disease is characterized by elevated serum IgG4 levels and infiltration of the target organ by IgG4-positive plasma cells. The complete gamut of visceral involvement is still being outlined. The purpose of this article is to highlight the plethora of lesions under the spectrum of IgG4-related disease of the abdomen and pelvis, describe their imaging appearances on multimodality cross-sectional imaging, and discuss the differential diagnoses. It is important for radiologists to recognize the multiorgan involvement and few classic features of IgG4-related disease that often tend to simulate malignancy.
AbstractList IgG4-related disease was not recognized as a specific clinical entity until 2003 when extrapancreatic lesions were reported in patients with autoimmune pancreatitis. IgG4-related disease is characterized by elevated serum IgG4 levels and infiltration of the target organ by IgG4-positive plasma cells. The complete gamut of visceral involvement is still being outlined. The purpose of this article is to highlight the plethora of lesions under the spectrum of IgG4-related disease of the abdomen and pelvis, describe their imaging appearances on multimodality cross-sectional imaging, and discuss the differential diagnoses.OBJECTIVEIgG4-related disease was not recognized as a specific clinical entity until 2003 when extrapancreatic lesions were reported in patients with autoimmune pancreatitis. IgG4-related disease is characterized by elevated serum IgG4 levels and infiltration of the target organ by IgG4-positive plasma cells. The complete gamut of visceral involvement is still being outlined. The purpose of this article is to highlight the plethora of lesions under the spectrum of IgG4-related disease of the abdomen and pelvis, describe their imaging appearances on multimodality cross-sectional imaging, and discuss the differential diagnoses.It is important for radiologists to recognize the multiorgan involvement and few classic features of IgG4-related disease that often tend to simulate malignancy.CONCLUSIONIt is important for radiologists to recognize the multiorgan involvement and few classic features of IgG4-related disease that often tend to simulate malignancy.
IgG4-related disease was not recognized as a specific clinical entity until 2003 when extrapancreatic lesions were reported in patients with autoimmune pancreatitis. IgG4-related disease is characterized by elevated serum IgG4 levels and infiltration of the target organ by IgG4-positive plasma cells. The complete gamut of visceral involvement is still being outlined. The purpose of this article is to highlight the plethora of lesions under the spectrum of IgG4-related disease of the abdomen and pelvis, describe their imaging appearances on multimodality cross-sectional imaging, and discuss the differential diagnoses. It is important for radiologists to recognize the multiorgan involvement and few classic features of IgG4-related disease that often tend to simulate malignancy.
Author Elmi, Azadeh
McDermott, Shaunagh
Saini, Sanjay
Harisinghani, Mukesh G.
Borczuk, David
Hedgire, Sandeep S.
Author_xml – sequence: 1
  givenname: Sandeep S.
  surname: Hedgire
  fullname: Hedgire, Sandeep S.
  organization: All authors: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114
– sequence: 2
  givenname: Shaunagh
  surname: McDermott
  fullname: McDermott, Shaunagh
  organization: All authors: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114
– sequence: 3
  givenname: David
  surname: Borczuk
  fullname: Borczuk, David
  organization: All authors: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114
– sequence: 4
  givenname: Azadeh
  surname: Elmi
  fullname: Elmi, Azadeh
  organization: All authors: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114
– sequence: 5
  givenname: Sanjay
  surname: Saini
  fullname: Saini, Sanjay
  organization: All authors: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114
– sequence: 6
  givenname: Mukesh G.
  surname: Harisinghani
  fullname: Harisinghani, Mukesh G.
  organization: All authors: Department of Abdominal Imaging and Intervention, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23789654$$D View this record in MEDLINE/PubMed
BookMark eNptkEtLAzEUhYNU7ENX7iVLQabmMZnMbIRStVYKSq3gLmQytxqZR51kBP-9KW034uqexXfPPfcMUa9uakDonJIxYzS-njwux5SNsywTR2hARZxEnMa0hwaEJzRKCX_ro6Fzn4QQmWbyBPUZDyIR8QDdrD4Av2zA-LarcLPG8_dZHC2h1B4KfGsdaAfY1tgHbpIXTQU11nWBn6H8tu4UHa916eBsP0fo9f5uNX2IFk-z-XSyiAwXwocMkodzWSJTUfBU8syEBCbRoFNKJItz4EbSmBU0XQttdJCMZpqbPJEMGB-hy53vpm2-OnBeVdYZKEtdQ9M5RbmkLKCCBPRij3Z5BYXatLbS7Y86_BwAugNM2zjXwloZ67W3Te1bbUtFidr2qkKvijK17TXsXP3ZOdj-R_8CyOd0pA
CitedBy_id crossref_primary_10_1097_RLU_0000000000002214
crossref_primary_10_1093_rheumatology_kev203
crossref_primary_10_3348_jksr_2020_0025
crossref_primary_10_1148_rg_220097
crossref_primary_10_1590_0100_3984_2013_1911
crossref_primary_10_1007_s00261_016_0903_8
crossref_primary_10_1093_rheumatology_kez280
crossref_primary_10_1186_s13244_021_01046_x
crossref_primary_10_1007_s00261_023_03996_w
crossref_primary_10_2214_AJR_19_22192
crossref_primary_10_1016_j_radcr_2024_06_053
crossref_primary_10_1007_s00261_019_01946_z
crossref_primary_10_1007_s00261_019_02085_1
crossref_primary_10_1007_s00261_020_02526_2
crossref_primary_10_1016_j_clinimag_2015_04_017
crossref_primary_10_1093_rheumatology_keaa411
crossref_primary_10_33590_emj_ZUOR9664
crossref_primary_10_1038_s41598_020_79899_3
crossref_primary_10_1186_s13550_017_0268_1
crossref_primary_10_1053_j_tvir_2015_07_001
crossref_primary_10_1186_s13075_021_02489_9
crossref_primary_10_3348_jksr_2019_80_2_351
crossref_primary_10_1111_1754_9485_12511
crossref_primary_10_1016_j_gore_2023_101137
crossref_primary_10_1186_s13244_019_0813_8
crossref_primary_10_1097_MD_0000000000016934
crossref_primary_10_1111_nep_12345
crossref_primary_10_1148_rg_210168
crossref_primary_10_1007_s00261_024_04638_5
crossref_primary_10_1259_bjr_20210105
crossref_primary_10_1259_bjr_20190448
crossref_primary_10_1186_s43055_020_00391_z
crossref_primary_10_3348_kjr_2015_16_5_1056
crossref_primary_10_1148_rg_2016150213
crossref_primary_10_1097_RLU_0000000000002140
Cites_doi 10.1038/nrgastro.2010.81
10.1038/ki.2011.357
10.1056/NEJMcpc0902221
10.1002/acr.20215
10.1016/j.humpath.2010.03.011
10.1111/j.1440-1827.2009.02456.x
10.2214/AJR.08.2297
10.1007/s11604-011-0047-2
10.1002/art.24798
10.1111/j.1440-1827.2007.02199.x
10.1097/BOR.0b013e3283418057
10.1159/000078433
10.1007/s00535-006-1908-9
10.1007/s00428-004-1140-z
10.3349/ymj.2012.53.1.15
10.1038/modpathol.3800836
10.1148/rg.315105735
10.1097/PAS.0b013e3181342f0d
10.1016/j.cgh.2007.02.032
10.1097/PAS.0b013e318157c068
10.1148/rg.294085748
10.1002/ibd.20898
10.1016/S0140-6736(06)68035-5
10.4076/1757-1626-2-7029
10.1097/01.mpa.0000179732.46210.da
10.1007/s00535-003-1175-y
10.2214/ajr.172.3.10063848
10.1038/modpathol.2010.226
10.1097/PAP.0b013e3181ee63ce
10.1097/BOR.0b013e32833ee95f
10.1097/MPA.0b013e318233bec5
10.1056/NEJMra1104650
10.1016/S0016-5107(04)02229-1
10.1097/00000478-200308000-00009
10.1097/01.pas.0000136449.37936.6c
10.1016/j.jvs.2008.11.072
10.2169/internalmedicine.46.6430
10.1097/MNH.0b013e32835265ac
10.1007/s00795-008-0425-8
10.2214/AJR.08.1883
10.1148/radiol.2423060003
10.1038/ajg.2010.87
10.2169/internalmedicine.46.0452
10.1136/gut.2007.122283
ContentType Journal Article
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.2214/AJR.12.9995
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1546-3141
EndPage 22
ExternalDocumentID 23789654
10_2214_AJR_12_9995
Genre Journal Article
Review
GroupedDBID ---
-DD
.55
.GJ
1CY
1KJ
23M
2WC
34G
39C
3O-
53G
5GY
5RE
AAEJM
AAWTL
AAYXX
ABOCM
ADBBV
AENEX
AFFNX
AI.
AJJEV
ALMA_UNASSIGNED_HOLDINGS
BAWUL
C1A
CITATION
CS3
DIK
E3Z
EBS
EJD
F5P
GX1
H13
J5H
L7B
LSO
MJL
P2P
SJN
TR2
TRR
TWZ
UDS
VH1
W2D
W8F
WH7
WOQ
X7M
YJK
YQI
YQJ
ZGI
ZVN
ZXP
ACRZS
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ID FETCH-LOGICAL-c355t-807365496785d38739c378c6aea810724be3c7142d18f5aca142219a3cb672e23
ISSN 0361-803X
1546-3141
IngestDate Fri Jul 11 08:38:00 EDT 2025
Thu Apr 03 06:59:43 EDT 2025
Thu Apr 24 23:14:54 EDT 2025
Tue Jul 01 01:45:48 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c355t-807365496785d38739c378c6aea810724be3c7142d18f5aca142219a3cb672e23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
PMID 23789654
PQID 1371267250
PQPubID 23479
PageCount 9
ParticipantIDs proquest_miscellaneous_1371267250
pubmed_primary_23789654
crossref_citationtrail_10_2214_AJR_12_9995
crossref_primary_10_2214_AJR_12_9995
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2013-07-00
2013-Jul
20130701
PublicationDateYYYYMMDD 2013-07-01
PublicationDate_xml – month: 07
  year: 2013
  text: 2013-07-00
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle American journal of roentgenology (1976)
PublicationTitleAlternate AJR Am J Roentgenol
PublicationYear 2013
References Zhang L (R6) 2010; 3
R41
Anderson SW (R23) 2009; 29
R40
R21
R43
R20
R42
R45
R22
R44
R25
R24
R46
R27
R26
R29
R28
R1
R2
R3
R4
R5
R7
R8
R9
R30
R10
R32
R31
R12
R34
R11
R33
R14
R36
R13
R35
R16
R38
R15
R37
R18
R17
R39
R19
References_xml – ident: R2
  doi: 10.1038/nrgastro.2010.81
– volume: 29
  start-page: 211
  year: 2009
  ident: R23
  publication-title: Radio-Graphics
– ident: R32
  doi: 10.1038/ki.2011.357
– ident: R3
  doi: 10.1056/NEJMcpc0902221
– ident: R5
  doi: 10.1002/acr.20215
– ident: R28
  doi: 10.1016/j.humpath.2010.03.011
– ident: R45
  doi: 10.1111/j.1440-1827.2009.02456.x
– ident: R14
  doi: 10.2214/AJR.08.2297
– ident: R16
  doi: 10.1007/s11604-011-0047-2
– ident: R4
  doi: 10.1002/art.24798
– ident: R30
  doi: 10.1111/j.1440-1827.2007.02199.x
– ident: R7
  doi: 10.1097/BOR.0b013e3283418057
– ident: R8
  doi: 10.1159/000078433
– ident: R41
  doi: 10.1007/s00535-006-1908-9
– ident: R44
  doi: 10.1007/s00428-004-1140-z
– ident: R9
  doi: 10.3349/ymj.2012.53.1.15
– ident: R21
  doi: 10.1038/modpathol.3800836
– ident: R17
  doi: 10.1148/rg.315105735
– ident: R36
  doi: 10.1097/PAS.0b013e3181342f0d
– ident: R39
  doi: 10.1016/j.cgh.2007.02.032
– ident: R42
  doi: 10.1097/PAS.0b013e318157c068
– ident: R31
  doi: 10.1148/rg.294085748
– ident: R43
  doi: 10.1002/ibd.20898
– ident: R34
  doi: 10.1016/S0140-6736(06)68035-5
– ident: R22
  doi: 10.4076/1757-1626-2-7029
– ident: R25
  doi: 10.1097/01.mpa.0000179732.46210.da
– ident: R1
  doi: 10.1007/s00535-003-1175-y
– volume: 3
  start-page: 491
  year: 2010
  ident: R6
  publication-title: Int J Clin Exp Pathol
– ident: R40
  doi: 10.2214/ajr.172.3.10063848
– ident: R46
  doi: 10.1038/modpathol.2010.226
– ident: R15
  doi: 10.1097/PAP.0b013e3181ee63ce
– ident: R38
  doi: 10.1097/BOR.0b013e32833ee95f
– ident: R10
  doi: 10.1097/MPA.0b013e318233bec5
– ident: R35
  doi: 10.1056/NEJMra1104650
– ident: R20
  doi: 10.1016/S0016-5107(04)02229-1
– ident: R11
  doi: 10.1097/00000478-200308000-00009
– ident: R18
  doi: 10.1097/01.pas.0000136449.37936.6c
– ident: R37
  doi: 10.1016/j.jvs.2008.11.072
– ident: R24
  doi: 10.2169/internalmedicine.46.6430
– ident: R26
  doi: 10.1097/MNH.0b013e32835265ac
– ident: R27
  doi: 10.1007/s00795-008-0425-8
– ident: R12
  doi: 10.2214/AJR.08.1883
– ident: R29
  doi: 10.1148/radiol.2423060003
– ident: R13
  doi: 10.1038/ajg.2010.87
– ident: R33
  doi: 10.2169/internalmedicine.46.0452
– ident: R19
  doi: 10.1136/gut.2007.122283
SSID ssj0007897
Score 2.2666838
SecondaryResourceType review_article
Snippet IgG4-related disease was not recognized as a specific clinical entity until 2003 when extrapancreatic lesions were reported in patients with autoimmune...
SourceID proquest
pubmed
crossref
SourceType Aggregation Database
Index Database
Enrichment Source
StartPage 14
SubjectTerms Autoimmune Diseases - blood
Autoimmune Diseases - diagnosis
Autoimmune Diseases - immunology
Diagnostic Imaging
Digestive System Diseases - blood
Digestive System Diseases - diagnosis
Digestive System Diseases - immunology
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Lymphatic Diseases - blood
Lymphatic Diseases - diagnosis
Lymphatic Diseases - immunology
Male
Male Urogenital Diseases - blood
Male Urogenital Diseases - diagnosis
Male Urogenital Diseases - immunology
Title The Spectrum of IgG4-Related Disease in the Abdomen and Pelvis
URI https://www.ncbi.nlm.nih.gov/pubmed/23789654
https://www.proquest.com/docview/1371267250
Volume 201
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfKkBAvaHyPATLSnpAy6o_E6QvSYBtlrEOirdS3yHGcbmJLpq7hoX89d7GThqlIg5eoshI3ufvp_Lvz3ZmQPSkykcXhIBDaqEAyq4M4Yyywsi9TFuXcpFjgPDqLhlN5Mgtnvd64k7VULdN9s9pYV_I_WoUx0CtWyf6DZttJYQB-g37hChqG6511XJdKLqqruiZk_kUGdXUK0Ei_9dIkMuo0w2YLrjGAvfx1cdPlpe3GTaeTxKKEBQl7uNZdmrChE5CKTuRgaLO5j2yPMRRtr9dx1JE5BJPvk0HG57oq9LwNPH8qF2ZV_byVUo_5I1d1bsHBSmf2vBuPwLMhVBOP8CZURmDZXTurfbthzNtdvn6qBZizoq6s9LZx55xJbDJx8gMDuEBsw_Ua1uzbn31Pjqenp8nkaDa5R-5zpRjmeR5-_dYuzyp2J-40r-SKNnHyD52p_6Qpf_E9ag4y2SaPvPNADxwSHpOeLZ6QByOfHvGUfARA0AYQtMxpFxDUA4JeFBQAQT0gKKiOOkA8I9Pjo8nnYeAPyAgM0MQlNpIWETj4QDjCTMRKDIxQsYm01TG49VymVhjFJM9YnIfaaAz4sYEWJo0Ut1w8J1tFWdiXhBrgibnNYdnsazDjUgONSzVLcR8b7HR_h7xv5JEY3z0eDzG5TMCLROElILyE8QSFt0P22puvXdOUzbe9awSbgFHDnSpd2LK6SZhQjMMrhvC_L5zE24k4fOIAvvrVHZ7eJQ_XEH1NtkD69g2QyGX6tgbFb1KvbUg
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+spectrum+of+IgG4-related+disease+in+the+abdomen+and+pelvis&rft.jtitle=American+journal+of+roentgenology+%281976%29&rft.au=Hedgire%2C+Sandeep+S&rft.au=McDermott%2C+Shaunagh&rft.au=Borczuk%2C+David&rft.au=Elmi%2C+Azadeh&rft.date=2013-07-01&rft.issn=1546-3141&rft.eissn=1546-3141&rft.volume=201&rft.issue=1&rft.spage=14&rft_id=info:doi/10.2214%2FAJR.12.9995&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0361-803X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0361-803X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0361-803X&client=summon