Investigating associations of childhood abuse and serum brain-derived neurotrophic factor levels with suicidal behaviours in patients with depressive disorders

The role of childhood abuse and serum brain-derived neurotrophic factor (BDNF) levels in suicidal behaviour is controversial. We aimed to investigate the individual and interactive effects of the childhood abuse and serum BDNF on suicidal behaviour before and after pharmacologic treatment in patient...

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Published in	British journal of psychiatry Vol. 219; no. 5; pp. 598 - 605
Main Authors	Kim, Jae-Min, Kim, Ju-Wan, Kang, Hee-Ju, Lee, Ju-Yeon, Kim, Sung-Wan, Shin, Il-Seon, Chun, Byung-Jo, Stewart, Robert
Format	Journal Article
Language	English
Published	Cambridge, UK Cambridge University Press 01.11.2021
Subjects	Alcohol Anxiety Associations Behavior Biomarkers Brain Brain research Brain-Derived Neurotrophic Factor Child Child Abuse Child abuse & neglect Child sexual abuse Childhood Children Depressive Disorder - epidemiology Depressive personality disorders Disorders Drug therapy Emotional abuse General Adult Humans Informed consent Mental depression Mental disorders Patients Pharmacology Psychiatry Psychosis Questionnaires Regression analysis Risk Factors Self destructive behavior Serum Severity Sex crimes Sexual abuse Sociodemographics Suicidal behavior Suicidal Ideation Suicide Suicide, Attempted - psychology Suicides & suicide attempts Trauma interaction Child abuse suicidality brain-derived neurotrophic factor depression
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ISSN	0007-1250 1472-1465 1472-1465
DOI	10.1192/bjp.2021.82

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Abstract	The role of childhood abuse and serum brain-derived neurotrophic factor (BDNF) levels in suicidal behaviour is controversial. We aimed to investigate the individual and interactive effects of the childhood abuse and serum BDNF on suicidal behaviour before and after pharmacologic treatment in patients with depressive disorders. At baseline, reported childhood emotional, physical and sexual abuse were ascertained and serum BDNF levels were measured in 1094 patients with depressive disorder, 884 of whom were followed during a 1-year period of stepwise pharmacotherapy. Suicidal behaviours evaluated at baseline were previous suicide attempt and baseline suicide severity, and suicidal behaviours evaluated at follow-up were increased suicide severity and fatal/non-fatal suicide attempt. Individual and interactive associations of any childhood abuse and serum BDNF levels with four types of suicidal behaviours were analysed using logistic regression models, after adjusting relevant covariates. Individual associations of childhood abuse were significant only with previous suicide attempt, and no significant individual associations were found for serum BDNF with any suicide outcome. However, the presence of both childhood abuse and lower serum BDNF levels was associated with the highest prevalence/incidence of all four suicidal behaviours, with significant interactions for baseline suicide severity and fatal/non-fatal suicide attempt during follow-up. Synergistic interactive effects of child abuse and serum BDNF levels on suicidal behaviours were found before and after pharmacologic treatment in patients with depressive disorders. Information combining childhood abuse and serum BDNF levels could improve predictions of suicidal behaviour in patients with depressive disorders.
AbstractList	The role of childhood abuse and serum brain-derived neurotrophic factor (BDNF) levels in suicidal behaviour is controversial.BACKGROUNDThe role of childhood abuse and serum brain-derived neurotrophic factor (BDNF) levels in suicidal behaviour is controversial.We aimed to investigate the individual and interactive effects of the childhood abuse and serum BDNF on suicidal behaviour before and after pharmacologic treatment in patients with depressive disorders.AIMSWe aimed to investigate the individual and interactive effects of the childhood abuse and serum BDNF on suicidal behaviour before and after pharmacologic treatment in patients with depressive disorders.At baseline, reported childhood emotional, physical and sexual abuse were ascertained and serum BDNF levels were measured in 1094 patients with depressive disorder, 884 of whom were followed during a 1-year period of stepwise pharmacotherapy. Suicidal behaviours evaluated at baseline were previous suicide attempt and baseline suicide severity, and suicidal behaviours evaluated at follow-up were increased suicide severity and fatal/non-fatal suicide attempt. Individual and interactive associations of any childhood abuse and serum BDNF levels with four types of suicidal behaviours were analysed using logistic regression models, after adjusting relevant covariates.METHODAt baseline, reported childhood emotional, physical and sexual abuse were ascertained and serum BDNF levels were measured in 1094 patients with depressive disorder, 884 of whom were followed during a 1-year period of stepwise pharmacotherapy. Suicidal behaviours evaluated at baseline were previous suicide attempt and baseline suicide severity, and suicidal behaviours evaluated at follow-up were increased suicide severity and fatal/non-fatal suicide attempt. Individual and interactive associations of any childhood abuse and serum BDNF levels with four types of suicidal behaviours were analysed using logistic regression models, after adjusting relevant covariates.Individual associations of childhood abuse were significant only with previous suicide attempt, and no significant individual associations were found for serum BDNF with any suicide outcome. However, the presence of both childhood abuse and lower serum BDNF levels was associated with the highest prevalence/incidence of all four suicidal behaviours, with significant interactions for baseline suicide severity and fatal/non-fatal suicide attempt during follow-up.RESULTSIndividual associations of childhood abuse were significant only with previous suicide attempt, and no significant individual associations were found for serum BDNF with any suicide outcome. However, the presence of both childhood abuse and lower serum BDNF levels was associated with the highest prevalence/incidence of all four suicidal behaviours, with significant interactions for baseline suicide severity and fatal/non-fatal suicide attempt during follow-up.Synergistic interactive effects of child abuse and serum BDNF levels on suicidal behaviours were found before and after pharmacologic treatment in patients with depressive disorders. Information combining childhood abuse and serum BDNF levels could improve predictions of suicidal behaviour in patients with depressive disorders.CONCLUSIONSSynergistic interactive effects of child abuse and serum BDNF levels on suicidal behaviours were found before and after pharmacologic treatment in patients with depressive disorders. Information combining childhood abuse and serum BDNF levels could improve predictions of suicidal behaviour in patients with depressive disorders. The role of childhood abuse and serum brain-derived neurotrophic factor (BDNF) levels in suicidal behaviour is controversial. We aimed to investigate the individual and interactive effects of the childhood abuse and serum BDNF on suicidal behaviour before and after pharmacologic treatment in patients with depressive disorders. At baseline, reported childhood emotional, physical and sexual abuse were ascertained and serum BDNF levels were measured in 1094 patients with depressive disorder, 884 of whom were followed during a 1-year period of stepwise pharmacotherapy. Suicidal behaviours evaluated at baseline were previous suicide attempt and baseline suicide severity, and suicidal behaviours evaluated at follow-up were increased suicide severity and fatal/non-fatal suicide attempt. Individual and interactive associations of any childhood abuse and serum BDNF levels with four types of suicidal behaviours were analysed using logistic regression models, after adjusting relevant covariates. Individual associations of childhood abuse were significant only with previous suicide attempt, and no significant individual associations were found for serum BDNF with any suicide outcome. However, the presence of both childhood abuse and lower serum BDNF levels was associated with the highest prevalence/incidence of all four suicidal behaviours, with significant interactions for baseline suicide severity and fatal/non-fatal suicide attempt during follow-up. Synergistic interactive effects of child abuse and serum BDNF levels on suicidal behaviours were found before and after pharmacologic treatment in patients with depressive disorders. Information combining childhood abuse and serum BDNF levels could improve predictions of suicidal behaviour in patients with depressive disorders. BackgroundThe role of childhood abuse and serum brain-derived neurotrophic factor (BDNF) levels in suicidal behaviour is controversial.AimsWe aimed to investigate the individual and interactive effects of the childhood abuse and serum BDNF on suicidal behaviour before and after pharmacologic treatment in patients with depressive disorders.MethodAt baseline, reported childhood emotional, physical and sexual abuse were ascertained and serum BDNF levels were measured in 1094 patients with depressive disorder, 884 of whom were followed during a 1-year period of stepwise pharmacotherapy. Suicidal behaviours evaluated at baseline were previous suicide attempt and baseline suicide severity, and suicidal behaviours evaluated at follow-up were increased suicide severity and fatal/non-fatal suicide attempt. Individual and interactive associations of any childhood abuse and serum BDNF levels with four types of suicidal behaviours were analysed using logistic regression models, after adjusting relevant covariates.ResultsIndividual associations of childhood abuse were significant only with previous suicide attempt, and no significant individual associations were found for serum BDNF with any suicide outcome. However, the presence of both childhood abuse and lower serum BDNF levels was associated with the highest prevalence/incidence of all four suicidal behaviours, with significant interactions for baseline suicide severity and fatal/non-fatal suicide attempt during follow-up.ConclusionsSynergistic interactive effects of child abuse and serum BDNF levels on suicidal behaviours were found before and after pharmacologic treatment in patients with depressive disorders. Information combining childhood abuse and serum BDNF levels could improve predictions of suicidal behaviour in patients with depressive disorders.
Author	Chun, Byung-Jo Kang, Hee-Ju Shin, Il-Seon Kim, Sung-Wan Kim, Jae-Min Kim, Ju-Wan Lee, Ju-Yeon Stewart, Robert
Author_xml	– sequence: 1 givenname: Jae-Min orcidid: 0000-0001-7409-6306 surname: Kim fullname: Kim, Jae-Min email: jmkim@chonnam.ac.kr organization: Department of Psychiatry, Chonnam National University Medical School, Republic of Korea – sequence: 2 givenname: Ju-Wan surname: Kim fullname: Kim, Ju-Wan organization: Department of Psychiatry, Chonnam National University Medical School, Republic of Korea – sequence: 3 givenname: Hee-Ju surname: Kang fullname: Kang, Hee-Ju organization: Department of Psychiatry, Chonnam National University Medical School, Republic of Korea – sequence: 4 givenname: Ju-Yeon surname: Lee fullname: Lee, Ju-Yeon organization: Department of Psychiatry, Chonnam National University Medical School, Republic of Korea – sequence: 5 givenname: Sung-Wan surname: Kim fullname: Kim, Sung-Wan organization: Department of Psychiatry, Chonnam National University Medical School, Republic of Korea – sequence: 6 givenname: Il-Seon surname: Shin fullname: Shin, Il-Seon organization: Department of Psychiatry, Chonnam National University Medical School, Republic of Korea – sequence: 7 givenname: Byung-Jo surname: Chun fullname: Chun, Byung-Jo organization: Department of Emergency Medicine, Chonnam National University Medical School, Republic of Korea – sequence: 8 givenname: Robert surname: Stewart fullname: Stewart, Robert organization: Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; and The National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust, UK
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CitedBy_id	crossref_primary_10_1016_j_janxdis_2024_102943 crossref_primary_10_1016_j_jad_2024_10_030 crossref_primary_10_1016_j_jad_2022_11_059
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Snippet	The role of childhood abuse and serum brain-derived neurotrophic factor (BDNF) levels in suicidal behaviour is controversial. We aimed to investigate the... BackgroundThe role of childhood abuse and serum brain-derived neurotrophic factor (BDNF) levels in suicidal behaviour is controversial.AimsWe aimed to... The role of childhood abuse and serum brain-derived neurotrophic factor (BDNF) levels in suicidal behaviour is controversial.BACKGROUNDThe role of childhood...
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SubjectTerms	Alcohol Anxiety Associations Behavior Biomarkers Brain Brain research Brain-Derived Neurotrophic Factor Child Child Abuse Child abuse & neglect Child sexual abuse Childhood Children Depressive Disorder - epidemiology Depressive personality disorders Disorders Drug therapy Emotional abuse General Adult Humans Informed consent Mental depression Mental disorders Patients Pharmacology Psychiatry Psychosis Questionnaires Regression analysis Risk Factors Self destructive behavior Serum Severity Sex crimes Sexual abuse Sociodemographics Suicidal behavior Suicidal Ideation Suicide Suicide, Attempted - psychology Suicides & suicide attempts Trauma
Title	Investigating associations of childhood abuse and serum brain-derived neurotrophic factor levels with suicidal behaviours in patients with depressive disorders
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