Serological AFP/Golgi protein 73 could be a new diagnostic parameter of hepatic diseases

• Published in: International journal of cancer Vol. 129; no. 8; pp. 1923 - 1931
• Main Authors: Tian, Liyuan, Wang, Yu, Xu, Dabin, Gui, Junhao, Jia, Xingwang, Tong, Hongli, Wen, Xinyu, Dong, Zhennan, Tian, Yaping
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.10.2011; Wiley-Blackwell
• Subjects: Adult; Aged; alpha fetoprotein; Biological and medical sciences; Biomarkers - blood; Biomarkers, Tumor - blood; Carcinoma, Hepatocellular - blood; cirrhosis; Female; Gastroenterology. Liver. Pancreas. Abdomen; golgi protein 73; hepatocellular carcinoma; Humans; Liver Cirrhosis - blood; Liver Diseases - blood; Liver Neoplasms - blood; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Membrane Proteins - blood; Middle Aged; Sensitivity and Specificity; serum; Tumors; Human; Hepatic disease; Hepatocellular carcinoma; Tumoral marker; Malignant tumor; Biliary tract disease; α-Fetoprotein; alpha fetoprotein; Focal nodular hyperplasia; Liver cancer; Cirrhosis; Hepatitis; Cancerology; Golgi membrane protein 1; Malignant cholangioma; Digestive diseases; Serum; Benign neoplasm; Diagnosis; golgi protein; Cancer
• ISSN: 0020-7136; 1097-0215; 1097-0215
• DOI: 10.1002/ijc.25838

We have investigated the changing rule of serum form of GP73 (sGP73) in different hepato‐pathologic processes and identified the sGP73 role in inflammation, fibrosis and carcinogenesis since sGP73 has been regarded as a candidate tumor marker. Quantitative enzyme‐linked immunosorbent assay detected sGP73 in 535 subjects with hepatocellular carcinoma (HCC), liver cirrhosis (LC), hepatitis, focal nodular hyperplasia (FNH), angioma, intra‐hepatic cholangio‐carcinoma (ICC) and metastatic cancer from adenocarcinomas (MC). Median sGP73 in LC was higher than in HCC and hepatitis (p = 0.001), and sGP73 in all three groups were higher than those in healthy individuals (p < 0.001); sGP73 in LC patients with Child‐Pugh class A was lower than in class B and C (p = 0.001), no significant difference was found between early and advanced HCC groups (110.4 μg/L vs. 102.8 μg/L). AFP/GP73 had a sensitivity of 75.8% and specificity of 79.7% with an area under the receiver operating curve (AUROC) of 0.844 vs. 0.812 for AFP (p = 0.055) with a sensitivity of 95.2% and specificity of 47.1%; in detecting early HCC, AUROC of AFP/GP73 was 0. 804 vs. 0.766 for AFP (p = 0.086). sGP73 correlated with AST, AST/ALT, ALB, A/G and ALP in LC. The positive rate of sGP73 in angioma, FNH, ICC, and MC was 0, 50, 63.3, 53.3%, respectively; AFP/GP73 was 0.796 with the sensitivity of 81.4% and specificity of 70.0% when differentiating MC from AFP‐negative HCC. Increased sGP73 is related to hepatic impairment and chronic fibrosis, and when combined with AFP could improve the differential diagnosis of hepatic diseases.