Human genetics: international projects and personalized medicine

In this article, we present the progress driven by the recent technological advances and new revolutionary massive sequencing technologies in the field of human genetics. We discuss this knowledge in relation with drug response prediction, from the germline genetic variation compiled in the 1000 Gen...

Full description

Saved in:
Bibliographic Details
Published inDrug metabolism and drug interactions Vol. 31; no. 1; pp. 3 - 8
Main Authors Apellaniz-Ruiz, Maria, Gallego, Cristina, Ruiz-Pinto, Sara, Carracedo, Angel, Rodríguez-Antona, Cristina
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 01.03.2016
Walter de Gruyter GmbH
Subjects
Epigenesis, Genetic
epigenetics
Genetic Variation
Genetics, Medical - trends
Genome, Human
human genome
Humans
International Cooperation
Pharmacogenetics - trends
pharmacogenomics
Precision medicine
Precision Medicine - trends
Sequence Analysis, DNA - methods
Sequence Analysis, DNA - trends
Online AccessGet full text
ISSN2363-8907
0792-5077
2363-8915
2191-0162
DOI10.1515/dmpt-2015-0032

Cover

Abstract In this article, we present the progress driven by the recent technological advances and new revolutionary massive sequencing technologies in the field of human genetics. We discuss this knowledge in relation with drug response prediction, from the germline genetic variation compiled in the 1000 Genomes Project or in the Genotype-Tissue Expression project, to the phenome-genome archives, the international cancer projects, such as The Cancer Genome Atlas or the International Cancer Genome Consortium, and the epigenetic variation and its influence in gene expression, including the regulation of drug metabolism. This review is based on the lectures presented by the speakers of the Symposium “Human Genetics: International Projects & New Technologies” from the VII Conference of the Spanish Pharmacogenetics and Pharmacogenomics Society, held on the 20th and 21st of April 2015.
AbstractList In this article, we present the progress driven by the recent technological advances and new revolutionary massive sequencing technologies in the field of human genetics. We discuss this knowledge in relation with drug response prediction, from the germline genetic variation compiled in the 1000 Genomes Project or in the Genotype-Tissue Expression project, to the phenome-genome archives, the international cancer projects, such as The Cancer Genome Atlas or the International Cancer Genome Consortium, and the epigenetic variation and its influence in gene expression, including the regulation of drug metabolism. This review is based on the lectures presented by the speakers of the Symposium “Human Genetics: International Projects & New Technologies” from the VII Conference of the Spanish Pharmacogenetics and Pharmacogenomics Society, held on the 20th and 21st of April 2015.
Author Apellaniz-Ruiz, Maria
Rodríguez-Antona, Cristina
Gallego, Cristina
Ruiz-Pinto, Sara
Carracedo, Angel
Author_xml – sequence: 1
  givenname: Maria
  surname: Apellaniz-Ruiz
  fullname: Apellaniz-Ruiz, Maria
– sequence: 2
  givenname: Cristina
  surname: Gallego
  fullname: Gallego, Cristina
– sequence: 3
  givenname: Sara
  surname: Ruiz-Pinto
  fullname: Ruiz-Pinto, Sara
– sequence: 4
  givenname: Angel
  surname: Carracedo
  fullname: Carracedo, Angel
  organization: Fundación Pública de Medicina Xenómica-SERGAS. Grupo de Medicina Xenómica, CIBERER, IDIS, Santiago de Compostela, Spain
– sequence: 5
  givenname: Cristina
  surname: Rodríguez-Antona
  fullname: Rodríguez-Antona, Cristina
  email: crodriguez@cnio.es
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26581075$$D View this record in MEDLINE/PubMed
BookMark eNp1UE1Lw0AUXKRia-3VowQ8p-5HNt30pBS1QsGLnpfN5qVsSTZ1N0Hqr3djWxHR0xseM8PMnKOBbSwgdEnwlHDCb4p628YUEx5jzOgJGlGWslhkhA--MZ4N0cT7DcaYJBllQpyhIU25IHjGR-h22dXKRmuw0Brt55GxLTirWtNYVUVb12xAtz5Stoi24Hz_NR9QRDUURhsLF-i0VJWHyeGO0evD_ctiGa-eH58Wd6tYM85ZTFlJec6A87xQJUnoTGRCCGBAtAqIsQwKzFOqcyJynGjKVJomVGmmkiQBNkbXe98Q6a0D38pN04WglZckeOGMZ4QF1tWB1eUhodw6Uyu3k8fCgZDsCdo13jsopTbtV9vWKVNJgmU_reynlf20sp82yKa_ZEfnfwXzveBdVWHQAtau2wXwI_XfQhJafAKTZI1d
CitedBy_id crossref_primary_10_18632_aging_101107
crossref_primary_10_1080_17425255_2016_1215423
crossref_primary_10_1007_s40291_019_00412_2
crossref_primary_10_1016_j_arcped_2017_01_008
crossref_primary_10_17116_klinderma202120011124
crossref_primary_10_1294_jes_27_107
crossref_primary_10_1515_dmpt_2017_0027
Cites_doi 10.1101/gad.1787609
10.1038/171737a0
10.1073/pnas.74.12.5463
10.1371/journal.pcbi.1004220
10.1101/007211
10.1073/pnas.0500398102
10.1126/science.aaa0355
10.1038/489052a
10.1038/518313a
10.1089/rej.2012.1324
10.1038/nrc1279
10.1056/NEJMra020526
10.1038/nature14217
10.1038/ng1435
10.1101/gr.192278.115
10.1124/pr.110.003533
10.1016/j.arr.2009.03.004
10.1038/mp.2013.41
ContentType Journal Article
Copyright Copyright Walter de Gruyter GmbH 2016
Copyright_xml – notice: Copyright Walter de Gruyter GmbH 2016
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7RV
7X7
7XB
88E
8AO
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
CCPQU
FYUFA
GHDGH
K9.
KB0
M0S
M1P
NAPCQ
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
DOI 10.1515/dmpt-2015-0032
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
ProQuest Nursing & Allied Health Database
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central
ProQuest One Community College
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Nursing and Allied Health Premium
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
DatabaseTitleList
MEDLINE
CrossRef
ProQuest One Academic Middle East (New)
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 2363-8915
2191-0162
EndPage 8
ExternalDocumentID 4057326891
26581075
10_1515_dmpt_2015_0032
10_1515_dmpt_2015_00323113
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID 4.4
53G
AAAEU
AABBZ
AAFPC
AAGVJ
AAILP
AALGR
AAONY
AAOQK
AAOWA
AAPJK
AAQCX
AARRE
AAWFC
AAXCG
ABAQN
ABDRH
ABFKT
ABFQV
ABJNI
ABMIY
ABPLS
ABRDF
ABRQL
ABWLS
ABYBW
ACDEB
ACEFL
ACGFS
ACMKP
ACPMA
ACUND
ACXLN
ACYCL
ACZBO
ADDWE
ADEQT
ADGQD
ADGYE
ADNPR
ADOZN
AECWL
AEDGQ
AEGVQ
AEICA
AEKEB
AEQDQ
AERZL
AFBAA
AFBDD
AFBQV
AFCXV
AFGNR
AFYRI
AGBEV
AHVWV
AHXUK
AIKXB
AIWOI
AJHHK
AKXKS
ALMA_UNASSIGNED_HOLDINGS
ALUKF
AMAVY
ASYPN
AZMOX
BAKPI
BBCWN
BCIFA
BWHEM
CGQUA
DSRVY
EBS
EJD
EMOBN
FSTRU
IY9
KDIRW
QD8
UK5
WTRAM
AAYXX
ALYBR
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
---
0R~
0~D
3V.
5GY
7RV
7X7
7XB
88E
8AO
8FI
8FJ
8FK
AASQH
ABAOT
ABIQR
ABUVI
ABUWG
ABXMZ
ADALX
ADBBV
AEJTT
AFGDO
AFKRA
AFQUK
AHMBA
AHOVO
AIERV
AJATJ
BENPR
BKEYQ
BPHCQ
BVXVI
CCPQU
F5P
FYUFA
HMCUK
HZ~
K9.
M1P
NAPCQ
O9-
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
PROAC
PSQYO
RDG
SA.
UKHRP
ID FETCH-LOGICAL-c3553-23f25b3e55bdaf142789888e3e1ca988339ed0562cb18b04c23a6642ac3a444e3
IEDL.DBID 7X7
ISSN 2363-8907
0792-5077
IngestDate Fri Jul 25 10:04:00 EDT 2025
Thu Jan 02 22:25:19 EST 2025
Thu Apr 24 23:12:44 EDT 2025
Tue Jul 01 04:28:16 EDT 2025
Sat Sep 06 17:02:46 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License This content is free.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3553-23f25b3e55bdaf142789888e3e1ca988339ed0562cb18b04c23a6642ac3a444e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
OpenAccessLink https://proxy.k.utb.cz/login?url=https://www.degruyter.com/document/doi/10.1515/dmpt-2015-0032/pdf
PMID 26581075
PQID 1789095913
PQPubID 2031356
PageCount 6
ParticipantIDs proquest_journals_1789095913
pubmed_primary_26581075
crossref_citationtrail_10_1515_dmpt_2015_0032
crossref_primary_10_1515_dmpt_2015_0032
walterdegruyter_journals_10_1515_dmpt_2015_00323113
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2016-3-1
PublicationDateYYYYMMDD 2016-03-01
PublicationDate_xml – month: 03
  year: 2016
  text: 2016-3-1
  day: 01
PublicationDecade 2010
PublicationPlace Germany
PublicationPlace_xml – name: Germany
– name: Berlin
PublicationTitle Drug metabolism and drug interactions
PublicationTitleAlternate Drug Metab Pers Ther
PublicationYear 2016
Publisher De Gruyter
Walter de Gruyter GmbH
Publisher_xml – name: De Gruyter
– name: Walter de Gruyter GmbH
References 2023103015064114928_j_dmpt-2015-0032_ref_003_w2aab2b8b6b1b7b1ab2b2b3Aa
2023103015064114928_j_dmpt-2015-0032_ref_005_w2aab2b8b6b1b7b1ab2b2b5Aa
2023103015064114928_j_dmpt-2015-0032_ref_007_w2aab2b8b6b1b7b1ab2b2b7Aa
2023103015064114928_j_dmpt-2015-0032_ref_010_w2aab2b8b6b1b7b1ab2b2c10Aa
2023103015064114928_j_dmpt-2015-0032_ref_021_w2aab2b8b6b1b7b1ab2b2c21Aa
2023103015064114928_j_dmpt-2015-0032_ref_001_w2aab2b8b6b1b7b1ab2b2b1Aa
2023103015064114928_j_dmpt-2015-0032_ref_012_w2aab2b8b6b1b7b1ab2b2c12Aa
2023103015064114928_j_dmpt-2015-0032_ref_023_w2aab2b8b6b1b7b1ab2b2c23Aa
2023103015064114928_j_dmpt-2015-0032_ref_014_w2aab2b8b6b1b7b1ab2b2c14Aa
2023103015064114928_j_dmpt-2015-0032_ref_008_w2aab2b8b6b1b7b1ab2b2b8Aa
2023103015064114928_j_dmpt-2015-0032_ref_016_w2aab2b8b6b1b7b1ab2b2c16Aa
2023103015064114928_j_dmpt-2015-0032_ref_018_w2aab2b8b6b1b7b1ab2b2c18Aa
2023103015064114928_j_dmpt-2015-0032_ref_002_w2aab2b8b6b1b7b1ab2b2b2Aa
2023103015064114928_j_dmpt-2015-0032_ref_006_w2aab2b8b6b1b7b1ab2b2b6Aa
2023103015064114928_j_dmpt-2015-0032_ref_020_w2aab2b8b6b1b7b1ab2b2c20Aa
2023103015064114928_j_dmpt-2015-0032_ref_011_w2aab2b8b6b1b7b1ab2b2c11Aa
2023103015064114928_j_dmpt-2015-0032_ref_022_w2aab2b8b6b1b7b1ab2b2c22Aa
2023103015064114928_j_dmpt-2015-0032_ref_013_w2aab2b8b6b1b7b1ab2b2c13Aa
2023103015064114928_j_dmpt-2015-0032_ref_015_w2aab2b8b6b1b7b1ab2b2c15Aa
2023103015064114928_j_dmpt-2015-0032_ref_017_w2aab2b8b6b1b7b1ab2b2c17Aa
2023103015064114928_j_dmpt-2015-0032_ref_004_w2aab2b8b6b1b7b1ab2b2b4Aa
2023103015064114928_j_dmpt-2015-0032_ref_009_w2aab2b8b6b1b7b1ab2b2b9Aa
2023103015064114928_j_dmpt-2015-0032_ref_019_w2aab2b8b6b1b7b1ab2b2c19Aa
References_xml – ident: 2023103015064114928_j_dmpt-2015-0032_ref_011_w2aab2b8b6b1b7b1ab2b2c11Aa
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_017_w2aab2b8b6b1b7b1ab2b2c17Aa
  doi: 10.1101/gad.1787609
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_006_w2aab2b8b6b1b7b1ab2b2b6Aa
  doi: 10.1038/171737a0
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_007_w2aab2b8b6b1b7b1ab2b2b7Aa
  doi: 10.1073/pnas.74.12.5463
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_015_w2aab2b8b6b1b7b1ab2b2c15Aa
  doi: 10.1371/journal.pcbi.1004220
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_016_w2aab2b8b6b1b7b1ab2b2c16Aa
  doi: 10.1101/007211
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_020_w2aab2b8b6b1b7b1ab2b2c20Aa
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_013_w2aab2b8b6b1b7b1ab2b2c13Aa
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_005_w2aab2b8b6b1b7b1ab2b2b5Aa
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_009_w2aab2b8b6b1b7b1ab2b2b9Aa
  doi: 10.1073/pnas.0500398102
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_004_w2aab2b8b6b1b7b1ab2b2b4Aa
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_012_w2aab2b8b6b1b7b1ab2b2c12Aa
  doi: 10.1126/science.aaa0355
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_018_w2aab2b8b6b1b7b1ab2b2c18Aa
  doi: 10.1038/489052a
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_019_w2aab2b8b6b1b7b1ab2b2c19Aa
  doi: 10.1038/518313a
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_023_w2aab2b8b6b1b7b1ab2b2c23Aa
  doi: 10.1089/rej.2012.1324
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_008_w2aab2b8b6b1b7b1ab2b2b8Aa
  doi: 10.1038/nrc1279
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_003_w2aab2b8b6b1b7b1ab2b2b3Aa
  doi: 10.1056/NEJMra020526
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_021_w2aab2b8b6b1b7b1ab2b2c21Aa
  doi: 10.1038/nature14217
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_001_w2aab2b8b6b1b7b1ab2b2b1Aa
  doi: 10.1038/ng1435
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_014_w2aab2b8b6b1b7b1ab2b2c14Aa
  doi: 10.1101/gr.192278.115
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_002_w2aab2b8b6b1b7b1ab2b2b2Aa
  doi: 10.1124/pr.110.003533
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_022_w2aab2b8b6b1b7b1ab2b2c22Aa
  doi: 10.1016/j.arr.2009.03.004
– ident: 2023103015064114928_j_dmpt-2015-0032_ref_010_w2aab2b8b6b1b7b1ab2b2c10Aa
  doi: 10.1038/mp.2013.41
SSID ssj0001492388
ssj0000491565
Score 2.0787833
SecondaryResourceType review_article
Snippet In this article, we present the progress driven by the recent technological advances and new revolutionary massive sequencing technologies in the field of...
SourceID proquest
pubmed
crossref
walterdegruyter
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3
SubjectTerms Epigenesis, Genetic
epigenetics
Genetic Variation
Genetics, Medical - trends
Genome, Human
human genome
Humans
International Cooperation
Pharmacogenetics - trends
pharmacogenomics
Precision medicine
Precision Medicine - trends
Sequence Analysis, DNA - methods
Sequence Analysis, DNA - trends
Title Human genetics: international projects and personalized medicine
URI https://www.degruyter.com/doi/10.1515/dmpt-2015-0032
https://www.ncbi.nlm.nih.gov/pubmed/26581075
https://www.proquest.com/docview/1789095913
Volume 31
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2363-8915
  dateEnd: 20231031
  omitProxy: true
  ssIdentifier: ssj0000491565
  issn: 2363-8907
  databaseCode: 7X7
  dateStart: 20140101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 2363-8915
  dateEnd: 20231031
  omitProxy: true
  ssIdentifier: ssj0000491565
  issn: 2363-8907
  databaseCode: BENPR
  dateStart: 20140101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVAZK
  databaseName: De Gruyter Complete Journal Package 2023
  customDbUrl:
  eissn: 2363-8915
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0001492388
  issn: 2363-8907
  databaseCode: AGBEV
  dateStart: 19950301
  isFulltext: true
  titleUrlDefault: https://www.degruyterbrill.com
  providerName: Walter de Gruyter
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9tAEB6V5AKHqC2PhqZoDwgurMh6vTbLpQUUGiERRQhQbta-gipBEuKgKv31zNrrBGjLyZI1tqWZ8e73zezMAOwmNtHKcEXTxCJBETaimjFLmeOpGrZVJIUvcL7sJd2b-GIgBiHglodjldWaWCzUdmx8jPyQ-YpNKSTj3yeP1E-N8tnVMEJjBeoMoYr36nSQLmIsiH6RnhSnGFOJnKudpqFvI-7ih_ZhMkMnYYKiZ0ev96W_wOYaNH4X-Wvr7qZP81mVLy22ofOP0Aj4kZyUBv8EH9zoM-z1ywbU8wNyvaynyg_IHukvW1PP1-FHEbMn6DS-djE_Jr9eBgRJCMvkRI0smVQw_Y-zpErBb8DNeef6rEvDDAVqEElwGvFhJDR3QmirhswP1pBIeh13zCjpJw1LZz0IMpod6XZsIq4S5CTefnEcO74JtdF45L4AMSiMy6qScazixOgjYRIrDeITqw13ugm00mBmQoNxP-fiPvNEAzWeeY1nXuO-I2nUhP2F_KRsrfFfyVZlkCz8Ynm2dIgmbJVGWrwmQlyFvFY0gb-x2ovn__kpzhjffv9zX2EVxZPyIFoLarPpk_uGyGSmdwr324H6yc_Tzi1eTzu9_hXe7fUvnwEaS-V-
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LTxRBEK4gHtQDwReuovZB8UKH7dcMbULUqGSRRzgsyd6Gfi0hwWVllpD1R_kbrZrHLj5v3LunM1XV3d9X1VUF8CqLmXdBOZ5nEQmKiZJ7ISIXSeVu2HXSGkpw3j_Iekf6y8AMFuBHmwtDzyrbM7E6qON5IB_5hqCMTWusUO_G3zh1jaLoattCozaL3TS9QspWbu18Qv2-lnL7c_9jjzddBXjAu1VxqYbSeJWM8dENBbWasEgDk0oiOEu9d22KBAuCF5u-q4NULkOUTn-ktU4Kv3sLbmvV1VSrPx_kM58Oom2kQ9Wrydwix-vmeVMnElHDRvw6nqBRCsNxJ8lf78E_wO09WLqq4uUxnVxcTidtfLa69raXYanBq-xDbWD3YSGNHsDaYV3werrO-vP8rXKdrbHDeSns6UN4X8UIGBop5UqWb9npdQcka9xAJXOjyMYtLfieImtD_o_g6Eak-xgWR-ej9ARYwMF4jDurtdNZ8JsmZNEGxEPRB5V8B3grwSI0Bc2pr8ZZQcQGJV6QxAuSOFVAlR14Mxs_rkt5_HPkaquQotnSZTE3wA6s1EqafUYijkMebTqgftPatfl_XUoJoZ7-f7mXcKfX398r9nYOdp_BXZya1Y_gVmFxcnGZniMqmvgXlSkyOL5p2_8Joq0cuw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT8MwDLZgkxAcBojXePaAxKkbSZrScuK18Z44AOJW5TWEgG5inRD79ThrO8YGFzg3SVvbrT87zmeAbV_7Uigm3D1fY4DCNXUlIdolhu2J5q6gIbcHnK8b_tmdd_HA82rCTlZWqc3jW_cjSRlSq7qlujZRNuAaQA9c1a_tBBVMuItWSatt3ZyEIvr6AOOv4uHpUe3-K9FiKcj6_Sep3bMMMBrMyBvHF_runMYQ5wyU3vub2IMnHPJF9VmQ-VukJSjPlW4iK6o3QvD4r9ecg1KGVJ3D1LTmYcLEC3DQT_o7aHX28GNn33kazig6WV6n44hYO-0c5_eMdvI9_EW4q9duj8_crAmDqxCKMJeyJuWSGc6lFk1iO3OEGDUbZogSoW1VHBptUZSSJJC7nqJM-BjUWAPwPM-wJSjErdisgKNwMP6XReh5wvOVDLjydagQ4GipmJFlcHPpRypjKLeNMl4iG6mgPCIrj8jKw1Ka0jLsDMa3U26OX0eu58qMsm-0ExF7BjjkIWFlWE4VPFiGIjDDwJiXgY1ofGj-j7dihLDVP83agqmbk3p0dd64XINpvOSntW7rUEjeumYDwU8iNzPz_gSgGP_d
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Human+genetics%3A+international+projects+and+personalized+medicine&rft.jtitle=Drug+metabolism+and+personalized+therapy&rft.au=Apellaniz-Ruiz%2C+Maria&rft.au=Gallego%2C+Cristina&rft.au=Ruiz-Pinto%2C+Sara&rft.au=Carracedo%2C+Angel&rft.date=2016-03-01&rft.pub=De+Gruyter&rft.issn=2363-8907&rft.eissn=2363-8915&rft.volume=31&rft.issue=1&rft.spage=3&rft.epage=8&rft_id=info:doi/10.1515%2Fdmpt-2015-0032&rft.externalDBID=n%2Fa&rft.externalDocID=10_1515_dmpt_2015_00323113
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2363-8907&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2363-8907&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2363-8907&client=summon