Xanthigen attenuates high-fat diet-induced obesity through down-regulation of PPARγ and activation of the AMPK pathway

• Published in: Food science and biotechnology Vol. 23; no. 3; pp. 931 - 935
• Main Authors: Choi, Kyeong-Mi, Jeon, Young Soo, Kim, Wonkyun, Lee, Anna, Kim, Yong-Gil, Lee, Ju Hyun, Kang, Young Eun, Jung, Jae-Chul, Lee, Jeongrai, Min, Bokkee, Kwon, Suk Hyung, Davis, Barbara, Lee, Mi Kyeong, Yoo, Hwan-Soo
• Format: Journal Article
• Language: English
• Published: Heidelberg The Korean Society of Food Science and Technology 01.06.2014; 한국식품과학회
• Subjects: Chemistry; Chemistry and Materials Science; Food Science; Nutrition; Research Article; 식품과학; AMPK; Xanthigen; leptin; PPARγ; obesity
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-014-0125-1

Xanthigen, a mixture of brown seaweed and pomegranate seed extracts, has weight loss properties and lipid-lowering effects in mice and humans. This study elucidated the Xanthigen mechanism of an anti-obesity activity in high-fat diet (HFD)-fed mice. Xanthigen decreased expression of peroxisome proliferator-activated receptor γ (PPARγ) in the adipose tissue of HFD-fed mice. The serum leptin level and the adipose tissue leptin expression in mice fed HFD plus Xanthigen were significantly decreased, compared to HFD-fed mice. Phosphorylation of AMPactivated protein kinase (AMPK) α and β and acetyl-CoA carboxylase (ACC) in the adipose tissue of HFD plus Xanthigen-fed mice was elevated, and HMG-CoA reductase (HMGCR) expression was decreased. Xanthigen may have an anti-obesity activity by down-regulation of PPARγ and activation of the AMPK pathway.