Disseminated Cryptococcosis in Man: Decreased Lymphocyte Transformation in Response to Cryptococcus neoformans
Heat-killed Cryptococcus neoformans, a yeast-like fungus, was used to stimulate in-vitro incorporation of thymidine by human lymphocytes. Lymphocytes from control subjects previously exposed to cryptococci (positive skin tests) had significantly higher uptake of thymidine than cells from unexposed c...
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| Published in | The Journal of infectious diseases Vol. 127; no. 6; pp. 694 - 697 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
The University of Chicago Press
01.06.1973
University of Chicago Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-1899 1537-6613 |
| DOI | 10.1093/infdis/127.6.694 |
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| Abstract | Heat-killed Cryptococcus neoformans, a yeast-like fungus, was used to stimulate in-vitro incorporation of thymidine by human lymphocytes. Lymphocytes from control subjects previously exposed to cryptococci (positive skin tests) had significantly higher uptake of thymidine than cells from unexposed control subjects (negative skin tests). Uptake by lymphocytes from successfully treated patients with cryptococcosis was low when compared with that of exposed control subjects. It is suggested that defective function of lymphocytes may reflect increased susceptibility to cryptococcal infection in some patients with cryptococcosis without any other known predisposing factors. |
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| AbstractList | Heat-killed Cryptococcus neoformans, a yeast-like fungus, was used to stimulate in-vitro incorporation of thymidine by human lymphocytes. Lymphocytes from control subjects previously exposed to cryptococci (positive skin tests) had significantly higher uptake of thymidine than cells from unexposed control subjects (negative skin tests). Uptake by lymphocytes from successfully treated patients with cryptococcosis was low when compared with that of exposed control subjects. It is suggested that defective function of lymphocytes may reflect increased susceptibility to cryptococcal infection in some patients with cryptococcosis without any other known predisposing factors. |
| Author | Diamond, Richard D. Bennett, John E. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/4575001$$D View this record in MEDLINE/PubMed |
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| Snippet | Heat-killed Cryptococcus neoformans, a yeast-like fungus, was used to stimulate in-vitro incorporation of thymidine by human lymphocytes. Lymphocytes from... |
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| SubjectTerms | Antigens Antigens, Fungal Corticosteroids Cryptococcosis Cryptococcosis - immunology Cryptococcus - immunology Cryptococcus neoformans Cryptococcus neoformans - immunology DNA - biosynthesis Fungal infections Humans Infections Lymphocyte Activation Lymphocytes Predisposing factors Skin Tests Thymidine - metabolism |
| Title | Disseminated Cryptococcosis in Man: Decreased Lymphocyte Transformation in Response to Cryptococcus neoformans |
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