Catalytic Kinetics of the Schiff Base Metal Complexes Bearing Side Chain of Cyclic morpholine in Carboxylic Ester Hydrolysis

• Published in: Chinese journal of chemistry Vol. 25; no. 6; pp. 736 - 742
• Main Author: 张述林 李敏娇 欧忠文 陈国需 刘富安 谢家庆
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.06.2007; WILEY‐VCH Verlag; Wiley
• Subjects: catalytic kinetics; Chemistry; Chemistry, Multidisciplinary; Physical Sciences; PNPP hydrolysis; Schiff base complex; Schiff碱金属配合物; Science & Technology; simulative hydrolase; synthesis; 催化动力学; 环状吗啉侧链; 羧酸酯; DNA CLEAVAGE; simulative hydrolase; DINUCLEAR; BRIDGE; Schiff base complex; catalytic kinetics; PHOSPHODIESTER; COPPER(II) COMPLEXES; LIGANDS; synthesis PNPP hydrolysis; METALLOMICELLAR CATALYSIS; PHOSPHATE DIESTER; ENANTIOSELECTIVE HYDROLYSIS; AMINO-ACID ESTERS
• ISSN: 1001-604X; 1614-7065
• DOI: 10.1002/cjoc.200790137

It has been reported that two Schiff base transition metal complexes bearing the side chain of the morpholine ring were synthesized and characterized, and two complexes with the same base agent but different metal ions were used as a simulant hydrolase in the catalytic hydrolysis of p-nitrophenyl picolinate in this paper. The mechanism of PNPP catalytic hydrolysis is proposed and supported by the results of the spectral analysis and the kinetic calculation. A kinetic mathematical model, applied to the calculation of the kinetic and thermodynamics parameters of PNPP catalytic hydrolysis, has been established on the foundation of the mechanism proposed. The result of the study shows that the two complexes have a good catalytic activity in PNPP catalytic hydrolysis, and the rate of the PNPP catalytic hydrolysis was increased with the increase of the pH values in the buffer solution and affected by the polarization effect of metal ion of the complexes.