Synthesis of Chiral Aza‐[n.2.1] Skeletons by Separable Epimers of Intramolecular [3+2] Cross Cycloaddition of Cyclopropane 1,1‐Diesters with Chiral Sulfinylimines

Reported herein is the construction of chiral aza‐[n.2.1] skeletons by separable epimers of intramolecular [3+2] cross cycloaddition of cyclopropane 1,1‐diesters with chiral sulfinylimines. The epimer products can be separated by silica gel column chromatography.

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Bibliographic Details
Published in	Advanced synthesis & catalysis Vol. 362; no. 5; pp. 1112 - 1124
Main Authors	Xia, Miao‐Miao, Li, Feng‐Xing, Ma, You‐Ping, Song, Le‐Le, Hou, Yan‐Ni, Shi, Zi‐Fa, Cao, Xiao‐Ping
Format	Journal Article
Language	English
Published	WEINHEIM Wiley 04.03.2020 Wiley Subscription Services, Inc
Subjects	aza-[n.2.1] skeleton Chemistry Chemistry, Applied Chemistry, Organic chiral sulfinylimine Column chromatography cross cycloaddition Cycloaddition Cyclopropane cyclopropanes Diesters Physical Sciences Science & Technology Silica gel Silicon dioxide CARBONYLS DONOR-ACCEPTOR CYCLOPROPANES ASYMMETRIC-SYNTHESIS ACID STRATEGY ARYLATION cyclopropanes aza-[n.2.1] skeleton ALDEHYDES chiral sulfinylimine cycloaddition CONSTRUCTION MULTIDRUG-RESISTANCE cross cycloaddition ALKALOIDS
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ISSN	1615-4150 1615-4169
DOI	10.1002/adsc.201901543

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Summary:	Reported herein is the construction of chiral aza‐[n.2.1] skeletons by separable epimers of intramolecular [3+2] cross cycloaddition of cyclopropane 1,1‐diesters with chiral sulfinylimines. The epimer products can be separated by silica gel column chromatography.
Bibliography:	The authors contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201901543