Vulvovaginal candidiasis in Iranian women: Molecular identification and antifungal susceptibility pattern
Aim Vulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and assessment of the antifungal susceptibility profile of Candida species, causing VVC in southeast Iran. Methods A cross‐sectional investigatio...
Saved in:
| Published in | The journal of obstetrics and gynaecology research Vol. 48; no. 12; pp. 3292 - 3303 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Kyoto, Japan
John Wiley & Sons Australia, Ltd
01.12.2022
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1341-8076 1447-0756 1447-0756 |
| DOI | 10.1111/jog.15442 |
Cover
| Abstract | Aim
Vulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and assessment of the antifungal susceptibility profile of Candida species, causing VVC in southeast Iran.
Methods
A cross‐sectional investigation was carried out on 119 nonpregnant females suspected of VVC between February 2019 and May 2021. Yeast samples were characterized to the species level by conventional and molecular methods. All Candida isolates were examined for in vitro susceptibility profile to six conventional antifungal drugs using Clinical and Laboratory Standards Institute guidelines.
Results
Out of 119 subjects, 52 (43.7%) cases were affected by VVC, out of whom 11 (21.15%) cases had recurrent vulvovaginal candidiasis (RVVC). The species distribution was as follows; Candida albicans (n = 21; 40.4%), C. glabrata (n = 11; 21.2%), C. tropicalis (n = 9; 17.3%), C. parapsilosis (n = 5; 9.7%), C. africana (n = 3; 5.7%), C. famata (n = 1; 1.9%), C. lusitaniae (n = 1; 1.9%), and C. dubliniensis (n = 1; 1.9%). The resistance rate of Candida isolates to fluconazole, itraconazole, and voriconazole were 15.38%, 11.5%, and 3.8%, respectively. Resistance to fluconazole was obtained in 46% (5/11) of RVVC cases but only in 7% (3/41) of VVC cases.
Conclusion
This study demonstrated that the majority of VVC cases were caused by non‐albicans Candida species which also were resistant to some antifungal agents. Hence, our findings revealed the importance of conducting periodical epidemiological studies to determine changes in species distribution. Moreover, for effective management of treatment and infection, it is imperative to evaluate the susceptibility profiles of Candida species isolated from VVC patients. |
|---|---|
| AbstractList | AimVulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and assessment of the antifungal susceptibility profile of Candida species, causing VVC in southeast Iran.MethodsA cross‐sectional investigation was carried out on 119 nonpregnant females suspected of VVC between February 2019 and May 2021. Yeast samples were characterized to the species level by conventional and molecular methods. All Candida isolates were examined for in vitro susceptibility profile to six conventional antifungal drugs using Clinical and Laboratory Standards Institute guidelines.ResultsOut of 119 subjects, 52 (43.7%) cases were affected by VVC, out of whom 11 (21.15%) cases had recurrent vulvovaginal candidiasis (RVVC). The species distribution was as follows; Candida albicans (n = 21; 40.4%), C. glabrata (n = 11; 21.2%), C. tropicalis (n = 9; 17.3%), C. parapsilosis (n = 5; 9.7%), C. africana (n = 3; 5.7%), C. famata (n = 1; 1.9%), C. lusitaniae (n = 1; 1.9%), and C. dubliniensis (n = 1; 1.9%). The resistance rate of Candida isolates to fluconazole, itraconazole, and voriconazole were 15.38%, 11.5%, and 3.8%, respectively. Resistance to fluconazole was obtained in 46% (5/11) of RVVC cases but only in 7% (3/41) of VVC cases.ConclusionThis study demonstrated that the majority of VVC cases were caused by non‐albicans Candida species which also were resistant to some antifungal agents. Hence, our findings revealed the importance of conducting periodical epidemiological studies to determine changes in species distribution. Moreover, for effective management of treatment and infection, it is imperative to evaluate the susceptibility profiles of Candida species isolated from VVC patients. Aim Vulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and assessment of the antifungal susceptibility profile of Candida species, causing VVC in southeast Iran. Methods A cross‐sectional investigation was carried out on 119 nonpregnant females suspected of VVC between February 2019 and May 2021. Yeast samples were characterized to the species level by conventional and molecular methods. All Candida isolates were examined for in vitro susceptibility profile to six conventional antifungal drugs using Clinical and Laboratory Standards Institute guidelines. Results Out of 119 subjects, 52 (43.7%) cases were affected by VVC, out of whom 11 (21.15%) cases had recurrent vulvovaginal candidiasis (RVVC). The species distribution was as follows; Candida albicans (n = 21; 40.4%), C. glabrata (n = 11; 21.2%), C. tropicalis (n = 9; 17.3%), C. parapsilosis (n = 5; 9.7%), C. africana (n = 3; 5.7%), C. famata (n = 1; 1.9%), C. lusitaniae (n = 1; 1.9%), and C. dubliniensis (n = 1; 1.9%). The resistance rate of Candida isolates to fluconazole, itraconazole, and voriconazole were 15.38%, 11.5%, and 3.8%, respectively. Resistance to fluconazole was obtained in 46% (5/11) of RVVC cases but only in 7% (3/41) of VVC cases. Conclusion This study demonstrated that the majority of VVC cases were caused by non‐albicans Candida species which also were resistant to some antifungal agents. Hence, our findings revealed the importance of conducting periodical epidemiological studies to determine changes in species distribution. Moreover, for effective management of treatment and infection, it is imperative to evaluate the susceptibility profiles of Candida species isolated from VVC patients. Vulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and assessment of the antifungal susceptibility profile of Candida species, causing VVC in southeast Iran.AIMVulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and assessment of the antifungal susceptibility profile of Candida species, causing VVC in southeast Iran.A cross-sectional investigation was carried out on 119 nonpregnant females suspected of VVC between February 2019 and May 2021. Yeast samples were characterized to the species level by conventional and molecular methods. All Candida isolates were examined for in vitro susceptibility profile to six conventional antifungal drugs using Clinical and Laboratory Standards Institute guidelines.METHODSA cross-sectional investigation was carried out on 119 nonpregnant females suspected of VVC between February 2019 and May 2021. Yeast samples were characterized to the species level by conventional and molecular methods. All Candida isolates were examined for in vitro susceptibility profile to six conventional antifungal drugs using Clinical and Laboratory Standards Institute guidelines.Out of 119 subjects, 52 (43.7%) cases were affected by VVC, out of whom 11 (21.15%) cases had recurrent vulvovaginal candidiasis (RVVC). The species distribution was as follows; Candida albicans (n = 21; 40.4%), C. glabrata (n = 11; 21.2%), C. tropicalis (n = 9; 17.3%), C. parapsilosis (n = 5; 9.7%), C. africana (n = 3; 5.7%), C. famata (n = 1; 1.9%), C. lusitaniae (n = 1; 1.9%), and C. dubliniensis (n = 1; 1.9%). The resistance rate of Candida isolates to fluconazole, itraconazole, and voriconazole were 15.38%, 11.5%, and 3.8%, respectively. Resistance to fluconazole was obtained in 46% (5/11) of RVVC cases but only in 7% (3/41) of VVC cases.RESULTSOut of 119 subjects, 52 (43.7%) cases were affected by VVC, out of whom 11 (21.15%) cases had recurrent vulvovaginal candidiasis (RVVC). The species distribution was as follows; Candida albicans (n = 21; 40.4%), C. glabrata (n = 11; 21.2%), C. tropicalis (n = 9; 17.3%), C. parapsilosis (n = 5; 9.7%), C. africana (n = 3; 5.7%), C. famata (n = 1; 1.9%), C. lusitaniae (n = 1; 1.9%), and C. dubliniensis (n = 1; 1.9%). The resistance rate of Candida isolates to fluconazole, itraconazole, and voriconazole were 15.38%, 11.5%, and 3.8%, respectively. Resistance to fluconazole was obtained in 46% (5/11) of RVVC cases but only in 7% (3/41) of VVC cases.This study demonstrated that the majority of VVC cases were caused by non-albicans Candida species which also were resistant to some antifungal agents. Hence, our findings revealed the importance of conducting periodical epidemiological studies to determine changes in species distribution. Moreover, for effective management of treatment and infection, it is imperative to evaluate the susceptibility profiles of Candida species isolated from VVC patients.CONCLUSIONThis study demonstrated that the majority of VVC cases were caused by non-albicans Candida species which also were resistant to some antifungal agents. Hence, our findings revealed the importance of conducting periodical epidemiological studies to determine changes in species distribution. Moreover, for effective management of treatment and infection, it is imperative to evaluate the susceptibility profiles of Candida species isolated from VVC patients. |
| Author | Khaksar Baniasadi, Ali Agha Kuchak Afshari, Setareh Amanizadeh, Azam Salari, Samira Ahmadi, Atefeh Ayatollahi Mosavi, Seyyed Amin Sharifi, Iraj Bamorovat, Mehdi |
| Author_xml | – sequence: 1 givenname: Ali surname: Khaksar Baniasadi fullname: Khaksar Baniasadi, Ali organization: Kerman University of Medical Sciences – sequence: 2 givenname: Seyyed Amin surname: Ayatollahi Mosavi fullname: Ayatollahi Mosavi, Seyyed Amin organization: Kerman University of Medical Sciences – sequence: 3 givenname: Iraj orcidid: 0000-0002-6894-6834 surname: Sharifi fullname: Sharifi, Iraj organization: Kerman University of Medical Sciences – sequence: 4 givenname: Mehdi orcidid: 0000-0002-4900-4278 surname: Bamorovat fullname: Bamorovat, Mehdi organization: Kerman University of Medical Sciences – sequence: 5 givenname: Samira surname: Salari fullname: Salari, Samira organization: Kerman University of Medical Sciences – sequence: 6 givenname: Atefeh surname: Ahmadi fullname: Ahmadi, Atefeh organization: Kerman University of Medical Sciences – sequence: 7 givenname: Azam surname: Amanizadeh fullname: Amanizadeh, Azam organization: Kerman University of Medical Sciences – sequence: 8 givenname: Setareh orcidid: 0000-0003-2978-9095 surname: Agha Kuchak Afshari fullname: Agha Kuchak Afshari, Setareh email: afshari_setareh@yahoo.com organization: Kerman University of Medical Sciences |
| BookMark | eNp1kE9PwyAYh4nRxPnn4Ddo4kUPVSiltN6M0Tkz40W9NpTC8i4MJtAt-_Yyt5NREgIhz_PLy-8EHVpnFUIXBN-QtG7nbnZDWFkWB2hEypLnmLPqMN1pSfIa8-oYnYQwx5jwhtQjBJ-DWbmVmIEVJpPC9tCDCBAysNnECwvCZmu3UPYue3VGycEIn0GvbAQNUkRwNktW2ulhsLOUEoYg1TJCBwbiJluKGJW3Z-hICxPU-f48RR9Pj-8Pz_n0bTx5uJ_mkrKyyHnHO10RyVjHeq6JUFKWohFaYSo1JzUtGsU7RaueYV1zSigjum_qjlS1ZpSeoqtd7tK7r0GF2C4gzWOMsMoNoS14gZuC4bpO6OUvdO4Gn4rYUiXlFa34NvB2R0nvQvBKtxLiz8ejF2Bagttt9cmdtT_VJ-P6l7H0sBB-8ye7T1-DUZv_wfblbbwzvgERW5b3 |
| CitedBy_id | crossref_primary_10_1186_s41512_024_00180_6 crossref_primary_10_3390_jof9121159 crossref_primary_10_1016_j_diagmicrobio_2024_116606 crossref_primary_10_3390_jof11010005 crossref_primary_10_1177_09564624241296582 |
| Cites_doi | 10.1016/j.heliyon.2020.e03619 10.1093/genetics/iyaa004 10.1093/cid/civ933 10.1007/s11908-010-0137-9 10.4314/ahs.v14i4.10 10.1097/AOG.0b013e31827307b2 10.1016/j.ram.2015.10.003 10.5812/jjm.8(4)2015.15992 10.1111/myc.12204 10.5812/jjm.56117 10.1016/j.mycmed.2020.100968 10.1016/j.jiac.2015.08.008 10.1186/s12905-018-0607-z 10.3314/jjmm.47.225 10.1089/mdr.2020.0139 10.5812/jjm.113716 10.1016/j.micpath.2021.104802 10.1007/s11046-010-9388-0 10.1016/j.diagmicrobio.2008.05.014 10.3390/jof8010014 10.1016/j.mycmed.2014.10.021 10.1186/1477-7525-11-169 10.2478/rrlm-2021-0012 10.1016/j.micpath.2020.104471 10.3390/jof5040117 10.1016/j.mimet.2015.02.004 10.1111/aji.12811 10.1128/JCM.02363-09 10.1016/j.cmi.2019.03.028 10.1111/myc.13280 10.1155/2018/9703754 10.1111/jog.15267 10.1016/j.genrep.2019.100484 10.1016/S0140-6736(07)60917-9 10.1371/journal.pone.0237046 10.1016/j.micpath.2018.12.028 10.1111/j.1439-0507.2009.01752.x 10.1007/s11046-021-00556-y 10.1186/s12879-020-04985-w 10.1007/s11046-018-0305-2 10.3390/jof6010027 10.1016/S1473-3099(18)30103-8 10.3389/fpubh.2018.00078 10.1111/myc.12946 |
| ContentType | Journal Article |
| Copyright | 2022 Japan Society of Obstetrics and Gynecology. 2022 Japan Society of Obstetrics and Gynecology |
| Copyright_xml | – notice: 2022 Japan Society of Obstetrics and Gynecology. – notice: 2022 Japan Society of Obstetrics and Gynecology |
| DBID | AAYXX CITATION 7T5 7TO H94 K9. 7X8 |
| DOI | 10.1111/jog.15442 |
| DatabaseName | CrossRef Immunology Abstracts Oncogenes and Growth Factors Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Oncogenes and Growth Factors Abstracts MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE - Academic |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1447-0756 |
| EndPage | 3303 |
| ExternalDocumentID | 10_1111_jog_15442 JOG15442 |
| Genre | article |
| GeographicLocations | Iran |
| GeographicLocations_xml | – name: Iran |
| GrantInformation_xml | – fundername: Kerman University of Medical Sciences funderid: 98000762 |
| GroupedDBID | --- .3N .55 .GA .Y3 05W 0R~ 10A 1OB 1OC 29L 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAHQN AAIPD AAMNL AANHP AANLZ AAONW AASGY AAWTL AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFWVQ AFZJQ AHBTC AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 DUUFO EBS EJD EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI UB1 W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WVDHM WXI WXSBR X7M XG1 ZZTAW ~IA ~WT AAMMB AAYXX AEFGJ AEYWJ AGHNM AGQPQ AGXDD AGYGG AIDQK AIDYY AIQQE CITATION 7T5 7TO H94 K9. 7X8 |
| ID | FETCH-LOGICAL-c3542-7b7bf61c55b5d7f1aecc4a9afe03cf718329e7be36d50f8731351fd98b168f533 |
| IEDL.DBID | DR2 |
| ISSN | 1341-8076 1447-0756 |
| IngestDate | Fri Jul 11 16:05:43 EDT 2025 Tue Oct 07 06:56:19 EDT 2025 Wed Oct 01 03:13:01 EDT 2025 Thu Apr 24 23:05:57 EDT 2025 Wed Jan 22 16:21:08 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3542-7b7bf61c55b5d7f1aecc4a9afe03cf718329e7be36d50f8731351fd98b168f533 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-6894-6834 0000-0002-4900-4278 0000-0003-2978-9095 |
| PQID | 2743763673 |
| PQPubID | 2045132 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_2720925088 proquest_journals_2743763673 crossref_citationtrail_10_1111_jog_15442 crossref_primary_10_1111_jog_15442 wiley_primary_10_1111_jog_15442_JOG15442 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | December 2022 2022-12-00 20221201 |
| PublicationDateYYYYMMDD | 2022-12-01 |
| PublicationDate_xml | – month: 12 year: 2022 text: December 2022 |
| PublicationDecade | 2020 |
| PublicationPlace | Kyoto, Japan |
| PublicationPlace_xml | – name: Kyoto, Japan – name: Hoboken |
| PublicationTitle | The journal of obstetrics and gynaecology research |
| PublicationYear | 2022 |
| Publisher | John Wiley & Sons Australia, Ltd Wiley Subscription Services, Inc |
| Publisher_xml | – name: John Wiley & Sons Australia, Ltd – name: Wiley Subscription Services, Inc |
| References | 2010; 12 2021; 8 2021; 27 2012; 120 2021; 64 2007; 369 2019; 5 2020; 20 2021; 29 2019; 12 2020; 148 2019; 17 2020; 15 2011; 54 2022; 48 2021; 186 2019; 128 2019; 184 2018; 22 2015; 8 2011; 171 2021; 14 2018; 6 2018; 18 2020; 6 2015; 25 2018; 2018 2010; 48 2019; 62 2013; 11 2020; 30 2021 2015; 111 2017; 10 2006; 47 2021; 217 2019; 25 2022; 14 2014; 14 2014; 57 2016; 62 2021; 154 2008; 62 2016; 48 2018; 79 2016; 22 e_1_2_8_28_1 Faridi A (e_1_2_8_23_1) 2022; 14 e_1_2_8_24_1 e_1_2_8_47_1 e_1_2_8_26_1 e_1_2_8_49_1 e_1_2_8_3_1 e_1_2_8_5_1 e_1_2_8_7_1 e_1_2_8_9_1 e_1_2_8_20_1 e_1_2_8_43_1 e_1_2_8_22_1 e_1_2_8_45_1 Zeng X (e_1_2_8_25_1) 2018; 2018 e_1_2_8_41_1 e_1_2_8_17_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_32_1 e_1_2_8_11_1 e_1_2_8_30_1 Jeanmonod R (e_1_2_8_2_1) 2021 e_1_2_8_46_1 e_1_2_8_27_1 e_1_2_8_48_1 Nejat ZA (e_1_2_8_29_1) 2018; 22 Kiasat N (e_1_2_8_34_1) 2019; 12 e_1_2_8_4_1 e_1_2_8_6_1 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_44_1 Hashemi SE (e_1_2_8_35_1) 2019; 5 e_1_2_8_40_1 e_1_2_8_18_1 e_1_2_8_39_1 e_1_2_8_14_1 e_1_2_8_16_1 e_1_2_8_37_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_50_1 |
| References_xml | – volume: 111 start-page: 50 year: 2015 end-page: 6 article-title: Current methods for identifying clinically important cryptic Candida species publication-title: J Microbiol Methods – volume: 154 year: 2021 article-title: Vulvovaginal candidiasis in Iran: a systematic review and meta‐analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis publication-title: Microb Pathog – volume: 217 issue: 2 year: 2021 article-title: Extreme diversification driven by parallel events of massive loss of heterozygosity in the hybrid lineage of Candida albicans publication-title: Genetics – volume: 8 start-page: 14 issue: 1 year: 2021 article-title: Antifungal resistance in clinical isolates of Candida glabrata in Ibero‐America publication-title: J Fungi (Basel) – volume: 128 start-page: 13 year: 2019 end-page: 9 article-title: Correlation between antifungal resistance and virulence factors in Candida albicans recovered from vaginal specimens publication-title: Microb Pathog – volume: 369 start-page: 1961 issue: 9577 year: 2007 end-page: 71 article-title: Vulvovaginal candidosis publication-title: Lancet – volume: 48 start-page: 43 issue: 1 year: 2016 end-page: 9 article-title: Prevalence and antifungal susceptibility of Candida albicans and its related species Candida dubliniensis and Candida africana isolated from vulvovaginal samples in a hospital of Argentina publication-title: Rev Argent Microbiol – volume: 14 start-page: 423 issue: 3 year: 2022 end-page: 9 article-title: Molecular discrimination and antifungal susceptibility profile of cryptic Candida albicans complex species isolated from patients in Iran publication-title: Iran J Microbiol – volume: 18 start-page: 1 issue: 1 year: 2018 end-page: 10 article-title: Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern publication-title: BMC Womens Health – volume: 57 start-page: 584 issue: 10 year: 2014 end-page: 91 article-title: Vulvovaginal candidiasis: species distribution, fluconazole resistance and drug efflux pump gene overexpression publication-title: Mycoses – year: 2021 – volume: 8 issue: 4 year: 2015 article-title: Isolation of different species of Candida in patients with vulvovaginal candidiasis from Sari, Iran publication-title: Jundishapur J Microbiol – volume: 6 issue: 3 year: 2020 article-title: Low prevalence of antifungal resistant Candida africana, in the C. albicans complex causing vulvovaginal candidiasis publication-title: Heliyon – volume: 64 start-page: 771 issue: 7 year: 2021 end-page: 9 article-title: Molecular identification and antifungal susceptibility profiles of Candida dubliniensis and Candida africana isolated from vulvovaginal candidiasis: a single‐centre experience in Iran publication-title: Mycoses – volume: 184 start-page: 413 issue: 3 year: 2019 end-page: 22 article-title: Antifungal susceptibility profile of Candida albicans isolated from vulvovaginal candidiasis in Xinjiang province of China publication-title: Mycopathologia – volume: 11 start-page: 169 year: 2013 article-title: Subjective health status and health‐related quality of life among women with recurrent vulvovaginal candidosis (RVVC) in Europe and the USA publication-title: Health Qual Life Outcomes – volume: 54 start-page: 34 issue: 1 year: 2011 end-page: 8 article-title: Susceptibility profile of vaginal isolates of Candida albicans prior to and following fluconazole introduction–impact of two decades publication-title: Mycoses – volume: 25 start-page: 792 issue: 7 year: 2019 end-page: 8 article-title: Resistance of Candida to azoles and echinocandins worldwide publication-title: Clin Microbiol Infect – volume: 2018 start-page: 1 year: 2018 end-page: 8 article-title: Risk factors of vulvovaginal candidiasis among women of reproductive age in Xi'an: a cross‐sectional study publication-title: Biomed Res Int – volume: 48 start-page: 1270 issue: 4 year: 2010 end-page: 5 article-title: Antifungal susceptibility testing of Candida isolates from the Candida surveillance study publication-title: J Clin Microbiol – volume: 22 start-page: 33 issue: 1 year: 2018 article-title: Molecular identification and antifungal susceptibility pattern of non‐albicans Candida species isolated from vulvovaginal candidiasis publication-title: Iran Biomed J – volume: 15 issue: 8 year: 2020 article-title: Distribution, antifungal susceptibility pattern and intra‐Candida albicans species complex prevalence of Candida africana: a systematic review and meta‐analysis publication-title: PLoS One – volume: 148 year: 2020 article-title: Recurrent vulvovaginal Candida spp isolates phenotypically express less virulence traits publication-title: Microb Pathog – volume: 6 start-page: 78 year: 2018 article-title: Vaginal microbiomes associated with aerobic vaginitis and bacterial vaginosis publication-title: Front Public Health – volume: 27 start-page: 1087 issue: 8 year: 2021 end-page: 95 article-title: Species distribution and antifungal susceptibility profiles of isolates from women with nonrecurrent and recurrent vulvovaginal candidiasis publication-title: Microb Drug Resist – volume: 5 start-page: 26 issue: 4 year: 2019 end-page: 34 article-title: Species distribution and susceptibility profiles of Candida species isolated from vulvovaginal candidiasis, emergence of C. lusitaniae publication-title: Curr Med Mycol – volume: 120 start-page: 1407 issue: 6 year: 2012 end-page: 14 article-title: Fluconazole‐resistant Candida albicans vulvovaginitis publication-title: Obstet Gynecol – volume: 47 start-page: 225 issue: 3 year: 2006 end-page: 9 article-title: A one‐enzyme PCR‐RFLP assay for identification of six medically important Candida species publication-title: Nippon Ishinkin Gakkai Zasshi – volume: 20 start-page: 1 issue: 1 year: 2020 end-page: 10 article-title: Molecular identification and antifungal susceptibility profile of yeast from vulvovaginal candidiasis publication-title: BMC Infect Dis – volume: 14 issue: 1 year: 2021 article-title: Genetic analysis of Candida glabrata from Candiduric patients using microsatellite length polymorphism, antifungal susceptibility, and enzymatic profiles publication-title: Jundishapur J Microbiol – volume: 79 issue: 4 year: 2018 article-title: Is non‐response to fluconazole maintenance therapy for recurrent Candida vaginitis related to sensitization to atopic reactions? publication-title: Am J Reprod Immunol – volume: 186 start-page: 411 issue: 3 year: 2021 end-page: 21 article-title: Difference between the profiles presented by yeasts that colonize the vaginal mucosa or cause primary or recurrent candidiasis publication-title: Mycopathologia – volume: 12 start-page: 465 issue: 6 year: 2010 end-page: 70 article-title: Vulvovaginal candidiasis caused by non‐albicans Candida species: new insights publication-title: Curr Infect Dis Rep – volume: 30 issue: 3 year: 2020 article-title: Comparative in vitro activities of seven antifungal drugs against clinical isolates of Candida parapsilosis complex publication-title: J Mycol Med – volume: 17 year: 2019 article-title: Molecular identification of Candida species, assessment of the antifungal susceptibility and the genetic relationship of Candida albicans isolated from immunocompromised patients in Kerman, Iran publication-title: Gene Rep – volume: 48 start-page: 1546 year: 2022 end-page: 60 article-title: Vulvovaginal candidiasis: An overview of mycological, clinical, and immunological aspects publication-title: J Obstet Gynaecol Res – volume: 62 start-page: 692 issue: 8 year: 2019 end-page: 7 article-title: Epidemiology and antifungal susceptibility patterns of Candida isolates from Greek women with vulvovaginal candidiasis publication-title: Mycoses – volume: 14 start-page: 835 issue: 4 year: 2014 end-page: 9 article-title: Risk factors for candida infection of the genital tract in the tropics publication-title: Afr Health Sci – volume: 10 issue: 12 year: 2017 article-title: Multicenter identification and antifungal susceptibility patterns of candida species isolated from clinical samples publication-title: Jundishapur J Microbiol – volume: 62 start-page: 230 issue: 2 year: 2008 end-page: 3 article-title: First molecular method for discriminating between Candida africana, Candida albicans, and Candida dubliniensis by using hwp1 gene publication-title: Diagn Microbiol Infect Dis – volume: 6 start-page: 27 issue: 1 year: 2020 article-title: Vulvovaginal candidiasis: a current understanding and burning questions publication-title: J Fungi (Basel) – volume: 62 start-page: e1 issue: 4 year: 2016 end-page: e50 article-title: Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America publication-title: Clin Infect Dis – volume: 25 start-page: 23 issue: 1 year: 2015 end-page: 8 article-title: Species spectrum and antifungal susceptibility profile of vaginal isolates of Candida in Kuwait publication-title: J Mycol Med – volume: 171 start-page: 417 issue: 6 year: 2011 end-page: 22 article-title: Antifungal susceptibility of bloodstream Candida isolates in Sfax hospital: Tunisia publication-title: Mycopathologia – volume: 18 start-page: e339 issue: 11 year: 2018 end-page: e47 article-title: Global burden of recurrent vulvovaginal candidiasis: a systematic review publication-title: Lancet Infect Dis – volume: 29 start-page: 201 issue: 2 year: 2021 end-page: 15 article-title: Vaginal candidiasis in Konya area: etiology, risk factors, virulence patterns, and antifungal susceptibility publication-title: Rev Rom Med Lab – volume: 22 start-page: 124 issue: 2 year: 2016 end-page: 6 article-title: Antifungal susceptibilities of Candida species isolated from the patients with vaginal candidiasis publication-title: J Infect Chemother – volume: 5 start-page: 117 issue: 4 year: 2019 article-title: Identification of cryptic species of four Candida complexes in a culture collection publication-title: J Fungi (Basel) – volume: 12 start-page: 1 issue: 3 year: 2019 end-page: 6 article-title: Prevalence of vulvovaginal candidiasis in Ahvaz, Southwest Iran: a semi‐large scale study publication-title: Jundishapur J Microbiol – ident: e_1_2_8_38_1 doi: 10.1016/j.heliyon.2020.e03619 – ident: e_1_2_8_12_1 doi: 10.1093/genetics/iyaa004 – ident: e_1_2_8_17_1 doi: 10.1093/cid/civ933 – ident: e_1_2_8_8_1 doi: 10.1007/s11908-010-0137-9 – ident: e_1_2_8_26_1 doi: 10.4314/ahs.v14i4.10 – ident: e_1_2_8_19_1 doi: 10.1097/AOG.0b013e31827307b2 – ident: e_1_2_8_39_1 doi: 10.1016/j.ram.2015.10.003 – volume: 14 start-page: 423 issue: 3 year: 2022 ident: e_1_2_8_23_1 article-title: Molecular discrimination and antifungal susceptibility profile of cryptic Candida albicans complex species isolated from patients in Iran publication-title: Iran J Microbiol – ident: e_1_2_8_30_1 doi: 10.5812/jjm.8(4)2015.15992 – volume: 5 start-page: 26 issue: 4 year: 2019 ident: e_1_2_8_35_1 article-title: Species distribution and susceptibility profiles of Candida species isolated from vulvovaginal candidiasis, emergence of C. lusitaniae publication-title: Curr Med Mycol – ident: e_1_2_8_16_1 doi: 10.1111/myc.12204 – ident: e_1_2_8_45_1 doi: 10.5812/jjm.56117 – ident: e_1_2_8_14_1 doi: 10.1016/j.mycmed.2020.100968 – ident: e_1_2_8_44_1 doi: 10.1016/j.jiac.2015.08.008 – ident: e_1_2_8_36_1 doi: 10.1186/s12905-018-0607-z – ident: e_1_2_8_22_1 doi: 10.3314/jjmm.47.225 – ident: e_1_2_8_33_1 doi: 10.1089/mdr.2020.0139 – ident: e_1_2_8_47_1 doi: 10.5812/jjm.113716 – ident: e_1_2_8_21_1 doi: 10.1016/j.micpath.2021.104802 – ident: e_1_2_8_46_1 doi: 10.1007/s11046-010-9388-0 – ident: e_1_2_8_24_1 doi: 10.1016/j.diagmicrobio.2008.05.014 – ident: e_1_2_8_20_1 doi: 10.3390/jof8010014 – ident: e_1_2_8_40_1 doi: 10.1016/j.mycmed.2014.10.021 – ident: e_1_2_8_27_1 doi: 10.1186/1477-7525-11-169 – volume-title: Vaginal candidiasis year: 2021 ident: e_1_2_8_2_1 – volume: 12 start-page: 1 issue: 3 year: 2019 ident: e_1_2_8_34_1 article-title: Prevalence of vulvovaginal candidiasis in Ahvaz, Southwest Iran: a semi‐large scale study publication-title: Jundishapur J Microbiol – ident: e_1_2_8_50_1 doi: 10.2478/rrlm-2021-0012 – ident: e_1_2_8_28_1 doi: 10.1016/j.micpath.2020.104471 – ident: e_1_2_8_9_1 doi: 10.3390/jof5040117 – ident: e_1_2_8_10_1 doi: 10.1016/j.mimet.2015.02.004 – ident: e_1_2_8_18_1 doi: 10.1111/aji.12811 – ident: e_1_2_8_49_1 doi: 10.1128/JCM.02363-09 – ident: e_1_2_8_13_1 doi: 10.1016/j.cmi.2019.03.028 – ident: e_1_2_8_37_1 doi: 10.1111/myc.13280 – volume: 2018 start-page: 1 year: 2018 ident: e_1_2_8_25_1 article-title: Risk factors of vulvovaginal candidiasis among women of reproductive age in Xi'an: a cross‐sectional study publication-title: Biomed Res Int doi: 10.1155/2018/9703754 – ident: e_1_2_8_31_1 doi: 10.1111/jog.15267 – ident: e_1_2_8_42_1 doi: 10.1016/j.genrep.2019.100484 – ident: e_1_2_8_3_1 doi: 10.1016/S0140-6736(07)60917-9 – ident: e_1_2_8_11_1 doi: 10.1371/journal.pone.0237046 – ident: e_1_2_8_43_1 doi: 10.1016/j.micpath.2018.12.028 – ident: e_1_2_8_15_1 doi: 10.1111/j.1439-0507.2009.01752.x – ident: e_1_2_8_32_1 doi: 10.1007/s11046-021-00556-y – volume: 22 start-page: 33 issue: 1 year: 2018 ident: e_1_2_8_29_1 article-title: Molecular identification and antifungal susceptibility pattern of non‐albicans Candida species isolated from vulvovaginal candidiasis publication-title: Iran Biomed J – ident: e_1_2_8_7_1 doi: 10.1186/s12879-020-04985-w – ident: e_1_2_8_41_1 doi: 10.1007/s11046-018-0305-2 – ident: e_1_2_8_6_1 doi: 10.3390/jof6010027 – ident: e_1_2_8_4_1 doi: 10.1016/S1473-3099(18)30103-8 – ident: e_1_2_8_5_1 doi: 10.3389/fpubh.2018.00078 – ident: e_1_2_8_48_1 doi: 10.1111/myc.12946 |
| SSID | ssj0017918 |
| Score | 2.3317647 |
| Snippet | Aim
Vulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and... AimVulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and... Vulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and... |
| SourceID | proquest crossref wiley |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 3292 |
| SubjectTerms | Antifungal agents Candida Candidiasis Epidemiology Fluconazole Fungal infections Geographical distribution Iran Itraconazole polymerase chain reaction Species Susceptibility Voriconazole vulvovaginal candidiasis |
| Title | Vulvovaginal candidiasis in Iranian women: Molecular identification and antifungal susceptibility pattern |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjog.15442 https://www.proquest.com/docview/2743763673 https://www.proquest.com/docview/2720925088 |
| Volume | 48 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library - Core collection (SURFmarket) issn: 1341-8076 databaseCode: DR2 dateStart: 19970101 customDbUrl: isFulltext: true eissn: 1447-0756 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017918 providerName: Wiley-Blackwell |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwEA9jD-KL3-J0ShQffKn0M231ScSvwRTEiQ9CadJkFEc77DrQv967rK1TFMSHQmkvbdrLfSS5-x0hh6ZwOVjywJCJqQw34MqIE86MQDpgr4LAEgKzkfu37Hrg9p68pxY5rXNhZvgQzYIbSobW1yjgMS_mhTwf4rKIi_rXcpieTt030FGIuqnT4EBLI-Auq1CFdBRP3fKrLfp0MOfdVG1nLpfJc93DWXjJy3E54cfi_Rt44z8_YYUsVf4nPZsNmFXSktkaWehXO-zrJH0sR9N8GutqWVRg0guMoCItaJrRGzBsMJyohm04of26tC5NkyroSPOZQis44AJoEnhKURY6eEbH4b7RsYb0zDbI4PLi4fzaqMoxGMLxXPDDuc8Vs4TncS_xlRUD9904jJU0HaF81A2h9Ll0WOKZKvAdLP6nkjDgFgsUuJWbpJ3lmdwi1OS-7XqmnTDkD2c8YVzAYzlz_Th0VIcc1YyJRIVVjiUzRlEzZ8mHkf51HXLQkI5nAB0_EXVr7kaVjBYRzMdRuzLf6ZD95jZIF26ZxJnMS6SxzdBGJxa6pFn5-0ui3t2VPtn-O-kOWbQxn0LHx3RJe_Jayl3wciZ8Tw_nD2VR-nU |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bS-QwFD6Igvriellxdr1E8cGXSqdN01Z8EVHHyyiILr4spUkTGZRWtlNBf73nZNp6wQXxoVDapE17rknO-Q7Apqu4REseOTpzjcMjaZw0k8KJtI_2Koq6SlE2cv9c9K75yU1wMwa7TS7MCB-iXXAjybD6mgScFqTfSnlxS-siHBXwBBc4TyGX6LIFjyLcTZsIh3qaIHdFjStk43iaru-t0auL-dZRtZbm8Af8bcY4CjC5266Gcls9f4Bv_O5HzMJM7YKyvRHPzMGYzudhsl9vsi_A4E91_1g8prZgFlOU94JMVA5KNsjZMdo25ChmkRt2WL-prssGWR13ZEnNsBceeAGVCT6lrEobP2NDcZ_Yg0X1zH_C9eHB1X7PqSsyOMoPOLriMpRGdFUQyCALTTdFBuBpnBrt-sqEpB5iHUrtiyxwTRT6VP_PZHEkuyIy6Fkuwnhe5HoJmCtDjweulwkikBQyE1LhY6XgYRr7pgNbDWUSVcOVU9WM-6SdthS3if11Hdhomz6MMDo-a7TckDepxbRMcEpOClaEfgfW29soYLRrkua6qKiN58Ye-bE4JEvL_78kObk4sie_vt50DaZ6V_2z5Oz4_PQ3THuUXmHDZZZhfPiv0ivo9AzlquXtFxC6_pY |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9RAEB9KC8UXbavi2WpX6YMvKblks9kUX8T2-mGviljpi4TsVzlakqO5FPSvd2YvST-wIH0IhGQ32WQ-d3fmNwBboeYKLbkMrAldwKVyQWGUCKSN0V5JOdSaspHHJ-LglB-dJWcL8LHLhZnjQ_QLbiQZXl-TgNupcbelvDqndRGOCniJJ5mkgL7d7z14FOFu-kQ41NMEuStaXCEfx9N1vWuNblzM246qtzSjZ_CrG-M8wORiu5mpbf3nHnzjYz9iBZ62Lij7NOeZVViw5Rosj9tN9ucw-dlcXlfXhS-YxTTlvSAT1ZOaTUp2iLYNOYp55IYdNu6q67KJaeOOPKkZ9sIDL6AywafUTe3jZ3wo7m829aie5Qs4He39-HwQtBUZAh0nHF1xlSonhjpJVGJSNyyQAXiRFc6GsXYpqYfMpsrGwiShk2lM9f-cyaQaCunQs3wJi2VV2lfAQpVGPAkjI4hASigjlMbHKsHTIovdAD50lMl1C1dOVTMu837aUp3n_tcN4H3fdDrH6PhXo42OvHkrpnWOU3JSsCKNB_Cuv40CRrsmRWmrhtpEYRaRH4tD8rR8-CX50dd9f_L6_5tuwvK33VF-fHjyZR2eRJRd4aNlNmBxdtXYN-jzzNRbz9p_Absa_ho |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Vulvovaginal+candidiasis+in+Iranian+women%3A+Molecular+identification+and+antifungal+susceptibility+pattern&rft.jtitle=The+journal+of+obstetrics+and+gynaecology+research&rft.au=Khaksar+Baniasadi%2C+Ali&rft.au=Ayatollahi+Mosavi%2C+Seyyed+Amin&rft.au=Sharifi%2C+Iraj&rft.au=Bamorovat%2C+Mehdi&rft.date=2022-12-01&rft.issn=1341-8076&rft.eissn=1447-0756&rft.volume=48&rft.issue=12&rft.spage=3292&rft.epage=3303&rft_id=info:doi/10.1111%2Fjog.15442&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_jog_15442 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1341-8076&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1341-8076&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1341-8076&client=summon |