Potential Dextromethorphan-Induced Serotonin Syndrome Leading to Homicide and Suicide

Limited case reports have been published regarding serotonin syndrome due to the combined effects of supratherapeutic levels of dextromethorphan and selective serotonin reuptake inhibitor. We report a case of an adolescent with postmortem findings suggestive of a diagnosis of serotonin syndrome-indu...

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Bibliographic Details
Published inAcademic forensic pathology Vol. 14; no. 1; pp. 21 - 25
Main Authors Pavelka, Matthew M., Kohr, Roland
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.03.2024
Subjects
Case of the Months
Forensic Pathology
Dextromethorphan
Serotonin syndrome
Fluoxetine
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ISSN1925-3621
1925-3621
DOI10.1177/19253621231224531

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Summary:Limited case reports have been published regarding serotonin syndrome due to the combined effects of supratherapeutic levels of dextromethorphan and selective serotonin reuptake inhibitor. We report a case of an adolescent with postmortem findings suggestive of a diagnosis of serotonin syndrome-induced psychosis associated with a double homicide and suicide. Postmortem toxicology of the suicide victim was remarkable for elevated serotonergic metabolites of fluoxetine and dextromethorphan in a 14-year-old male.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1925-3621
1925-3621
DOI:10.1177/19253621231224531