The first 4-way liver paired exchange from an interdisciplinary collaboration between health care professionals and design economists
We report initial results of a liver paired exchange (LPE) program established at the Liver Transplant Institute at Inonu University through collaboration with design economists. Since June 2022, the program has been using a matching procedure that maximizes the number of living donor liver transpla...
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| Published in | American journal of transplantation Vol. 23; no. 10; pp. 1612 - 1621 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.10.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1600-6135 1600-6143 1600-6143 |
| DOI | 10.1016/j.ajt.2023.06.016 |
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| Abstract | We report initial results of a liver paired exchange (LPE) program established at the Liver Transplant Institute at Inonu University through collaboration with design economists. Since June 2022, the program has been using a matching procedure that maximizes the number of living donor liver transplants (LDLTs) to the patients in the pool subject to the ethical framework and the logistical constraints of the program. In 1 4-way and 4 2-way exchanges, 12 LDLTs have been performed via LPE in 2022. The 4-way exchange, generated in the same match run with a 2-way exchange, is a first worldwide. This match run generated LDLTs for 6 patients, revealing the value of the capacity to carry out larger than 2-way exchanges. With only 2-way exchanges, only 4 of these patients would receive a LDLT. The number of LDLTs from LPE can be increased by developing the capacity to perform larger than 2-way exchanges in either high-volume centers or multicenter programs. |
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| AbstractList | We report initial results of a liver paired exchange (LPE) program established at the Liver Transplant Institute at Inonu University through collaboration with design economists. Since June 2022, the program has been using a matching procedure that maximizes the number of living donor liver transplants (LDLTs) to the patients in the pool subject to the ethical framework and the logistical constraints of the program. In 1 4-way and 4 2-way exchanges, 12 LDLTs have been performed via LPE in 2022. The 4-way exchange, generated in the same match run with a 2-way exchange, is a first worldwide. This match run generated LDLTs for 6 patients, revealing the value of the capacity to carry out larger than 2-way exchanges. With only 2-way exchanges, only 4 of these patients would receive a LDLT. The number of LDLTs from LPE can be increased by developing the capacity to perform larger than 2-way exchanges in either high-volume centers or multicenter programs. We report initial results of a liver paired exchange (LPE) program established at the Liver Transplant Institute at Inonu University through collaboration with design economists. Since June 2022, the program has been using a matching procedure that maximizes the number of living donor liver transplants (LDLTs) to the patients in the pool subject to the ethical framework and the logistical constraints of the program. In 1 4-way and 4 2-way exchanges, 12 LDLTs have been performed via LPE in 2022. The 4-way exchange, generated in the same match run with a 2-way exchange, is a first worldwide. This match run generated LDLTs for 6 patients, revealing the value of the capacity to carry out larger than 2-way exchanges. With only 2-way exchanges, only 4 of these patients would receive a LDLT. The number of LDLTs from LPE can be increased by developing the capacity to perform larger than 2-way exchanges in either high-volume centers or multicenter programs.We report initial results of a liver paired exchange (LPE) program established at the Liver Transplant Institute at Inonu University through collaboration with design economists. Since June 2022, the program has been using a matching procedure that maximizes the number of living donor liver transplants (LDLTs) to the patients in the pool subject to the ethical framework and the logistical constraints of the program. In 1 4-way and 4 2-way exchanges, 12 LDLTs have been performed via LPE in 2022. The 4-way exchange, generated in the same match run with a 2-way exchange, is a first worldwide. This match run generated LDLTs for 6 patients, revealing the value of the capacity to carry out larger than 2-way exchanges. With only 2-way exchanges, only 4 of these patients would receive a LDLT. The number of LDLTs from LPE can be increased by developing the capacity to perform larger than 2-way exchanges in either high-volume centers or multicenter programs. |
| Author | Akbulut, Sami Emre, Sukru Sönmez, Tayfun Isik, Burak Yilmaz, Sezai Ünver, M. Utku Ince, Volkan |
| Author_xml | – sequence: 1 givenname: Sezai orcidid: 0000-0002-8044-0297 surname: Yilmaz fullname: Yilmaz, Sezai email: sezai.yilmaz@inonu.edu.tr organization: Inonu University Liver Transplant Institute, Malatya, Turkey – sequence: 2 givenname: Tayfun orcidid: 0000-0002-9153-0466 surname: Sönmez fullname: Sönmez, Tayfun organization: Boston College, Department of Economics, Chestnut Hill, Massachusetts, USA – sequence: 3 givenname: M. Utku orcidid: 0000-0001-7693-1635 surname: Ünver fullname: Ünver, M. Utku organization: Boston College, Department of Economics, Chestnut Hill, Massachusetts, USA – sequence: 4 givenname: Volkan orcidid: 0000-0002-0714-490X surname: Ince fullname: Ince, Volkan organization: Inonu University Liver Transplant Institute, Malatya, Turkey – sequence: 5 givenname: Sami orcidid: 0000-0002-6864-7711 surname: Akbulut fullname: Akbulut, Sami organization: Inonu University Liver Transplant Institute, Malatya, Turkey – sequence: 6 givenname: Burak orcidid: 0000-0002-2395-3985 surname: Isik fullname: Isik, Burak organization: Inonu University Liver Transplant Institute, Malatya, Turkey – sequence: 7 givenname: Sukru orcidid: 0000-0001-7562-8570 surname: Emre fullname: Emre, Sukru organization: Inonu University Liver Transplant Institute, Malatya, Turkey |
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| Cites_doi | 10.1016/j.transproceed.2023.02.009 10.1097/00007890-199901270-00027 10.1097/01.tp.0000446280.81922.bb 10.1016/j.ejor.2019.09.006 10.1111/ajt.16396 10.3982/ECTA16400 10.1257/aer.97.3.828 10.1002/lt.25639 10.1002/lt.21970 10.1097/TP.0000000000004211 10.1002/lt.22017 10.1287/inte.2014.0766 10.1093/oxrep/grx048 10.1016/j.jet.2005.04.004 10.1001/jamasurg.2022.5440 10.1097/SLA.0000000000004122 10.1097/01.tp.0000250906.66728.8d 10.1097/TP.0000000000004210 10.1097/TP.0000000000002432 10.1097/01.tp.0000195775.77081.25 10.1111/ajt.16137 10.1002/lt.25030 10.1257/000282805774669989 10.1097/XCS.0000000000000036 |
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| Keywords | LL LPE KPE liver paired exchange ABOi HRS PELD economic design ABOc living donors PBC ABOid HBV 4-way liver exchange LDLT GRWR HCC NASH MELD SEG 2-3 liver paired donation HCV RL liver transplantation living donor liver transplantation |
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| Title | The first 4-way liver paired exchange from an interdisciplinary collaboration between health care professionals and design economists |
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