Nano-biomarker-Based Surface-Enhanced Raman Spectroscopy for Selective Diagnosis of Gallbladder and Liver Injury

During living donor liver transplantation, a number of blood vessels and bile ducts are anastomosed while the liver and gallbladder are resected in the donor and recipient. Early detection and treatment of complications after surgery by evaluating the function of blood vessels and the biliary tract...

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Published inBiochip journal Vol. 16; no. 1; pp. 49 - 57
Main Authors Lee, Sanghwa, Tak, Eunyoung, Cho, Yu Jeong, Kim, Jiye, Lee, Jooyoung, Lee, Ryunjin, Lee, Kwanhee, Kwon, Minsung, Yoon, Young-In, Lee, Sung-Gyu, Namgoong, Jung-Man, Kim, Jun Ki
Format Journal Article
LanguageEnglish
Published Seoul The Korean BioChip Society (KBCS) 01.03.2022
Springer Nature B.V
한국바이오칩학회
Subjects
Abdomen
Animal models
Bile ducts
Biliary tract
Biomarkers
Biomedical Engineering and Bioengineering
Biopsy
Biosensors
Biotechnology
Blood vessels
Chemistry
Chemistry and Materials Science
Comparative analysis
Damage
Gallbladder
Inflammation
Liver
Liver transplantation
Liver transplants
Original Article
Raman spectroscopy
Recovery
Software
Spectrum analysis
Surgery
생물공학
United States > US
Japan
Bile duct ligation
Gallbladder cauterization
Surface-enhanced Raman spectroscopy
Nano-biomarker
Principal component analysis
Online AccessGet full text
ISSN1976-0280
2092-7843
DOI10.1007/s13206-022-00045-4

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Abstract During living donor liver transplantation, a number of blood vessels and bile ducts are anastomosed while the liver and gallbladder are resected in the donor and recipient. Early detection and treatment of complications after surgery by evaluating the function of blood vessels and the biliary tract is crucial. A biosensing chip that can monitor patient health status from the bile excreted during the recovery process has been developed using a surface-enhanced Raman sensing chip. Surface-enhanced Raman spectroscopy signals of bile obtained from normal bile duct ligation and gallbladder damage mouse models using a cautery device were identified and analyzed. The surface-enhanced Raman chip with a nanometer-level porous structure can selectively separate the nanometer biomarkers and measure the Raman signal. Through the detection of nanometer biomarkers in the bile and comparative analysis of histopathology, the Raman signal in the damaged gallbladder was compared with that caused by liver damage due to bile duct ligation, showing that it becomes a biosensing chip for monitoring recovery.
AbstractList During living donor liver transplantation, a number of blood vessels and bile ducts are anastomosed while the liver and gallbladder are resected in the donor and recipient. Early detection and treatment of complications after surgery by evaluating the function of blood vessels and the biliary tract is crucial. A biosensing chip that can monitor patient health status from the bile excreted during the recovery process has been developed using a surface-enhanced Raman sensing chip. Surface-enhanced Raman spectroscopy signals of bile obtained from normal bile duct ligation and gallbladder damage mouse models using a cautery device were identified and analyzed. The surface-enhanced Raman chip with a nanometer-level porous structure can selectively separate the nanometer biomarkers and measure the Raman signal. Through the detection of nanometer biomarkers in the bile and comparative analysis of histopathology, the Raman signal in the damaged gallbladder was compared with that caused by liver damage due to bile duct ligation, showing that it becomes a biosensing chip for monitoring recovery.
During living donor liver transplantation, a number of blood vessels and bile ducts are anastomosed while the liver and gallbladder are resected in the donor and recipient. Early detection and treatment of complications after surgery by evaluating the function of blood vessels and the biliary tract is crucial. A biosensing chip that can monitor patient health status from the bile excreted during the recovery process has been developed using a surface-enhanced Raman sensing chip. Surface-enhanced Raman spectroscopy signals of bile obtained from normal bile duct ligation and gallbladder damage mouse models using a cautery device were identified and analyzed. The surface-enhanced Raman chip with a nanometer-level porous structure can selectively separate the nanometer biomarkers and measure the Raman signal. Through the detection of nanometer biomarkers in the bile and comparative analysis of histopathology, the Raman signal in the damaged gallbladder was compared with that caused by liver damage due to bile duct ligation, showing that it becomes a biosensing chip for monitoring recovery. KCI Citation Count: 0
Author Tak, Eunyoung
Namgoong, Jung-Man
Kim, Jiye
Lee, Sung-Gyu
Kwon, Minsung
Kim, Jun Ki
Lee, Kwanhee
Yoon, Young-In
Lee, Sanghwa
Lee, Ryunjin
Lee, Jooyoung
Cho, Yu Jeong
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– sequence: 10
  givenname: Sung-Gyu
  surname: Lee
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  givenname: Jung-Man
  surname: Namgoong
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  email: namgoong2940@gmail.com
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  givenname: Jun Ki
  orcidid: 0000-0002-0099-9681
  surname: Kim
  fullname: Kim, Jun Ki
  email: kim@amc.seoul.kr
  organization: Biomedical Engineering Research Center, Asan Medical Center, Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine
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The Korean BioChip Society 2022.
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Keywords Bile duct ligation
Gallbladder cauterization
Surface-enhanced Raman spectroscopy
Nano-biomarker
Principal component analysis
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Snippet During living donor liver transplantation, a number of blood vessels and bile ducts are anastomosed while the liver and gallbladder are resected in the donor...
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SubjectTerms Abdomen
Animal models
Bile ducts
Biliary tract
Biomarkers
Biomedical Engineering and Bioengineering
Biopsy
Biosensors
Biotechnology
Blood vessels
Chemistry
Chemistry and Materials Science
Comparative analysis
Damage
Gallbladder
Inflammation
Liver
Liver transplantation
Liver transplants
Original Article
Raman spectroscopy
Recovery
Software
Spectrum analysis
Surgery
생물공학
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