Low vitamin D and high cholesterol facilitate oral carcinogenesis in 4NQO‐induced rat models via regulating glycolysis
Objectives Diets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal origin facilitates carcinogenesis. In this study, we aimed at investigating the possible involvement of vitamin D deficiency (VDD)...
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Published in | Oral diseases Vol. 29; no. 3; pp. 978 - 989 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Denmark
Wiley Subscription Services, Inc
01.04.2023
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Online Access | Get full text |
ISSN | 1354-523X 1601-0825 1601-0825 |
DOI | 10.1111/odi.14117 |
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Abstract | Objectives
Diets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal origin facilitates carcinogenesis. In this study, we aimed at investigating the possible involvement of vitamin D deficiency (VDD) and high cholesterol (HC) together in oral squamous cell carcinoma (OSCC) through modulating glycolysis.
Subjects and Methods
We compared total cholesterol, LDL, HDL, triglycerides, LDH, and vitamin D levels of OSCC patients and control individuals. We used GEO datasets for gene set enrichment and 4‐nitroquinoline‐1‐oxide induced in vivo oral carcinogenesis models to investigate contribution of VDD and HC during carcinogenesis via possible modulation of glycolysis.
Results
We found that VDD and HC co‐exist in OSCC patients, and deregulation of cholesterol and vitamin D levels results in enrichment of genes related to glycolysis. We, then, demonstrated that VDD and HC on their own and together facilitated the formation of larger tumors in 4NQO‐induced in vivo cancer models, which are suppressed by glycolysis inhibition.
Conclusion
We reported collaborative contribution of HC and VDD during oral carcinogenesis, which is mainly carried out via altering energy metabolism in tumor cells. |
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AbstractList | Diets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal origin facilitates carcinogenesis. In this study, we aimed at investigating the possible involvement of vitamin D deficiency (VDD) and high cholesterol (HC) together in oral squamous cell carcinoma (OSCC) through modulating glycolysis.OBJECTIVESDiets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal origin facilitates carcinogenesis. In this study, we aimed at investigating the possible involvement of vitamin D deficiency (VDD) and high cholesterol (HC) together in oral squamous cell carcinoma (OSCC) through modulating glycolysis.We compared total cholesterol, LDL, HDL, triglycerides, LDH, and vitamin D levels of OSCC patients and control individuals. We used GEO datasets for gene set enrichment and 4-nitroquinoline-1-oxide induced in vivo oral carcinogenesis models to investigate contribution of VDD and HC during carcinogenesis via possible modulation of glycolysis.SUBJECTS AND METHODSWe compared total cholesterol, LDL, HDL, triglycerides, LDH, and vitamin D levels of OSCC patients and control individuals. We used GEO datasets for gene set enrichment and 4-nitroquinoline-1-oxide induced in vivo oral carcinogenesis models to investigate contribution of VDD and HC during carcinogenesis via possible modulation of glycolysis.We found that VDD and HC co-exist in OSCC patients, and deregulation of cholesterol and vitamin D levels results in enrichment of genes related to glycolysis. We, then, demonstrated that VDD and HC on their own and together facilitated the formation of larger tumors in 4NQO-induced in vivo cancer models, which are suppressed by glycolysis inhibition.RESULTSWe found that VDD and HC co-exist in OSCC patients, and deregulation of cholesterol and vitamin D levels results in enrichment of genes related to glycolysis. We, then, demonstrated that VDD and HC on their own and together facilitated the formation of larger tumors in 4NQO-induced in vivo cancer models, which are suppressed by glycolysis inhibition.We reported collaborative contribution of HC and VDD during oral carcinogenesis, which is mainly carried out via altering energy metabolism in tumor cells.CONCLUSIONWe reported collaborative contribution of HC and VDD during oral carcinogenesis, which is mainly carried out via altering energy metabolism in tumor cells. Objectives Diets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal origin facilitates carcinogenesis. In this study, we aimed at investigating the possible involvement of vitamin D deficiency (VDD) and high cholesterol (HC) together in oral squamous cell carcinoma (OSCC) through modulating glycolysis. Subjects and Methods We compared total cholesterol, LDL, HDL, triglycerides, LDH, and vitamin D levels of OSCC patients and control individuals. We used GEO datasets for gene set enrichment and 4‐nitroquinoline‐1‐oxide induced in vivo oral carcinogenesis models to investigate contribution of VDD and HC during carcinogenesis via possible modulation of glycolysis. Results We found that VDD and HC co‐exist in OSCC patients, and deregulation of cholesterol and vitamin D levels results in enrichment of genes related to glycolysis. We, then, demonstrated that VDD and HC on their own and together facilitated the formation of larger tumors in 4NQO‐induced in vivo cancer models, which are suppressed by glycolysis inhibition. Conclusion We reported collaborative contribution of HC and VDD during oral carcinogenesis, which is mainly carried out via altering energy metabolism in tumor cells. Diets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal origin facilitates carcinogenesis. In this study, we aimed at investigating the possible involvement of vitamin D deficiency (VDD) and high cholesterol (HC) together in oral squamous cell carcinoma (OSCC) through modulating glycolysis. We compared total cholesterol, LDL, HDL, triglycerides, LDH, and vitamin D levels of OSCC patients and control individuals. We used GEO datasets for gene set enrichment and 4-nitroquinoline-1-oxide induced in vivo oral carcinogenesis models to investigate contribution of VDD and HC during carcinogenesis via possible modulation of glycolysis. We found that VDD and HC co-exist in OSCC patients, and deregulation of cholesterol and vitamin D levels results in enrichment of genes related to glycolysis. We, then, demonstrated that VDD and HC on their own and together facilitated the formation of larger tumors in 4NQO-induced in vivo cancer models, which are suppressed by glycolysis inhibition. We reported collaborative contribution of HC and VDD during oral carcinogenesis, which is mainly carried out via altering energy metabolism in tumor cells. ObjectivesDiets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal origin facilitates carcinogenesis. In this study, we aimed at investigating the possible involvement of vitamin D deficiency (VDD) and high cholesterol (HC) together in oral squamous cell carcinoma (OSCC) through modulating glycolysis.Subjects and MethodsWe compared total cholesterol, LDL, HDL, triglycerides, LDH, and vitamin D levels of OSCC patients and control individuals. We used GEO datasets for gene set enrichment and 4‐nitroquinoline‐1‐oxide induced in vivo oral carcinogenesis models to investigate contribution of VDD and HC during carcinogenesis via possible modulation of glycolysis.ResultsWe found that VDD and HC co‐exist in OSCC patients, and deregulation of cholesterol and vitamin D levels results in enrichment of genes related to glycolysis. We, then, demonstrated that VDD and HC on their own and together facilitated the formation of larger tumors in 4NQO‐induced in vivo cancer models, which are suppressed by glycolysis inhibition.ConclusionWe reported collaborative contribution of HC and VDD during oral carcinogenesis, which is mainly carried out via altering energy metabolism in tumor cells. |
Author | Altinkaynak, Konca Karatas, Omer Faruk Gundogdu, Betul Tatar, Arzu Capik, Ozel Gumus, Rasim Ozdemir Tozlu, Ozlem |
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Cites_doi | 10.5114/wo.2017.68623 10.3322/caac.21660 10.7314/apjcp.2013.14.10.5567 10.1038/bjc.2013.667 10.1093/jnci/djx071 10.3892/mmr.2014.2945 10.1155/2020/5490468 10.1093/annonc/mdp036 10.14219/jada.archive.2011.0059 10.1002/mnfr.201500425 10.1093/nar/gkz401 10.1016/j.archoralbio.2018.02.001 10.1017/S1368980018000204 10.1016/j.cell.2011.02.013 10.1042/BJ20060914 10.1016/j.cell.2005.12.022 10.1016/j.biopha.2018.10.102 10.1001/archotol.133.11.1149 10.1111/jop.13041 10.3390/nu12051471 10.3109/19390211.2013.859209 10.1210/en.2009‐0676 10.1007/s10735‐009‐9215‐4 10.1111/odi.13308 10.1080/13813450600935263 10.4317/medoral.20368 10.1016/j.cmet.2015.05.014 10.3390/ijerph17249160 10.3390/ijms21186835 |
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Keywords | 4NQO cholesterol oral squamous cell carcinoma LDL vitamin D deficiency glycolysis |
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Notes | Funding information This work was supported by the Scientific and Technological Research Council of Turkey, Grant/Award Number: 119Z195 Rasim Gumus and Ozel Capik authors contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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References | 2021; 27 2009; 40 2009; 20 2013; 109 2017; 21 2015; 11 2020; 17 2009; 150 2020; 12 2019; 109 2021; 50 2018; 89 2021; 71 2007; 10 2018; 21 2006; 112 2017; 109 2013; 14 2020; 2020 2015; 20 2007; 133 2019; 47 2015; 21 2016; 60 2020; 21 2011; 144 2014; 11 2006; 400 2011; 142 2006; 124 e_1_2_9_30_1 e_1_2_9_31_1 e_1_2_9_11_1 e_1_2_9_10_1 e_1_2_9_13_1 e_1_2_9_12_1 e_1_2_9_15_1 e_1_2_9_14_1 e_1_2_9_17_1 e_1_2_9_16_1 Taghavi N. (e_1_2_9_27_1) 2007; 10 e_1_2_9_19_1 e_1_2_9_18_1 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_21_1 e_1_2_9_24_1 e_1_2_9_23_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_3_1 e_1_2_9_2_1 e_1_2_9_9_1 e_1_2_9_26_1 e_1_2_9_25_1 e_1_2_9_28_1 e_1_2_9_29_1 |
References_xml | – volume: 124 start-page: 35 issue: 1 year: 2006 end-page: 46 article-title: Protein sensors for membrane sterols publication-title: Cell – volume: 20 start-page: e188 issue: 2 year: 2015 end-page: 195 article-title: Serum vitamin D levels of patients with oral squamous cell carcinoma (OSCC) and expression of vitamin D receptor in oral precancerous lesions and OSCC publication-title: Med Oral Patol Oral Cir Bucal – volume: 112 start-page: 139 issue: 3 year: 2006 end-page: 149 article-title: Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases publication-title: Archives of Physiology and Biochemistry – volume: 71 start-page: 209 issue: 3 year: 2021 end-page: 249 article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA: A Cancer Journal for Clinicians – volume: 50 start-page: 1 issue: 1 year: 2021 end-page: 9 article-title: Prognostic and clinicopathological significance of podoplanin immunoexpression in oral and oropharyngeal squamous cell carcinoma: A systematic review publication-title: Journal of Oral Pathology and Medicine – volume: 109 start-page: 2904 issue: 11 year: 2013 end-page: 2910 article-title: Foods, nutrients and the risk of oral and pharyngeal cancer publication-title: British Journal of Cancer – volume: 47 start-page: W199 issue: W1 year: 2019 end-page: W205 article-title: WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs publication-title: Nucleic Acids Research – volume: 400 start-page: 485 issue: 3 year: 2006 end-page: 491 article-title: SREBP‐2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR publication-title: The Biochemical Journal – volume: 109 start-page: 391 year: 2019 end-page: 401 article-title: Role of vitamin D and vitamin D receptor (VDR) in oral cancer publication-title: Biomedicine & Pharmacotherapy – volume: 21 start-page: 2004 issue: 11 year: 2018 end-page: 2012 article-title: Lower vitamin D intake is associated with low HDL cholesterol and vitamin D insufficiency/deficiency in Brazilian children publication-title: Public Health Nutr – volume: 14 start-page: 5567 issue: 10 year: 2013 end-page: 5577 article-title: Epidemiology of oral cancer in Asia in the past decade–an update (2000–2012) publication-title: Asian Pacific Journal of Cancer Prevention – volume: 21 start-page: 145 issue: 2 year: 2017 end-page: 151 article-title: Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment publication-title: Contemporary Oncology (Pozn) – volume: 142 start-page: 166 issue: 2 year: 2011 end-page: 169 article-title: Diet and prevention of oral cancer: strategies for clinical practice publication-title: Journal of the American Dental Association – volume: 2020 start-page: 5490468 year: 2020 article-title: Antitumor activity of extract on oral cancer: An in vivo study publication-title: Journal of Oncology – volume: 21 start-page: 805 issue: 6 year: 2015 end-page: 821 article-title: Acetyl coenzyme A: a central metabolite and second messenger publication-title: Cell Metabolism – volume: 144 start-page: 646 issue: 5 year: 2011 end-page: 674 article-title: Hallmarks of cancer: the next generation publication-title: Cell – volume: 60 start-page: 798 issue: 4 year: 2016 end-page: 809 article-title: Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig‐2/SREBP‐2 pathway publication-title: Molecular Nutrition & Food Research – volume: 10 start-page: 227 issue: 2 year: 2007 end-page: 232 article-title: Type of food and risk of oral cancer publication-title: Archives of Iranian Medicine – volume: 12 issue: 5 year: 2020 article-title: Vitamin D deficiency and oral health: A comprehensive review publication-title: Nutrients – volume: 11 start-page: 145 issue: 2 year: 2014 end-page: 154 article-title: Differential effects of 1,25‐dihydroxyvitamin D₃ on oral squamous cell carcinomas in vitro publication-title: J Diet Suppl – volume: 17 start-page: 9160 issue: 24 year: 2020 article-title: Oral cancer and precancer: A narrative review on the relevance of early diagnosis publication-title: International Journal of Environmental Research and Public Health – volume: 11 start-page: 1917 issue: 3 year: 2015 end-page: 1924 article-title: Glycolysis inhibitor 2‐deoxy‐D‐glucose suppresses carcinogen‐induced rat hepatocarcinogenesis by restricting cancer cell metabolism publication-title: Molecular Medicine Reports – volume: 21 start-page: 6835 issue: 18 year: 2020 article-title: RNA‐binding proteins as regulators of migration, invasion and metastasis in oral squamous cell carcinoma publication-title: International Journal of Molecular Sciences – volume: 133 start-page: 1149 issue: 11 year: 2007 end-page: 1152 article-title: Treatment with 1‐alpha,25‐dihydroxyvitamin D3 (vitamin D3) to inhibit carcinogenesis in the hamster buccal pouch model publication-title: Archives of Otolaryngology ‐ Head and Neck Surgery – volume: 150 start-page: 4104 issue: 9 year: 2009 end-page: 4113 article-title: Activation of liver X receptor regulates substrate oxidation in white adipocytes publication-title: Endocrinology – volume: 89 start-page: 44 year: 2018 end-page: 48 article-title: Spontaneous alveolar bone loss after 4NQO exposure in Wistar rats publication-title: Archives of Oral Biology – volume: 40 start-page: 71 issue: 1 year: 2009 end-page: 76 article-title: No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4‐nitroquinoline‐1‐oxide publication-title: Journal of Molecular Histology – volume: 27 start-page: 21 issue: 1 year: 2021 end-page: 26 article-title: Improving oral cavity cancer diagnosis and treatment with fluorescence molecular imaging publication-title: Oral Diseases – volume: 109 start-page: 1 issue: 11 year: 2017 end-page: 14 article-title: Therapeutic targeting of the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis in cancer publication-title: Journal of the National Cancer Institute – volume: 20 start-page: 1576 issue: 9 year: 2009 end-page: 1581 article-title: Dietary vitamin D and cancers of the oral cavity and esophagus publication-title: Annals of Oncology – ident: e_1_2_9_2_1 doi: 10.5114/wo.2017.68623 – ident: e_1_2_9_26_1 doi: 10.3322/caac.21660 – ident: e_1_2_9_13_1 doi: 10.7314/apjcp.2013.14.10.5567 – ident: e_1_2_9_6_1 doi: 10.1038/bjc.2013.667 – ident: e_1_2_9_23_1 doi: 10.1093/jnci/djx071 – ident: e_1_2_9_29_1 doi: 10.3892/mmr.2014.2945 – ident: e_1_2_9_4_1 doi: 10.1155/2020/5490468 – ident: e_1_2_9_16_1 doi: 10.1093/annonc/mdp036 – ident: e_1_2_9_7_1 doi: 10.14219/jada.archive.2011.0059 – ident: e_1_2_9_14_1 doi: 10.1002/mnfr.201500425 – ident: e_1_2_9_15_1 doi: 10.1093/nar/gkz401 – ident: e_1_2_9_20_1 doi: 10.1016/j.archoralbio.2018.02.001 – ident: e_1_2_9_9_1 doi: 10.1017/S1368980018000204 – ident: e_1_2_9_12_1 doi: 10.1016/j.cell.2011.02.013 – ident: e_1_2_9_31_1 doi: 10.1042/BJ20060914 – ident: e_1_2_9_10_1 doi: 10.1016/j.cell.2005.12.022 – ident: e_1_2_9_8_1 doi: 10.1016/j.biopha.2018.10.102 – ident: e_1_2_9_17_1 doi: 10.1001/archotol.133.11.1149 – ident: e_1_2_9_18_1 doi: 10.1111/jop.13041 – ident: e_1_2_9_5_1 doi: 10.3390/nu12051471 – ident: e_1_2_9_21_1 doi: 10.3109/19390211.2013.859209 – ident: e_1_2_9_24_1 doi: 10.1210/en.2009‐0676 – ident: e_1_2_9_19_1 doi: 10.1007/s10735‐009‐9215‐4 – volume: 10 start-page: 227 issue: 2 year: 2007 ident: e_1_2_9_27_1 article-title: Type of food and risk of oral cancer publication-title: Archives of Iranian Medicine – ident: e_1_2_9_28_1 doi: 10.1111/odi.13308 – ident: e_1_2_9_25_1 doi: 10.1080/13813450600935263 – ident: e_1_2_9_11_1 doi: 10.4317/medoral.20368 – ident: e_1_2_9_22_1 doi: 10.1016/j.cmet.2015.05.014 – ident: e_1_2_9_3_1 doi: 10.3390/ijerph17249160 – ident: e_1_2_9_30_1 doi: 10.3390/ijms21186835 |
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Diets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods... Diets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods of animal... ObjectivesDiets and nutritional habits are critical during carcinogenic processes, where a diet poor in fruits and vegetables and rich in meat and other foods... |
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SubjectTerms | 4NQO Animal models Animals Carcinogenesis Carcinogenesis - metabolism Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cholesterol Diet Energy metabolism Glycolysis Head and Neck Neoplasms High density lipoprotein Hyperlipidemia LDL Low density lipoprotein Mouth Neoplasms - genetics Nutrient deficiency Nutrition Oral cancer Oral carcinoma Oral squamous cell carcinoma Rats Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Triglycerides Tumor cells Vitamin D vitamin D deficiency Vitamin D Deficiency - complications Vitamin deficiency |
Title | Low vitamin D and high cholesterol facilitate oral carcinogenesis in 4NQO‐induced rat models via regulating glycolysis |
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