HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF‐IIR expression for hypertension‐induced cardiomyocyte hypertrophy - Huang, Chih‐Yang; Lee, Fa‐Lun; Peng, Shu‐Fen; Lin, Kuan‐Ho; Chen, Ray‐Jade; Ho, Tsung‐Jung; Tsai, Fu‐Jen; Padma, Vijaya V.; Kuo, Wei‐Wen; Huang, Chih‐Yang (Journal of cellular physiology, 2018)
Keywords: Angiotensin; Angiotensin II; Angiotensin II - pharmacology; Angiotensin II Type 1 Receptor Blockers - pharmacology; Animals; Antihypertensive Agents - pharmacology; Apoptosis; Biphenyl Compounds - pharmacology; cardiac hypertrophy; Cardiomegaly - enzymology; Cardiomegaly - etiology; Cardiomegaly - pathology; Cardiomegaly - prevention & control; Cardiomyocytes; Cell Line; Coronary artery disease; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular signal-regulated kinase; Extracellular Signal-Regulated MAP Kinases - metabolism; Female; Glycogen; Glycogen synthase kinase 3; Glycogen Synthase Kinase 3 beta - metabolism; Heart; Heart diseases; Heat Shock Transcription Factors - metabolism; Heat-Shock Proteins - metabolism; HSF1; HSF1 protein; Hypertension; Hypertension - complications; Hypertension - drug therapy; Hypertension - enzymology; Hypertension - pathology; Hypertrophy; IGF‐IIR; Insulin; Insulin-like growth factor II; Insulin-like growth factors; Kinases; Lithium Chloride - pharmacology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - enzymology; Myocytes, Cardiac - pathology; Phosphorylation; Protein Stability; Protein Transport; Proteins; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1 - metabolism; Receptor, IGF Type 2 - metabolism; RNF126; Signal Transduction; Signaling; Stability; Tetrazoles - pharmacology; Time Factors; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; RNF126; IGF-IIR; cardiac hypertrophy; hypertension; HSF1