Androgen receptor transcriptional activity and chromatin modifications on the ABCB1/MDR gene are critical for taxol resistance in ovarian cancer cells - Sun, Nian‐Kang; Kohli, Abhidha; Huang, Shang‐Lang; Chang, Ting‐Chang; Chao, Chuck C.‐K. (Journal of cellular physiology, 2019)
Keywords: 1-Phosphatidylinositol 3-kinase; ABCB1; Acetyltransferase; AKT; AKT protein; androgen receptor (AR); Androgen receptors; Androgens; Antineoplastic Agents - pharmacology; ATP Binding Cassette Transporter, Subfamily B; Binding; Cell Line, Tumor; Chromatin - genetics; Chromatin - metabolism; Chromatin remodeling; Clonal deletion; Cytotoxicity; Deactivation; Dihydrotestosterone; Drug Resistance, Neoplasm; Event-related potentials; Female; Gene deletion; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genes, MDR - genetics; Humans; Immunoprecipitation; Inactivation; Kinases; MRP protein; Ovarian cancer; Ovarian carcinoma; Ovarian Neoplasms - drug therapy; Paclitaxel; Paclitaxel - pharmacology; Protein kinase; Protein-serine/threonine kinase; Proteins; Receptors, Androgen - genetics; Receptors, Androgen - metabolism; Regulatory sequences; Taxol; taxol resistance; Toxicity; Transcription; Transcription, Genetic - drug effects; taxol resistance; androgen receptor (AR); ovarian carcinoma; AKT; ABCB1