Combining non‐invasive brain stimulation with functional magnetic resonance imaging to investigate the neural substrates of cognitive aging

As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non‐invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provide...

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Published in	Journal of neuroscience research Vol. 100; no. 5; pp. 1159 - 1170
Main Authors	Abellaneda‐Pérez, Kilian, Vaqué‐Alcázar, Lídia, Solé‐Padullés, Cristina, Bartrés‐Faz, David
Format	Journal Article
Language	English
Published	United States Wiley Subscription Services, Inc 01.05.2022
Subjects	Adults Aging Brain Brain - diagnostic imaging Brain - physiology Brain mapping Cognitive ability Cognitive Aging Functional magnetic resonance imaging Magnetic resonance imaging Magnetic Resonance Imaging - methods Mental health Nervous system Neural networks Neuroimaging Neuronal Plasticity Neuroplasticity non‐invasive brain stimulation Older people repetitive transcranial magnetic stimulation Stimulation Substrates transcranial direct current stimulation Transcranial Magnetic Stimulation - methods functional magnetic resonance imaging non-invasive brain stimulation transcranial direct current stimulation cognitive aging repetitive transcranial magnetic stimulation
Online Access	Get full text
ISSN	0360-4012 1097-4547 1097-4547
DOI	10.1002/jnr.24514

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Abstract	As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non‐invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provides novel experimental data on the putative neurophysiological mechanisms underlying inter‐individual differences in cognitive status among older adults, also further illuminating our understanding of theoretical models proposed within the cognitive neuroscience of aging literature. In addition, it explores published evidence of how this combined procedure entails the capacity to modify the activity and connectivity of specific brain networks in older adults, potentially leading to improvements in cognitive function and other measures reflecting mental health status. Although additional research is needed, combining NIBS with fMRI might provide innovative understanding of how fundamental brain plasticity mechanisms operate in advancing age, a knowledge that may be eventually used to refine more individually tailored approaches to promote brain health in aged populations.
AbstractList	As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non-invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provides novel experimental data on the putative neurophysiological mechanisms underlying inter-individual differences in cognitive status among older adults, also further illuminating our understanding of theoretical models proposed within the cognitive neuroscience of aging literature. In addition, it explores published evidence of how this combined procedure entails the capacity to modify the activity and connectivity of specific brain networks in older adults, potentially leading to improvements in cognitive function and other measures reflecting mental health status. Although additional research is needed, combining NIBS with fMRI might provide innovative understanding of how fundamental brain plasticity mechanisms operate in advancing age, a knowledge that may be eventually used to refine more individually tailored approaches to promote brain health in aged populations. As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non-invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provides novel experimental data on the putative neurophysiological mechanisms underlying inter-individual differences in cognitive status among older adults, also further illuminating our understanding of theoretical models proposed within the cognitive neuroscience of aging literature. In addition, it explores published evidence of how this combined procedure entails the capacity to modify the activity and connectivity of specific brain networks in older adults, potentially leading to improvements in cognitive function and other measures reflecting mental health status. Although additional research is needed, combining NIBS with fMRI might provide innovative understanding of how fundamental brain plasticity mechanisms operate in advancing age, a knowledge that may be eventually used to refine more individually tailored approaches to promote brain health in aged populations.As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non-invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provides novel experimental data on the putative neurophysiological mechanisms underlying inter-individual differences in cognitive status among older adults, also further illuminating our understanding of theoretical models proposed within the cognitive neuroscience of aging literature. In addition, it explores published evidence of how this combined procedure entails the capacity to modify the activity and connectivity of specific brain networks in older adults, potentially leading to improvements in cognitive function and other measures reflecting mental health status. Although additional research is needed, combining NIBS with fMRI might provide innovative understanding of how fundamental brain plasticity mechanisms operate in advancing age, a knowledge that may be eventually used to refine more individually tailored approaches to promote brain health in aged populations.
Author	Vaqué‐Alcázar, Lídia Bartrés‐Faz, David Solé‐Padullés, Cristina Abellaneda‐Pérez, Kilian
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Keywords	functional magnetic resonance imaging non-invasive brain stimulation transcranial direct current stimulation cognitive aging repetitive transcranial magnetic stimulation
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Notes	Funding information This work was supported by grants from the Spanish Ministry of Economy and Competitiveness (MINECO/FEDER; PSI2015‐64227‐R) and the Spanish Ministry of Science, Innovation and Universities (MICIU/FEDER; RTI2018‐095181‐B‐C21) to D.B.‐F. K.A.‐P. was supported by a fellowship from the Spanish Ministry of Education, Culture and Sport (MECD; reference number, FPU14/02728). L.V.‐A. was supported by a fellowship associated with the MINECO/FEDER PSI2015‐64227‐R grant (reference number, BES‐2016‐077620). This research was also supported by the Government of Catalonia (2017SGR748). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
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Snippet	As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent....
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SubjectTerms	Adults Aging Brain Brain - diagnostic imaging Brain - physiology Brain mapping Cognitive ability Cognitive Aging Functional magnetic resonance imaging Magnetic resonance imaging Magnetic Resonance Imaging - methods Mental health Nervous system Neural networks Neuroimaging Neuronal Plasticity Neuroplasticity non‐invasive brain stimulation Older people repetitive transcranial magnetic stimulation Stimulation Substrates transcranial direct current stimulation Transcranial Magnetic Stimulation - methods
Title	Combining non‐invasive brain stimulation with functional magnetic resonance imaging to investigate the neural substrates of cognitive aging
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