Spiropiperidines. I. Synthesis of 1'-Substituted Spiro [4H-3, 1-benzoxazine-4, 4'-piperidin]-2 (1H)-one Derivatives and Evaluation of Their Antihypertensive Activity - TAKAI, HARUKI; SHUTO, KATSUICHI; TERANISHI, MASAYUKI; KUBO, KAZUHIRO; KASUYA, YUTAKA; KARASHIMA, NAOKO; OBASE, HIROYUKI; SHIGENOBU, KOKI; KARASAWA, AKIRA; HASHIKAMI, MAKIKO (Chemical & pharmaceutical bulletin, 1985)
Keywords: alpha receptor blocking; Animals; antihypertensive activity; Antihypertensive Agents - chemical synthesis; Blood Pressure - drug effects; Chemistry; Exact sciences and technology; Heart Rate - drug effects; Heterocyclic compounds; Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms; Indicators and Reagents; Male; Organic chemistry; oxazine; Oxazines - chemical synthesis; Oxazines - pharmacology; piperidine; Piperidines - chemical synthesis; Piperidines - pharmacology; Preparations and properties; Rats; Rats, Inbred SHR; Rats, Inbred Strains; spiro ring; Structure-Activity Relationship; Nitrogen heterocycle; Six membered ring; Bicyclic compound; Antihypertensive agent; Benzenic compound; Aromatic compound; Urethane; NMR spectrum; Biological activity; Spiran; Oxygen nitrogen heterocycle