Type 2 diabetes significantly modulates the cardiovascular risk conferred by the PAI-1 − 675 4G/5G polymorphism in angiographied coronary patients

The association of the − 675 4G/5G polymorphism of the plasminogen activator inhibitor-1 ( PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown. Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of...

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Published inClinica chimica acta Vol. 396; no. 1; pp. 18 - 22
Main Authors Saely, Christoph H., Muendlein, Axel, Vonbank, Alexander, Sonderegger, Gudrun, Aczel, Stefan, Rein, Philipp, Risch, Lorenz, Drexel, Heinz
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2008
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ISSN0009-8981
1873-3492
DOI10.1016/j.cca.2008.06.015

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Abstract The association of the − 675 4G/5G polymorphism of the plasminogen activator inhibitor-1 ( PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown. Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years. In non-diabetic subjects ( n = 524), the homozygous PAI-1 4G4G genotype was significantly associated with significant coronary stenoses ≥ 50% (adjusted odds ratio (OR) OR = 1.84 [1.17–2.92]; p = 0.009); however, in T2DM patients ( n = 148) no such association was observed (OR = 0.67 [0.26–1.71]; p = 0.401). An interaction term T2DM × 4G4G genotype was significant ( p = 0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13–2.74]; p = 0.014 and 0.68 [0.30–1.54]; p = 0.360, respectively). Again, the interaction T2DM × 4G4G genotype was significant ( p = 0.018). Presence of T2DM significantly modulates the vascular risk conferred by the PAI-1 − 675 4G/5G polymorphism in angiographied coronary patients.
AbstractList The association of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown.BACKGROUNDThe association of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown.Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years.METHODSGenotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years.In non-diabetic subjects (n=524), the homozygous PAI-1 4G4G genotype was significantly associated with significant coronary stenoses>or=50% (adjusted odds ratio (OR) OR=1.84 [1.17-2.92]; p=0.009); however, in T2DM patients (n=148) no such association was observed (OR=0.67 [0.26-1.71]; p=0.401). An interaction term T2DMx4G4G genotype was significant (p=0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13-2.74]; p=0.014 and 0.68 [0.30-1.54]; p=0.360, respectively). Again, the interaction T2DMx4G4G genotype was significant (p=0.018).RESULTSIn non-diabetic subjects (n=524), the homozygous PAI-1 4G4G genotype was significantly associated with significant coronary stenoses>or=50% (adjusted odds ratio (OR) OR=1.84 [1.17-2.92]; p=0.009); however, in T2DM patients (n=148) no such association was observed (OR=0.67 [0.26-1.71]; p=0.401). An interaction term T2DMx4G4G genotype was significant (p=0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13-2.74]; p=0.014 and 0.68 [0.30-1.54]; p=0.360, respectively). Again, the interaction T2DMx4G4G genotype was significant (p=0.018).Presence of T2DM significantly modulates the vascular risk conferred by the PAI-1 -675 4G/5G polymorphism in angiographied coronary patients.CONCLUSIONSPresence of T2DM significantly modulates the vascular risk conferred by the PAI-1 -675 4G/5G polymorphism in angiographied coronary patients.
The association of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown. Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years. In non-diabetic subjects (n=524), the homozygous PAI-1 4G4G genotype was significantly associated with significant coronary stenoses>or=50% (adjusted odds ratio (OR) OR=1.84 [1.17-2.92]; p=0.009); however, in T2DM patients (n=148) no such association was observed (OR=0.67 [0.26-1.71]; p=0.401). An interaction term T2DMx4G4G genotype was significant (p=0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13-2.74]; p=0.014 and 0.68 [0.30-1.54]; p=0.360, respectively). Again, the interaction T2DMx4G4G genotype was significant (p=0.018). Presence of T2DM significantly modulates the vascular risk conferred by the PAI-1 -675 4G/5G polymorphism in angiographied coronary patients.
The association of the − 675 4G/5G polymorphism of the plasminogen activator inhibitor-1 ( PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown. Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years. In non-diabetic subjects ( n = 524), the homozygous PAI-1 4G4G genotype was significantly associated with significant coronary stenoses ≥ 50% (adjusted odds ratio (OR) OR = 1.84 [1.17–2.92]; p = 0.009); however, in T2DM patients ( n = 148) no such association was observed (OR = 0.67 [0.26–1.71]; p = 0.401). An interaction term T2DM × 4G4G genotype was significant ( p = 0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13–2.74]; p = 0.014 and 0.68 [0.30–1.54]; p = 0.360, respectively). Again, the interaction T2DM × 4G4G genotype was significant ( p = 0.018). Presence of T2DM significantly modulates the vascular risk conferred by the PAI-1 − 675 4G/5G polymorphism in angiographied coronary patients.
Author Rein, Philipp
Risch, Lorenz
Saely, Christoph H.
Muendlein, Axel
Sonderegger, Gudrun
Vonbank, Alexander
Aczel, Stefan
Drexel, Heinz
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Issue 1
Keywords Type 2 diabetes
Plasminogen activator inhibitor 1
Coronary atherosclerosis
Prospective study
Genetic polymorphism
Language English
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Snippet The association of the − 675 4G/5G polymorphism of the plasminogen activator inhibitor-1 ( PAI-1) gene with cardiovascular disease in patients with type 2...
The association of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene with cardiovascular disease in patients with type 2...
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SubjectTerms Angiography
Coronary Artery Disease - complications
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Artery Disease - genetics
Coronary atherosclerosis
Diabetes Complications - diagnostic imaging
Diabetes Complications - epidemiology
Diabetes Complications - genetics
Diabetes Complications - metabolism
Diabetes Mellitus, Type 2 - diagnostic imaging
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Disease-Free Survival
Female
Genetic polymorphism
Genotype
Humans
Male
Middle Aged
Plasminogen activator inhibitor 1
Plasminogen Activator Inhibitor 1 - genetics
Plasminogen Activator Inhibitor 1 - metabolism
Polymorphism, Genetic - genetics
Prospective study
Risk Factors
Type 2 diabetes
Title Type 2 diabetes significantly modulates the cardiovascular risk conferred by the PAI-1 − 675 4G/5G polymorphism in angiographied coronary patients
URI https://dx.doi.org/10.1016/j.cca.2008.06.015
https://www.ncbi.nlm.nih.gov/pubmed/18619429
https://www.proquest.com/docview/69486916
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