Type 2 diabetes significantly modulates the cardiovascular risk conferred by the PAI-1 − 675 4G/5G polymorphism in angiographied coronary patients
The association of the − 675 4G/5G polymorphism of the plasminogen activator inhibitor-1 ( PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown. Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of...
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Published in | Clinica chimica acta Vol. 396; no. 1; pp. 18 - 22 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.10.2008
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Subjects | |
Online Access | Get full text |
ISSN | 0009-8981 1873-3492 |
DOI | 10.1016/j.cca.2008.06.015 |
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Abstract | The association of the −
675 4G/5G polymorphism of the
plasminogen activator inhibitor-1 (
PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown.
Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years.
In non-diabetic subjects (
n
=
524), the homozygous
PAI-1 4G4G genotype was significantly associated with significant coronary stenoses ≥
50% (adjusted odds ratio (OR) OR
=
1.84 [1.17–2.92];
p
=
0.009); however, in T2DM patients (
n
=
148) no such association was observed (OR
=
0.67 [0.26–1.71];
p
=
0.401). An interaction term T2DM
×
4G4G genotype was significant (
p
=
0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13–2.74];
p
=
0.014 and 0.68 [0.30–1.54];
p
=
0.360, respectively). Again, the interaction T2DM
×
4G4G genotype was significant (
p
=
0.018).
Presence of T2DM significantly modulates the vascular risk conferred by the
PAI-1 −
675 4G/5G polymorphism in angiographied coronary patients. |
---|---|
AbstractList | The association of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown.BACKGROUNDThe association of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown.Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years.METHODSGenotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years.In non-diabetic subjects (n=524), the homozygous PAI-1 4G4G genotype was significantly associated with significant coronary stenoses>or=50% (adjusted odds ratio (OR) OR=1.84 [1.17-2.92]; p=0.009); however, in T2DM patients (n=148) no such association was observed (OR=0.67 [0.26-1.71]; p=0.401). An interaction term T2DMx4G4G genotype was significant (p=0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13-2.74]; p=0.014 and 0.68 [0.30-1.54]; p=0.360, respectively). Again, the interaction T2DMx4G4G genotype was significant (p=0.018).RESULTSIn non-diabetic subjects (n=524), the homozygous PAI-1 4G4G genotype was significantly associated with significant coronary stenoses>or=50% (adjusted odds ratio (OR) OR=1.84 [1.17-2.92]; p=0.009); however, in T2DM patients (n=148) no such association was observed (OR=0.67 [0.26-1.71]; p=0.401). An interaction term T2DMx4G4G genotype was significant (p=0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13-2.74]; p=0.014 and 0.68 [0.30-1.54]; p=0.360, respectively). Again, the interaction T2DMx4G4G genotype was significant (p=0.018).Presence of T2DM significantly modulates the vascular risk conferred by the PAI-1 -675 4G/5G polymorphism in angiographied coronary patients.CONCLUSIONSPresence of T2DM significantly modulates the vascular risk conferred by the PAI-1 -675 4G/5G polymorphism in angiographied coronary patients. The association of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown. Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years. In non-diabetic subjects (n=524), the homozygous PAI-1 4G4G genotype was significantly associated with significant coronary stenoses>or=50% (adjusted odds ratio (OR) OR=1.84 [1.17-2.92]; p=0.009); however, in T2DM patients (n=148) no such association was observed (OR=0.67 [0.26-1.71]; p=0.401). An interaction term T2DMx4G4G genotype was significant (p=0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13-2.74]; p=0.014 and 0.68 [0.30-1.54]; p=0.360, respectively). Again, the interaction T2DMx4G4G genotype was significant (p=0.018). Presence of T2DM significantly modulates the vascular risk conferred by the PAI-1 -675 4G/5G polymorphism in angiographied coronary patients. The association of the − 675 4G/5G polymorphism of the plasminogen activator inhibitor-1 ( PAI-1) gene with cardiovascular disease in patients with type 2 diabetes (T2DM) is unknown. Genotyping was performed in 672 consecutive Caucasian patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Vascular events were recorded over 4 years. In non-diabetic subjects ( n = 524), the homozygous PAI-1 4G4G genotype was significantly associated with significant coronary stenoses ≥ 50% (adjusted odds ratio (OR) OR = 1.84 [1.17–2.92]; p = 0.009); however, in T2DM patients ( n = 148) no such association was observed (OR = 0.67 [0.26–1.71]; p = 0.401). An interaction term T2DM × 4G4G genotype was significant ( p = 0.006), indicating a significantly stronger association of the polymorphism with CAD in non-diabetic subjects than in patients with T2DM. Also prospectively, the 4G4G genotype conferred an increased risk of vascular events in non-diabetic subjects but not in T2DM patients (hazard ratios 1.76 [1.13–2.74]; p = 0.014 and 0.68 [0.30–1.54]; p = 0.360, respectively). Again, the interaction T2DM × 4G4G genotype was significant ( p = 0.018). Presence of T2DM significantly modulates the vascular risk conferred by the PAI-1 − 675 4G/5G polymorphism in angiographied coronary patients. |
Author | Rein, Philipp Risch, Lorenz Saely, Christoph H. Muendlein, Axel Sonderegger, Gudrun Vonbank, Alexander Aczel, Stefan Drexel, Heinz |
Author_xml | – sequence: 1 givenname: Christoph H. surname: Saely fullname: Saely, Christoph H. organization: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria – sequence: 2 givenname: Axel surname: Muendlein fullname: Muendlein, Axel organization: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria – sequence: 3 givenname: Alexander surname: Vonbank fullname: Vonbank, Alexander organization: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria – sequence: 4 givenname: Gudrun surname: Sonderegger fullname: Sonderegger, Gudrun organization: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria – sequence: 5 givenname: Stefan surname: Aczel fullname: Aczel, Stefan organization: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria – sequence: 6 givenname: Philipp surname: Rein fullname: Rein, Philipp organization: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria – sequence: 7 givenname: Lorenz surname: Risch fullname: Risch, Lorenz organization: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria – sequence: 8 givenname: Heinz surname: Drexel fullname: Drexel, Heinz email: vivit@lkhf.at organization: Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18619429$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_ccl_2010_04_005 crossref_primary_10_1186_s12902_021_00837_z crossref_primary_10_1371_journal_pone_0079150 crossref_primary_10_23736_S2724_5683_20_05212_3 crossref_primary_10_3724_SP_J_1008_2009_00286 crossref_primary_10_1016_j_cca_2010_10_029 |
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Keywords | Type 2 diabetes Plasminogen activator inhibitor 1 Coronary atherosclerosis Prospective study Genetic polymorphism |
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675 4G/5G polymorphism of the
plasminogen activator inhibitor-1 (
PAI-1) gene with cardiovascular disease in patients with type 2... The association of the -675 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene with cardiovascular disease in patients with type 2... |
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SubjectTerms | Angiography Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Coronary atherosclerosis Diabetes Complications - diagnostic imaging Diabetes Complications - epidemiology Diabetes Complications - genetics Diabetes Complications - metabolism Diabetes Mellitus, Type 2 - diagnostic imaging Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Disease-Free Survival Female Genetic polymorphism Genotype Humans Male Middle Aged Plasminogen activator inhibitor 1 Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism Polymorphism, Genetic - genetics Prospective study Risk Factors Type 2 diabetes |
Title | Type 2 diabetes significantly modulates the cardiovascular risk conferred by the PAI-1 − 675 4G/5G polymorphism in angiographied coronary patients |
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