D-optimal designs for mixed discrete and continuous outcomes analyzed using nonlinear models - Coffey, T; Gennings, C (Journal of agricultural, biological, and environmental statistics, 2007)
Keywords: Agronomy. Soil science and plant productions; algorithms; Biological and medical sciences; Biometrics, statistics, experimental designs, modeling, agricultural computer applications; correlation; Covariance matrices; D-efficiency; Design analysis; Design efficiency; Dosage; dose response; Dose response relationship; dose threshold; equations; estimation; Experiment design; Fundamental and applied biological sciences. Psychology; Generalities. Biometrics, experimentation. Remote sensing; Modeling; multiple outcomes; nonlinear models; optimality criterion; Parametric models; Sample size; sampling; Statistical variance; toxicology; Multiple outcomes; Continuous; Non linear model; Dose threshold; Dose-response; Optimality criterion; D-efficiency; Intra-subject correlation; Threshold dose