Paediatric Traumatic Brain Injury and Long‐Term Antidepressant Use: A Nationwide Register‐Based Cohort Study
ABSTRACT Aim The association between paediatric traumatic brain injury (pTBI) and post‐traumatic antidepressant medication usage remains an understudied subject. Methods A nationwide Finnish retrospective cohort study (1998–2018) included 71 969 pTBI patients and 64 856 orthopaedic references. Antid...
Saved in:
| Published in | Acta Paediatrica Vol. 114; no. 10; pp. 2656 - 2664 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Norway
Wiley Subscription Services, Inc
01.10.2025
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0803-5253 1651-2227 1651-2227 |
| DOI | 10.1111/apa.70158 |
Cover
| Abstract | ABSTRACT
Aim
The association between paediatric traumatic brain injury (pTBI) and post‐traumatic antidepressant medication usage remains an understudied subject.
Methods
A nationwide Finnish retrospective cohort study (1998–2018) included 71 969 pTBI patients and 64 856 orthopaedic references. Antidepressant medication data were sourced from the Finnish Social Insurance Institution. The primary outcome was post‐traumatic paediatric antidepressant use.
Results
The study included 136 825 patients. Kaplan–Meier analyses showed higher antidepressant use in pTBI patients, especially after 5 years and following surgery. The cumulative incidence rate (CIR) after 1 year was 0.73% (pTBI) versus 0.34% (references), increasing to 26.95% versus 25.51% after 20 years. Cox regression showed a higher long‐term risk in pTBI patients (HR 1.31, up to 9 years). Operatively treated pTBI had an HR of 4.45 after 2 years. Among females, HR was 2.60 after 1 year, while in males, HR was 1.54.
Conclusions
The risk of antidepressant use following pTBI is notably higher after the first year, for both sexes and among patients who undergo operative treatment for pTBI. This elevated risk persists for 9 years but then declines. |
|---|---|
| AbstractList | The association between paediatric traumatic brain injury (pTBI) and post-traumatic antidepressant medication usage remains an understudied subject.AIMThe association between paediatric traumatic brain injury (pTBI) and post-traumatic antidepressant medication usage remains an understudied subject.A nationwide Finnish retrospective cohort study (1998-2018) included 71 969 pTBI patients and 64 856 orthopaedic references. Antidepressant medication data were sourced from the Finnish Social Insurance Institution. The primary outcome was post-traumatic paediatric antidepressant use.METHODSA nationwide Finnish retrospective cohort study (1998-2018) included 71 969 pTBI patients and 64 856 orthopaedic references. Antidepressant medication data were sourced from the Finnish Social Insurance Institution. The primary outcome was post-traumatic paediatric antidepressant use.The study included 136 825 patients. Kaplan-Meier analyses showed higher antidepressant use in pTBI patients, especially after 5 years and following surgery. The cumulative incidence rate (CIR) after 1 year was 0.73% (pTBI) versus 0.34% (references), increasing to 26.95% versus 25.51% after 20 years. Cox regression showed a higher long-term risk in pTBI patients (HR 1.31, up to 9 years). Operatively treated pTBI had an HR of 4.45 after 2 years. Among females, HR was 2.60 after 1 year, while in males, HR was 1.54.RESULTSThe study included 136 825 patients. Kaplan-Meier analyses showed higher antidepressant use in pTBI patients, especially after 5 years and following surgery. The cumulative incidence rate (CIR) after 1 year was 0.73% (pTBI) versus 0.34% (references), increasing to 26.95% versus 25.51% after 20 years. Cox regression showed a higher long-term risk in pTBI patients (HR 1.31, up to 9 years). Operatively treated pTBI had an HR of 4.45 after 2 years. Among females, HR was 2.60 after 1 year, while in males, HR was 1.54.The risk of antidepressant use following pTBI is notably higher after the first year, for both sexes and among patients who undergo operative treatment for pTBI. This elevated risk persists for 9 years but then declines.CONCLUSIONSThe risk of antidepressant use following pTBI is notably higher after the first year, for both sexes and among patients who undergo operative treatment for pTBI. This elevated risk persists for 9 years but then declines. ABSTRACT Aim The association between paediatric traumatic brain injury (pTBI) and post‐traumatic antidepressant medication usage remains an understudied subject. Methods A nationwide Finnish retrospective cohort study (1998–2018) included 71 969 pTBI patients and 64 856 orthopaedic references. Antidepressant medication data were sourced from the Finnish Social Insurance Institution. The primary outcome was post‐traumatic paediatric antidepressant use. Results The study included 136 825 patients. Kaplan–Meier analyses showed higher antidepressant use in pTBI patients, especially after 5 years and following surgery. The cumulative incidence rate (CIR) after 1 year was 0.73% (pTBI) versus 0.34% (references), increasing to 26.95% versus 25.51% after 20 years. Cox regression showed a higher long‐term risk in pTBI patients (HR 1.31, up to 9 years). Operatively treated pTBI had an HR of 4.45 after 2 years. Among females, HR was 2.60 after 1 year, while in males, HR was 1.54. Conclusions The risk of antidepressant use following pTBI is notably higher after the first year, for both sexes and among patients who undergo operative treatment for pTBI. This elevated risk persists for 9 years but then declines. Aim The association between paediatric traumatic brain injury (pTBI) and post‐traumatic antidepressant medication usage remains an understudied subject. Methods A nationwide Finnish retrospective cohort study (1998–2018) included 71 969 pTBI patients and 64 856 orthopaedic references. Antidepressant medication data were sourced from the Finnish Social Insurance Institution. The primary outcome was post‐traumatic paediatric antidepressant use. Results The study included 136 825 patients. Kaplan–Meier analyses showed higher antidepressant use in pTBI patients, especially after 5 years and following surgery. The cumulative incidence rate (CIR) after 1 year was 0.73% (pTBI) versus 0.34% (references), increasing to 26.95% versus 25.51% after 20 years. Cox regression showed a higher long‐term risk in pTBI patients (HR 1.31, up to 9 years). Operatively treated pTBI had an HR of 4.45 after 2 years. Among females, HR was 2.60 after 1 year, while in males, HR was 1.54. Conclusions The risk of antidepressant use following pTBI is notably higher after the first year, for both sexes and among patients who undergo operative treatment for pTBI. This elevated risk persists for 9 years but then declines. The association between paediatric traumatic brain injury (pTBI) and post-traumatic antidepressant medication usage remains an understudied subject. A nationwide Finnish retrospective cohort study (1998-2018) included 71 969 pTBI patients and 64 856 orthopaedic references. Antidepressant medication data were sourced from the Finnish Social Insurance Institution. The primary outcome was post-traumatic paediatric antidepressant use. The study included 136 825 patients. Kaplan-Meier analyses showed higher antidepressant use in pTBI patients, especially after 5 years and following surgery. The cumulative incidence rate (CIR) after 1 year was 0.73% (pTBI) versus 0.34% (references), increasing to 26.95% versus 25.51% after 20 years. Cox regression showed a higher long-term risk in pTBI patients (HR 1.31, up to 9 years). Operatively treated pTBI had an HR of 4.45 after 2 years. Among females, HR was 2.60 after 1 year, while in males, HR was 1.54. The risk of antidepressant use following pTBI is notably higher after the first year, for both sexes and among patients who undergo operative treatment for pTBI. This elevated risk persists for 9 years but then declines. |
| Author | Ponkilainen, Ville Kuitunen, Ilari Möttönen, Julius Laaksonen, Juho Mattila, Ville M. |
| Author_xml | – sequence: 1 givenname: Juho orcidid: 0000-0002-9328-4721 surname: Laaksonen fullname: Laaksonen, Juho email: juho.laaksonen@tuni.fi organization: Tampereen yliopisto Laaketieteen ja terveysteknologian tiedekunta – sequence: 2 givenname: Ville orcidid: 0000-0002-5026-4560 surname: Ponkilainen fullname: Ponkilainen, Ville organization: Tays Tuki‐ja liikuntaelinkeskuksen osasto – sequence: 3 givenname: Julius orcidid: 0000-0001-7366-5140 surname: Möttönen fullname: Möttönen, Julius organization: Tampereen yliopisto Laaketieteen ja terveysteknologian tiedekunta – sequence: 4 givenname: Ville M. orcidid: 0000-0001-9946-4830 surname: Mattila fullname: Mattila, Ville M. organization: Tekonivelsairaala COXA Oy – sequence: 5 givenname: Ilari orcidid: 0000-0001-8178-9610 surname: Kuitunen fullname: Kuitunen, Ilari organization: Kuopion yliopistollinen sairaala |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40457730$$D View this record in MEDLINE/PubMed |
| BookMark | eNp10c1u1DAQB3ALFdFt4cALIEtc4JDWju044Zau-Ki0ggq252jWHpesNnZqJ6r2xiP0GfskGLZwQMIXW_JvRqP5n5AjHzwS8pKzM57POYxwphlX9ROy4JXiRVmW-ogsWM1EoUoljslJSlvGStHI6hk5lkwqrQVbkPEK0PYwxd7QdYR5gCm_LiL0nl767Rz3FLylq-BvHn7crzEOtPVTb3GMmBL4iV4nfEdb-jkXBn-Xf-hXvOnThDEXXEBCS5fhe4gT_TbNdv-cPHWwS_ji8T4l1x_er5efitWXj5fLdlUYoVhd1HxjaikMNNKZZuOkrPP0CizYjdQCKqdtWTojNNOscUwIBKdR1aZpKuWsOCVvDn3HGG5nTFM39Mngbgcew5w6UXKVG1ZMZ_r6H7oNc_R5uqxkw1m2TVavHtW8GdB2Y-wHiPvuzy4zeHsAJoaUIrq_hLPuV05dzqn7nVO25wd71-9w_3_YtVftoeInRQSUkQ |
| Cites_doi | 10.1016/j.jad.2023.10.130 10.1097/HTR.0000000000000603 10.1016/j.injury.2022.12.023 10.1001/jama.2010.599 10.1007/s10787‐022‐01017‐8 10.1177/1403494812456637 10.1016/j.jadohealth.2018.12.023 10.1038/s41436‐021‐01261‐3 10.1097/HTR.0000000000000343 10.1186/1471‐2474‐15‐98 10.1016/j.wneu.2016.03.045 10.1097/00004583‐199808000‐00013 10.1097/00001199‐200511000‐00001 10.1176/appi.ajp.2009.09050617 10.1002/da.20398 10.1089/neu.2017.5379 10.21037/atm.2018.02.12 10.1016/j.ijdevneu.2011.12.005 10.1186/1471‐2288‐8‐70 10.1016/j.injury.2008.05.007 10.1186/s40478‐024‐01840‐w 10.1097/00004583‐200105000‐00017 10.1186/s12879‐020‐05555‐w 10.1177/0706743716643741 10.1111/papr.13301 |
| ContentType | Journal Article |
| Copyright | 2025 The Author(s). published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. 2025 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. 2025. This work is published under Creative Commons Attribution – Non-Commercial License~http://creativecommons.org/licenses/by-nc/3.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2025 The Author(s). published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. – notice: 2025 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. – notice: 2025. This work is published under Creative Commons Attribution – Non-Commercial License~http://creativecommons.org/licenses/by-nc/3.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 7TK 7TM 7TS 7U9 H94 K9. M7N 7X8 |
| DOI | 10.1111/apa.70158 |
| DatabaseName | Wiley Online Library Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Physical Education Index Virology and AIDS Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Algology Mycology and Protozoology Abstracts (Microbiology C) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Nucleic Acids Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Neurosciences Abstracts Physical Education Index MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Virology and AIDS Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1651-2227 |
| EndPage | 2664 |
| ExternalDocumentID | 40457730 10_1111_apa_70158 APA70158 |
| Genre | researchArticle Journal Article |
| GeographicLocations | Finland |
| GeographicLocations_xml | – name: Finland |
| GrantInformation_xml | – fundername: Päivikki ja Sakari Sohlbergin Säätiö – fundername: Maire Taposen Säätiö – fundername: Yrjö Jahnssonin Säätiö |
| GroupedDBID | .55 .GA .GJ 24P 3O- 51W 51X 52N 52O 52P 52R 52T 52W 52X 53G 5GY 5HH 5LA 5RE 66C 7PT 930 A01 A03 AAWTL ABDBF ABJNI ACGFS ACUHS AI. ALMA_UNASSIGNED_HOLDINGS BY8 EAD EAP EAS EBC EBD EBX EMB EMK EMOBN EPT ESX F5P LP6 LP7 N9D P4B P4D Q~Q SV3 TUS VH1 WQJ WXI X7M ZGI AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 7TK 7TM 7TS 7U9 H94 K9. M7N 7X8 |
| ID | FETCH-LOGICAL-c3508-81bc843ca94fc9bf4480235adadb473a6f7d22fc370709f033eaf7e58c9965fd3 |
| IEDL.DBID | 24P |
| ISSN | 0803-5253 1651-2227 |
| IngestDate | Fri Sep 05 15:56:19 EDT 2025 Fri Sep 12 01:30:51 EDT 2025 Sat Sep 13 02:30:36 EDT 2025 Thu Sep 18 00:14:14 EDT 2025 Wed Sep 10 09:20:24 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | traumatic brain injury depression antidepressant paediatric |
| Language | English |
| License | Attribution-NonCommercial 2025 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3508-81bc843ca94fc9bf4480235adadb473a6f7d22fc370709f033eaf7e58c9965fd3 |
| Notes | The funders were not involved in any aspect of the study or paper. 10.13039/501100007639 The study was supported by grants from Maire Taposen Säätiö and Yrjö Jahnssonin Säätiö Funding Päivikki ja Sakari Sohlbergin Säätiö 10.13039/100010114 10.13039/501100004212 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-9328-4721 0000-0001-7366-5140 0000-0001-9946-4830 0000-0002-5026-4560 0000-0001-8178-9610 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fapa.70158 |
| PMID | 40457730 |
| PQID | 3249103219 |
| PQPubID | 866347 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_3215235607 proquest_journals_3249103219 pubmed_primary_40457730 crossref_primary_10_1111_apa_70158 wiley_primary_10_1111_apa_70158_APA70158 |
| PublicationCentury | 2000 |
| PublicationDate | October 2025 |
| PublicationDateYYYYMMDD | 2025-10-01 |
| PublicationDate_xml | – month: 10 year: 2025 text: October 2025 |
| PublicationDecade | 2020 |
| PublicationPlace | Norway |
| PublicationPlace_xml | – name: Norway – name: Stockholm |
| PublicationTitle | Acta Paediatrica |
| PublicationTitleAlternate | Acta Paediatr |
| PublicationYear | 2025 |
| Publisher | Wiley Subscription Services, Inc |
| Publisher_xml | – name: Wiley Subscription Services, Inc |
| References | 2023; 54 2021; 23 2020; 20 2010; 303 2010 2010; 167 2008; 39 2005; 20 2008; 8 2024; 12 2024; 345 2016; 91 2001; 40 2012; 30 2021; 36 1998; 37 2018; 6 2019; 65 2019; 21 2008; 25 2014; 15 2017 2022; 30 2016; 61 2024; 24 2018; 33 2018; 35 2012; 40 e_1_2_13_25_1 e_1_2_13_24_1 e_1_2_13_27_1 e_1_2_13_26_1 e_1_2_13_21_1 e_1_2_13_20_1 e_1_2_13_23_1 e_1_2_13_22_1 e_1_2_13_9_1 e_1_2_13_8_1 e_1_2_13_7_1 e_1_2_13_6_1 Keskimaki I. (e_1_2_13_28_1) 2019; 21 e_1_2_13_17_1 e_1_2_13_18_1 e_1_2_13_19_1 e_1_2_13_13_1 e_1_2_13_14_1 e_1_2_13_15_1 e_1_2_13_16_1 e_1_2_13_10_1 e_1_2_13_11_1 e_1_2_13_12_1 e_1_2_13_5_1 e_1_2_13_4_1 e_1_2_13_3_1 e_1_2_13_2_1 World Health Organization (e_1_2_13_29_1) 2017 |
| References_xml | – volume: 30 start-page: 239 issue: 3 year: 2012 end-page: 245 article-title: Depression in Children and Adolescents in the First 6 Months After Traumatic Brain Injury publication-title: International Journal of Developmental Neuroscience – volume: 23 start-page: 2219 issue: 11 year: 2021 end-page: 2222 article-title: Increased Risk for Dementia in Neurofibromatosis Type 1 publication-title: Genetics in Medicine – volume: 25 start-page: 398 issue: 5 year: 2008 end-page: 407 article-title: New Onset Obsessive‐Compulsive Symptoms in Children and Adolescents With Severe Traumatic Brain Injury publication-title: Depression and Anxiety – volume: 345 start-page: 455 year: 2024 end-page: 466 article-title: Characterizing Depression After Traumatic Brain Injury Using a Symptom‐Oriented Approach publication-title: Journal of Affective Disorders – volume: 8 issue: 1 year: 2008 article-title: Reducing Bias Through Directed Acyclic Graphs publication-title: BMC Medical Research Methodology – volume: 24 start-page: 270 issue: 2 year: 2024 end-page: 277 article-title: A Retrospective Review of Elevated Lead Impedances in Impedance‐Dependent Magnetic Resonance‐Conditional Spinal Cord Stimulation Devices publication-title: Pain Practice – volume: 20 start-page: 819 issue: 1 year: 2020 article-title: Lyme Borreliosis in Finland: A Register‐Based Linkage Study publication-title: BMC Infectious Diseases – volume: 65 start-page: 79 issue: 1 year: 2019 end-page: 85 article-title: Mild Traumatic Brain Injury and Psychopathology in Adolescence: Evidence From the Project on Human Development in Chicago Neighborhoods publication-title: Journal of Adolescent Health – volume: 20 start-page: 475 issue: 6 year: 2005 end-page: 487 article-title: Pathophysiologic Aspects of Major Depression Following Traumatic Brain Injury publication-title: Journal of Head Trauma Rehabilitation – volume: 40 start-page: 505 issue: 6 year: 2012 end-page: 515 article-title: Quality of the Finnish Hospital Discharge Register: A Systematic Review publication-title: Scandinavian Journal of Public Health – volume: 37 start-page: 832 issue: 8 year: 1998 end-page: 840 article-title: Psychiatric Disorders in Children and Adolescents After Severe Traumatic Brain Injury: A Controlled Study publication-title: Journal of the American Academy of Child and Adolescent Psychiatry – volume: 35 start-page: 1620 issue: 14 year: 2018 end-page: 1629 article-title: Depression in the First Year After Traumatic Brain Injury publication-title: Journal of Neurotrauma – volume: 30 start-page: 1153 issue: 4 year: 2022 end-page: 1166 article-title: Pathogenesis and Management of Traumatic Brain Injury (TBI): Role of Neuroinflammation and Anti‐Inflammatory Drugs publication-title: Inflammopharmacology – volume: 91 start-page: 497 year: 2016 end-page: 509 article-title: Epidemiology of Global Pediatric Traumatic Brain Injury: Qualitative Review publication-title: World Neurosurgery – year: 2010 – volume: 6 issue: 7 year: 2018 article-title: Time‐Varying Covariates and Coefficients in Cox Regression Models publication-title: Annals of Translational Medicine – volume: 39 start-page: 1373 issue: 12 year: 2008 end-page: 1376 article-title: Coverage and Accuracy of Diagnosis of Cruciate Ligament Injury in the Finnish National Hospital Discharge Register publication-title: Injury – volume: 15 year: 2014 article-title: Pertrochanteric Fracture of the Femur in the Finnish National Hospital Discharge Register: Validity of Procedural Coding, External Cause for Injury and Diagnosis publication-title: BMC Musculoskeletal Disorders – volume: 21 start-page: 1 issue: 2 year: 2019 end-page: 166 article-title: Finland: Health System Review publication-title: Health Systems in Transition – volume: 12 start-page: 126 issue: 1 year: 2024 article-title: Social Deficits Mirror Delayed Cerebrovascular Dysfunction After Traumatic Brain Injury publication-title: Acta Neuropathologica Communications – volume: 54 start-page: 540 issue: 2 year: 2023 end-page: 546 article-title: Increasing Incidence of Pediatric Mild Traumatic Brain Injury in Finland ‐ a Nationwide Register Study From 1998 to 2018 publication-title: Injury – volume: 40 start-page: 572 issue: 5 year: 2001 end-page: 579 article-title: Lifetime and Novel Psychiatric Disorders After Pediatric Traumatic Brain Injury publication-title: Journal of the American Academy of Child and Adolescent Psychiatry – volume: 167 start-page: 312 issue: 3 year: 2010 end-page: 320 article-title: The Psychiatric Sequelae of Traumatic Injury publication-title: American Journal of Psychiatry – volume: 33 start-page: E18 issue: 3 year: 2018 end-page: E30 article-title: Depression and Depressive Symptoms in Pediatric Traumatic Brain Injury: A Scoping Review publication-title: Journal of Head Trauma Rehabilitation – volume: 61 start-page: 259 issue: 5 year: 2016 end-page: 269 article-title: A Systematic Review of Psychiatric, Psychological, and Behavioural Outcomes Following Mild Traumatic Brain Injury in Children and Adolescents publication-title: Canadian Journal of Psychiatry – year: 2017 – volume: 303 start-page: 1938 issue: 19 year: 2010 end-page: 1945 article-title: Rates of Major Depressive Disorder and Clinical Outcomes Following Traumatic Brain Injury publication-title: JAMA – volume: 36 start-page: E40 issue: 1 year: 2021 end-page: E49 article-title: Lifetime History of Traumatic Brain Injury With Loss of Consciousness and the Likelihood for Lifetime Depression and Risk Behaviors: 2017 BRFSS North Carolina publication-title: Journal of Head Trauma Rehabilitation – ident: e_1_2_13_4_1 doi: 10.1016/j.jad.2023.10.130 – ident: e_1_2_13_14_1 doi: 10.1097/HTR.0000000000000603 – ident: e_1_2_13_13_1 doi: 10.1016/j.injury.2022.12.023 – ident: e_1_2_13_7_1 doi: 10.1001/jama.2010.599 – ident: e_1_2_13_2_1 doi: 10.1007/s10787‐022‐01017‐8 – ident: e_1_2_13_24_1 doi: 10.1177/1403494812456637 – volume: 21 start-page: 1 issue: 2 year: 2019 ident: e_1_2_13_28_1 article-title: Finland: Health System Review publication-title: Health Systems in Transition – ident: e_1_2_13_12_1 – ident: e_1_2_13_15_1 doi: 10.1016/j.jadohealth.2018.12.023 – ident: e_1_2_13_26_1 doi: 10.1038/s41436‐021‐01261‐3 – ident: e_1_2_13_16_1 doi: 10.1097/HTR.0000000000000343 – ident: e_1_2_13_23_1 doi: 10.1186/1471‐2474‐15‐98 – ident: e_1_2_13_11_1 doi: 10.1016/j.wneu.2016.03.045 – ident: e_1_2_13_10_1 doi: 10.1097/00004583‐199808000‐00013 – ident: e_1_2_13_20_1 doi: 10.1097/00001199‐200511000‐00001 – ident: e_1_2_13_6_1 doi: 10.1176/appi.ajp.2009.09050617 – ident: e_1_2_13_3_1 doi: 10.1002/da.20398 – volume-title: Depression and Other Common Mental Disorders: Global Health Estimates (No. WHO/MSD/MER/2017.2) year: 2017 ident: e_1_2_13_29_1 – ident: e_1_2_13_5_1 doi: 10.1089/neu.2017.5379 – ident: e_1_2_13_19_1 doi: 10.21037/atm.2018.02.12 – ident: e_1_2_13_9_1 doi: 10.1016/j.ijdevneu.2011.12.005 – ident: e_1_2_13_18_1 doi: 10.1186/1471‐2288‐8‐70 – ident: e_1_2_13_25_1 doi: 10.1016/j.injury.2008.05.007 – ident: e_1_2_13_21_1 doi: 10.1186/s40478‐024‐01840‐w – ident: e_1_2_13_8_1 doi: 10.1097/00004583‐200105000‐00017 – ident: e_1_2_13_27_1 doi: 10.1186/s12879‐020‐05555‐w – ident: e_1_2_13_17_1 doi: 10.1177/0706743716643741 – ident: e_1_2_13_22_1 doi: 10.1111/papr.13301 |
| SSID | ssj0023946 ssj0004374 |
| Score | 2.455635 |
| Snippet | ABSTRACT
Aim
The association between paediatric traumatic brain injury (pTBI) and post‐traumatic antidepressant medication usage remains an understudied... The association between paediatric traumatic brain injury (pTBI) and post-traumatic antidepressant medication usage remains an understudied subject. A... Aim The association between paediatric traumatic brain injury (pTBI) and post‐traumatic antidepressant medication usage remains an understudied subject.... The association between paediatric traumatic brain injury (pTBI) and post-traumatic antidepressant medication usage remains an understudied subject.AIMThe... |
| SourceID | proquest pubmed crossref wiley |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 2656 |
| SubjectTerms | Adolescent antidepressant Antidepressive Agents - therapeutic use Brain Injuries, Traumatic - complications Brain Injuries, Traumatic - psychology Child Child, Preschool Cohort analysis Cohort Studies depression Female Finland - epidemiology Humans Infant Male paediatric Patients Pediatrics Registries Retrospective Studies Traumatic brain injury |
| Title | Paediatric Traumatic Brain Injury and Long‐Term Antidepressant Use: A Nationwide Register‐Based Cohort Study |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fapa.70158 https://www.ncbi.nlm.nih.gov/pubmed/40457730 https://www.proquest.com/docview/3249103219 https://www.proquest.com/docview/3215235607 |
| Volume | 114 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT9tAEB7xkCouFY8WzEtbxIGLK-NZZ7Pl5AQQrRoUISJxs_ZloAcnykOot_4EfiO_pLN-hEYVEhfL0q5taXZn5hvvzDcAx9zFzihuQ25RhVwaDHUiotCKyORae8opX5zcu25dDfiPu-RuCc6aWpiKH2L-w81rRmmvvYIrPflHycmXfBXkzNrLsEqgHv32jnn_tSgSPbCpQy-UVclOO0IKvRKsOYZ8Ts_8PYue6T-4uYheS_dzuQ4fa9zI0mqhN2DJFZvwoVefjG_BqK-aphuM_M-sZGJlHd8Agn0vfpHkmCos-zks7l_-PN-SPWZpMX2sE2FJvGwwcd9Yyiqi7CcaYTfOVwe5MT3QIWdnWXf4QGid-dzD359gcHlx270K624KoUFCYSHhU9PmaJTkuZE6p7jMc90oq6zmAlUrFzaOc4OCrIDMI0SncuGStqGQKMktfoaVYli4HWBCt4TUGlvCCq4cyshapPlGGSud0QEcNZLMRhVpRtYEGyTurBR3APuNjLNabyYZwTvpKf5OZQBf5sO04_0xhirccObnEOZAQmoigO1qbeZf4YRQBRmtAE7KxXr781naT8ub3fdP3YO12Lf_LXP59mFlOp65A8IkU31Y7j26nt_EfwG2s92j |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB5RkGgvFOgr5VG36qGXrNIdZ71GXAICLXQXIbQrcakivwJtpSyCXaFy4if0N_aXdOwk20KFVPUWyc7L45n5xp75DPCeu7YzituYW1QxlwZjnYoktiIxhdaecsoXJw-OOr0RPzxNT-dgu6mFqfghZgtuXjOCvfYK7hek_9ByciYtQd6s-wgWwv6ch0Qnv8mjOHpkU8deKKuanW6CFHulWJMM-aSe2XPuuqa_8OZd-Br8z_5T-Nx8eZV28q01neiWublH6vi_v7YMSzUwZVk1k1ZgzpWrsDiot96fwcWxak71YOTgpoHqle34EybYQfmVRMNUaVl_XJ79vP0xJIPPsnLypc60Jfmx0ZXbYhmrmLivqYWdOF9-5C7phh3yppbtjs8pHGA-ufH7cxjt7w13e3F9XENskGBeTADYdDkaJXlhpC4o8PNkOsoqq7lA1SmEbbcLg4LMjCwSRKcK4dKuoZgrLSy-gPlyXLpXwITuCKk1doQVXDmUibVI_Y0yVjqjI3jXSCq_qFg58iaaobHLw9hFsN7IMK8V8yon_Cg9h-BHGcHbWTOplN8nUaUbT30fAjVIUFBE8LKS_ewtnCCwIKsYwYcgwYdfn2fHWbh4_e9d38Dj3nDQz_sHR5_W4EnbnzUcEgfXYX5yOXUbBIAmejPM81_DnADk |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT9tAEB5RkFAviNKWmke7rXroxch41tksnAxtRNqAoopI3Kx9Fjg4UUiEuPET-hv7S5j1Iy2qkLhZ2rVXmp3HN96ZbwE-c5c6o7iNuUUVc2kw1plIYisS47UOlFOhOfn0rHMy4t8vsoslOGx7YWp-iMUPt2AZlb8OBj6x_h8jp1iyJyiYdV_ACie9C-qd8uHfpkgMwKZJvVDWLTvdBCn1yrDhGAo1PYvvPI5M_8HNx-i1Cj-9dVhrcCPL641-BUuu3IDV0-Zk_DVMhqq9dINR_JlXTKzsKFwAwfrlNUmOqdKywbj89ef-9zn5Y5aXs6umEJbEy0Y37oDlrCbKvqUR9tOF7iA3pReOKNhZdjy-JLTOQu3h3RsY9b6dH5_EzW0KsUFCYTHhU9PlaJTk3kjtKS8LXDfKKqu5QNXxwqapNyjIC0ifIDrlhcu6hlKizFt8C8vluHTvgAndEVJr7AgruHIoE2uR5htlrHRGR_CplWQxqUkzijbZIHEXlbgj2GllXDR2c1MQvJOB4m9fRvBxMUwaH44xVOnG8zCHMAcSUhMRbNZ7s1iFE0IV5LQi-FJt1tPLF_kwrx62nj_1A6wOv_aKQf_sxza8TMNNwFVZ3w4sz6Zzt0vwZKbfV2r4AE_B31s |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Paediatric+Traumatic+Brain+Injury+and+Long%E2%80%90Term+Antidepressant+Use%3A+A+Nationwide+Register%E2%80%90Based+Cohort+Study&rft.jtitle=Acta+Paediatrica&rft.au=Laaksonen%2C+Juho&rft.au=Ponkilainen%2C+Ville&rft.au=M%C3%B6tt%C3%B6nen%2C+Julius&rft.au=Mattila%2C+Ville+M.&rft.date=2025-10-01&rft.issn=0803-5253&rft.eissn=1651-2227&rft.volume=114&rft.issue=10&rft.spage=2656&rft.epage=2664&rft_id=info:doi/10.1111%2Fapa.70158&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_apa_70158 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0803-5253&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0803-5253&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0803-5253&client=summon |