Hepatitis C virus infection and diabetes: A complex bidirectional relationship
Chronic hepatitis C (CHC) and diabetes represent two severe chronic conditions responsible for a considerable number of deaths worldwide. They have a complex, bidirectional relationship. On the one hand, several cohort studies have shown that chronic HCV infection increases both the risk of developi...
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| Published in | Diabetes research and clinical practice Vol. 187; p. 109870 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
01.05.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0168-8227 1872-8227 1872-8227 |
| DOI | 10.1016/j.diabres.2022.109870 |
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| Abstract | Chronic hepatitis C (CHC) and diabetes represent two severe chronic conditions responsible for a considerable number of deaths worldwide. They have a complex, bidirectional relationship. On the one hand, several cohort studies have shown that chronic HCV infection increases both the risk of developing diabetes in non-diabetic subjects (by inducing insulin resistance and promoting β-cell dysfunction) as well as the risk of developing macro and microvascular complications in patients with known diabetes; on the other hand, diabetes is an independent risk factor for liver-related events among patients with CHC, including a higher incidence of hepatocellular carcinoma, liver-related death and transplantation. Importantly, sustained virological response, which can be obtained in the vast majority of patients with the use of direct antiviral agents, does not only lead to a lower rate of liver-related outcomes, but also to improvements of glycemic control and reduction in the rate of complications among patients with diabetes. The aim of this review is to summarize available clinical evidence on the association among CHC, diabetes and related clinical outcomes. We will also briefly discuss the biological mechanisms underpinning the association between CHC and diabetes, as well as the implications this relationship should have on everyday clinical practice. |
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| AbstractList | Chronic hepatitis C (CHC) and diabetes represent two severe chronic conditions responsible for a considerable number of deaths worldwide. They have a complex, bidirectional relationship. On the one hand, several cohort studies have shown that chronic HCV infection increases both the risk of developing diabetes in non-diabetic subjects (by inducing insulin resistance and promoting β-cell dysfunction) as well as the risk of developing macro and microvascular complications in patients with known diabetes; on the other hand, diabetes is an independent risk factor for liver-related events among patients with CHC, including a higher incidence of hepatocellular carcinoma, liver-related death and transplantation. Importantly, sustained virological response, which can be obtained in the vast majority of patients with the use of direct antiviral agents, does not only lead to a lower rate of liver-related outcomes, but also to improvements of glycemic control and reduction in the rate of complications among patients with diabetes. The aim of this review is to summarize available clinical evidence on the association among CHC, diabetes and related clinical outcomes. We will also briefly discuss the biological mechanisms underpinning the association between CHC and diabetes, as well as the implications this relationship should have on everyday clinical practice. Chronic hepatitis C (CHC) and diabetes represent two severe chronic conditions responsible for a considerable number of deaths worldwide. They have a complex, bidirectional relationship. On the one hand, several cohort studies have shown that chronic HCV infection increases both the risk of developing diabetes in non-diabetic subjects (by inducing insulin resistance and promoting β-cell dysfunction) as well as the risk of developing macro and microvascular complications in patients with known diabetes; on the other hand, diabetes is an independent risk factor for liver-related events among patients with CHC, including a higher incidence of hepatocellular carcinoma, liver-related death and transplantation. Importantly, sustained virological response, which can be obtained in the vast majority of patients with the use of direct antiviral agents, does not only lead to a lower rate of liver-related outcomes, but also to improvements of glycemic control and reduction in the rate of complications among patients with diabetes. The aim of this review is to summarize available clinical evidence on the association among CHC, diabetes and related clinical outcomes. We will also briefly discuss the biological mechanisms underpinning the association between CHC and diabetes, as well as the implications this relationship should have on everyday clinical practice.Chronic hepatitis C (CHC) and diabetes represent two severe chronic conditions responsible for a considerable number of deaths worldwide. They have a complex, bidirectional relationship. On the one hand, several cohort studies have shown that chronic HCV infection increases both the risk of developing diabetes in non-diabetic subjects (by inducing insulin resistance and promoting β-cell dysfunction) as well as the risk of developing macro and microvascular complications in patients with known diabetes; on the other hand, diabetes is an independent risk factor for liver-related events among patients with CHC, including a higher incidence of hepatocellular carcinoma, liver-related death and transplantation. Importantly, sustained virological response, which can be obtained in the vast majority of patients with the use of direct antiviral agents, does not only lead to a lower rate of liver-related outcomes, but also to improvements of glycemic control and reduction in the rate of complications among patients with diabetes. The aim of this review is to summarize available clinical evidence on the association among CHC, diabetes and related clinical outcomes. We will also briefly discuss the biological mechanisms underpinning the association between CHC and diabetes, as well as the implications this relationship should have on everyday clinical practice. |
| ArticleNumber | 109870 |
| Author | Ciardullo, Stefano Perseghin, Gianluca Carbone, Marco Ciaccio, Antonio Mantovani, Alessandro Invernizzi, Pietro |
| Author_xml | – sequence: 1 givenname: Stefano surname: Ciardullo fullname: Ciardullo, Stefano email: s.ciardullo@campus.unimib.it, stefano.ciardullo@policlinicodimonza.it organization: Department of Medicine and Rehabilitation, Monza Policlinico di Monza, Monza, Italy – sequence: 2 givenname: Alessandro surname: Mantovani fullname: Mantovani, Alessandro organization: Section of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, University of Verona – sequence: 3 givenname: Antonio surname: Ciaccio fullname: Ciaccio, Antonio organization: Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy – sequence: 4 givenname: Marco surname: Carbone fullname: Carbone, Marco organization: Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy – sequence: 5 givenname: Pietro surname: Invernizzi fullname: Invernizzi, Pietro organization: Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy – sequence: 6 givenname: Gianluca surname: Perseghin fullname: Perseghin, Gianluca organization: Department of Medicine and Rehabilitation, Monza Policlinico di Monza, Monza, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35398458$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_4239_wjd_v15_i2_220 crossref_primary_10_3389_fmicb_2024_1418301 crossref_primary_10_1016_j_metabol_2024_155917 crossref_primary_10_3389_fonc_2023_1218901 crossref_primary_10_1111_apt_18460 crossref_primary_10_62347_EQIR8735 |
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