A multiscale absorption and transit model for oral delivery of hydroxychloroquine: Pharmacokinetic modeling and intestinal concentration prediction to assess toxicity and drug‐induced damage in healthy subjects - Kannan, Ravishekar; Przekwas, Andrzej (International journal for numerical methods in biomedical engineering, 2020)
Keywords: Absorption; Administration, Oral; Bioavailability; CC50; Computer applications; Computer Simulation; COVID-19; COVID-19 - drug therapy; COVID-19 - metabolism; COVID-19 - pathology; Cytotoxicity; Damage; Data integration; Dissolution; Duodenum; gastrointestinal tract; GIT; HCQ; Healthy Volunteers; Humans; Hydroxychloroquine; Hydroxychloroquine - adverse effects; Hydroxychloroquine - pharmacokinetics; Hydroxychloroquine - therapeutic use; Intestine; Malaria; MAT; Medical treatment; Metabolism; Models, Biological; multiscale; multiscale absorption and transit; Optimization; Oral administration; Pharmacokinetics; Pharmacology; quasi‐3D (Q3D); Rheumatic diseases; SARS-CoV-2; Stomach; Toolkits; Toxicity; Vector-borne diseases; COVID-19; MAT; GIT; gastrointestinal tract; CC50; multiscale absorption and transit; HCQ; quasi-3D (Q3D); multiscale; cytotoxicity