The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study

• Published in: Cancer research and treatment Vol. 48; no. 4; pp. 1313 - 1320
• Main Authors: So, Kyeong A, Kim, Mi Jung, Lee, Ki-Heon, Lee, In-Ho, Kim, Mi Kyung, Lee, Yoo Kyung, Hwang, Chang-Sun, Jeong, Mi Seon, Kee, Mee-Kyung, Kang, Chun, Cho, Chi Heum, Kim, Seok Mo, Hong, Sung Ran, Kim, Ki Tae, Lee, Won-Chul, Park, Jong Sup, Kim, Tae Jin
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Cancer Association 01.10.2016; 대한암학회
• Subjects: Adult; Cervical Intraepithelial Neoplasia - diagnosis; Cervical Intraepithelial Neoplasia - genetics; Cervical Intraepithelial Neoplasia - pathology; Cervical Intraepithelial Neoplasia - virology; Cytodiagnosis; Female; Genotype; Human papillomavirus 16 - genetics; Human papillomavirus 16 - pathogenicity; Human papillomavirus 18 - genetics; Human papillomavirus 18 - pathogenicity; Humans; Middle Aged; Original; Papillomaviridae - genetics; Papillomaviridae - pathogenicity; Papillomavirus Infections - genetics; Papillomavirus Infections - pathology; Papillomavirus Infections - virology; Pregnancy; Risk Factors; Squamous Intraepithelial Lesions of the Cervix - diagnosis; Squamous Intraepithelial Lesions of the Cervix - genetics; Squamous Intraepithelial Lesions of the Cervix - pathology; Squamous Intraepithelial Lesions of the Cervix - virology; 의약학; Genotype; Human papillomavirus; Cytology
• ISSN: 1598-2998; 2005-9256; 2005-9256
• DOI: 10.4143/crt.2016.013

The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months. A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001). HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.