Time-series atlases of the rat brain after middle cerebral artery occlusion using FDG-PET images
The middle cerebral artery occlusion (MCAO) procedure is widely used in ischemic stroke research. When using functional 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images to study ischemic stroke, the difficulty in determining the region of interest (ROI) comes from two aspects: th...
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| Published in | Computers in biology and medicine Vol. 190; p. 109977 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Ltd
01.05.2025
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| Online Access | Get full text |
| ISSN | 0010-4825 1879-0534 1879-0534 |
| DOI | 10.1016/j.compbiomed.2025.109977 |
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| Abstract | The middle cerebral artery occlusion (MCAO) procedure is widely used in ischemic stroke research. When using functional 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images to study ischemic stroke, the difficulty in determining the region of interest (ROI) comes from two aspects: the large variations due to differences in uptake and reaction time and the consistency of different intensity normalization methods among subjects.
Using the rat as a model animal, we propose time-series atlases of ischemic stroke after MCAO based on the PET images to annotate changes in ROIs. Concretely, we spatially align serial scans with a built PET template, use histograms of orientated gradient (HOG) features to detect lesion boundaries, and combine them with results from an intensity-based detection method to construct probability maps at different time points with the Bernoulli mixture model (BMM). Simulated PET images with known ground truth and triphenyl tetrazolium chloride (TTC) staining slices validate the correctness of the time-series atlases. We demonstrate that these atlases could provide references when tracking the spatial–temporal dynamic development of lesions in rat brains.
•Using histograms of orientated gradients to improve detection of hypo-uptake regions.•Constructing serial atlases to capture voxel correlations and track temporal changes.•Using probability atlases to measure brain injury and affected functional regions. |
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| AbstractList | The middle cerebral artery occlusion (MCAO) procedure is widely used in ischemic stroke research. When using functional 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images to study ischemic stroke, the difficulty in determining the region of interest (ROI) comes from two aspects: the large variations due to differences in uptake and reaction time and the consistency of different intensity normalization methods among subjects.
Using the rat as a model animal, we propose time-series atlases of ischemic stroke after MCAO based on the PET images to annotate changes in ROIs. Concretely, we spatially align serial scans with a built PET template, use histograms of orientated gradient (HOG) features to detect lesion boundaries, and combine them with results from an intensity-based detection method to construct probability maps at different time points with the Bernoulli mixture model (BMM). Simulated PET images with known ground truth and triphenyl tetrazolium chloride (TTC) staining slices validate the correctness of the time-series atlases. We demonstrate that these atlases could provide references when tracking the spatial–temporal dynamic development of lesions in rat brains.
•Using histograms of orientated gradients to improve detection of hypo-uptake regions.•Constructing serial atlases to capture voxel correlations and track temporal changes.•Using probability atlases to measure brain injury and affected functional regions. The middle cerebral artery occlusion (MCAO) procedure is widely used in ischemic stroke research. When using functional 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images to study ischemic stroke, the difficulty in determining the region of interest (ROI) comes from two aspects: the large variations due to differences in uptake and reaction time and the consistency of different intensity normalization methods among subjects. Using the rat as a model animal, we propose time-series atlases of ischemic stroke after MCAO based on the PET images to annotate changes in ROIs. Concretely, we spatially align serial scans with a built PET template, use histograms of orientated gradient (HOG) features to detect lesion boundaries, and combine them with results from an intensity-based detection method to construct probability maps at different time points with the Bernoulli mixture model (BMM). Simulated PET images with known ground truth and triphenyl tetrazolium chloride (TTC) staining slices validate the correctness of the time-series atlases. We demonstrate that these atlases could provide references when tracking the spatial-temporal dynamic development of lesions in rat brains. The middle cerebral artery occlusion (MCAO) procedure is widely used in ischemic stroke research. When using functional 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images to study ischemic stroke, the difficulty in determining the region of interest (ROI) comes from two aspects: the large variations due to differences in uptake and reaction time and the consistency of different intensity normalization methods among subjects. Using the rat as a model animal, we propose time-series atlases of ischemic stroke after MCAO based on the PET images to annotate changes in ROIs. Concretely, we spatially align serial scans with a built PET template, use histograms of orientated gradient (HOG) features to detect lesion boundaries, and combine them with results from an intensity-based detection method to construct probability maps at different time points with the Bernoulli mixture model (BMM). Simulated PET images with known ground truth and triphenyl tetrazolium chloride (TTC) staining slices validate the correctness of the time-series atlases. We demonstrate that these atlases could provide references when tracking the spatial-temporal dynamic development of lesions in rat brains.The middle cerebral artery occlusion (MCAO) procedure is widely used in ischemic stroke research. When using functional 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images to study ischemic stroke, the difficulty in determining the region of interest (ROI) comes from two aspects: the large variations due to differences in uptake and reaction time and the consistency of different intensity normalization methods among subjects. Using the rat as a model animal, we propose time-series atlases of ischemic stroke after MCAO based on the PET images to annotate changes in ROIs. Concretely, we spatially align serial scans with a built PET template, use histograms of orientated gradient (HOG) features to detect lesion boundaries, and combine them with results from an intensity-based detection method to construct probability maps at different time points with the Bernoulli mixture model (BMM). Simulated PET images with known ground truth and triphenyl tetrazolium chloride (TTC) staining slices validate the correctness of the time-series atlases. We demonstrate that these atlases could provide references when tracking the spatial-temporal dynamic development of lesions in rat brains. AbstractThe middle cerebral artery occlusion (MCAO) procedure is widely used in ischemic stroke research. When using functional 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images to study ischemic stroke, the difficulty in determining the region of interest (ROI) comes from two aspects: the large variations due to differences in uptake and reaction time and the consistency of different intensity normalization methods among subjects. Using the rat as a model animal, we propose time-series atlases of ischemic stroke after MCAO based on the PET images to annotate changes in ROIs. Concretely, we spatially align serial scans with a built PET template, use histograms of orientated gradient (HOG) features to detect lesion boundaries, and combine them with results from an intensity-based detection method to construct probability maps at different time points with the Bernoulli mixture model (BMM). Simulated PET images with known ground truth and triphenyl tetrazolium chloride (TTC) staining slices validate the correctness of the time-series atlases. We demonstrate that these atlases could provide references when tracking the spatial–temporal dynamic development of lesions in rat brains. |
| ArticleNumber | 109977 |
| Author | Zhang, Xuechen Yu, Weichuan Shen, Xiaoyan Liu, Huafeng Li, Jia Tang, Hongtu He, Wuxian Li, Chenrui |
| Author_xml | – sequence: 1 givenname: Chenrui orcidid: 0000-0001-9535-4087 surname: Li fullname: Li, Chenrui organization: Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China – sequence: 2 givenname: Wuxian orcidid: 0000-0002-1355-0904 surname: He fullname: He, Wuxian organization: Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China – sequence: 3 givenname: Xuechen surname: Zhang fullname: Zhang, Xuechen organization: Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China – sequence: 4 givenname: Hongtu surname: Tang fullname: Tang, Hongtu organization: Department of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan, 430065, Hubei, China – sequence: 5 givenname: Jia surname: Li fullname: Li, Jia organization: Xianning Hospital of Traditional Chinese Medicine, Xianning, 437100, Hubei, China – sequence: 6 givenname: Xiaoyan surname: Shen fullname: Shen, Xiaoyan organization: College of Science, Zhejiang University of Technology, Hangzhou, 310023, Zhejiang, China – sequence: 7 givenname: Huafeng surname: Liu fullname: Liu, Huafeng organization: State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310027, Zhejiang, China – sequence: 8 givenname: Weichuan orcidid: 0000-0002-5510-6916 surname: Yu fullname: Yu, Weichuan email: eeyu@ust.hk organization: Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China |
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| Snippet | The middle cerebral artery occlusion (MCAO) procedure is widely used in ischemic stroke research. When using functional 18F-fluorodeoxyglucose positron... AbstractThe middle cerebral artery occlusion (MCAO) procedure is widely used in ischemic stroke research. When using functional 18F-fluorodeoxyglucose positron... |
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| SubjectTerms | Animals Brain - diagnostic imaging Disease Models, Animal FDG-PET Fluorodeoxyglucose F18 Image Processing, Computer-Assisted - methods Infarction, Middle Cerebral Artery - diagnostic imaging Internal Medicine Ischemic stroke Male MCAO Other Positron-Emission Tomography - methods Radiopharmaceuticals Rats Rats, Sprague-Dawley |
| Title | Time-series atlases of the rat brain after middle cerebral artery occlusion using FDG-PET images |
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