Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars
Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and...
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Published in | International journal of environmental research and public health Vol. 18; no. 8; p. 3936 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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MDPI AG
08.04.2021
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ISSN | 1660-4601 1661-7827 1660-4601 |
DOI | 10.3390/ijerph18083936 |
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Abstract | Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague–Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation (p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups (p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges. |
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AbstractList | Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague–Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation (p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups (p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges. Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague-Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation (p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups (p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges.Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague-Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation (p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups (p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges. Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague–Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation ( p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups ( p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges. Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague-Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation ( = 0.124). Significant differences were found in reparative dentin formation between the treatment groups ( = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges. |
Author | Pecci-Lloret, Miguel R. Rodríguez-Lozano, Francisco Javier Ortiz-Ruiz, Clara Guerrero-Gironés, Julia Pecci-Lloret, María P. Ortiz-Ruiz, Eduardo Alcaina-Lorente, Antonia Ortiz-Ruiz, Antonio José |
AuthorAffiliation | 3 Department of Physiology, School of Medicine and Biosanitary Research Murcian Institute (IMIB), University of Murcia, 30120 Murcia, Spain; clara@um.es 1 Special Care and Gerodontology Unit, IMIB-Arrixaca, Campus Regional de Excelencia Internacional “Campus Mare Nostrum”, University of Murcia, 30008 Murcia, Spain; julia.guerrero@um.es (J.G.-G.); fcojavier@um.es (F.J.R.-L.); miguelramon.pecci@um.es (M.R.P.-L.) 2 Department of Integral Pediatric Dentistry, University of Murcia, 30008 Murcia, Spain; alcainalorentea@gmail.com (A.A.-L.); ajortiz@um.es (A.J.O.-R.) 4 Department of Histopathology, University Hospital Virgen de la Arrixaca, 30120 Murcia, Spain; edu_or@yahoo.es |
AuthorAffiliation_xml | – name: 2 Department of Integral Pediatric Dentistry, University of Murcia, 30008 Murcia, Spain; alcainalorentea@gmail.com (A.A.-L.); ajortiz@um.es (A.J.O.-R.) – name: 1 Special Care and Gerodontology Unit, IMIB-Arrixaca, Campus Regional de Excelencia Internacional “Campus Mare Nostrum”, University of Murcia, 30008 Murcia, Spain; julia.guerrero@um.es (J.G.-G.); fcojavier@um.es (F.J.R.-L.); miguelramon.pecci@um.es (M.R.P.-L.) – name: 4 Department of Histopathology, University Hospital Virgen de la Arrixaca, 30120 Murcia, Spain; edu_or@yahoo.es – name: 3 Department of Physiology, School of Medicine and Biosanitary Research Murcian Institute (IMIB), University of Murcia, 30120 Murcia, Spain; clara@um.es |
Author_xml | – sequence: 1 givenname: Julia surname: Guerrero-Gironés fullname: Guerrero-Gironés, Julia – sequence: 2 givenname: Antonia surname: Alcaina-Lorente fullname: Alcaina-Lorente, Antonia – sequence: 3 givenname: Clara orcidid: 0000-0001-9430-6550 surname: Ortiz-Ruiz fullname: Ortiz-Ruiz, Clara – sequence: 4 givenname: Eduardo surname: Ortiz-Ruiz fullname: Ortiz-Ruiz, Eduardo – sequence: 5 givenname: María P. orcidid: 0000-0003-0512-8831 surname: Pecci-Lloret fullname: Pecci-Lloret, María P. – sequence: 6 givenname: Antonio José orcidid: 0000-0001-9113-8416 surname: Ortiz-Ruiz fullname: Ortiz-Ruiz, Antonio José – sequence: 7 givenname: Francisco Javier orcidid: 0000-0002-0623-740X surname: Rodríguez-Lozano fullname: Rodríguez-Lozano, Francisco Javier – sequence: 8 givenname: Miguel R. surname: Pecci-Lloret fullname: Pecci-Lloret, Miguel R. |
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Keywords | beta-tricalcium phosphate hydroxyapatite vital pulp therapy mineral trioxide aggregate scaffolds |
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SubjectTerms | Animals Biocompatibility Biomedical materials Bones Collagen Dental pulp Dentin Gene expression Hydroxyapatite Phosphatase Proteins Statistical analysis Stem cells Teeth |
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Title | Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars |
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