Multimodal data fusion based on IGERNNC algorithm for detecting pathogenic brain regions and genes in Alzheimer’s disease

• Published in: Briefings in bioinformatics Vol. 24; no. 1
• Main Authors: Wang, Shuaiqun, Zheng, Kai, Kong, Wei, Huang, Ruiwen, Liu, Lulu, Wen, Gen, Yu, Yaling
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 19.01.2023; Oxford Publishing Limited (England)
• Subjects: Algorithms; Alzheimer Disease - genetics; Alzheimer's disease; Brain; Brain - diagnostic imaging; Clusters; Correlation analysis; Data analysis; Data integration; Evolution & development; Evolutionary algorithms; Evolutionary genetics; Functional magnetic resonance imaging; Gene polymorphism; Genes; Genetic algorithms; Genetic analysis; Genetic diversity; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Neural networks; Neural Networks, Computer; Neurodegenerative diseases; Neuroimaging; Nucleotides; Pathogenesis; Polymorphism; Single-nucleotide polymorphism; improved genetic evolution random neural network cluster; pathogenic factors; Alzheimer’s disease; multimodal data fusion
• ISSN: 1467-5463; 1477-4054; 1477-4054
• DOI: 10.1093/bib/bbac515

Abstract At present, the study on the pathogenesis of Alzheimer’s disease (AD) by multimodal data fusion analysis has been attracted wide attention. It often has the problems of small sample size and high dimension with the multimodal medical data. In view of the characteristics of multimodal medical data, the existing genetic evolution random neural network cluster (GERNNC) model combine genetic evolution algorithm and neural network for the classification of AD patients and the extraction of pathogenic factors. However, the model does not take into account the non-linear relationship between brain regions and genes and the problem that the genetic evolution algorithm can fall into local optimal solutions, which leads to the overall performance of the model is not satisfactory. In order to solve the above two problems, this paper made some improvements on the construction of fusion features and genetic evolution algorithm in GERNNC model, and proposed an improved genetic evolution random neural network cluster (IGERNNC) model. The IGERNNC model uses mutual information correlation analysis method to combine resting-state functional magnetic resonance imaging data with single nucleotide polymorphism data for the construction of fusion features. Based on the traditional genetic evolution algorithm, elite retention strategy and large variation genetic algorithm are added to avoid the model falling into the local optimal solution. Through multiple independent experimental comparisons, the IGERNNC model can more effectively identify AD patients and extract relevant pathogenic factors, which is expected to become an effective tool in the field of AD research.