BRCA1 -mutated ovarian cancer with skin metastasis: a case report

The major risk factor for ovarian cancer (OC) is mutation of the or DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that - and -mutated OCs are associated with better prognosis than sporadic OCs. However, information about the pattern...

Full description

Saved in:
Bibliographic Details
Published inObstetrics & gynecology science Vol. 60; no. 5; pp. 477 - 480
Main Authors Oh, So Ra, Park, Jung-Woo, Kwon, Hyun Young, Rha, Seo-Hee
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 01.09.2017
대한산부인과학회
Subjects
Case Report
산부인과학
Ovarian neoplasms
BRCA mutation
Skin metastases
Online AccessGet full text
ISSN2287-8572
2287-8580
DOI10.5468/ogs.2017.60.5.477

Cover

Abstract The major risk factor for ovarian cancer (OC) is mutation of the or DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that - and -mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of -mutated OCs is limited. Herein, we describe a case of OC with a mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously.
AbstractList The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of BRCA-mutated OCs is limited. Herein, we describe a case of OC with a BRCA1 mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously. KCI Citation Count: 0
The major risk factor for ovarian cancer (OC) is mutation of the or DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that - and -mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of -mutated OCs is limited. Herein, we describe a case of OC with a mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously.
The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of BRCA-mutated OCs is limited. Herein, we describe a case of OC with a BRCA1 mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously.The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of BRCA-mutated OCs is limited. Herein, we describe a case of OC with a BRCA1 mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously.
The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous studies have demonstrated that BRCA1- and BRCA2-mutated OCs are associated with better prognosis than sporadic OCs. However, information about the patterns and clinical course of the metastatic spread of BRCA-mutated OCs is limited. Herein, we describe a case of OC with a BRCA1 mutation and skin metastases in a 49-year-old patient, which to the best of our knowledge has not been reported previously.
Author Oh, So Ra
Kwon, Hyun Young
Rha, Seo-Hee
Park, Jung-Woo
AuthorAffiliation 1 Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Busan, Korea
2 Department of Pathology, Dong-A University College of Medicine, Busan, Korea
AuthorAffiliation_xml – name: 2 Department of Pathology, Dong-A University College of Medicine, Busan, Korea
– name: 1 Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Busan, Korea
Author_xml – sequence: 1
  givenname: So Ra
  surname: Oh
  fullname: Oh, So Ra
  organization: Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Busan, Korea
– sequence: 2
  givenname: Jung-Woo
  orcidid: 0000-0001-6154-0834
  surname: Park
  fullname: Park, Jung-Woo
  organization: Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Busan, Korea
– sequence: 3
  givenname: Hyun Young
  surname: Kwon
  fullname: Kwon, Hyun Young
  organization: Department of Obstetrics and Gynecology, Dong-A University College of Medicine, Busan, Korea
– sequence: 4
  givenname: Seo-Hee
  surname: Rha
  fullname: Rha, Seo-Hee
  organization: Department of Pathology, Dong-A University College of Medicine, Busan, Korea
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28989926$$D View this record in MEDLINE/PubMed
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002262282$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNp1UVtLwzAUDjJxU_cDfJE-6sNm0jaX-iDM4WUgCKLPIU2TLa5NZtIp_ntT50QFk8AJJ98lnG8f9KyzCoAjBMc4J-zMzcM4hYiOSWyMc0p3wCBNGR0xzGDv-07TPhiG8AzjYhgxlu-BfsoKVhQpGYDJ5cN0gpJRs25Fq6rEvQpvhE2ksFL55M20iyQsjU0a1YoQjwnniYjPQSVerZxvD8GuFnVQw696AJ6urx6nt6O7-5vZdHI3klkef1KRTGQlwQJXcUuhBdEYslwrpjFFCmMmK1SSgmU6y1hRspxkuCoh1ZIqVGYH4HSja73mS2m4E-azzh1fej55eJxxVFBIIYrYiw12tS4bVUllWy9qvvKmEf79k_n7xZpF1HnlmKQI0iIKnHwJePeyVqHljQlS1bWwyq1DNMqLbpyogx7_9Po22c44AugGIL0LwSvNpYnDNq6zNjVHkHeB8hgo7wLlJDZ4DDQy0R_mVvx_zgeT0qMl
CitedBy_id crossref_primary_10_3892_ol_2024_14481
crossref_primary_10_1097_MD_0000000000040016
crossref_primary_10_1016_j_gore_2020_100607
Cites_doi 10.1200/JCO.2009.25.1082
10.1016/j.humpath.2009.04.017
10.1158/1078-0432.CCR-07-4806
10.1002/cncr.11310
10.1001/jama.283.17.2260
10.1056/NEJM199611073351901
10.1126/science.286.5442.1162
10.1038/nature03443
10.1086/375033
10.1001/jama.2011.1456
10.1002/1097-0142(19871001)60:7<1561::AID-CNCR2820600725>3.0.CO;2-V
10.1002/cncr.21536
10.1200/JCO.2008.16.1703
ContentType Journal Article
Copyright Copyright © 2017 Korean Society of Obstetrics and Gynecology 2017 Korean Society of Obstetrics and Gynecology
Copyright_xml – notice: Copyright © 2017 Korean Society of Obstetrics and Gynecology 2017 Korean Society of Obstetrics and Gynecology
DBID AAYXX
CITATION
NPM
7X8
5PM
ACYCR
DOI 10.5468/ogs.2017.60.5.477
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
Korean Citation Index
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2287-8580
EndPage 480
ExternalDocumentID oai_kci_go_kr_ARTI_1970701
PMC5621079
28989926
10_5468_ogs_2017_60_5_477
Genre Case Reports
GroupedDBID 5-W
8JR
8XY
AAYXX
ACYCR
ADBBV
ADRAZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
EF.
GROUPED_DOAJ
HYE
HZB
KQ8
M48
PGMZT
RPM
NPM
7X8
5PM
ID FETCH-LOGICAL-c3487-d63a3b65a5d5d5cafa6f5084fe8f571e558cd1b6983f3389b84635db07fc7e1b3
IEDL.DBID M48
ISSN 2287-8572
IngestDate Tue Nov 21 21:36:18 EST 2023
Tue Sep 30 16:33:53 EDT 2025
Thu Jul 10 21:58:40 EDT 2025
Thu Jan 02 22:34:39 EST 2025
Tue Jul 01 01:11:19 EDT 2025
Thu Apr 24 23:13:01 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Ovarian neoplasms
BRCA mutation
Skin metastases
Language English
License Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3487-d63a3b65a5d5d5cafa6f5084fe8f571e558cd1b6983f3389b84635db07fc7e1b3
Notes ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
www.ogscience.org
ORCID 0000-0001-6154-0834
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.5468/ogs.2017.60.5.477
PMID 28989926
PQID 1949085119
PQPubID 23479
PageCount 4
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_1970701
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5621079
proquest_miscellaneous_1949085119
pubmed_primary_28989926
crossref_citationtrail_10_5468_ogs_2017_60_5_477
crossref_primary_10_5468_ogs_2017_60_5_477
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2017-09-01
PublicationDateYYYYMMDD 2017-09-01
PublicationDate_xml – month: 09
  year: 2017
  text: 2017-09-01
  day: 01
PublicationDecade 2010
PublicationPlace Korea (South)
PublicationPlace_xml – name: Korea (South)
PublicationTitle Obstetrics & gynecology science
PublicationTitleAlternate Obstet Gynecol Sci
PublicationYear 2017
Publisher Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society
대한산부인과학회
Publisher_xml – name: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society
– name: 대한산부인과학회
References Soegaard (10.5468/ogs.2017.60.5.477_ref9) 2008; 14
Cass (10.5468/ogs.2017.60.5.477_ref4) 2003; 97
Kim (10.5468/ogs.2017.60.5.477_ref14) 2010; 48
Yang (10.5468/ogs.2017.60.5.477_ref12) 2011; 306
Rubin (10.5468/ogs.2017.60.5.477_ref3) 1996; 335
Pal (10.5468/ogs.2017.60.5.477_ref8) 2005; 104
Boyd (10.5468/ogs.2017.60.5.477_ref2) 2000; 283
Gilks (10.5468/ogs.2017.60.5.477_ref10) 2009; 40
Bryant (10.5468/ogs.2017.60.5.477_ref15) 2005; 434
Dauplat (10.5468/ogs.2017.60.5.477_ref6) 1987; 60
Cortez (10.5468/ogs.2017.60.5.477_ref5) 1999; 286
Tan (10.5468/ogs.2017.60.5.477_ref11) 2008; 26
Antoniou (10.5468/ogs.2017.60.5.477_ref1) 2003; 72
Spencer (10.5468/ogs.2017.60.5.477_ref7) 1987; 39
Gourley (10.5468/ogs.2017.60.5.477_ref13) 2010; 28
References_xml – volume: 28
  start-page: 2505
  year: 2010
  ident: 10.5468/ogs.2017.60.5.477_ref13
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2009.25.1082
– volume: 40
  start-page: 1213
  year: 2009
  ident: 10.5468/ogs.2017.60.5.477_ref10
  publication-title: Hum Pathol
  doi: 10.1016/j.humpath.2009.04.017
– volume: 14
  start-page: 3761
  year: 2008
  ident: 10.5468/ogs.2017.60.5.477_ref9
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-07-4806
– volume: 39
  start-page: 119
  year: 1987
  ident: 10.5468/ogs.2017.60.5.477_ref7
  publication-title: Cutis
– volume: 97
  start-page: 2187
  year: 2003
  ident: 10.5468/ogs.2017.60.5.477_ref4
  publication-title: Cancer
  doi: 10.1002/cncr.11310
– volume: 283
  start-page: 2260
  year: 2000
  ident: 10.5468/ogs.2017.60.5.477_ref2
  publication-title: JAMA
  doi: 10.1001/jama.283.17.2260
– volume: 335
  start-page: 1413
  year: 1996
  ident: 10.5468/ogs.2017.60.5.477_ref3
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199611073351901
– volume: 286
  start-page: 1162
  year: 1999
  ident: 10.5468/ogs.2017.60.5.477_ref5
  publication-title: Science
  doi: 10.1126/science.286.5442.1162
– volume: 434
  start-page: 913
  year: 2005
  ident: 10.5468/ogs.2017.60.5.477_ref15
  publication-title: Nature
  doi: 10.1038/nature03443
– volume: 72
  start-page: 1117
  year: 2003
  ident: 10.5468/ogs.2017.60.5.477_ref1
  publication-title: Am J Hum Genet
  doi: 10.1086/375033
– volume: 306
  start-page: 1557
  year: 2011
  ident: 10.5468/ogs.2017.60.5.477_ref12
  publication-title: JAMA
  doi: 10.1001/jama.2011.1456
– volume: 60
  start-page: 1561
  year: 1987
  ident: 10.5468/ogs.2017.60.5.477_ref6
  publication-title: Cancer
  doi: 10.1002/1097-0142(19871001)60:7<1561::AID-CNCR2820600725>3.0.CO;2-V
– volume: 104
  start-page: 2807
  year: 2005
  ident: 10.5468/ogs.2017.60.5.477_ref8
  publication-title: Cancer
  doi: 10.1002/cncr.21536
– volume: 26
  start-page: 5530
  year: 2008
  ident: 10.5468/ogs.2017.60.5.477_ref11
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2008.16.1703
– volume: 48
  start-page: 342
  year: 2010
  ident: 10.5468/ogs.2017.60.5.477_ref14
  publication-title: Korean J Dermatol
SSID ssj0000851884
Score 2.011782
Snippet The major risk factor for ovarian cancer (OC) is mutation of the or DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most previous...
The major risk factor for ovarian cancer (OC) is mutation of the BRCA1 or BRCA2 DNA mismatch repair genes, which occurs in approximately 10% of OC cases. Most...
SourceID nrf
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 477
SubjectTerms Case Report
산부인과학
Title BRCA1 -mutated ovarian cancer with skin metastasis: a case report
URI https://www.ncbi.nlm.nih.gov/pubmed/28989926
https://www.proquest.com/docview/1949085119
https://pubmed.ncbi.nlm.nih.gov/PMC5621079
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002262282
Volume 60
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Obstetrics & Gynecology Science, 2017, 60(5), 635, pp.477-480
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2287-8580
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000851884
  issn: 2287-8572
  databaseCode: KQ8
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2287-8580
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000851884
  issn: 2287-8572
  databaseCode: DOA
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 2287-8580
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000851884
  issn: 2287-8572
  databaseCode: DIK
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVERR
  databaseName: KoreaMed Open Access
  customDbUrl:
  eissn: 2287-8580
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000851884
  issn: 2287-8572
  databaseCode: 5-W
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: https://koreamed.org/journals
  providerName: Korean Association of Medical Journal Editors
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 2287-8580
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000851884
  issn: 2287-8572
  databaseCode: RPM
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 2287-8580
  dateEnd: 20250531
  omitProxy: true
  ssIdentifier: ssj0000851884
  issn: 2287-8572
  databaseCode: M48
  dateStart: 20130101
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED9tQ0K8IL4JH5OHeEJKaeL4ixdUJqYxqTwgKu3NsmN767olkLQI_nvOSVpRVCGhPCSxnVg527nfz3e6A3htnUWl7lwagnRIUCxNpcErRk0W1Jha27n8Tz_z01lxds7O92Cd3moQYLuT2sV8UrPmevTz-6_3uOARv45YweXb-iLG3c7EiGPBqBBiH26hYsrjJJ8OaP-qd8nKZJeDOEeekEom8t7OufstW5pqv2rCLhD6ty_lH8rp5B7cHVAlmfTT4D7s-eoB3J4OdvOHMPnw5XiSkfRmFbGlI_UPpMimImUc84bEzVjSLuYVufFLg3ixnbfviMHq1pPeqvAIZicfvx6fpkPyhLSkSEJSx6mhljPDHB6lCYYHBGNF8DIwkXnGZOkyy5WkAWmqsghEKHN2LEIpfGbpYzio6so_BYKQxoRc-jE1vojOU44p7hE6eFaqwqgExmtB6XKILB4TXFxrZBhRthplq6NsNccCjbJN4M3mkW99WI1_NX6F0teLcq5jMOx4vqj1otEI-T_pTAn8bWUJHK0HR-MKiWYPU_l61WKDaNyM9tIEnvSDtekzj9kzVc4TEFvDuGkQO9yuqeaXXRRuBI5IndWz__mS53An3vc-ai_gYNms_EsENUt72G0GHHYT9jcoRPO0
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=BRCA1+-mutated+ovarian+cancer+with+skin+metastasis%3A+a+case+report&rft.jtitle=Obstetrics+%26+gynecology+science&rft.au=Oh%2C+So+Ra&rft.au=Park%2C+Jung-Woo&rft.au=Kwon%2C+Hyun+Young&rft.au=Rha%2C+Seo-Hee&rft.date=2017-09-01&rft.issn=2287-8572&rft.eissn=2287-8580&rft.volume=60&rft.issue=5&rft.spage=477&rft_id=info:doi/10.5468%2Fogs.2017.60.5.477&rft.externalDBID=n%2Fa&rft.externalDocID=10_5468_ogs_2017_60_5_477
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2287-8572&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2287-8572&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2287-8572&client=summon