Oscillatory and anti-oscillatory motifs in genetic regulatory networks

Recently, self-sustained oscillatory genetic regulatory networks （GRNs） have attracted significant attention in the biological field. Given a GRN, it is important to anticipate whether the network could generate oscillation with proper parameters, and what the key ingredients for the oscillation are...

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Published inChinese physics B Vol. 21; no. 6; pp. 10 - 18
Main Author 叶纬明 张朝阳 吕彬彬 狄增如 胡岗 刘东 银振强 王双 王粉梅 陈巍 韩正甫
Format Journal Article
LanguageEnglish
Published 01.06.2012
Subjects
Biological
Construction
Genetics
Ingredients
Networks
Oscillations
Repressing
图案
基因调控网络
抑制效果
抗振动
持续振荡
振动性
波动
生物领域
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ISSN1674-1056
2058-3834
1741-4199
DOI10.1088/1674-1056/21/6/060203

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Summary:Recently, self-sustained oscillatory genetic regulatory networks （GRNs） have attracted significant attention in the biological field. Given a GRN, it is important to anticipate whether the network could generate oscillation with proper parameters, and what the key ingredients for the oscillation are. In this paper the ranges of some function-related parameters which are favorable to sustained oscillations are considered. In particular, some oscillatory motifs appearing with high-frequency in most of the oscillatory GRNs are observed. Moreover, there are some anti-oscillatory motifs which have a strong oscillation repressing effect. Some conclusions analyzing these motif effects and constructing oscillatory GRNs are provided.
Bibliography:Recently, self-sustained oscillatory genetic regulatory networks （GRNs） have attracted significant attention in the biological field. Given a GRN, it is important to anticipate whether the network could generate oscillation with proper parameters, and what the key ingredients for the oscillation are. In this paper the ranges of some function-related parameters which are favorable to sustained oscillations are considered. In particular, some oscillatory motifs appearing with high-frequency in most of the oscillatory GRNs are observed. Moreover, there are some anti-oscillatory motifs which have a strong oscillation repressing effect. Some conclusions analyzing these motif effects and constructing oscillatory GRNs are provided.
Ye Wei-Ming, Zhang Zhao-Yang, Lii Bin-Bin, Di Zeng-Ru, and Hu Gang （a） Department of Systems Science, School of Management and Center for Complexity Research, Beijing Normal University, Beijing 100875, Chin; b） Department of Physics, Beijing Normal University, Beijing 100875, China; c） Genera/Research Institute for Nonferrous Metals, and Grirem Advanced Materials Co. Ltd., Beijing 100088, China
11-5639/O4
genetic regulatory network, oscillatory motif; anti-oscillatory motif; feedback loop
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1674-1056
2058-3834
1741-4199
DOI:10.1088/1674-1056/21/6/060203