Clinical Predictors of Venetoclax Pharmacokinetics in Chronic Lymphocytic Leukemia and Non-Hodgkin’s Lymphoma Patients: a Pooled Population Pharmacokinetic Analysis - Jones, Aksana K.; Freise, Kevin J.; Agarwal, Suresh K.; Humerickhouse, Rod A.; Wong, Shekman L.; Salem, Ahmed Hamed (The AAPS journal, 2016)
Keywords: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - blood; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Bridged Bicyclo Compounds, Heterocyclic - administration & dosage; Bridged Bicyclo Compounds, Heterocyclic - blood; Cohort Studies; Dietary Fats - administration & dosage; Dietary Fats - blood; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell - blood; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; Lymphoma, Non-Hodgkin - blood; Lymphoma, Non-Hodgkin - drug therapy; Male; Middle Aged; Models, Biological; Pharmacology/Toxicology; Pharmacy; Predictive Value of Tests; Research Article; Sulfonamides - administration & dosage; Sulfonamides - blood; food effect; venetoclax; CYP3A interactions; rituximab; population pharmacokinetics; renal and hepatic impairment