Impact of strength training of large muscle groups on quality of life
Muscle-strengthening activities reduce the risk of various diseases and promote overall health. Physical activities targeting large muscle groups, such as weightlifting or resistance exercises, provide an additional health benefit. The present study investigated the relationship between strength tra...
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| Published in | Journal of Clinical Biochemistry and Nutrition p. 25-60 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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SOCIETY FOR FREE RADICAL RESEARCH JAPAN
2025
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| ISSN | 0912-0009 1880-5086 |
| DOI | 10.3164/jcbn.25-60 |
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| Abstract | Muscle-strengthening activities reduce the risk of various diseases and promote overall health. Physical activities targeting large muscle groups, such as weightlifting or resistance exercises, provide an additional health benefit. The present study investigated the relationship between strength training and health-related quality of life (HRQOL) through a cross-sectional study of 50 adults participating in large muscle group strengthening activities (LMG) and 50 adults who did not (NLMG). HRQOL was assessed using the SF-12v2 questionnaire, and sleep habits were assessed using the PSQI questionnaire. The LMG group had a significantly higher Role/Social component summary (RCS) score than the NLMG group (50.5 ± 7.2 vs 47.2 ± 8.3; respectively, p = 0.040). The physical component summary (PCS) and mental component summary (MCS) scores also tended to be higher in the LMG group than in the NLMG group (52.6 ± 8.4 vs 49.9 ± 10.2, respectively; p = 0.15 and 59.0 ± 7.9 vs 56.7 ± 6.0, respectively; p = 0.10). Linear regression analysis showed that a higher RCS score was significantly associated with LMG training, whereas higher PCS and MCS scores were associated with better sleep quality. These results suggest that strength training targeting large muscle groups may improve the social aspect of HRQOL, highlighting the potential benefits of incorporating such exercises into regular physical activity regimens. |
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| AbstractList | Muscle-strengthening activities reduce the risk of various diseases and promote overall health. Physical activities targeting large muscle groups, such as weightlifting or resistance exercises, provide an additional health benefit. The present study investigated the relationship between strength training and health-related quality of life (HRQOL) through a cross-sectional study of 50 adults participating in large muscle group strengthening activities (LMG) and 50 adults who did not (NLMG). HRQOL was assessed using the SF-12v2 questionnaire, and sleep habits were assessed using the PSQI questionnaire. The LMG group had a significantly higher Role/Social component summary (RCS) score than the NLMG group (50.5 ± 7.2 vs 47.2 ± 8.3; respectively, p = 0.040). The physical component summary (PCS) and mental component summary (MCS) scores also tended to be higher in the LMG group than in the NLMG group (52.6 ± 8.4 vs 49.9 ± 10.2, respectively; p = 0.15 and 59.0 ± 7.9 vs 56.7 ± 6.0, respectively; p = 0.10). Linear regression analysis showed that a higher RCS score was significantly associated with LMG training, whereas higher PCS and MCS scores were associated with better sleep quality. These results suggest that strength training targeting large muscle groups may improve the social aspect of HRQOL, highlighting the potential benefits of incorporating such exercises into regular physical activity regimens. |
| ArticleNumber | 25-60 |
| Author | Tsuyoshi Enomoto Tetsuya Takahashi Juntaro Matsuzaki Yoshimasa Saito |
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| Cites_doi | 10.1097/00005650-199603000-00003 10.1177/2050640617726466 10.1016/S0140-6736(16)30383-X 10.3164/jcbn.16-108 10.1080/10253890.2019.1617691 10.1242/jeb.211888 10.1007/s12035-023-03492-8 10.1016/j.neuroscience.2018.12.002 10.1016/S0165-1781(00)00232-8 10.12659/MSMBR.924085 10.1007/s11136-018-1851-2 10.3164/jcbn.19-81 10.1093/sleep/20.2.95 10.1016/j.neubiorev.2013.01.028 10.1136/bjsports-2020-102955 10.1016/0165-1781(89)90047-4 10.1016/j.jclinepi.2010.04.017 10.1136/bjsports-2021-105061 10.1371/journal.pone.0317303 10.3389/fpsyt.2021.664499 10.3164/jcbn.15-48 |
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| References | 12 Matsuzaki J, Suzuki H, Togawa K, et al. Burden of impaired sleep quality on work productivity in functional dyspepsia. United European Gastroenterol J 2018; 6: 398–406. 6 Singh NA, Clements KM, Fiatarone MA. A randomized controlled trial of the effect of exercise on sleep. Sleep 1997; 20: 95–101. 4 Wu K, Wei X. Analysis of psychological and sleep status and exercise rehabilitation of front-line clinical staff in the fight against COVID-19 in China. Med Sci Monit Basic Res 2020; 26: e924085. 9 White MK, Maher SM, Rizio AA, Bjorner JB. A meta-analytic review of measurement equivalence study findings of the SF-36® and SF-12® Health Surveys across electronic modes compared to paper administration. Qual Life Res 2018; 27: 1757–1767. 17 Kumagai H, Zempo-Miyaki A, Yoshikawa T, Tsujimoto T, Tanaka K, Maeda S. Increased physical activity has a greater effect than reduced energy intake on lifestyle modification-induced increases in testosterone. J Clin Biochem Nutr 2016; 58: 84–89. 5 Sasawaki Y, Shiotani H. The influence of chronotype and working condition on sleep status and health related quality of life of daytime office workers. Kobe J Med Sci 2019; 64: E189–E196. 1 Momma H, Kawakami R, Honda T, Sawada SS. Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies. Br J Sports Med 2022; 56: 755–763. 2 Ding D, Lawson KD, Kolbe-Alexander TL, et al. The economic burden of physical inactivity: a global analysis of major non-communicable diseases. Lancet 2016; 388: 1311–1324. 21 Abbey-Lee RN, Kreshchenko A, Fernandez Sala X, Petkova I, Løvlie H. Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks. J Exp Biol 2019; 222 (Pt 20): jeb211888. 11 Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193–213. 14 Augusto-Oliveira M, Arrifano GP, Leal-Nazaré CG, et al. Exercise reshapes the brain: molecular, cellular, and structural changes associated with cognitive improvements. Mol Neurobiol 2023; 60: 6950–6974. 15 Tsukiyama Y, Ito T, Nagaoka K, Eguchi E, Ogino K. Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes. J Clin Biochem Nutr 2017; 60: 180–186. 20 Shou J, Tran A, Snyder N, Bleem E, Kim S. Distinct roles of GluA2-lacking AMPA receptor expression in dopamine D1 or D2 receptor neurons in animal behavior. Neuroscience 2019; 398: 102–112. 22 Watanasriyakul WT, Normann MC, Akinbo OI, Colburn W, Dagner A, Grippo AJ. Protective neuroendocrine effects of environmental enrichment and voluntary exercise against social isolation: evidence for mediation by limbic structures. Stress 2019; 22: 603–618. 16 Nerattini M, Williams S, Andy C, et al. Sex-specific associations of serum testosterone with gray matter volume and cerebral blood flow in midlife individuals at risk for Alzheimer’s disease. PLoS One 2025; 20: e0317303. 8 Suzukamo Y, Fukuhara S, Green J, et al. Validation testing of a three-component model of Short Form-36 scores. J Clin Epidemiol 2011; 64: 301–308. 10 Doi Y, Minowa M, Uchiyama M, et al. Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) in psychiatric disordered and control subjects. Psychiatry Res 2000; 97: 165–172. 7 Ware J Jr., Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996; 34: 220–233. 3 Bull FC, Al-Ansari SS, Biddle S, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med 2020; 54: 1451–1462. 13 Xie Y, Liu S, Chen XJ, Yu HH, Yang Y, Wang W. Effects of exercise on sleep quality and insomnia in adults: a systematic review and meta-analysis of randomized controlled trials. Front Psychiatry 2021; 12: 664499. 18 Otsuki T, Namatame H, Yoshikawa T, Zempo-Miyaki A. Combined aerobic and low-intensity resistance exercise training increases basal nitric oxide production and decreases arterial stiffness in healthy older adults. J Clin Biochem Nutr 2020; 66: 62–66. 19 Voelcker-Rehage C, Niemann C. Structural and functional brain changes related to different types of physical activity across the life span. Neurosci Biobehav Rev 2013; 37 (9 Pt B): 2268–2295. 11 22 12 13 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 10 21 |
| References_xml | – reference: 5 Sasawaki Y, Shiotani H. The influence of chronotype and working condition on sleep status and health related quality of life of daytime office workers. Kobe J Med Sci 2019; 64: E189–E196. – reference: 8 Suzukamo Y, Fukuhara S, Green J, et al. Validation testing of a three-component model of Short Form-36 scores. J Clin Epidemiol 2011; 64: 301–308. – reference: 22 Watanasriyakul WT, Normann MC, Akinbo OI, Colburn W, Dagner A, Grippo AJ. Protective neuroendocrine effects of environmental enrichment and voluntary exercise against social isolation: evidence for mediation by limbic structures. Stress 2019; 22: 603–618. – reference: 7 Ware J Jr., Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996; 34: 220–233. – reference: 19 Voelcker-Rehage C, Niemann C. Structural and functional brain changes related to different types of physical activity across the life span. Neurosci Biobehav Rev 2013; 37 (9 Pt B): 2268–2295. – reference: 4 Wu K, Wei X. Analysis of psychological and sleep status and exercise rehabilitation of front-line clinical staff in the fight against COVID-19 in China. Med Sci Monit Basic Res 2020; 26: e924085. – reference: 6 Singh NA, Clements KM, Fiatarone MA. A randomized controlled trial of the effect of exercise on sleep. Sleep 1997; 20: 95–101. – reference: 20 Shou J, Tran A, Snyder N, Bleem E, Kim S. Distinct roles of GluA2-lacking AMPA receptor expression in dopamine D1 or D2 receptor neurons in animal behavior. Neuroscience 2019; 398: 102–112. – reference: 14 Augusto-Oliveira M, Arrifano GP, Leal-Nazaré CG, et al. Exercise reshapes the brain: molecular, cellular, and structural changes associated with cognitive improvements. Mol Neurobiol 2023; 60: 6950–6974. – reference: 21 Abbey-Lee RN, Kreshchenko A, Fernandez Sala X, Petkova I, Løvlie H. Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks. J Exp Biol 2019; 222 (Pt 20): jeb211888. – reference: 9 White MK, Maher SM, Rizio AA, Bjorner JB. A meta-analytic review of measurement equivalence study findings of the SF-36® and SF-12® Health Surveys across electronic modes compared to paper administration. Qual Life Res 2018; 27: 1757–1767. – reference: 13 Xie Y, Liu S, Chen XJ, Yu HH, Yang Y, Wang W. Effects of exercise on sleep quality and insomnia in adults: a systematic review and meta-analysis of randomized controlled trials. Front Psychiatry 2021; 12: 664499. – reference: 17 Kumagai H, Zempo-Miyaki A, Yoshikawa T, Tsujimoto T, Tanaka K, Maeda S. Increased physical activity has a greater effect than reduced energy intake on lifestyle modification-induced increases in testosterone. J Clin Biochem Nutr 2016; 58: 84–89. – reference: 18 Otsuki T, Namatame H, Yoshikawa T, Zempo-Miyaki A. Combined aerobic and low-intensity resistance exercise training increases basal nitric oxide production and decreases arterial stiffness in healthy older adults. J Clin Biochem Nutr 2020; 66: 62–66. – reference: 11 Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193–213. – reference: 2 Ding D, Lawson KD, Kolbe-Alexander TL, et al. The economic burden of physical inactivity: a global analysis of major non-communicable diseases. Lancet 2016; 388: 1311–1324. – reference: 12 Matsuzaki J, Suzuki H, Togawa K, et al. Burden of impaired sleep quality on work productivity in functional dyspepsia. United European Gastroenterol J 2018; 6: 398–406. – reference: 15 Tsukiyama Y, Ito T, Nagaoka K, Eguchi E, Ogino K. Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes. J Clin Biochem Nutr 2017; 60: 180–186. – reference: 16 Nerattini M, Williams S, Andy C, et al. Sex-specific associations of serum testosterone with gray matter volume and cerebral blood flow in midlife individuals at risk for Alzheimer’s disease. PLoS One 2025; 20: e0317303. – reference: 1 Momma H, Kawakami R, Honda T, Sawada SS. Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies. Br J Sports Med 2022; 56: 755–763. – reference: 3 Bull FC, Al-Ansari SS, Biddle S, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med 2020; 54: 1451–1462. – reference: 10 Doi Y, Minowa M, Uchiyama M, et al. Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) in psychiatric disordered and control subjects. Psychiatry Res 2000; 97: 165–172. – ident: 7 doi: 10.1097/00005650-199603000-00003 – ident: 12 doi: 10.1177/2050640617726466 – ident: 2 doi: 10.1016/S0140-6736(16)30383-X – ident: 5 – ident: 15 doi: 10.3164/jcbn.16-108 – ident: 22 doi: 10.1080/10253890.2019.1617691 – ident: 21 doi: 10.1242/jeb.211888 – ident: 14 doi: 10.1007/s12035-023-03492-8 – ident: 20 doi: 10.1016/j.neuroscience.2018.12.002 – ident: 10 doi: 10.1016/S0165-1781(00)00232-8 – ident: 4 doi: 10.12659/MSMBR.924085 – ident: 9 doi: 10.1007/s11136-018-1851-2 – ident: 18 doi: 10.3164/jcbn.19-81 – ident: 6 doi: 10.1093/sleep/20.2.95 – ident: 19 doi: 10.1016/j.neubiorev.2013.01.028 – ident: 3 doi: 10.1136/bjsports-2020-102955 – ident: 11 doi: 10.1016/0165-1781(89)90047-4 – ident: 8 doi: 10.1016/j.jclinepi.2010.04.017 – ident: 1 doi: 10.1136/bjsports-2021-105061 – ident: 16 doi: 10.1371/journal.pone.0317303 – ident: 13 doi: 10.3389/fpsyt.2021.664499 – ident: 17 doi: 10.3164/jcbn.15-48 |
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| Title | Impact of strength training of large muscle groups on quality of life |
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