Dopamine transporter availability in alcohol and opioid dependent subjects – a 99mTc-TRODAT-1SPECT imaging and genetic association study
•Dopamine transporter regulates dopamine levels through epigenetic mechanisms.•SPECT/CT revealed significantly reduced DAT availability in AD compared to controls.•Significant increase in DAT promoter methylation in AD compared to controls and OD.•DAT1 promotermethylation in AD significantly associa...
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| Published in | Psychiatry research. Neuroimaging Vol. 305; p. 111187 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
30.11.2020
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| Online Access | Get full text |
| ISSN | 0925-4927 1872-7506 1872-7506 |
| DOI | 10.1016/j.pscychresns.2020.111187 |
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| Abstract | •Dopamine transporter regulates dopamine levels through epigenetic mechanisms.•SPECT/CT revealed significantly reduced DAT availability in AD compared to controls.•Significant increase in DAT promoter methylation in AD compared to controls and OD.•DAT1 promotermethylation in AD significantly associated with lower TRODAT-1 uptake.
Drug dependence associated with increased dopamine neurotransmission and neuroplastic changes is influenced by Dopamine transporters (DAT) which are modulated by genetic and epigenetic factors. This study assesses DAT availability in relation to the 40bp DAT1 VNTR (genetic) and DAT1 promoter methylation (epigenetic) changes in patients with alcohol dependence (AD) and opioid dependence (OD). A total of 60 subjects (n=20 each of AD, OD and controls) were recruited. SPECT/CT imaging using 99mTc-TRODAT-1 was performed for measuring striatal DAT availability and DNA screened to check DAT1promoter methylation and 40bp VNTR polymorphism. SPECT/CT imaging revealed significant decrease in DAT availability in the striatum and putamen and significant increase in DAT1 promoter methylation in AD compared to control and OD. The 40bp VNTR distribution was similar in all three groups with 10repeat and 9repeat alleles being the most common. The AD individuals with DAT1promoter methylation showed significantly lower TRODAT-1 uptake compared to the ones with no methylation. AD individuals homozygous for the 10repeat VNTR also showed reduced DAT availability. This is the first imaging study using 99mTc-TRODAT-1 from India documenting significantly reduced striatal DAT availability, increased DAT methylation and frequency of 10repeat individuals associated with decreased DAT availability in AD. |
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| AbstractList | •Dopamine transporter regulates dopamine levels through epigenetic mechanisms.•SPECT/CT revealed significantly reduced DAT availability in AD compared to controls.•Significant increase in DAT promoter methylation in AD compared to controls and OD.•DAT1 promotermethylation in AD significantly associated with lower TRODAT-1 uptake.
Drug dependence associated with increased dopamine neurotransmission and neuroplastic changes is influenced by Dopamine transporters (DAT) which are modulated by genetic and epigenetic factors. This study assesses DAT availability in relation to the 40bp DAT1 VNTR (genetic) and DAT1 promoter methylation (epigenetic) changes in patients with alcohol dependence (AD) and opioid dependence (OD). A total of 60 subjects (n=20 each of AD, OD and controls) were recruited. SPECT/CT imaging using 99mTc-TRODAT-1 was performed for measuring striatal DAT availability and DNA screened to check DAT1promoter methylation and 40bp VNTR polymorphism. SPECT/CT imaging revealed significant decrease in DAT availability in the striatum and putamen and significant increase in DAT1 promoter methylation in AD compared to control and OD. The 40bp VNTR distribution was similar in all three groups with 10repeat and 9repeat alleles being the most common. The AD individuals with DAT1promoter methylation showed significantly lower TRODAT-1 uptake compared to the ones with no methylation. AD individuals homozygous for the 10repeat VNTR also showed reduced DAT availability. This is the first imaging study using 99mTc-TRODAT-1 from India documenting significantly reduced striatal DAT availability, increased DAT methylation and frequency of 10repeat individuals associated with decreased DAT availability in AD. Drug dependence associated with increased dopamine neurotransmission and neuroplastic changes is influenced by Dopamine transporters (DAT) which are modulated by genetic and epigenetic factors. This study assesses DAT availability in relation to the 40bp DAT1 VNTR (genetic) and DAT1 promoter methylation (epigenetic) changes in patients with alcohol dependence (AD) and opioid dependence (OD). A total of 60 subjects (n=20 each of AD, OD and controls) were recruited. SPECT/CT imaging using 99mTc-TRODAT-1 was performed for measuring striatal DAT availability and DNA screened to check DAT1promoter methylation and 40bp VNTR polymorphism. SPECT/CT imaging revealed significant decrease in DAT availability in the striatum and putamen and significant increase in DAT1 promoter methylation in AD compared to control and OD. The 40bp VNTR distribution was similar in all three groups with 10repeat and 9repeat alleles being the most common. The AD individuals with DAT1promoter methylation showed significantly lower TRODAT-1 uptake compared to the ones with no methylation. AD individuals homozygous for the 10repeat VNTR also showed reduced DAT availability. This is the first imaging study using 99mTc-TRODAT-1 from India documenting significantly reduced striatal DAT availability, increased DAT methylation and frequency of 10repeat individuals associated with decreased DAT availability in AD.Drug dependence associated with increased dopamine neurotransmission and neuroplastic changes is influenced by Dopamine transporters (DAT) which are modulated by genetic and epigenetic factors. This study assesses DAT availability in relation to the 40bp DAT1 VNTR (genetic) and DAT1 promoter methylation (epigenetic) changes in patients with alcohol dependence (AD) and opioid dependence (OD). A total of 60 subjects (n=20 each of AD, OD and controls) were recruited. SPECT/CT imaging using 99mTc-TRODAT-1 was performed for measuring striatal DAT availability and DNA screened to check DAT1promoter methylation and 40bp VNTR polymorphism. SPECT/CT imaging revealed significant decrease in DAT availability in the striatum and putamen and significant increase in DAT1 promoter methylation in AD compared to control and OD. The 40bp VNTR distribution was similar in all three groups with 10repeat and 9repeat alleles being the most common. The AD individuals with DAT1promoter methylation showed significantly lower TRODAT-1 uptake compared to the ones with no methylation. AD individuals homozygous for the 10repeat VNTR also showed reduced DAT availability. This is the first imaging study using 99mTc-TRODAT-1 from India documenting significantly reduced striatal DAT availability, increased DAT methylation and frequency of 10repeat individuals associated with decreased DAT availability in AD. |
| ArticleNumber | 111187 |
| Author | Arora, Geetanjali Bal, Chandra Shekhar Sharma, Arundhati Ambekar, Atul Gupta, Ranjan Grover, Tripti Basu Ray, Subrata Vaswani, Meera |
| Author_xml | – sequence: 1 givenname: Tripti surname: Grover fullname: Grover, Tripti organization: Laboratory of Cyto-Molecular Genetics, Department of Anatomy, AIIMS, New Delhi 110029, India – sequence: 2 givenname: Ranjan surname: Gupta fullname: Gupta, Ranjan organization: Laboratory of Cyto-Molecular Genetics, Department of Anatomy, AIIMS, New Delhi 110029, India – sequence: 3 givenname: Geetanjali surname: Arora fullname: Arora, Geetanjali organization: Department of Nuclear Medicine, AIIMS, New Delhi 110029, India – sequence: 4 givenname: Chandra Shekhar surname: Bal fullname: Bal, Chandra Shekhar organization: Department of Nuclear Medicine, AIIMS, New Delhi 110029, India – sequence: 5 givenname: Atul surname: Ambekar fullname: Ambekar, Atul organization: National Drug Dependence Treatment Center, Department of Psychiatry, AIIMS, New Delhi 110029, India – sequence: 6 givenname: Subrata surname: Basu Ray fullname: Basu Ray, Subrata organization: Laboratory of Cyto-Molecular Genetics, Department of Anatomy, AIIMS, New Delhi 110029, India – sequence: 7 givenname: Meera surname: Vaswani fullname: Vaswani, Meera organization: National Drug Dependence Treatment Center, Department of Psychiatry, AIIMS, New Delhi 110029, India – sequence: 8 givenname: Arundhati surname: Sharma fullname: Sharma, Arundhati email: arundhatisharma1@gmail.com organization: Laboratory of Cyto-Molecular Genetics, Department of Anatomy, AIIMS, New Delhi 110029, India |
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| Cites_doi | 10.1038/379606a0 10.1111/j.1530-0277.1996.tb05936.x 10.1007/s00213-015-3992-0 10.1111/adb.12271 10.1002/ana.410360218 10.1001/jamapsychiatry.2017.0135 10.1016/j.jpsychires.2008.04.006 10.1111/acer.12625 10.1371/journal.pone.0131017 10.1016/j.neulet.2013.10.060 10.1111/adb.12203 10.1006/nimg.2001.0793 10.1038/mp.2013.126 10.1007/s002130051173 10.2967/jnumed.108.053652 10.1016/0163-7258(87)90108-2 10.1016/j.pscychresns.2010.08.001 10.1038/sj.mp.4000514 10.1186/s12993-015-0066-8 10.1002/syn.20927 10.1111/ejn.14067 10.1016/0165-6147(93)90029-J 10.15761/JSIN.1000144 10.1523/JNEUROSCI.0740-06.2006 10.1007/s002590050191 10.1016/j.biopsych.2005.04.044 10.1016/S0893-133X(00)00209-8 10.1016/S0924-9338(02)00628-4 10.1001/jama.285.6.811 10.1080/13556210500222456 10.1073/pnas.93.20.11202 10.1016/S0006-3223(99)00122-5 10.1007/978-1-59745-205-2_9 10.1038/nm0795-654 10.1016/S0006-3223(99)00101-8 10.1016/j.neulet.2017.10.013 10.1016/j.pscychresns.2017.03.011 10.1007/s00213-013-3148-z 10.1007/s00213-015-3891-4 10.1073/pnas.85.14.5274 10.1196/annals.1369.045 |
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| Keywords | Opioid Epigenetics Alcohol Dopamine transporter DAT1, VNTR SPECT |
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| References | Costa, Riedel, Müller, Möller, Ettinger (bib0005) 2011; 65 Laine, Ahonen, Torniainen, Heikkilä, Pyhtinen, Räsänen, Niemelä, Hillbom (bib0019) 1999; 4 Kenny, Chen, Kitamura, Markou, Koob (bib0017) 2006; 26 Faraone, Spencer, Madras, Zhang-James, Biederman (bib0009) 2014; 19 Di Chiara, Imperato (bib0006) 1988; 85 Gainetdinov, Jones, Caron (bib0010) 1999; 46 Heinz (bib0013) 2002; 17 Jia, Wang, Liu, Wu (bib0015) 2005; 10 Martinez, Gil, Slifstein, Hwang, Huang, Perez, Kegeles, Talbot, Evans, Krystal, Laruelle, Abi-Dargham (bib0023) 2005; 58 Volkow, Ding, Fowler, Wang, Logan, Gatley, Hitzemann, Smith, Fields, Gur (bib0035) 1996; 37 Diana, Spiga, Acquas (bib0007) 2006; 1074 (bib0002) 2001; 285 Xu, Liu, Li, Deng, Huang, Yuan, Lv, Wang, Zhang, Guo, Han, Liu, Fu (bib0040) 2015; 232 Xu, Liu, Li, Deng, Yuan, Lv, Wang, Zhang, Guo, Fu, Zeng, Han, Liu (bib0041) 2017; 263 Šerý, Paclt, Drtílková, Theiner, Kopečková, Zvolský, Balcar (bib0027) 2015; 11 van Dyck, Malison, Jacobsen, Seibyl, Staley, Laruelle, Baldwin, Innis, Gelernter (bib0032) 2005; 46 Sklair-Tavron, Shi, Lane, Harris, Bunney, Nestler (bib0028) 1996; 93 Ma, Zhu (bib0022) 2014; 26 Giros, Caron (bib0011) 1993; 14 Gordon (bib0037) 2016; 3 Yuan, Liu, Han, Lv, Wang, Zhang, Li (bib0043) 2017; 22 Abdolmaleky, Smith, Zhou, Thiagalingam (bib0001) 2008; 448 (accessed May 2020). Kish, Kalasinsky, Derkach, Schmunk, Guttman, Ang, Adams, Furukawa, Haycock (bib0018) 2001; 24 Kang, Palmatier, Kidd (bib0016) 1999; 46 Tiihonen, Kuikka, Bergström, Hakola, Karhu, Ryynänen, Föhr (bib0029) 1995; 1 Tupala, Kuikka, Hall, Bergström, Särkioja, Räsänen, Mantere, Hiltunen, Vepsäläinen, Tiihonen (bib0030) 2001; 14 NIDA. 2020. Drugs and the brain. Volkow, Wang, Fowler, Logan, Hitzemann, Ding, Pappas, Shea, Psicani (bib0036) 1996; 20 Zaaijer, Van Dijk, De Bruin, Goudriaan, Lammers, Koeter, Van Den Brink, Booij (bib0044) 2015; 232 Wiers, Lohoff, Lee, Muench, Freeman, Zehra, Marenco, Lipska, Auluck, Feng, Sun., Goldman, Swanson, Wang, Volkow (bib0038) 2018; 48 Giros, Jaber, Jones, Wightman, Caron (bib0012) 1996; 379 van de Giessen, de Win, Tanck, van den Brink, Baas, Booij (bib0031) 2008; 50 Dresel, Kung, Plössl, Meegalla, Kung (bib0008) 1998; 25 Repo, Kuikka, Bergström, Karhu, Hiltunen, Tiihonen (bib0026) 1999; 147 Mozley, Acton, Barraclough, Plössl, Gur, AlaviA., Saffer, Kung (bib0024) 1999; 40 Hillemacher, Frieling, Hartl, Wilhelm, Kornhuber, Bleich (bib0014) 2009; 43 Yen, Yeh, Liang, Ho, Kuo, Huang, Chen, Shih, Ma, Peng, Lu, Huang (bib0042) 2015; 10 Liu, Han, Liu, Deng, Li, Yuan, Lv, Wang, Zhang, Gao (bib0021) 2013; 230 Zhai, Li, Zhao, Lin (bib0045) 2014; 564 Zhai, Li, Dong, Zhou, Yang, Wang, Zhao, Lin (bib0046) 2018; 662 Wise (bib0039) 1987; 35 Ashok, Mizuno, Volkow, Howes (bib0003) 2017; 74 Cosgrove, Tellez-Jacques, Pittman, Petrakis, Baldwin, Tamagnan, Seibyl, Kosten, Staley (bib0004) 2010; 184 Vasconcelos, Neto, de, Pinto, Yoshioka, Motta, Vasconcelos, Canalle (bib0033) 2015; 39 Volkow, Fowler, Wang, Logan, Schlyer, MacGregor, Hitzemann, Wolf (bib0034) 1994; 36 Liang, Ho, Yen, Yeh, Kuo, Huang, Chen, Shih, Ma, Huang (bib0020) 2016; 21 Giros (10.1016/j.pscychresns.2020.111187_bib0011) 1993; 14 Abdolmaleky (10.1016/j.pscychresns.2020.111187_bib0001) 2008; 448 Faraone (10.1016/j.pscychresns.2020.111187_bib0009) 2014; 19 Zhai (10.1016/j.pscychresns.2020.111187_bib0045) 2014; 564 Diana (10.1016/j.pscychresns.2020.111187_bib0007) 2006; 1074 Yuan (10.1016/j.pscychresns.2020.111187_bib0043) 2017; 22 Costa (10.1016/j.pscychresns.2020.111187_bib0005) 2011; 65 Giros (10.1016/j.pscychresns.2020.111187_bib0012) 1996; 379 Ma (10.1016/j.pscychresns.2020.111187_bib0022) 2014; 26 van Dyck (10.1016/j.pscychresns.2020.111187_bib0032) 2005; 46 Ashok (10.1016/j.pscychresns.2020.111187_bib0003) 2017; 74 Wiers (10.1016/j.pscychresns.2020.111187_bib0038) 2018; 48 Dresel (10.1016/j.pscychresns.2020.111187_bib0008) 1998; 25 Liu (10.1016/j.pscychresns.2020.111187_bib0021) 2013; 230 Wise (10.1016/j.pscychresns.2020.111187_bib0039) 1987; 35 Volkow (10.1016/j.pscychresns.2020.111187_bib0035) 1996; 37 Tupala (10.1016/j.pscychresns.2020.111187_bib0030) 2001; 14 Repo (10.1016/j.pscychresns.2020.111187_bib0026) 1999; 147 Laine (10.1016/j.pscychresns.2020.111187_bib0019) 1999; 4 Volkow (10.1016/j.pscychresns.2020.111187_bib0034) 1994; 36 Mozley (10.1016/j.pscychresns.2020.111187_bib0024) 1999; 40 Xu (10.1016/j.pscychresns.2020.111187_bib0040) 2015; 232 Volkow (10.1016/j.pscychresns.2020.111187_bib0036) 1996; 20 Vasconcelos (10.1016/j.pscychresns.2020.111187_bib0033) 2015; 39 van de Giessen (10.1016/j.pscychresns.2020.111187_bib0031) 2008; 50 10.1016/j.pscychresns.2020.111187_bib0025 Sklair-Tavron (10.1016/j.pscychresns.2020.111187_bib0028) 1996; 93 Šerý (10.1016/j.pscychresns.2020.111187_bib0027) 2015; 11 Hillemacher (10.1016/j.pscychresns.2020.111187_bib0014) 2009; 43 Zhai (10.1016/j.pscychresns.2020.111187_bib0046) 2018; 662 Martinez (10.1016/j.pscychresns.2020.111187_bib0023) 2005; 58 Zaaijer (10.1016/j.pscychresns.2020.111187_bib0044) 2015; 232 Yen (10.1016/j.pscychresns.2020.111187_bib0042) 2015; 10 (10.1016/j.pscychresns.2020.111187_bib0002) 2001; 285 Cosgrove (10.1016/j.pscychresns.2020.111187_bib0004) 2010; 184 Liang (10.1016/j.pscychresns.2020.111187_bib0020) 2016; 21 Kenny (10.1016/j.pscychresns.2020.111187_bib0017) 2006; 26 Kish (10.1016/j.pscychresns.2020.111187_bib0018) 2001; 24 Tiihonen (10.1016/j.pscychresns.2020.111187_bib0029) 1995; 1 Jia (10.1016/j.pscychresns.2020.111187_bib0015) 2005; 10 Kang (10.1016/j.pscychresns.2020.111187_bib0016) 1999; 46 Di Chiara (10.1016/j.pscychresns.2020.111187_bib0006) 1988; 85 Heinz (10.1016/j.pscychresns.2020.111187_bib0013) 2002; 17 Gordon (10.1016/j.pscychresns.2020.111187_bib0037) 2016; 3 Xu (10.1016/j.pscychresns.2020.111187_bib0041) 2017; 263 Gainetdinov (10.1016/j.pscychresns.2020.111187_bib0010) 1999; 46 |
| References_xml | – volume: 74 start-page: 511 year: 2017 end-page: 519 ident: bib0003 article-title: Association of stimulant use with dopaminergic alterations in users of cocaine, amphetamine, or methamphetamine - A systematic review and meta-analysis publication-title: JAMA Psychiatry – volume: 26 start-page: 61 year: 2014 end-page: 68 ident: bib0022 article-title: The dopamine system and alcohol dependence publication-title: Shanghai Arch. psychiatry. – volume: 35 start-page: 227 year: 1987 end-page: 263 ident: bib0039 article-title: The role of reward pathways in the development of drug dependence publication-title: Pharmacol. Ther. – volume: 22 start-page: 229 year: 2017 end-page: 234 ident: bib0043 article-title: Comparison of striatal dopamine transporter levels in chronic heroin-dependent and methamphetamine-dependent subjects publication-title: Addict. Biol. – volume: 50 start-page: 45 year: 2008 end-page: 52 ident: bib0031 article-title: Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3 publication-title: J. Nucl. Med. – volume: 24 start-page: 561 year: 2001 end-page: 567 ident: bib0018 article-title: Striatal dopaminergic and serotonergic markers in human heroin users publication-title: Neuropsychopharmacology – volume: 11 start-page: 1 year: 2015 end-page: 8 ident: bib0027 article-title: A 40-bp VNTR polymorphism in the 3’-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism publication-title: Behav. Brain Funct. – volume: 20 start-page: 1594 year: 1996 end-page: 1598 ident: bib0036 article-title: Decrease in dopamine receptors but not in dopamine transporters in alcoholics publication-title: Alcohol. Clin. Exp. Reearch. – volume: 564 start-page: 99 year: 2014 end-page: 104 ident: bib0045 article-title: SLC6A3 is a risk factor for Parkinson's disease: a meta-analysis of sixteen years’ studies publication-title: Neurosci. Lett. – volume: 93 start-page: 11202 year: 1996 end-page: 11207 ident: bib0028 article-title: Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 46 start-page: 745 year: 2005 end-page: 751 ident: bib0032 article-title: Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene publication-title: J. Nucl. Med. – volume: 230 start-page: 235 year: 2013 end-page: 244 ident: bib0021 article-title: Dopamine transporter availability in heroin-dependent subjects and controls: Longitudinal changes during abstinence and the effects of Jitai tablets treatment publication-title: Psychopharmacology (Berl.) – reference: (accessed May 2020). – volume: 232 start-page: 3391 year: 2015 end-page: 3401 ident: bib0040 article-title: Longitudinal changes of dopamine transporters in heroin users during abstinence publication-title: Psychopharmacology (Berl) – volume: 43 start-page: 388 year: 2009 end-page: 392 ident: bib0014 article-title: Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving publication-title: J. Psychiatr. Res. – volume: 17 start-page: 9 year: 2002 end-page: 16 ident: bib0013 article-title: Dopaminergic dysfunction in alcoholism and schizophrenia - psychopathological and behavioral correlates publication-title: Eur. Psychiatry. – volume: 39 start-page: 205 year: 2015 end-page: 211 ident: bib0033 article-title: Association study of the SLC6A3 VNTR (DAT) and DRD2/ANKK1 Taq1A polymorphisms with alcohol dependence in a population from Northeastern Brazil publication-title: Alcohol. Clin. Exp. Res. – volume: 263 start-page: 121 year: 2017 end-page: 126 ident: bib0041 article-title: Availability of dopamine transporters in heroin-dependent subjects: a 18F-FECNT PET imaging study publication-title: Psychiatry Res. - Neuroimage. – volume: 65 start-page: 998 year: 2011 end-page: 1005 ident: bib0005 article-title: Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studies publication-title: Synapse – volume: 232 start-page: 2597 year: 2015 end-page: 2607 ident: bib0044 article-title: Effect of extended-release naltrexone on striatal dopamine transporter availability, depression and anhedonia in heroin-dependent patients publication-title: Psychopharmacology (Berl) – volume: 37 start-page: 554 year: 1996 end-page: 559 ident: bib0035 article-title: Dopamine transporters decrease with age publication-title: J. Nucl. Med. – volume: 1074 start-page: 446 year: 2006 end-page: 457 ident: bib0007 article-title: Persistent and reversible morphine withdrawal-induced morphological changes in the nucleus accumbens publication-title: Ann. NY Acad. Sci. – volume: 4 start-page: 189 year: 1999 end-page: 191 ident: bib0019 article-title: Dopamine transporters increase in human brain after alcohol withdrawal publication-title: Mol. Psychiatry – volume: 662 start-page: 91 year: 2018 end-page: 97 ident: bib0046 article-title: The correlation between DNA methylation and transcriptional expression of human dopamine transporter in cell lines publication-title: Neurosci Lett. – volume: 48 start-page: 1884 year: 2018 end-page: 1895 ident: bib0038 article-title: Methylation of the dopamine transporter gene in blood is associated with striatal dopamine transporter availability in ADHD: a preliminary study publication-title: Eur. J. Neurosci. – volume: 3 year: 2016 ident: bib0037 article-title: Putting hemispheric asymmetry to use in understanding brain diseases publication-title: J. Syst. Integr. Neurosci. – volume: 14 start-page: 43 year: 1993 end-page: 49 ident: bib0011 article-title: Molecular characterization of the dopamine transporter publication-title: Trends. Pharmacol. Sci. – volume: 21 start-page: 196 year: 2016 end-page: 204 ident: bib0020 article-title: Reduced striatal dopamine transporter density associated with working memory deficits in opioid-dependent male subjects: a SPECT study publication-title: Addict. Biol. – reference: NIDA. 2020. Drugs and the brain. – volume: 448 start-page: 187 year: 2008 end-page: 212 ident: bib0001 article-title: Epigenetic alterations of the dopaminergic system in major psychiatric disorders publication-title: Methods. Mol. Biol. – volume: 25 start-page: 31 year: 1998 end-page: 39 ident: bib0008 article-title: Pharmacological effects of dopaminergic drugs on in vivo binding of [99mTc]TRODAT-1 to the central dopamine transporters in rats publication-title: Eur. J. Nucl. Med. – volume: 26 start-page: 5894 year: 2006 end-page: 5900 ident: bib0017 article-title: Conditioned withdrawal drives heroin consumption and decreases reward sensitivity publication-title: J. Neurosci. – volume: 85 start-page: 5274 year: 1988 end-page: 5278 ident: bib0006 article-title: Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 46 start-page: 303 year: 1999 end-page: 311 ident: bib0010 article-title: Functional hyperdopaminergia in dopamine transporter knock-out mice publication-title: Biol. Psychiatry – volume: 46 start-page: 151 year: 1999 end-page: 160 ident: bib0016 article-title: Global variation of a 40-bp VNTR in the 3’-untranslated region of the dopamine transporter gene (SLC6A3) publication-title: Biol. Psychiatry. – volume: 379 start-page: 606 year: 1996 end-page: 612 ident: bib0012 article-title: Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter publication-title: Nature – volume: 1 start-page: 654 year: 1995 end-page: 657 ident: bib0029 article-title: Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics publication-title: Nat. Med. – volume: 285 start-page: 811 year: 2001 end-page: 812 ident: bib0002 article-title: Diagnostic and statistical manual of mental disorders DSM-IV-TR fourth edition (text revision) publication-title: JAMA – volume: 19 start-page: 880 year: 2014 end-page: 889 ident: bib0009 article-title: Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis publication-title: Mol. Psychiatry – volume: 14 start-page: 87 year: 2001 end-page: 94 ident: bib0030 article-title: Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography publication-title: Neuroimage – volume: 36 start-page: 237 year: 1994 end-page: 239 ident: bib0034 article-title: Decreased dopamine transporters with age in health human subjects publication-title: Ann. Neurol. – volume: 10 start-page: 293 year: 2005 end-page: 297 ident: bib0015 article-title: Neuroimaging studies of brain corpus striatum changes among heroin-dependent patients treated with herbal medicine, U'finer publication-title: Addict. Biol. – volume: 184 start-page: 192 year: 2010 end-page: 195 ident: bib0004 article-title: Dopamine and serotonin transporteravailability in chronic heroin users: a [123I]β-CIT SPECT imaging study publication-title: Psychiatry Res. – volume: 40 start-page: 1812 year: 1999 end-page: 1817 ident: bib0024 article-title: Effects of age on dopamine transporters in healthy humans publication-title: J. Nucl. Med. – volume: 10 year: 2015 ident: bib0042 article-title: Reduced dopamine transporter availability and neurocognitive deficits in male patients with alcohol dependence publication-title: PLoS One – volume: 58 start-page: 779 year: 2005 end-page: 786 ident: bib0023 article-title: Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum publication-title: Biol. Psychiatry – volume: 147 start-page: 314 year: 1999 end-page: 318 ident: bib0026 article-title: Dopamine transporter and D2-receptor density in late-onset alcoholism publication-title: Psychopharmacology (Berl.) – volume: 379 start-page: 606 year: 1996 ident: 10.1016/j.pscychresns.2020.111187_bib0012 article-title: Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter publication-title: Nature doi: 10.1038/379606a0 – volume: 20 start-page: 1594 year: 1996 ident: 10.1016/j.pscychresns.2020.111187_bib0036 article-title: Decrease in dopamine receptors but not in dopamine transporters in alcoholics publication-title: Alcohol. Clin. Exp. Reearch. doi: 10.1111/j.1530-0277.1996.tb05936.x – volume: 232 start-page: 3391 year: 2015 ident: 10.1016/j.pscychresns.2020.111187_bib0040 article-title: Longitudinal changes of dopamine transporters in heroin users during abstinence publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-015-3992-0 – volume: 22 start-page: 229 year: 2017 ident: 10.1016/j.pscychresns.2020.111187_bib0043 article-title: Comparison of striatal dopamine transporter levels in chronic heroin-dependent and methamphetamine-dependent subjects publication-title: Addict. Biol. doi: 10.1111/adb.12271 – volume: 36 start-page: 237 issue: 2 year: 1994 ident: 10.1016/j.pscychresns.2020.111187_bib0034 article-title: Decreased dopamine transporters with age in health human subjects publication-title: Ann. Neurol. doi: 10.1002/ana.410360218 – volume: 26 start-page: 61 year: 2014 ident: 10.1016/j.pscychresns.2020.111187_bib0022 article-title: The dopamine system and alcohol dependence publication-title: Shanghai Arch. psychiatry. – volume: 74 start-page: 511 year: 2017 ident: 10.1016/j.pscychresns.2020.111187_bib0003 article-title: Association of stimulant use with dopaminergic alterations in users of cocaine, amphetamine, or methamphetamine - A systematic review and meta-analysis publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2017.0135 – volume: 43 start-page: 388 year: 2009 ident: 10.1016/j.pscychresns.2020.111187_bib0014 article-title: Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2008.04.006 – volume: 39 start-page: 205 year: 2015 ident: 10.1016/j.pscychresns.2020.111187_bib0033 article-title: Association study of the SLC6A3 VNTR (DAT) and DRD2/ANKK1 Taq1A polymorphisms with alcohol dependence in a population from Northeastern Brazil publication-title: Alcohol. Clin. Exp. Res. doi: 10.1111/acer.12625 – volume: 10 year: 2015 ident: 10.1016/j.pscychresns.2020.111187_bib0042 article-title: Reduced dopamine transporter availability and neurocognitive deficits in male patients with alcohol dependence publication-title: PLoS One doi: 10.1371/journal.pone.0131017 – volume: 564 start-page: 99 year: 2014 ident: 10.1016/j.pscychresns.2020.111187_bib0045 article-title: SLC6A3 is a risk factor for Parkinson's disease: a meta-analysis of sixteen years’ studies publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2013.10.060 – volume: 21 start-page: 196 year: 2016 ident: 10.1016/j.pscychresns.2020.111187_bib0020 article-title: Reduced striatal dopamine transporter density associated with working memory deficits in opioid-dependent male subjects: a SPECT study publication-title: Addict. Biol. doi: 10.1111/adb.12203 – volume: 14 start-page: 87 year: 2001 ident: 10.1016/j.pscychresns.2020.111187_bib0030 article-title: Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography publication-title: Neuroimage doi: 10.1006/nimg.2001.0793 – volume: 19 start-page: 880 year: 2014 ident: 10.1016/j.pscychresns.2020.111187_bib0009 article-title: Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis publication-title: Mol. Psychiatry doi: 10.1038/mp.2013.126 – volume: 147 start-page: 314 year: 1999 ident: 10.1016/j.pscychresns.2020.111187_bib0026 article-title: Dopamine transporter and D2-receptor density in late-onset alcoholism publication-title: Psychopharmacology (Berl.) doi: 10.1007/s002130051173 – volume: 50 start-page: 45 year: 2008 ident: 10.1016/j.pscychresns.2020.111187_bib0031 article-title: Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3 publication-title: J. Nucl. Med. doi: 10.2967/jnumed.108.053652 – volume: 35 start-page: 227 year: 1987 ident: 10.1016/j.pscychresns.2020.111187_bib0039 article-title: The role of reward pathways in the development of drug dependence publication-title: Pharmacol. Ther. doi: 10.1016/0163-7258(87)90108-2 – volume: 184 start-page: 192 year: 2010 ident: 10.1016/j.pscychresns.2020.111187_bib0004 article-title: Dopamine and serotonin transporteravailability in chronic heroin users: a [123I]β-CIT SPECT imaging study publication-title: Psychiatry Res. doi: 10.1016/j.pscychresns.2010.08.001 – volume: 4 start-page: 189 year: 1999 ident: 10.1016/j.pscychresns.2020.111187_bib0019 article-title: Dopamine transporters increase in human brain after alcohol withdrawal publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4000514 – volume: 11 start-page: 1 year: 2015 ident: 10.1016/j.pscychresns.2020.111187_bib0027 article-title: A 40-bp VNTR polymorphism in the 3’-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism publication-title: Behav. Brain Funct. doi: 10.1186/s12993-015-0066-8 – volume: 65 start-page: 998 year: 2011 ident: 10.1016/j.pscychresns.2020.111187_bib0005 article-title: Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studies publication-title: Synapse doi: 10.1002/syn.20927 – volume: 48 start-page: 1884 issue: 3 year: 2018 ident: 10.1016/j.pscychresns.2020.111187_bib0038 article-title: Methylation of the dopamine transporter gene in blood is associated with striatal dopamine transporter availability in ADHD: a preliminary study publication-title: Eur. J. Neurosci. doi: 10.1111/ejn.14067 – volume: 14 start-page: 43 year: 1993 ident: 10.1016/j.pscychresns.2020.111187_bib0011 article-title: Molecular characterization of the dopamine transporter publication-title: Trends. Pharmacol. Sci. doi: 10.1016/0165-6147(93)90029-J – volume: 3 year: 2016 ident: 10.1016/j.pscychresns.2020.111187_bib0037 article-title: Putting hemispheric asymmetry to use in understanding brain diseases publication-title: J. Syst. Integr. Neurosci. doi: 10.15761/JSIN.1000144 – volume: 26 start-page: 5894 year: 2006 ident: 10.1016/j.pscychresns.2020.111187_bib0017 article-title: Conditioned withdrawal drives heroin consumption and decreases reward sensitivity publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0740-06.2006 – volume: 25 start-page: 31 year: 1998 ident: 10.1016/j.pscychresns.2020.111187_bib0008 article-title: Pharmacological effects of dopaminergic drugs on in vivo binding of [99mTc]TRODAT-1 to the central dopamine transporters in rats publication-title: Eur. J. Nucl. Med. doi: 10.1007/s002590050191 – volume: 58 start-page: 779 year: 2005 ident: 10.1016/j.pscychresns.2020.111187_bib0023 article-title: Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2005.04.044 – volume: 24 start-page: 561 year: 2001 ident: 10.1016/j.pscychresns.2020.111187_bib0018 article-title: Striatal dopaminergic and serotonergic markers in human heroin users publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(00)00209-8 – volume: 17 start-page: 9 year: 2002 ident: 10.1016/j.pscychresns.2020.111187_bib0013 article-title: Dopaminergic dysfunction in alcoholism and schizophrenia - psychopathological and behavioral correlates publication-title: Eur. Psychiatry. doi: 10.1016/S0924-9338(02)00628-4 – volume: 285 start-page: 811 year: 2001 ident: 10.1016/j.pscychresns.2020.111187_bib0002 article-title: Diagnostic and statistical manual of mental disorders DSM-IV-TR fourth edition (text revision) publication-title: JAMA doi: 10.1001/jama.285.6.811 – volume: 10 start-page: 293 year: 2005 ident: 10.1016/j.pscychresns.2020.111187_bib0015 article-title: Neuroimaging studies of brain corpus striatum changes among heroin-dependent patients treated with herbal medicine, U'finerTM capsule publication-title: Addict. Biol. doi: 10.1080/13556210500222456 – volume: 93 start-page: 11202 year: 1996 ident: 10.1016/j.pscychresns.2020.111187_bib0028 article-title: Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.93.20.11202 – volume: 40 start-page: 1812 issue: 11 year: 1999 ident: 10.1016/j.pscychresns.2020.111187_bib0024 article-title: Effects of age on dopamine transporters in healthy humans publication-title: J. Nucl. Med. – volume: 46 start-page: 303 year: 1999 ident: 10.1016/j.pscychresns.2020.111187_bib0010 article-title: Functional hyperdopaminergia in dopamine transporter knock-out mice publication-title: Biol. Psychiatry doi: 10.1016/S0006-3223(99)00122-5 – volume: 448 start-page: 187 year: 2008 ident: 10.1016/j.pscychresns.2020.111187_bib0001 article-title: Epigenetic alterations of the dopaminergic system in major psychiatric disorders publication-title: Methods. Mol. Biol. doi: 10.1007/978-1-59745-205-2_9 – volume: 1 start-page: 654 year: 1995 ident: 10.1016/j.pscychresns.2020.111187_bib0029 article-title: Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics publication-title: Nat. Med. doi: 10.1038/nm0795-654 – volume: 46 start-page: 151 year: 1999 ident: 10.1016/j.pscychresns.2020.111187_bib0016 article-title: Global variation of a 40-bp VNTR in the 3’-untranslated region of the dopamine transporter gene (SLC6A3) publication-title: Biol. Psychiatry. doi: 10.1016/S0006-3223(99)00101-8 – volume: 46 start-page: 745 year: 2005 ident: 10.1016/j.pscychresns.2020.111187_bib0032 article-title: Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene publication-title: J. Nucl. Med. – volume: 662 start-page: 91 year: 2018 ident: 10.1016/j.pscychresns.2020.111187_bib0046 article-title: The correlation between DNA methylation and transcriptional expression of human dopamine transporter in cell lines publication-title: Neurosci Lett. doi: 10.1016/j.neulet.2017.10.013 – volume: 263 start-page: 121 year: 2017 ident: 10.1016/j.pscychresns.2020.111187_bib0041 article-title: Availability of dopamine transporters in heroin-dependent subjects: a 18F-FECNT PET imaging study publication-title: Psychiatry Res. - Neuroimage. doi: 10.1016/j.pscychresns.2017.03.011 – volume: 230 start-page: 235 year: 2013 ident: 10.1016/j.pscychresns.2020.111187_bib0021 article-title: Dopamine transporter availability in heroin-dependent subjects and controls: Longitudinal changes during abstinence and the effects of Jitai tablets treatment publication-title: Psychopharmacology (Berl.) doi: 10.1007/s00213-013-3148-z – volume: 37 start-page: 554 year: 1996 ident: 10.1016/j.pscychresns.2020.111187_bib0035 article-title: Dopamine transporters decrease with age publication-title: J. Nucl. Med. – volume: 232 start-page: 2597 year: 2015 ident: 10.1016/j.pscychresns.2020.111187_bib0044 article-title: Effect of extended-release naltrexone on striatal dopamine transporter availability, depression and anhedonia in heroin-dependent patients publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-015-3891-4 – volume: 85 start-page: 5274 year: 1988 ident: 10.1016/j.pscychresns.2020.111187_bib0006 article-title: Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.85.14.5274 – volume: 1074 start-page: 446 year: 2006 ident: 10.1016/j.pscychresns.2020.111187_bib0007 article-title: Persistent and reversible morphine withdrawal-induced morphological changes in the nucleus accumbens publication-title: Ann. NY Acad. Sci. doi: 10.1196/annals.1369.045 – ident: 10.1016/j.pscychresns.2020.111187_bib0025 |
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