Ginsenoside Rg1 treats ischemic stroke by regulating CKLF1/CCR5 axis-induced neuronal cell pyroptosis - Long, Junpeng; Sun, Yang; Liu, Shasha; Chen, Chen; Yan, Qian; Lin, Yuting; Zhang, Zhao; Chu, Shifeng; Yang, Yantao; Yang, Songwei; Lin, Meiyu; Liu, Xuan; et al. (Phytomedicine (Stuttgart), 2024)
Keywords: Animals; antioxidants; Brain Ischemia - drug therapy; Brain Ischemia - metabolism; CCR5 receptor; chemokines; drugs; fluorescent antibody technique; Ginsenosides; Humans; immunohistochemistry; inflammasomes; ischemia; Ischemic Stroke - drug therapy; mechanism of action; neurons; pharmacodynamics; Pyroptosis; quantitative polymerase chain reaction; Rats; Receptors, CCR5 - therapeutic use; Receptors, Chemokine - therapeutic use; Reperfusion Injury - drug therapy; stroke; therapeutics; Western blotting; pyroptosis; Ischemic stroke; ginsenoside Rg1; C-C chemokine receptor type 5 (CCR5); chemokine like factor 1 (CKLF1); NOD-like receptor thremal protein domain associated protein 3 (NLRP3)