Coupled Imaging with [18F]FBB and [18F]FDG in AD Subjects Show a Selective Association Between Amyloid Burden and Cortical Dysfunction in the Brain

• Published in: Molecular imaging and biology Vol. 20; no. 4; pp. 659 - 666
• Main Authors: Chiaravalloti, Agostino, Castellano, Anna Elisa, Ricci, Maria, Barbagallo, Gaetano, Sannino, Pasqualina, Ursini, Francesco, Karalis, Georgios, Schillaci, Orazio
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2018; Springer Nature B.V
• Subjects: Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - physiopathology; Alzheimer's disease; Amyloid - metabolism; Aniline Compounds - chemistry; Brain; Case-Control Studies; Cerebellum; Cerebral Cortex - physiopathology; Computed tomography; Female; Fluorodeoxyglucose F18 - chemistry; Glucose; Glucose metabolism; Humans; Hypometabolism; Image processing; Imaging; Imaging, Three-Dimensional; Lobes; Male; Medical imaging; Medicine; Medicine & Public Health; Metabolism; Neurodegenerative diseases; Neuroimaging; Patients; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography; Radiology; Regression Analysis; Research Article; Statistical analysis; Stilbenes - chemistry; Temporal cortex; Tomography; F]FBB; Brain imaging; [; Alzheimer; PET; F]FDG; [18F]FDG; [18F]FBB
• ISSN: 1536-1632; 1860-2002
• DOI: 10.1007/s11307-018-1167-1

Purpose The present study was aimed to investigate the relationships between dysfunction of cortical glucose metabolism as detectable by means of 2-deoxy-2-[ 18 F]fluoro -D-glucose ([ 18 F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) and amyloid burden as detectable by means of 4-{(E)-2-[4-(2-{2-[2-[ 18 F]fluoroethoxy]ethoxy}ethoxy)phenyl]vinyl}-N-methylaniline (florbetaben; [ 18 F]FBB) in a group of patients affected by Alzheimer’s disease (AD). Procedures We examined 38 patients newly diagnosed with AD according to the NINCDS-ADRDA criteria. All the subjects underwent a PET/CT scan using both [ 18 F]FDG and [ 18 F]FBB with an average interval of 1 month. We used statistical parametric mapping (SPM8) implemented in Matlab R2012b and WFU pickatlas for the definition of a region of interest (ROI) mask including the whole cortex. These data were then normalized on the counts of the cerebellum and then used for a regression analysis on [ 18 F]FDG scans in SPM. Furthermore, 58 control subjects were used as control group for [ 18 F]FDG PET/CT scans. Results SPM analysis in AD patients showed a significant negative correlation between [ 18 F] FBB and [ 18 F] FDG uptake in temporal and parietal lobes bilaterally. Of note, these areas in AD patients displayed a marked glucose hypometabolism compared to control group. Conclusions Combined imaging with [ 18 F]FBB and [ 18 FFDG shows that amyloid burden in the brain is related to cortical dysfunction of temporal and parietal lobes in AD.