One-pot synthesis of PDMAEMA nanocapsules for controlled release of hydrophobic cargo

In this work, poly((N,N-dimethyl amino)ethyl methacrylate) (PDMAEMA) homopolymers are synthesized using RAFT technique, which is then used as stabilizers to prepare miniemulsion droplets in a toluene/hexadecane(HD)/1,2-Bis-(2-iodoethyl)ethane(BIEE)/hydrophobic molecule/water mixture. Upon the reacti...

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Published inJournal of macromolecular science. Part A, Pure and applied chemistry Vol. 54; no. 11; pp. 805 - 812
Main Authors Wu, Lin, Li, Yiguo, Pang, Tao, Guan, Ye-bin
Format Journal Article
LanguageEnglish
Published New York Taylor & Francis 02.11.2017
Marcel Dekker, Inc
Subjects
Controlled release
Droplets
Ethane
Hexadecane
hydrophobic cargo
miniemulsion crosslinking
PDMAEMA homopolymer
Polymeric nanocapsules
Stabilizers (agents)
Sustained release
Toluene
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ISSN1060-1325
1520-5738
DOI10.1080/10601325.2017.1336725

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Summary:In this work, poly((N,N-dimethyl amino)ethyl methacrylate) (PDMAEMA) homopolymers are synthesized using RAFT technique, which is then used as stabilizers to prepare miniemulsion droplets in a toluene/hexadecane(HD)/1,2-Bis-(2-iodoethyl)ethane(BIEE)/hydrophobic molecule/water mixture. Upon the reaction between BIEE and the stabilizers of miniemulsion droplets, the polymeric nanocapsules are formed and capable of encapsulating hydrophobic molecule in their oil core in one-step reaction. The release of hydrophobic cargo from the nanocapsules can be controlled by the variation of amount of surfactant (Tween®20) in the release medium and a long duration sustained release was achieved.
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ISSN:1060-1325
1520-5738
DOI:10.1080/10601325.2017.1336725