Comparative Toxic Effect of Bulk Copper Oxide (CuO) and CuO Nanoparticles on Human Red Blood Cells
Destruction of red blood cell is associated with anemia and other pathological status; hence, the hemolytic effects of all chemicals and particles which come into contact with blood components must be considered. Nanomaterials and nanoparticles are potential substitutes for common material and parti...
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| Published in | Biological trace element research Vol. 201; no. 1; pp. 149 - 155 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.01.2023
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0163-4984 1559-0720 1559-0720 |
| DOI | 10.1007/s12011-022-03149-y |
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| Abstract | Destruction of red blood cell is associated with anemia and other pathological status; hence, the hemolytic effects of all chemicals and particles which come into contact with blood components must be considered. Nanomaterials and nanoparticles are potential substitutes for common material and particles, and assessment of their effect on blood components is a necessary part of their safety evaluation. High surface-to-volume ratio of nanoparticles may cause their toxic effects differ from those observed for bulk material. The aim of this study was to compare the hemolytic effects of CuO nanoparticles and bulk CuO. Red blood cells were isolated from blood of healthy subjects and hemolytic effects assayed following treatment of cells with 0.005–0.25 mM of CuO (bulk and nanoparticles) for 6 h. For assessment of other parameters, cells were incubated with 0.01, 0.05, and 0.25 mM of CuO nanoparticles and bulk CuO for 1, 2, and 3 h. Our results demonstrate that CuO nanoparticles, in particular, caused toxic hemolytic effects in concentration-dependent manner, and this effect maybe through formation of ROS, glutathione depletion, and lipid peroxidation. In conclusion, CuO nanoparticles are shown to effectively destruct human red blood cells in comparison to bulk CuO. |
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| AbstractList | Destruction of red blood cell is associated with anemia and other pathological status; hence, the hemolytic effects of all chemicals and particles which come into contact with blood components must be considered. Nanomaterials and nanoparticles are potential substitutes for common material and particles, and assessment of their effect on blood components is a necessary part of their safety evaluation. High surface-to-volume ratio of nanoparticles may cause their toxic effects differ from those observed for bulk material. The aim of this study was to compare the hemolytic effects of CuO nanoparticles and bulk CuO. Red blood cells were isolated from blood of healthy subjects and hemolytic effects assayed following treatment of cells with 0.005–0.25 mM of CuO (bulk and nanoparticles) for 6 h. For assessment of other parameters, cells were incubated with 0.01, 0.05, and 0.25 mM of CuO nanoparticles and bulk CuO for 1, 2, and 3 h. Our results demonstrate that CuO nanoparticles, in particular, caused toxic hemolytic effects in concentration-dependent manner, and this effect maybe through formation of ROS, glutathione depletion, and lipid peroxidation. In conclusion, CuO nanoparticles are shown to effectively destruct human red blood cells in comparison to bulk CuO. Abstract Destruction of red blood cell is associated with anemia and other pathological status; hence, the hemolytic effects of all chemicals and particles which come into contact with blood components must be considered. Nanomaterials and nanoparticles are potential substitutes for common material and particles, and assessment of their effect on blood components is a necessary part of their safety evaluation. High surface-to-volume ratio of nanoparticles may cause their toxic effects differ from those observed for bulk material. The aim of this study was to compare the hemolytic effects of CuO nanoparticles and bulk CuO. Red blood cells were isolated from blood of healthy subjects and hemolytic effects assayed following treatment of cells with 0.005–0.25 mM of CuO (bulk and nanoparticles) for 6 h. For assessment of other parameters, cells were incubated with 0.01, 0.05, and 0.25 mM of CuO nanoparticles and bulk CuO for 1, 2, and 3 h. Our results demonstrate that CuO nanoparticles, in particular, caused toxic hemolytic effects in concentration-dependent manner, and this effect maybe through formation of ROS, glutathione depletion, and lipid peroxidation. In conclusion, CuO nanoparticles are shown to effectively destruct human red blood cells in comparison to bulk CuO. Destruction of red blood cell is associated with anemia and other pathological status; hence, the hemolytic effects of all chemicals and particles which come into contact with blood components must be considered. Nanomaterials and nanoparticles are potential substitutes for common material and particles, and assessment of their effect on blood components is a necessary part of their safety evaluation. High surface-to-volume ratio of nanoparticles may cause their toxic effects differ from those observed for bulk material. The aim of this study was to compare the hemolytic effects of CuO nanoparticles and bulk CuO. Red blood cells were isolated from blood of healthy subjects and hemolytic effects assayed following treatment of cells with 0.005-0.25 mM of CuO (bulk and nanoparticles) for 6 h. For assessment of other parameters, cells were incubated with 0.01, 0.05, and 0.25 mM of CuO nanoparticles and bulk CuO for 1, 2, and 3 h. Our results demonstrate that CuO nanoparticles, in particular, caused toxic hemolytic effects in concentration-dependent manner, and this effect maybe through formation of ROS, glutathione depletion, and lipid peroxidation. In conclusion, CuO nanoparticles are shown to effectively destruct human red blood cells in comparison to bulk CuO.Destruction of red blood cell is associated with anemia and other pathological status; hence, the hemolytic effects of all chemicals and particles which come into contact with blood components must be considered. Nanomaterials and nanoparticles are potential substitutes for common material and particles, and assessment of their effect on blood components is a necessary part of their safety evaluation. High surface-to-volume ratio of nanoparticles may cause their toxic effects differ from those observed for bulk material. The aim of this study was to compare the hemolytic effects of CuO nanoparticles and bulk CuO. Red blood cells were isolated from blood of healthy subjects and hemolytic effects assayed following treatment of cells with 0.005-0.25 mM of CuO (bulk and nanoparticles) for 6 h. For assessment of other parameters, cells were incubated with 0.01, 0.05, and 0.25 mM of CuO nanoparticles and bulk CuO for 1, 2, and 3 h. Our results demonstrate that CuO nanoparticles, in particular, caused toxic hemolytic effects in concentration-dependent manner, and this effect maybe through formation of ROS, glutathione depletion, and lipid peroxidation. In conclusion, CuO nanoparticles are shown to effectively destruct human red blood cells in comparison to bulk CuO. Destruction of red blood cell is associated with anemia and other pathological status; hence, the hemolytic effects of all chemicals and particles which come into contact with blood components must be considered. Nanomaterials and nanoparticles are potential substitutes for common material and particles, and assessment of their effect on blood components is a necessary part of their safety evaluation. High surface-to-volume ratio of nanoparticles may cause their toxic effects differ from those observed for bulk material. The aim of this study was to compare the hemolytic effects of CuO nanoparticles and bulk CuO. Red blood cells were isolated from blood of healthy subjects and hemolytic effects assayed following treatment of cells with 0.005-0.25 mM of CuO (bulk and nanoparticles) for 6 h. For assessment of other parameters, cells were incubated with 0.01, 0.05, and 0.25 mM of CuO nanoparticles and bulk CuO for 1, 2, and 3 h. Our results demonstrate that CuO nanoparticles, in particular, caused toxic hemolytic effects in concentration-dependent manner, and this effect maybe through formation of ROS, glutathione depletion, and lipid peroxidation. In conclusion, CuO nanoparticles are shown to effectively destruct human red blood cells in comparison to bulk CuO. |
| Author | Salami, Maryam Zarei, Mohammad Hadi Pourahmad, Jalal |
| Author_xml | – sequence: 1 givenname: Jalal surname: Pourahmad fullname: Pourahmad, Jalal organization: Department of Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences – sequence: 2 givenname: Maryam surname: Salami fullname: Salami, Maryam organization: Department of Chemistry, Faculty Of Science, Qom University – sequence: 3 givenname: Mohammad Hadi surname: Zarei fullname: Zarei, Mohammad Hadi email: Zarei.MH@SKUMS.ac.ir organization: Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35378668$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. |
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| Keywords | Oxidative stress Hemolytic toxic effects CuO nanoparticles |
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| SubjectTerms | Anaemia Anemia Biochemistry Biomedical and Life Sciences Biotechnology Blood Blood cells Components Copper - toxicity Copper oxides cupric oxide Depletion Erythrocytes Glutathione Humans Life Sciences Lipid peroxidation Lipids Materials substitution Metal Nanoparticles - toxicity Nanomaterials Nanoparticles Nanoparticles - toxicity Nanotechnology Nutrition Oncology Oxidative stress Peroxidation toxicity |
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| Title | Comparative Toxic Effect of Bulk Copper Oxide (CuO) and CuO Nanoparticles on Human Red Blood Cells |
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