Synthesis, α-Glucosidase and β-Galactosidase Inhibitory Potentials and Molecular Docking of Some Novel Benzofuran-Pyridazine Derivatives
A novel series of benzofuran-pyridazine derivatives have been synthesized and characterized by different spectroscopic techniques including FT-IR, 1 H-NMR, 13 C-NMR, and ESI-MS spectrometry. All synthesized compounds were evaluated in vitro for their antidiabetic activity against α-glucosidase and β...
Saved in:
| Published in | Polycyclic aromatic compounds Vol. 43; no. 9; pp. 8482 - 8493 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Philadelphia
Taylor & Francis
21.10.2023
Taylor & Francis Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1040-6638 1563-5333 |
| DOI | 10.1080/10406638.2022.2149561 |
Cover
| Abstract | A novel series of benzofuran-pyridazine derivatives have been synthesized and characterized by different spectroscopic techniques including FT-IR,
1
H-NMR,
13
C-NMR, and ESI-MS spectrometry. All synthesized compounds were evaluated in vitro for their antidiabetic activity against α-glucosidase and β-galactosidase enzymes. All derivatives (3a-3h) and (4a-4b) showed a remarkable inhibitory potential greater than 89% against α-glucosidase enzyme compared to standard acarbose (42.50%), and compounds 3 b and 4a exhibited significant inhibitory potential against β-galactosidase enzyme with 50.33% and 57.67% respectively, compared to standard Queretin (52.00%). A molecular docking study was conducted to understand the binding interactions of the compounds with the active site of the α-glucosidase enzyme. |
|---|---|
| AbstractList | A novel series of benzofuran-pyridazine derivatives have been synthesized and characterized by different spectroscopic techniques including FT-IR, 1H-NMR, 13C-NMR, and ESI-MS spectrometry. All synthesized compounds were evaluated in vitro for their antidiabetic activity against α-glucosidase and β-galactosidase enzymes. All derivatives (3a-3h) and (4a-4b) showed a remarkable inhibitory potential greater than 89% against α-glucosidase enzyme compared to standard acarbose (42.50%), and compounds 3 b and 4a exhibited significant inhibitory potential against β-galactosidase enzyme with 50.33% and 57.67% respectively, compared to standard Queretin (52.00%). A molecular docking study was conducted to understand the binding interactions of the compounds with the active site of the α-glucosidase enzyme. A novel series of benzofuran-pyridazine derivatives have been synthesized and characterized by different spectroscopic techniques including FT-IR, 1 H-NMR, 13 C-NMR, and ESI-MS spectrometry. All synthesized compounds were evaluated in vitro for their antidiabetic activity against α-glucosidase and β-galactosidase enzymes. All derivatives (3a-3h) and (4a-4b) showed a remarkable inhibitory potential greater than 89% against α-glucosidase enzyme compared to standard acarbose (42.50%), and compounds 3 b and 4a exhibited significant inhibitory potential against β-galactosidase enzyme with 50.33% and 57.67% respectively, compared to standard Queretin (52.00%). A molecular docking study was conducted to understand the binding interactions of the compounds with the active site of the α-glucosidase enzyme. |
| Author | Albalwi, Hanan Jarbi, Ibtissam Ramli, Youssef Karrouchi, Khalid Faouzi, My El Abbes Boukharsa, Youness Anouar, El Hassane Ansar, M'hammed |
| Author_xml | – sequence: 1 givenname: Youness surname: Boukharsa fullname: Boukharsa, Youness organization: Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat – sequence: 2 givenname: Khalid orcidid: 0000-0002-8075-8051 surname: Karrouchi fullname: Karrouchi, Khalid organization: Laboratory of Analytical Chemistry and Bromatology, Team of Formulation and Quality Control of Health Products, Faculty of Medicine and Pharmacy, Mohammed V University – sequence: 3 givenname: El Hassane orcidid: 0000-0001-9240-7163 surname: Anouar fullname: Anouar, El Hassane organization: Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University – sequence: 4 givenname: Hanan surname: Albalwi fullname: Albalwi, Hanan organization: Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University – sequence: 5 givenname: Ibtissam surname: Jarbi fullname: Jarbi, Ibtissam organization: Laboratory of Pharmacology and Toxicology, Biopharmaceutical and Toxicological Analysis Research Team, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat – sequence: 6 givenname: Youssef surname: Ramli fullname: Ramli, Youssef organization: Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat – sequence: 7 givenname: My El Abbes orcidid: 0000-0003-3863-4677 surname: Faouzi fullname: Faouzi, My El Abbes organization: Laboratory of Pharmacology and Toxicology, Biopharmaceutical and Toxicological Analysis Research Team, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat – sequence: 8 givenname: M'hammed surname: Ansar fullname: Ansar, M'hammed organization: Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat |
| BookMark | eNqFkMtu1DAUhi3USvTCIyBZYksGXxInERughaFSC5UKa-vEOaEuGbu1nUHpI_A28CB9pnqYdsMCVj6yvv8_R98-2XHeISHPOVtw1rBXnJVMKdksBBNiIXjZVoo_IXu8UrKopJQ7ec5MsYGekv0YrxgTXCmxR35ezC5dYrTxJb37VSzHyfhoe4hIwfX07nexhBFMevw8cZe2s8mHmZ77hC5ZGOMf9MyPaKYRAj325rt136gf6IVfIf3k1zjSd-hu_TAFcMX5HHLbrXVIjzHYNSS7xnhIdodchs8e3gPy9cP7L0cfi9PPy5Ojt6eFkbJJhRS8MmB6wLLEsmpr2ffYYKkUE4zXdVcrWbdQI-tE3wEaxpE1nAmUvGsB5AF5se29Dv5mwpj0lZ-Cyyu1aOq6aoVsRKZebykTfIwBB21syod6lwLYUXOmN_L1o3y9ka8f5Od09Vf6OtgVhPm_uTfbnHWDDyv44cPY6wTz6MOQ1Rkbtfx3xT0O4qDi |
| CitedBy_id | crossref_primary_10_1007_s00044_024_03335_8 crossref_primary_10_1002_slct_202402996 crossref_primary_10_1002_slct_202401557 |
| Cites_doi | 10.1021/jf301156v 10.1016/j.diabres.2017.03.024 10.1007/s00044-010-9539-3 10.1016/j.ejmech.2018.01.035 10.1007/s00044-017-1930-x 10.1016/j.bmcl.2010.12.028 10.1007/s00044-015-1490-x 10.1007/s11426-010-0014-2 10.1016/j.bmcl.2020.127514 10.1007/s00894-009-0625-8 10.1016/j.molstruc.2017.09.092 10.1111/cbdd.13038 10.1007/s00044-009-9232-6 10.1016/S0005-2728(98)00034-6 10.1016/j.molstruc.2018.09.037 10.1007/s00044-013-0685-2 10.1016/j.bioorg.2017.02.003 10.1007/s00044-012-0253-1 10.1517/14656566.2015.1070827 10.1016/j.bioorg.2020.103945 10.1007/s00044-022-02916-9 10.1016/j.molstruc.2020.128541 10.1107/S139900471500721X 10.1007/s12272-010-2222-x 10.1016/j.molstruc.2022.133652 10.1002/jcc.21256 10.2522/ptj.20080020 10.1007/s00044-011-9770-6 10.1016/j.molstruc.2021.131506 10.3390/molecules22071094 10.1016/j.diabres.2019.107843 10.1007/s12257-010-0070-7 10.1016/j.pharma.2016.03.005 10.1007/s00044-013-0618-0 10.1016/j.ejmech.2014.11.039 10.1007/s11094-019-01927-y |
| ContentType | Journal Article |
| Copyright | 2022 Taylor & Francis Group, LLC 2022 2022 Taylor & Francis Group, LLC |
| Copyright_xml | – notice: 2022 Taylor & Francis Group, LLC 2022 – notice: 2022 Taylor & Francis Group, LLC |
| DBID | AAYXX CITATION 7QF 7QQ 7SC 7SE 7SP 7SR 7ST 7T5 7TA 7TB 7U5 7U7 8BQ 8FD C1K F28 FR3 H8D H8G H94 JG9 JQ2 KR7 L7M L~C L~D SOI |
| DOI | 10.1080/10406638.2022.2149561 |
| DatabaseName | CrossRef Aluminium Industry Abstracts Ceramic Abstracts Computer and Information Systems Abstracts Corrosion Abstracts Electronics & Communications Abstracts Engineered Materials Abstracts Environment Abstracts Immunology Abstracts Materials Business File Mechanical & Transportation Engineering Abstracts Solid State and Superconductivity Abstracts Toxicology Abstracts METADEX Technology Research Database Environmental Sciences and Pollution Management ANTE: Abstracts in New Technology & Engineering Engineering Research Database Aerospace Database Copper Technical Reference Library AIDS and Cancer Research Abstracts Materials Research Database ProQuest Computer Science Collection Civil Engineering Abstracts Advanced Technologies Database with Aerospace Computer and Information Systems Abstracts Academic Computer and Information Systems Abstracts Professional Environment Abstracts |
| DatabaseTitle | CrossRef Materials Research Database Technology Research Database Computer and Information Systems Abstracts – Academic Mechanical & Transportation Engineering Abstracts ProQuest Computer Science Collection Computer and Information Systems Abstracts Materials Business File Environmental Sciences and Pollution Management Aerospace Database Copper Technical Reference Library Engineered Materials Abstracts AIDS and Cancer Research Abstracts Advanced Technologies Database with Aerospace ANTE: Abstracts in New Technology & Engineering Civil Engineering Abstracts Aluminium Industry Abstracts Toxicology Abstracts Electronics & Communications Abstracts Ceramic Abstracts METADEX Computer and Information Systems Abstracts Professional Immunology Abstracts Solid State and Superconductivity Abstracts Engineering Research Database Corrosion Abstracts Environment Abstracts |
| DatabaseTitleList | Materials Research Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1563-5333 |
| EndPage | 8493 |
| ExternalDocumentID | 10_1080_10406638_2022_2149561 2149561 |
| Genre | Research Article |
| GroupedDBID | .7F .QJ 0BK 0R~ 123 29O 30N 4.4 5VS A8Z AAENE AAJMT AALDU AAMIU AAPUL AAQRR ABCCY ABDBF ABFIM ABHAV ABJNI ABLIJ ABOCM ABPAQ ABPEM ABTAI ABXUL ABXYU ACGEJ ACGFS ACGOD ACIWK ACPRK ACTIO ACUHS ADCVX ADGTB ADXPE AEISY AENEX AEOZL AEPSL AEYOC AFKVX AFRAH AGDLA AGMYJ AHDZW AIJEM AJWEG AKBVH AKOOK ALMA_UNASSIGNED_HOLDINGS ALQZU AQRUH AVBZW AWYRJ BLEHA CCCUG CE4 CS3 DGEBU DKSSO DU5 EAP EBS EMK EPL EST ESTFP ESX E~A E~B F5P GTTXZ H13 HF~ HZ~ H~P IPNFZ J.P KYCEM LJTGL M4Z NA5 NW0 O9- PQQKQ RIG RNANH ROSJB RTWRZ S-T SNACF TBQAZ TCY TDBHL TFL TFT TFW TTHFI TUROJ TUS TWF UT5 UU3 ZGOLN ~S~ AAGDL AAHIA AAYXX ADYSH AFRVT AIYEW AMPGV CITATION 7QF 7QQ 7SC 7SE 7SP 7SR 7ST 7T5 7TA 7TB 7U5 7U7 8BQ 8FD C1K F28 FR3 H8D H8G H94 JG9 JQ2 KR7 L7M L~C L~D SOI TASJS |
| ID | FETCH-LOGICAL-c338t-3215cacdae44e45973dde8e466020177b76379a7e0b2dbaec01e08102e31b9aa3 |
| ISSN | 1040-6638 |
| IngestDate | Wed Aug 13 07:27:31 EDT 2025 Thu Apr 24 22:51:24 EDT 2025 Tue Jul 01 02:16:52 EDT 2025 Wed Dec 25 09:02:51 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c338t-3215cacdae44e45973dde8e466020177b76379a7e0b2dbaec01e08102e31b9aa3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 |
| ORCID | 0000-0002-8075-8051 0000-0001-9240-7163 0000-0003-3863-4677 |
| PQID | 2877592382 |
| PQPubID | 52960 |
| PageCount | 12 |
| ParticipantIDs | proquest_journals_2877592382 crossref_primary_10_1080_10406638_2022_2149561 crossref_citationtrail_10_1080_10406638_2022_2149561 informaworld_taylorfrancis_310_1080_10406638_2022_2149561 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-10-21 |
| PublicationDateYYYYMMDD | 2023-10-21 |
| PublicationDate_xml | – month: 10 year: 2023 text: 2023-10-21 day: 21 |
| PublicationDecade | 2020 |
| PublicationPlace | Philadelphia |
| PublicationPlace_xml | – name: Philadelphia |
| PublicationTitle | Polycyclic aromatic compounds |
| PublicationYear | 2023 |
| Publisher | Taylor & Francis Taylor & Francis Ltd |
| Publisher_xml | – name: Taylor & Francis – name: Taylor & Francis Ltd |
| References | e_1_3_2_27_1 e_1_3_2_28_1 e_1_3_2_29_1 e_1_3_2_20_1 e_1_3_2_41_1 e_1_3_2_21_1 e_1_3_2_22_1 Mao Haibin. (e_1_3_2_23_1) 2014; 20 e_1_3_2_24_1 e_1_3_2_25_1 e_1_3_2_26_1 e_1_3_2_40_1 e_1_3_2_16_1 e_1_3_2_39_1 e_1_3_2_17_1 e_1_3_2_38_1 e_1_3_2_8_1 e_1_3_2_18_1 e_1_3_2_7_1 e_1_3_2_19_1 e_1_3_2_2_1 e_1_3_2_31_1 e_1_3_2_30_1 e_1_3_2_10_1 e_1_3_2_33_1 e_1_3_2_11_1 e_1_3_2_32_1 e_1_3_2_6_1 e_1_3_2_12_1 Karrouchi Khalid. (e_1_3_2_35_1) 2022 e_1_3_2_5_1 e_1_3_2_13_1 e_1_3_2_34_1 e_1_3_2_4_1 e_1_3_2_14_1 e_1_3_2_37_1 e_1_3_2_3_1 e_1_3_2_15_1 El-Hashash Maher A. (e_1_3_2_9_1) 2014; 5 Karrouchi Khalid (e_1_3_2_36_1) 2022 |
| References_xml | – ident: e_1_3_2_38_1 doi: 10.1021/jf301156v – ident: e_1_3_2_4_1 doi: 10.1016/j.diabres.2017.03.024 – ident: e_1_3_2_20_1 doi: 10.1007/s00044-010-9539-3 – ident: e_1_3_2_13_1 doi: 10.1016/j.ejmech.2018.01.035 – ident: e_1_3_2_14_1 doi: 10.1007/s00044-017-1930-x – start-page: 1 year: 2022 ident: e_1_3_2_36_1 article-title: Synthesis, Spectroscopic Characterization, DFT, Molecular Docking and Antidiabetic Activity of N-Isonicotinoyl Arylaldehyde Hydrazones publication-title: Polycyclic Aromatic Compounds – ident: e_1_3_2_17_1 doi: 10.1016/j.bmcl.2010.12.028 – ident: e_1_3_2_30_1 doi: 10.1007/s00044-015-1490-x – ident: e_1_3_2_22_1 doi: 10.1007/s11426-010-0014-2 – ident: e_1_3_2_28_1 doi: 10.1016/j.bmcl.2020.127514 – ident: e_1_3_2_10_1 doi: 10.1007/s00894-009-0625-8 – ident: e_1_3_2_29_1 doi: 10.1016/j.molstruc.2017.09.092 – ident: e_1_3_2_27_1 doi: 10.1111/cbdd.13038 – ident: e_1_3_2_18_1 doi: 10.1007/s00044-009-9232-6 – ident: e_1_3_2_21_1 doi: 10.1016/S0005-2728(98)00034-6 – volume: 5 start-page: 1000191 issue: 4 year: 2014 ident: e_1_3_2_9_1 article-title: Synthesis of Novel Series of Phthalazine Derivatives with Antibacterial and Antifungal Evaluation publication-title: J. Chem. Eng. Process Technol – start-page: 1 year: 2022 ident: e_1_3_2_35_1 article-title: Synthesis, α-Glucosidase Inhibition, Anticancer, DFT and Molecular Docking Investigations of Pyrazole Hydrazone Derivatives publication-title: Polycyclic Aromatic Compounds – ident: e_1_3_2_5_1 doi: 10.1016/j.molstruc.2018.09.037 – ident: e_1_3_2_8_1 doi: 10.1007/s00044-013-0685-2 – ident: e_1_3_2_24_1 doi: 10.1016/j.bioorg.2017.02.003 – volume: 20 start-page: 2454 issue: 9 year: 2014 ident: e_1_3_2_23_1 article-title: Organocatalytic One‐Pot Synthesis of Highly Substituted Pyridazines from Morita–Baylis–Hillman Carbonates and Diazo Compounds publication-title: Chemistry (Weinheim an Der Bergstrasse, Germany) – ident: e_1_3_2_12_1 doi: 10.1007/s00044-012-0253-1 – ident: e_1_3_2_7_1 doi: 10.1517/14656566.2015.1070827 – ident: e_1_3_2_26_1 doi: 10.1016/j.bioorg.2020.103945 – ident: e_1_3_2_34_1 doi: 10.1007/s00044-022-02916-9 – ident: e_1_3_2_32_1 doi: 10.1016/j.molstruc.2020.128541 – ident: e_1_3_2_40_1 doi: 10.1107/S139900471500721X – ident: e_1_3_2_16_1 doi: 10.1007/s12272-010-2222-x – ident: e_1_3_2_33_1 doi: 10.1016/j.molstruc.2022.133652 – ident: e_1_3_2_39_1 doi: 10.1002/jcc.21256 – ident: e_1_3_2_2_1 doi: 10.2522/ptj.20080020 – ident: e_1_3_2_19_1 doi: 10.1007/s00044-011-9770-6 – ident: e_1_3_2_37_1 doi: 10.1016/j.molstruc.2021.131506 – ident: e_1_3_2_41_1 doi: 10.3390/molecules22071094 – ident: e_1_3_2_3_1 doi: 10.1016/j.diabres.2019.107843 – ident: e_1_3_2_6_1 doi: 10.1007/s12257-010-0070-7 – ident: e_1_3_2_31_1 doi: 10.1016/j.pharma.2016.03.005 – ident: e_1_3_2_15_1 doi: 10.1007/s00044-013-0618-0 – ident: e_1_3_2_25_1 doi: 10.1016/j.ejmech.2014.11.039 – ident: e_1_3_2_11_1 doi: 10.1007/s11094-019-01927-y |
| SSID | ssj0021662 |
| Score | 2.34138 |
| Snippet | A novel series of benzofuran-pyridazine derivatives have been synthesized and characterized by different spectroscopic techniques including FT-IR,
1
H-NMR,
13... A novel series of benzofuran-pyridazine derivatives have been synthesized and characterized by different spectroscopic techniques including FT-IR, 1H-NMR,... |
| SourceID | proquest crossref informaworld |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 8482 |
| SubjectTerms | Acarbose Benzofuran Diabetes mellitus Galactosidase Glucosidase Molecular docking NMR Nuclear magnetic resonance pyridazin-3(2H)-one pyridazin-3(2H)-thione Pyridazines Spectrometry Synthesis α-Glucosidase β-Galactosidase |
| Title | Synthesis, α-Glucosidase and β-Galactosidase Inhibitory Potentials and Molecular Docking of Some Novel Benzofuran-Pyridazine Derivatives |
| URI | https://www.tandfonline.com/doi/abs/10.1080/10406638.2022.2149561 https://www.proquest.com/docview/2877592382 |
| Volume | 43 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JbtswECXc9NBeiq5omrTgoTm5crXQonRMDDduD4aBOEBuAknRsBFVKhw5gfMJ_Zv2Q9Jf6nDRYthAulwEgxJJwfM0C_k4g9D7gM5izjzmUC5ch3AawyclqUP7nKZhnxLQy4ptMQ5H5-TLRf-i0_nVYi2tSt4TtzvPlfyLVKEN5KpOyf6FZOtBoQF-g3zhChKG6x_J-Gydg_92ZdIEHA2GRyeec6o56IsUrJPeGNDNvnPKMlVZx974nM8XfKH31ydFqQhDKouy5lxU5XLBtRaXlhJ9VnyV3XFxLbPuicxvi9kKLJwzWS9hNJWdGrTWUldJu7aMROvtTopsLdZC5dFmy8Ikh1UcdlXKqVmeL1aXcwivtRerlE_FCVFmQKWIVOVatD6aQ8yQttYtVoYcPsy6IwgBWEMQOM44y25MPW6WW_zbpQ1fk-T8ZmljulVlpKWoFRMSvCWju6VV3mHggPsatLW7SQJlURy3VHVETNWjyuwTU6lxy6QYDqaaT03Xg_f0e76OK73GhtbMRnvnAXroU3henSlyx_UKgBeGZvvdvnx1pCxyP-6cYMNZ2kilu-U6aH9o-hQ9sYEMPjaofIY6Mn-OHg2q-oEv0PcanR_w3Y82LjEADd_93MQkbjCJG0zqR2tMYotJXMywwiTWmMQ7MYlbmHyJzj8Np4ORYyt_OCIIotIJwBEVTKRMEiIJxLwBWOFIkjCE6MajlINVpDGj0uV-ypkUrifBt3V9GXg8Zix4hfbyIpevEZaEyQjidCbiGQkJ5a7oC8KYOr0XuTzdR6T6ixNh0-Kr6ixZ4tnsuZVkEiWZxEpmH_Xqbt9MXpj7OsRt-SWlBvfM4DoJ7ul7WAk7sernKvEjSvsQnkX-m_8Y-gA9br68Q7RXLlfyLbjZJX-nofsbgZPQuw |
| linkProvider | Taylor & Francis |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LbtswECUKZ-FumvSH5tdy0WVp6EOJ1jJNEzttbARIAnhHkBSFCnWlIpYDJEfobdqD5EydoSTDbhB44ZUASUNJ1HDmDfk4Q8jHUGSJVr5iQhuPcS0SGFJWMBFpkcaR4GCXkW0xjofX_OskmizthUFaJcbQWZ0owtlqHNw4Gd1S4uDI0VMiMysIeoED-RABbUUAx5HWF3rjRdDlx3G94ok0d5Bpd_E81cyKf1rJXvrIWjsXdLpNTPvyNfPkR29e6Z65_y-v42Zft0NeNAiVHtUq9ZI8s8Ur0j1uC8O9Jr8v7wqAjbN89ok-_GEDR3rPU3CHFB5KH_6ygZpiGZ_m5FnxPdc5LubTi7JCdhKovLt11NbmpeDrcM6elhm9LH9aOi5v7ZR-tsV9mc3BnbKLuxtoDVNh0y8waG5dvvLZG3J9enJ1PGRNSQdmIBauWAgIwyiTKsu55RDMhGBe-5bHMcBWXwgN5k4kSlhPB6lW1ni-BdDiBTb0daJU-JZ0irKw7wi1XNk-BGDKJBmPudCeiQxXCrdl9T2d7hLe_khpmnznWHZjKv0mLWrb0RI7WjYdvUt6C7FfdcKPdQLJspbIys20ZHVZFBmukT1oVUo2tmMmIYYVEeDufrC3QdMfSHd4NTqX52fjb_vkOVxyHMTAPyCd6mZuDwFLVfq9Gyz_ADz9ErU |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bT9swFLYmJg1eBuOildv8wCOucnHi5hFaWtigqgRIvFm244hqXVI1KRL9Cfs37Ifwm3bsxGgwIR54ipTkOIlzfC725-8gdBCyLJHCF4RJ5REqWQJDSjPCIsnSOGIU7LJBWwzj02v6_SZyaMKygVWaHDqriSKsrTaDe5pmDhEHR2ocpQFmBUE7sDE-JEAfYy9MDH1-6A2fci4_jusFT4NyBxm3iee1Zp65p2fkpf8Za-uB-qtIunevgSc_2_NKttXiBa3juz5uDX1u4lN8VCvUF_RB5-touevKwm2g35f3OQSN5bg8xI8PZGAh7-MUnCGGZ-LHP2QgJqaIT3PyLL8dy7FZysejojLYJFB4e-uFq8yLwdOZGXtcZPiy-KXxsLjTE3ys80WRzcGZktH9DFozRNi4B0PmzrKVl5voun9y1T0lTUEHoiATrkgI8YUSKhWaUk0hlQnBuHY0jWMIWn3GJBg7lgimPRmkUmjl-RpCFi_QoS8TIcIttJQXuf6KsKZCdyD9EirJaEyZ9FSkqBBmU1bHk2kLUfcfuWrYzk3RjQn3G1JU19HcdDRvOrqF2k9i05ru4y2B5F8l4ZWdZ8nqoig8fEN212kUbyxHySGDZRFE3Z1g-x1Nf0OfRr0-Pz8b_thBK3DFAhADfxctVbO53oNAqpL7dqj8BeXREWI |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis%2C+%CE%B1-Glucosidase+and+%CE%B2-Galactosidase+Inhibitory+Potentials+and+Molecular+Docking+of+Some+Novel+Benzofuran-Pyridazine+Derivatives&rft.jtitle=Polycyclic+aromatic+compounds&rft.au=Boukharsa%2C+Youness&rft.au=Karrouchi%2C+Khalid&rft.au=Anouar%2C+El+Hassane&rft.au=Albalwi%2C+Hanan&rft.date=2023-10-21&rft.pub=Taylor+%26+Francis&rft.issn=1040-6638&rft.eissn=1563-5333&rft.volume=43&rft.issue=9&rft.spage=8482&rft.epage=8493&rft_id=info:doi/10.1080%2F10406638.2022.2149561&rft.externalDocID=2149561 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1040-6638&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1040-6638&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1040-6638&client=summon |