Microstructural Integrity of Peripheral Nerves in Charcot–Marie–Tooth Disease: An MRI Evaluation Study

Background Charcot–Marie–Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional scales in CMT, objective disease biomarkers that can facilitate in monitoring disease progression are limited. Purpose To investig...

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Published inJournal of magnetic resonance imaging Vol. 53; no. 2; pp. 437 - 444
Main Authors Cheah, Peng Loon, Krisnan, Thiagu, Wong, Jeannie Hsiu Ding, Rozalli, Faizatul Izza, Fadzli, Farhana, Rahmat, Kartini, Shahrizaila, Nortina, Tan, Li Kuo, Nawawi, Ouzreiah, Ramli, Norlisah
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.02.2021
Wiley Subscription Services, Inc
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Online AccessGet full text
ISSN1053-1807
1522-2586
1522-2586
DOI10.1002/jmri.27354

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Abstract Background Charcot–Marie–Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional scales in CMT, objective disease biomarkers that can facilitate in monitoring disease progression are limited. Purpose To investigate the utility of diffusion tensor imaging (DTI) in determining the microstructural integrity of sciatic and peroneal nerves and its correlation with the MRI grading of muscle atrophy severity and clinical function in CMT as determined by the CMT neuropathy score (CMTNS). Study Type Prospective case–control. Subjects Nine CMT patients and nine age‐matched controls. Field Strength/Sequence 3 T T1‐weighted in‐/out‐of phase spoiled gradient recalled echo (SPGR) and DTI sequences. Assessment Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values for sciatic and peroneal nerves were obtained from DTI. Muscle atrophy was graded according to the Goutallier classification using in‐/out‐of phase SPGRs. DTI parameters and muscle atrophy grades were compared between CMT and controls, and the relationship between DTI parameters, muscle atrophy grades, and CMTNS were assessed. Statistical Tests The Wilcoxon Signed Ranks test was used to compare DTI parameters between CMT and controls. The relationship between DTI parameters, muscle atrophy grades, and CMTNS were analyzed using the Spearman correlation. Receiver operating characteristic (ROC) analyses of DTI parameters that can differentiate CMT from healthy controls were done. Results There was a significant reduction in FA and increase in RD of both nerves (P < 0.05) in CMT, with significant correlations between FA (negative; P < 0.05) and RD (positive; P < 0.05) with muscle atrophy grade. In the sciatic nerve, there was significant correlation between FA and CMTNS (r = –0.795; P < 0.05). FA and RD could discriminate CMT from controls with high sensitivity (77.8–100%) and specificity (88.9–100%). Data Conclusion There were significant differences of DTI parameters between CMT and controls, with significant correlations between DTI parameters, muscle atrophy grade, and CMTNS. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:437–444.
AbstractList Charcot-Marie-Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional scales in CMT, objective disease biomarkers that can facilitate in monitoring disease progression are limited. To investigate the utility of diffusion tensor imaging (DTI) in determining the microstructural integrity of sciatic and peroneal nerves and its correlation with the MRI grading of muscle atrophy severity and clinical function in CMT as determined by the CMT neuropathy score (CMTNS). Prospective case-control. Nine CMT patients and nine age-matched controls. 3 T T -weighted in-/out-of phase spoiled gradient recalled echo (SPGR) and DTI sequences. Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values for sciatic and peroneal nerves were obtained from DTI. Muscle atrophy was graded according to the Goutallier classification using in-/out-of phase SPGRs. DTI parameters and muscle atrophy grades were compared between CMT and controls, and the relationship between DTI parameters, muscle atrophy grades, and CMTNS were assessed. The Wilcoxon Signed Ranks test was used to compare DTI parameters between CMT and controls. The relationship between DTI parameters, muscle atrophy grades, and CMTNS were analyzed using the Spearman correlation. Receiver operating characteristic (ROC) analyses of DTI parameters that can differentiate CMT from healthy controls were done. There was a significant reduction in FA and increase in RD of both nerves (P < 0.05) in CMT, with significant correlations between FA (negative; P < 0.05) and RD (positive; P < 0.05) with muscle atrophy grade. In the sciatic nerve, there was significant correlation between FA and CMTNS (r = -0.795; P < 0.05). FA and RD could discriminate CMT from controls with high sensitivity (77.8-100%) and specificity (88.9-100%). There were significant differences of DTI parameters between CMT and controls, with significant correlations between DTI parameters, muscle atrophy grade, and CMTNS. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:437-444.
BackgroundCharcot–Marie–Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional scales in CMT, objective disease biomarkers that can facilitate in monitoring disease progression are limited.PurposeTo investigate the utility of diffusion tensor imaging (DTI) in determining the microstructural integrity of sciatic and peroneal nerves and its correlation with the MRI grading of muscle atrophy severity and clinical function in CMT as determined by the CMT neuropathy score (CMTNS).Study TypeProspective case–control.SubjectsNine CMT patients and nine age‐matched controls.Field Strength/Sequence3 T T1‐weighted in‐/out‐of phase spoiled gradient recalled echo (SPGR) and DTI sequences.AssessmentFractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values for sciatic and peroneal nerves were obtained from DTI. Muscle atrophy was graded according to the Goutallier classification using in‐/out‐of phase SPGRs. DTI parameters and muscle atrophy grades were compared between CMT and controls, and the relationship between DTI parameters, muscle atrophy grades, and CMTNS were assessed.Statistical TestsThe Wilcoxon Signed Ranks test was used to compare DTI parameters between CMT and controls. The relationship between DTI parameters, muscle atrophy grades, and CMTNS were analyzed using the Spearman correlation. Receiver operating characteristic (ROC) analyses of DTI parameters that can differentiate CMT from healthy controls were done.ResultsThere was a significant reduction in FA and increase in RD of both nerves (P < 0.05) in CMT, with significant correlations between FA (negative; P < 0.05) and RD (positive; P < 0.05) with muscle atrophy grade. In the sciatic nerve, there was significant correlation between FA and CMTNS (r = –0.795; P < 0.05). FA and RD could discriminate CMT from controls with high sensitivity (77.8–100%) and specificity (88.9–100%).Data ConclusionThere were significant differences of DTI parameters between CMT and controls, with significant correlations between DTI parameters, muscle atrophy grade, and CMTNS.Level of Evidence 2Technical Efficacy Stage 2J. MAGN. RESON. IMAGING 2021;53:437–444.
Charcot-Marie-Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional scales in CMT, objective disease biomarkers that can facilitate in monitoring disease progression are limited.BACKGROUNDCharcot-Marie-Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional scales in CMT, objective disease biomarkers that can facilitate in monitoring disease progression are limited.To investigate the utility of diffusion tensor imaging (DTI) in determining the microstructural integrity of sciatic and peroneal nerves and its correlation with the MRI grading of muscle atrophy severity and clinical function in CMT as determined by the CMT neuropathy score (CMTNS).PURPOSETo investigate the utility of diffusion tensor imaging (DTI) in determining the microstructural integrity of sciatic and peroneal nerves and its correlation with the MRI grading of muscle atrophy severity and clinical function in CMT as determined by the CMT neuropathy score (CMTNS).Prospective case-control.STUDY TYPEProspective case-control.Nine CMT patients and nine age-matched controls.SUBJECTSNine CMT patients and nine age-matched controls.3 T T1 -weighted in-/out-of phase spoiled gradient recalled echo (SPGR) and DTI sequences.FIELD STRENGTH/SEQUENCE3 T T1 -weighted in-/out-of phase spoiled gradient recalled echo (SPGR) and DTI sequences.Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values for sciatic and peroneal nerves were obtained from DTI. Muscle atrophy was graded according to the Goutallier classification using in-/out-of phase SPGRs. DTI parameters and muscle atrophy grades were compared between CMT and controls, and the relationship between DTI parameters, muscle atrophy grades, and CMTNS were assessed.ASSESSMENTFractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values for sciatic and peroneal nerves were obtained from DTI. Muscle atrophy was graded according to the Goutallier classification using in-/out-of phase SPGRs. DTI parameters and muscle atrophy grades were compared between CMT and controls, and the relationship between DTI parameters, muscle atrophy grades, and CMTNS were assessed.The Wilcoxon Signed Ranks test was used to compare DTI parameters between CMT and controls. The relationship between DTI parameters, muscle atrophy grades, and CMTNS were analyzed using the Spearman correlation. Receiver operating characteristic (ROC) analyses of DTI parameters that can differentiate CMT from healthy controls were done.STATISTICAL TESTSThe Wilcoxon Signed Ranks test was used to compare DTI parameters between CMT and controls. The relationship between DTI parameters, muscle atrophy grades, and CMTNS were analyzed using the Spearman correlation. Receiver operating characteristic (ROC) analyses of DTI parameters that can differentiate CMT from healthy controls were done.There was a significant reduction in FA and increase in RD of both nerves (P < 0.05) in CMT, with significant correlations between FA (negative; P < 0.05) and RD (positive; P < 0.05) with muscle atrophy grade. In the sciatic nerve, there was significant correlation between FA and CMTNS (r = -0.795; P < 0.05). FA and RD could discriminate CMT from controls with high sensitivity (77.8-100%) and specificity (88.9-100%).RESULTSThere was a significant reduction in FA and increase in RD of both nerves (P < 0.05) in CMT, with significant correlations between FA (negative; P < 0.05) and RD (positive; P < 0.05) with muscle atrophy grade. In the sciatic nerve, there was significant correlation between FA and CMTNS (r = -0.795; P < 0.05). FA and RD could discriminate CMT from controls with high sensitivity (77.8-100%) and specificity (88.9-100%).There were significant differences of DTI parameters between CMT and controls, with significant correlations between DTI parameters, muscle atrophy grade, and CMTNS. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:437-444.DATA CONCLUSIONThere were significant differences of DTI parameters between CMT and controls, with significant correlations between DTI parameters, muscle atrophy grade, and CMTNS. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:437-444.
Background Charcot–Marie–Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional scales in CMT, objective disease biomarkers that can facilitate in monitoring disease progression are limited. Purpose To investigate the utility of diffusion tensor imaging (DTI) in determining the microstructural integrity of sciatic and peroneal nerves and its correlation with the MRI grading of muscle atrophy severity and clinical function in CMT as determined by the CMT neuropathy score (CMTNS). Study Type Prospective case–control. Subjects Nine CMT patients and nine age‐matched controls. Field Strength/Sequence 3 T T1‐weighted in‐/out‐of phase spoiled gradient recalled echo (SPGR) and DTI sequences. Assessment Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values for sciatic and peroneal nerves were obtained from DTI. Muscle atrophy was graded according to the Goutallier classification using in‐/out‐of phase SPGRs. DTI parameters and muscle atrophy grades were compared between CMT and controls, and the relationship between DTI parameters, muscle atrophy grades, and CMTNS were assessed. Statistical Tests The Wilcoxon Signed Ranks test was used to compare DTI parameters between CMT and controls. The relationship between DTI parameters, muscle atrophy grades, and CMTNS were analyzed using the Spearman correlation. Receiver operating characteristic (ROC) analyses of DTI parameters that can differentiate CMT from healthy controls were done. Results There was a significant reduction in FA and increase in RD of both nerves (P < 0.05) in CMT, with significant correlations between FA (negative; P < 0.05) and RD (positive; P < 0.05) with muscle atrophy grade. In the sciatic nerve, there was significant correlation between FA and CMTNS (r = –0.795; P < 0.05). FA and RD could discriminate CMT from controls with high sensitivity (77.8–100%) and specificity (88.9–100%). Data Conclusion There were significant differences of DTI parameters between CMT and controls, with significant correlations between DTI parameters, muscle atrophy grade, and CMTNS. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:437–444.
Author Nawawi, Ouzreiah
Shahrizaila, Nortina
Fadzli, Farhana
Cheah, Peng Loon
Rozalli, Faizatul Izza
Ramli, Norlisah
Krisnan, Thiagu
Rahmat, Kartini
Wong, Jeannie Hsiu Ding
Tan, Li Kuo
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Cites_doi 10.1002/acn3.502
10.1111/j.1529-8027.2011.00350.x
10.1111/j.1529-8027.2011.00324.x
10.1007/s00330-018-5958-1
10.1177/1938640008326247
10.1007/s00256-011-1199-y
10.1002/mus.23855
10.1007/s00234-016-1692-z
10.1212/WNL.0000000000000919
10.1093/brain/awh693
10.1002/jmri.25056
10.1111/ene.12783
10.1136/jnnp.2005.069138
10.1212/WNL.0000000000002292
10.1016/j.nec.2010.12.004
10.1016/j.clinph.2016.11.010
10.1002/mus.23322
10.1016/j.mri.2012.05.001
10.1016/j.jelekin.2008.09.004
10.1002/jmri.25415
10.1038/ejhg.2009.31
10.3233/JND-170243
10.1016/S1474-4422(15)00242-2
10.1097/00003086-199407000-00014
10.1002/mus.25691
10.1371/journal.pone.0189876
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Keywords diffusion tensor imaging
Charcot-Marie-Tooth disease
peripheral nervous system diseases
peroneal nerve
sciatic nerve
Language English
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References 2013; 48
2017; 4
2017; 45
2008; 1
2011; 16
2014; 83
2016; 15
2016; 58
2012; 30
2010; 20
1994; 304
2018; 5
2015; 22
2017; 56
2017; 12
2016; 43
2016; 86
2011; 41
2011; 22
2005; 76
2019; 29
2012; 46
2006; 129
2017; 128
2009; 17
e_1_2_7_6_1
e_1_2_7_5_1
e_1_2_7_4_1
e_1_2_7_3_1
e_1_2_7_8_1
e_1_2_7_7_1
e_1_2_7_18_1
e_1_2_7_17_1
Goutallier D (e_1_2_7_19_1) 1994; 304
e_1_2_7_2_1
e_1_2_7_15_1
e_1_2_7_13_1
e_1_2_7_12_1
Mallik A (e_1_2_7_9_1) 2005; 76
e_1_2_7_11_1
e_1_2_7_10_1
e_1_2_7_26_1
Melick N (e_1_2_7_21_1) 2017; 12
e_1_2_7_27_1
Vaeggemose M (e_1_2_7_14_1) 2017; 56
e_1_2_7_25_1
e_1_2_7_24_1
e_1_2_7_23_1
e_1_2_7_22_1
e_1_2_7_20_1
Gaeta M (e_1_2_7_16_1) 2011; 41
References_xml – volume: 29
  start-page: 3241
  year: 2019
  end-page: 3252
  article-title: Diffusion tensor imaging of the sciatic nerve in Charcot‐Marie‐Tooth disease type I patients: A prospective case‐control study
  publication-title: Eur Radiol
– volume: 1
  start-page: 350
  issue: 6
  year: 2008
  end-page: 354
  article-title: Charcot‐Marie‐Tooth disease
  publication-title: Foot Ankle Spec
– volume: 58
  start-page: 745
  issue: 8
  year: 2016
  end-page: 752
  article-title: Diffusion tensor imaging can be used to detect lesions in peripheral nerves in patients with chronic inflammatory demyelinating polyneuropathy treated with subcutaneous immunoglobulin
  publication-title: Neuroradiology
– volume: 4
  start-page: 209
  issue: 3
  year: 2017
  end-page: 215
  article-title: Nerve conduction studies as a measure of disease progression: Objectivity or illusion?
  publication-title: J Neuromuscul Dis
– volume: 22
  start-page: 1556
  year: 2015
  end-page: 1563
  article-title: Responsiveness of clinical outcome measures in Charcot‐Marie‐Tooth disease
  publication-title: Eur J Neurol
– volume: 48
  start-page: 889
  issue: 6
  year: 2013
  end-page: 896
  article-title: Peripheral neuropathy: Assessment of proximal nerve integrity by diffusion tensor imaging
  publication-title: Muscle Nerve
– volume: 304
  start-page: 78
  year: 1994
  end-page: 83
  article-title: Fatty muscle degeneration in cuff ruptures
  publication-title: Clin Orthop Relat Res
– volume: 30
  start-page: 1323
  issue: 9
  year: 2012
  end-page: 1341
  article-title: 3D slicer as an image computing platform for the quantitative imaging network
  publication-title: Magn Reson Imaging
– volume: 56
  start-page: E78
  issue: 7
  year: 2017
  end-page: E84
  article-title: Magnetic resonance neurography and diffusion tensor imaging of the peripheral nerves in patients with Charcot‐Marie‐Tooth type 1A
  publication-title: Muscle Nerve
– volume: 16
  start-page: 1
  issue: 1
  year: 2011
  end-page: 14
  article-title: Charcot‐Marie‐Tooth disease
  publication-title: J Peripher Nerv Syst
– volume: 45
  start-page: 1125
  issue: 4
  year: 2017
  end-page: 1134
  article-title: Diffusion tensor imaging MR neurography for the detection of polyneuropathy in type 1 diabetes
  publication-title: J Magn Reson Imaging
– volume: 46
  start-page: 566
  issue: 4
  year: 2012
  end-page: 576
  article-title: Reliability of neuromuscular measurements during explosive isometric contractions, with special reference to electromyography normalization techniques
  publication-title: Muscle Nerve
– volume: 76
  start-page: ii23
  issue: Suppl II
  year: 2005
  end-page: ii31
  article-title: Nerve conduction studies: Essentials and pitfalls in practice
  publication-title: J Neurol Neurosurg Psychiatry
– volume: 5
  start-page: 19
  issue: 1
  year: 2018
  end-page: 28
  article-title: MRI biomarkers of proximal nerve injury in CIDP
  publication-title: Ann Clin Trans Neurol
– volume: 17
  start-page: 703
  issue: 6
  year: 2009
  end-page: 710
  article-title: Charcot‐Marie‐Tooth disease
  publication-title: Eur J Hum Genet
– volume: 22
  start-page: 185
  issue: 2
  year: 2011
  end-page: viii
  article-title: An introduction to diffusion tensor image analysis
  publication-title: Neurosurg Clin N Am
– volume: 20
  start-page: 81
  issue: 1
  year: 2010
  end-page: 88
  article-title: An assessment of the reliability and standardisation of tests used to elicit reference muscular actions for electromyographical normalisation
  publication-title: J Electromyogr Kinesiol
– volume: 83
  start-page: 1545
  year: 2014
  end-page: 1553
  article-title: Proximal nerve magnetization transfer MRI relates to disability in Charcot‐Marie‐Tooth diseases
  publication-title: Neurology
– volume: 15
  start-page: 65
  year: 2016
  end-page: 77
  article-title: MRI biomarker assessment of neuromuscular disease progression: A prospective observational cohort study
  publication-title: Lancet Neurol
– volume: 12
  issue: 12
  year: 2017
  article-title: How to determine leg dominance: The agreement between self‐reported and observed performance in healthy adults
  publication-title: PLOS One
– volume: 16
  start-page: 191
  year: 2011
  end-page: 198
  article-title: Reliability of the CMT neuropathy score (second version) in Charcot‐Marie‐Tooth disease
  publication-title: J Peripher Nerv Syst
– volume: 86
  start-page: 218
  issue: 3
  year: 2016
  end-page: 223
  article-title: Critically re‐evaluating a common technique: Accuracy, reliability, and confirmation bias of EMG
  publication-title: Neurology
– volume: 128
  start-page: 227
  year: 2017
  end-page: 232
  article-title: Quantitative muscle ultrasound as a biomarker in Charcot‐Marie‐Tooth neuropathy
  publication-title: Clin Neurophysiol
– volume: 43
  start-page: 962
  issue: 4
  year: 2016
  end-page: 969
  article-title: Peripheral nerve diffusion tensor imaging is reliable and reproducible
  publication-title: J Magn Reson Imaging
– volume: 41
  start-page: 515
  year: 2011
  end-page: 524
  article-title: MRI findings, patterns of disease distribution, and muscle fat fraction calculation in five patients with Charcot‐Marie‐Tooth type 2 F disease
  publication-title: Skeletal Radiol
– volume: 129
  start-page: 426
  year: 2006
  end-page: 437
  article-title: Charcot‐Marie‐Tooth disease type 1A duplication: Spectrum of clinical and magnetic resonance imaging features in leg and foot muscles
  publication-title: Brain
– ident: e_1_2_7_12_1
  doi: 10.1002/acn3.502
– ident: e_1_2_7_20_1
  doi: 10.1111/j.1529-8027.2011.00350.x
– ident: e_1_2_7_2_1
  doi: 10.1111/j.1529-8027.2011.00324.x
– ident: e_1_2_7_15_1
  doi: 10.1007/s00330-018-5958-1
– ident: e_1_2_7_3_1
  doi: 10.1177/1938640008326247
– volume: 41
  start-page: 515
  year: 2011
  ident: e_1_2_7_16_1
  article-title: MRI findings, patterns of disease distribution, and muscle fat fraction calculation in five patients with Charcot‐Marie‐Tooth type 2 F disease
  publication-title: Skeletal Radiol
  doi: 10.1007/s00256-011-1199-y
– ident: e_1_2_7_13_1
  doi: 10.1002/mus.23855
– ident: e_1_2_7_11_1
  doi: 10.1007/s00234-016-1692-z
– ident: e_1_2_7_17_1
  doi: 10.1212/WNL.0000000000000919
– ident: e_1_2_7_26_1
  doi: 10.1093/brain/awh693
– ident: e_1_2_7_27_1
  doi: 10.1002/jmri.25056
– ident: e_1_2_7_25_1
  doi: 10.1111/ene.12783
– volume: 76
  start-page: ii23
  year: 2005
  ident: e_1_2_7_9_1
  article-title: Nerve conduction studies: Essentials and pitfalls in practice
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.2005.069138
– ident: e_1_2_7_7_1
  doi: 10.1212/WNL.0000000000002292
– ident: e_1_2_7_23_1
  doi: 10.1016/j.nec.2010.12.004
– ident: e_1_2_7_24_1
  doi: 10.1016/j.clinph.2016.11.010
– ident: e_1_2_7_6_1
  doi: 10.1002/mus.23322
– ident: e_1_2_7_22_1
  doi: 10.1016/j.mri.2012.05.001
– ident: e_1_2_7_5_1
  doi: 10.1016/j.jelekin.2008.09.004
– ident: e_1_2_7_10_1
  doi: 10.1002/jmri.25415
– ident: e_1_2_7_4_1
  doi: 10.1038/ejhg.2009.31
– ident: e_1_2_7_8_1
  doi: 10.3233/JND-170243
– ident: e_1_2_7_18_1
  doi: 10.1016/S1474-4422(15)00242-2
– volume: 304
  start-page: 78
  year: 1994
  ident: e_1_2_7_19_1
  article-title: Fatty muscle degeneration in cuff ruptures
  publication-title: Clin Orthop Relat Res
  doi: 10.1097/00003086-199407000-00014
– volume: 56
  start-page: E78
  issue: 7
  year: 2017
  ident: e_1_2_7_14_1
  article-title: Magnetic resonance neurography and diffusion tensor imaging of the peripheral nerves in patients with Charcot‐Marie‐Tooth type 1A
  publication-title: Muscle Nerve
  doi: 10.1002/mus.25691
– volume: 12
  start-page: e0189876
  issue: 12
  year: 2017
  ident: e_1_2_7_21_1
  article-title: How to determine leg dominance: The agreement between self‐reported and observed performance in healthy adults
  publication-title: PLOS One
  doi: 10.1371/journal.pone.0189876
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Snippet Background Charcot–Marie–Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical...
Charcot-Marie-Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical functional...
BackgroundCharcot–Marie–Tooth (CMT) disease is diagnosed through clinical findings and genetic testing. While there are neurophysiological tools and clinical...
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SubjectTerms Anisotropy
Atrophy
Biomarkers
Charcot-Marie-Tooth disease
Charcot-Marie-Tooth Disease - diagnostic imaging
Correlation analysis
Diffusion Tensor Imaging
Diffusivity
Field strength
Genetic screening
Humans
Integrity
Magnetic Resonance Imaging
Medical imaging
Muscles
Parameters
Peripheral nerves
Peripheral Nerves - diagnostic imaging
peripheral nervous system diseases
Peripheral neuropathy
peroneal nerve
Prospective Studies
Sciatic nerve
Statistical analysis
Statistical tests
Tensors
Title Microstructural Integrity of Peripheral Nerves in Charcot–Marie–Tooth Disease: An MRI Evaluation Study
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmri.27354
https://www.ncbi.nlm.nih.gov/pubmed/32918328
https://www.proquest.com/docview/2476853671
https://www.proquest.com/docview/2442226231
Volume 53
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