Can personalized use of NSAIDs be a reality in the clinic?

The use of NSAIDs in rheumatology could be improved by an appropriate risk scoring system that accounts for adverse events such as bleeding and thrombosis. Such a risk score has now been developed using data from the PRECISION trial, but is this score ready to be applied in clinical practice?

Saved in:
Bibliographic Details
Published inNature reviews. Rheumatology Vol. 15; no. 7; pp. 387 - 388
Main Author Nurmohamed, Michael T
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.07.2019
Subjects
Anti-Inflammatory Agents, Non-Steroidal
Drug Users
Humans
Nonsteroidal anti-inflammatory drugs
Thrombosis
Online AccessGet full text
ISSN1759-4790
1759-4804
DOI10.1038/s41584-019-0225-7

Cover

Abstract The use of NSAIDs in rheumatology could be improved by an appropriate risk scoring system that accounts for adverse events such as bleeding and thrombosis. Such a risk score has now been developed using data from the PRECISION trial, but is this score ready to be applied in clinical practice?
AbstractList The use of NSAIDs in rheumatology could be improved by an appropriate risk scoring system that accounts for adverse events such as bleeding and thrombosis. Such a risk score has now been developed using data from the PRECISION trial, but is this score ready to be applied in clinical practice?
Author Nurmohamed, Michael T
Author_xml – sequence: 1
  givenname: Michael T
  surname: Nurmohamed
  fullname: Nurmohamed, Michael T
  email: mt.nurmohamed@amsterdamumc.nl
  organization: Amsterdam Rheumatology & Immunology Centre: Amsterdam UMC-Vrije Universiteit Amsterdam & Reade Rheumatology, Amsterdam, Netherlands. mt.nurmohamed@amsterdamumc.nl
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31040441$$D View this record in MEDLINE/PubMed
BookMark eNo1j8tLw0AYxBep2If-AV5kwfPqPr7sw4uU-CoUPajnsJt8iyltUrPNof71DdieZmB-DDNTMmraBgm5FvxOcGXvE4jMAuPCMS5lxswZmQiTOQaWw-jkjeNjMk1pxbkGbd0FGSvBgQOICXnIfUO32KW28ev6DyvaJ6RtpO-f88VTogGppx0O2W5P64bufpCW67qpy8dLch79OuHVUWfk--X5K39jy4_XRT5fslIpY5gWRmP0XAbUunI2DGp9xIxHJUvhNGDmFVRVqGKQ3vNorA4SnHJag0c1I7f_vduu_e0x7YpV23fD3FRICdoJrW02UDdHqg8brIptV298ty9OV9UBjV9VfQ
ContentType Journal Article
Copyright Springer Nature Limited 2019.
Copyright_xml – notice: Springer Nature Limited 2019.
DBID CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
DOI 10.1038/s41584-019-0225-7
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection (subscription)
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni)
PML(ProQuest Medical Library)
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
DatabaseTitleList ProQuest Central Student
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1759-4804
EndPage 388
ExternalDocumentID 31040441
Genre Comment
Journal Article
GroupedDBID ---
.XZ
0R~
29M
39C
3V.
53G
70F
7X7
88E
8FE
8FH
8FI
8FJ
AAEEF
AARCD
AAWTL
AAWYQ
AAYZH
AAZLF
ABAWZ
ABJNI
ABLJU
ABUWG
ACGFS
ADBBV
AENEX
AFFVI
AFKRA
AFSHS
AGAYW
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
ALFFA
ALMA_UNASSIGNED_HOLDINGS
ARMCB
AXYYD
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CCPQU
CGR
CUY
CVF
DB5
EBS
ECM
EE.
EIF
EJD
EXGXG
F5P
FQGFK
FSGXE
FYUFA
HCIFZ
HMCUK
HZ~
IAO
IHR
IHW
INH
INR
ITC
LK8
M1P
M7P
NNMJJ
NPM
ODYON
OVD
PQQKQ
PROAC
PSQYO
RNR
RNT
RNTTT
S70
SHXYY
SIXXV
SNYQT
SOJ
TAOOD
TBHMF
TDRGL
TEORI
TSG
UKHRP
7XB
8FK
ABFSG
ACSTC
AEZWR
AFANA
AFHIU
AHWEU
AIXLP
ALPWD
ATHPR
AZQEC
DWQXO
GNUQQ
K9.
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
PUEGO
ID FETCH-LOGICAL-c3377-6176efa02be66d98bbe68afe50f32c1964e5a34ddbdfb2aa0f786b24939664ae3
IEDL.DBID 7X7
ISSN 1759-4790
IngestDate Sat Aug 23 12:43:17 EDT 2025
Wed Feb 19 02:31:23 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3377-6176efa02be66d98bbe68afe50f32c1964e5a34ddbdfb2aa0f786b24939664ae3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
PMID 31040441
PQID 2246916685
PQPubID 2041929
PageCount 2
ParticipantIDs proquest_journals_2246916685
pubmed_primary_31040441
PublicationCentury 2000
PublicationDate 20190700
PublicationDateYYYYMMDD 2019-07-01
PublicationDate_xml – month: 7
  year: 2019
  text: 20190700
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: London
PublicationTitle Nature reviews. Rheumatology
PublicationTitleAlternate Nat Rev Rheumatol
PublicationYear 2019
Publisher Nature Publishing Group
Publisher_xml – name: Nature Publishing Group
References 30801994 - Arthritis Rheumatol. 2019 Aug;71(8):1225-1231
References_xml – reference: 30801994 - Arthritis Rheumatol. 2019 Aug;71(8):1225-1231
SSID ssj0064689
Score 2.2500908
Snippet The use of NSAIDs in rheumatology could be improved by an appropriate risk scoring system that accounts for adverse events such as bleeding and thrombosis....
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 387
SubjectTerms Anti-Inflammatory Agents, Non-Steroidal
Drug Users
Humans
Nonsteroidal anti-inflammatory drugs
Thrombosis
Title Can personalized use of NSAIDs be a reality in the clinic?
URI https://www.ncbi.nlm.nih.gov/pubmed/31040441
https://www.proquest.com/docview/2246916685
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV07T8MwELaglRAL4k15VB5Yoyax4zgsVSmtClKjCqjULbLjs8SSFtIu_HrOSVommCIP8XC2_H33-o6Qe8klcCc5Gxjj0ows9nTEAw-U1BAkeQ7W9Q5PUzGZ85dFtGgCbmVTVrl9E6uH2ixzFyPvOeEzpDJCRv3Vp-emRrnsajNCY5-0A2QibnRDvNg5XIKLagQeImTiIki7rCaTvRKBS7r6i8RDFIu8-G-GWSHN-JgcNRSRDuozPSF7UJySg2mTBD8jD0NV0NWWRH-DoZsS6NLS9G3w_FRSDVRR5IKOYNOPgiLFo3UDZP-czMej9-HEa0YgeDljcdXAJ9BafqhBCJNIjV-pLES-ZWHuxLQgUowbo43VoVK-jaXQ6FIxdGO4AnZBWsWygCtCc18Z67Q4E-5U1kLchVtQASQitwC8Q263Bsiae1xmv1bvkMvaKNmqlsHIkBhyH9nU9f8_3pDDsDKzK3G9Ja311wbuEMjXuludVpe0H0fp7BVX6Wz6A0WrnNU
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LT8MwDLZ4SMAF8X5DDnCs1rVpmiKhaRqgDdgubNJuJWkciUs3KAjBj-I34rQrnODGqadGke3En2P7M8Cp5BK5o5xtGuPSjGHs6Yg3PVRSYzPJMrSud7g_EN0RvxlH4zn4rHthXFllfSeWF7WZZO6NvOGIzwjKCBm1pk-emxrlsqv1CI3KLG7x_Y1CtuKid0n6PQuC66thp-vNpgp4WRjGZU-coA34gUYhTCI1faWyGPk2DDLHT4WRCrkx2lgdKOXbWApNUUpIkQFXGNK687DIXYqRzk88_g7wBBflyD3yyIl7sfrOooayUZCjlK7eI_HIa0Ze_DuiLT3b9RqsziApa1c2tA5zmG_AUn-WdN-E847K2bQG7R9o2GuBbGLZ4L7duyyYRqYYYU8H6NljzghSsqrhsrUFo38RzjYs5JMcd4FlvjLWcX8m3LG6BbQKt6iamIjMIvI9OKwFkM7OTZH-aHkPdiqhpNOKdiMlIMp9Qm_7f_94AsvdYf8uvesNbg9gJShF7sprD2Hh5fkVjwhEvOjjUnMMHv7bVL4AcRDX9A
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LT8MwDLYGkxAXxPsNOcCxWtemaYqEEDCmjcGEeEjcStI4EpduUBCCn8ivwulaOMGNU0-NKsfN9zm2PwPsSS6RO8nZtjEuzRjGno5420MlNbaTLEPreocvh6J3x8_vo_sGfNa9MK6ssj4Ty4PajDJ3R95ywmdEZYSMWrYqi7jqdI_GT56bIOUyrfU4DVWNWTCHpdxY1eQxwPc3CueKw36H9n4_CLpnt6c9r5o44GVhGJf9coI-zg80CmESqekplcXIt2GQOe0qjFTIjdHG6kAp38ZSaIpgQooauMKQ1p2CZkyoT4Fg8-RseHVd44LgohzIR3iduPus7xxrKFsFwah01SCJR5gaefHvfLfEve48zFWElR1PPGwBGpgvwsxllZJfgoNTlbNxTek_0LDXAtnIsuHNcb9TMI1MMWKmju6zx5wR4WSTdsyjZbj7F_OswHQ-ynENWOYrY50yaMKd5ltAq3CLqo2JyCwiX4et2gBp9VcV6Y8PrMPqxCjpeCLKkRJN5T5xu42_X9yFGXKb9KI_HGzCbFBa3NXebsH0y_MrbhPDeNE71dYxePhvb_kCfK3izw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Can+personalized+use+of+NSAIDs+be+a+reality+in+the+clinic%3F&rft.jtitle=Nature+reviews.+Rheumatology&rft.au=Nurmohamed+Michael+T&rft.date=2019-07-01&rft.pub=Nature+Publishing+Group&rft.issn=1759-4790&rft.eissn=1759-4804&rft.volume=15&rft.issue=7&rft.spage=387&rft.epage=388&rft_id=info:doi/10.1038%2Fs41584-019-0225-7&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1759-4790&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1759-4790&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1759-4790&client=summon