Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System
The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system （ASES） and characterized by scanning electronic microscope （SEM）, X-ray diffraction （XRD）, and Fourier transform infrared （FT-IR） analysis. The effects of operational parameters including pressure, temp...
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| Published in | Chinese journal of chemical engineering Vol. 16; no. 6; pp. 956 - 960 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.12.2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1004-9541 2210-321X |
| DOI | 10.1016/S1004-9541(09)60023-9 |
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| Abstract | The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system （ASES） and characterized by scanning electronic microscope （SEM）, X-ray diffraction （XRD）, and Fourier transform infrared （FT-IR） analysis. The effects of operational parameters including pressure, temperature, solution concentration, and ratio of flow rate （CO2/solution, r） on particle size （PS）, yield, and morphology were investigated. The results showed that microparticles of β-sitosterol （less than 1000 nm size and larger than 70% yield） could be obtained at 10-15 MPa, 35 50℃, 15 mg·ml^-1, 10/1（r）; β-sitosterol particles were found to occur as three mophologies： flakes, rods, and spheres by varying ratio of flow rate or solution concentration. In contrast, the crystallinity of β-sitosterol decreased, whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore, ASES was an effective method to produce submicroparticles of β-sitosterol. |
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| AbstractList | The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system （ASES） and characterized by scanning electronic microscope （SEM）, X-ray diffraction （XRD）, and Fourier transform infrared （FT-IR） analysis. The effects of operational parameters including pressure, temperature, solution concentration, and ratio of flow rate （CO2/solution, r） on particle size （PS）, yield, and morphology were investigated. The results showed that microparticles of β-sitosterol （less than 1000 nm size and larger than 70% yield） could be obtained at 10-15 MPa, 35 50℃, 15 mg·ml^-1, 10/1（r）; β-sitosterol particles were found to occur as three mophologies： flakes, rods, and spheres by varying ratio of flow rate or solution concentration. In contrast, the crystallinity of β-sitosterol decreased, whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore, ASES was an effective method to produce submicroparticles of β-sitosterol. The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system (ASES) and characterized by scanning electronic microscope (SEM), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR) analysis. The effects of operational parameters including pressure, temperature, solution concentration, and ratio of flow rate (CO 2/solution, r) on particle size (PS), yield, and morphology were investigated. The results showed that microparticles of β-sitosterol (less than 1000 nm size and larger than 70% yield) could be obtained at 10-15 MPa, 35–50°C, 15 mg·ml −1, 10/1( r); β-sitosterol particles were found to occur as three mophologies: flakes, rods, and spheres by varying ratio of flow rate or solution concentration. In contrast, the crystallinity of β-sitosterol decreased, whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore, ASES was an effective method to produce submicroparticles of β-sitosterol. |
| Author | 于文利 夏菲 金鹤阳 林长春 赵亚平 蒋思源 何琳 |
| AuthorAffiliation | School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, China Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China |
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| Cites_doi | 10.1016/j.supflu.2006.07.003 10.1016/S0896-8446(01)00064-X 10.1021/ie0608051 10.1016/0378-5173(93)90131-X 10.1016/0024-3205(95)00263-6 10.1016/S0378-5173(97)00071-9 10.1016/0378-5173(86)90188-2 10.1016/S0032-5910(99)00062-5 10.1016/j.supflu.2003.10.001 10.1139/y97-011 10.1016/S0896-8446(01)00109-7 |
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| Keywords | submicroparticle aerosol solvent extraction system supercritical CO 2 β-sitosterol micronization |
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| Snippet | The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system （ASES） and characterized by scanning electronic microscope... The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system (ASES) and characterized by scanning electronic microscope... |
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| SubjectTerms | aerosol solvent extraction system micronization submicroparticle supercritical CO 2 β-sitosterol β-谷甾醇亚微粒 气溶胶溶剂 萃取技术 |
| Title | Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System |
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