Prevalence of 52-kd and 60-kd Ro/SS-A autoantibodies in Japanese patients with polymyositis/dermatomyositis

• Published in: Journal of the American Academy of Dermatology Vol. 47; no. 1; pp. 148 - 151
• Main Authors: Kubo, Masahide, Ihn, Hironobu, Asano, Yoshihide, Yamane, Kenichi, Yazawa, Norihito, Tamaki, Kunihiko
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.07.2002; Elsevier
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Antinuclear - blood; Antibodies, Antinuclear - genetics; Antigens, Viral, Tumor - blood; Autoantibodies - blood; Biological and medical sciences; Child; Dermatology; Dermatomyositis - genetics; Enzyme-Linked Immunosorbent Assay; Female; Genetic Markers - genetics; Humans; Japan; Male; Medical sciences; Middle Aged; Polymyositis - genetics; Prevalence; Probability; Sampling Studies; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sensitivity and Specificity; Skin involvement in other diseases. Miscellaneous. General aspects; Statistics, Nonparametric; Asia; Japan; Human; Immunopathology; Connective tissue disease; Skin disease; Prevalence; Antibody; Dermatomyositis; Autoantibody; Autoimmune disease; Serology; Striated muscle disease; Polymyositis; Immunological investigation; Systemic disease
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1067/mjd.2002.121037

To determine the prevalence of 52-kd and 60-kd Ro/SS-A antibodies in Japanese patients with polymyositis/dermatomyositis, we examined serum samples from 61 patients with PM/DM, 10 patients with primary Sjögren's syndrome, and 25 healthy control subjects. Six serum samples possessed anti-Ro/SS-A antibodies and were positive for anti-Ro52, anti-Ro60, or both. Two reacted with both Ro52 and Ro60, and 4 reacted with Ro52 alone. The results suggest that Ro52 is the main antigen of anti-Ro/SS-A antibodies in patients with polymyositis/dermatomyositis and that its coexistence with other defined antibodies suggests the existence of a subgroup of patients with various serologic abnormalities. (J Am Acad Dermatol 2002;47:148-51.)