Calcium peroxide-mediated bioactive hydrogels for enhanced angiogenic paracrine effect and osteoblast proliferation

[Display omitted] Polymeric hydrogels have been extensively utilized as therapeutic vehicles for delivering cells or bioactive molecules to enhance bone tissue regeneration. Among these factors, growing evidence demonstrates that oxygen (O2) and calcium ions (Ca2+) play pivotal roles in bone repair...

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Published inJournal of industrial and engineering chemistry (Seoul, Korea) Vol. 120; pp. 121 - 130
Main Authors Han, Min Ji, An, Jeong Ah, Kim, Jeong Min, Heo, Dong Nyoung, Kwon, Il Keun, Park, Kyung Min
Format Journal Article
LanguageEnglish
Published Elsevier B.V 25.04.2023
한국공업화학회
Subjects
Angiogenesis
Bone regeneration
Calcium
Osteogenesis
Oxygen
Polymeric hydrogels
화학공학
Gtn
NBCS
Calcium
Bone regeneration
Calcein-AM
G
GtnSH
DO
DS
Angiogenesis
DMEM
MSCs
TCPS
FBS
DOmax
CaO2
EthD-1
Polymeric hydrogels
Oxygen
Alpha MEM
HIF
VEGF
qRT-PCR
1H NMR
ECM
ROS
SEM
DPBS
Osteogenesis
Online AccessGet full text
ISSN1226-086X
1876-794X
DOI10.1016/j.jiec.2022.12.017

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Abstract [Display omitted] Polymeric hydrogels have been extensively utilized as therapeutic vehicles for delivering cells or bioactive molecules to enhance bone tissue regeneration. Among these factors, growing evidence demonstrates that oxygen (O2) and calcium ions (Ca2+) play pivotal roles in bone repair and regeneration, including cell proliferation and vascularization. Herein, we report on gelatin-based bioactive matrices as dual carriers of O2 and Ca2+ for vascularized bone tissue regeneration. Bioactive hydrogels were prepared through a calcium peroxide (CaO2)-mediated crosslinking reaction. We demonstrated that the hydrogels have controllable mechanical properties depending on the composition (G′:300–1700 Pa). We also demonstrated that the hydrogels released Ca2+ in a sustained manner for two days (2.6–2.8 mM) and released O2 (DOmax: G7C0.5, 97.9% pO2; G7C0.25, 82.7% pO2; G7C0.125, 65.5% pO2), providing transient hyperoxic conditions to cells in vitro. Notably, we found that our bioactive hydrogels enhanced the proliferation of pre-osteoblasts (MC3T3-E1) and gene expression of vascular endothelial growth factor (VEGF) from mesenchymal stem cells (MSCs). In summary, our O2- and Ca2+-releasing hydrogels show potential as bioactive hydrogels for vascularized bone tissue regeneration.
AbstractList Polymeric hydrogels have been extensively utilized as therapeutic vehicles for delivering cells or bioactivemolecules to enhance bone tissue regeneration. Among these factors, growing evidence demonstratesthat oxygen (O2) and calcium ions (Ca2+) play pivotal roles in bone repair and regeneration,including cell proliferation and vascularization. Herein, we report on gelatin-based bioactive matricesas dual carriers of O2 and Ca2+ for vascularized bone tissue regeneration. Bioactive hydrogels were preparedthrough a calcium peroxide (CaO2)-mediated crosslinking reaction. We demonstrated that thehydrogels have controllable mechanical properties depending on the composition (G0:300–1700 Pa). We also demonstrated that the hydrogels released Ca2+ in a sustained manner for two days (2.6–2.8 mM) and released O2 (DOmax: G7C0.5, 97.9% pO2; G7C0.25, 82.7% pO2; G7C0.125, 65.5% pO2), providingtransient hyperoxic conditions to cells in vitro. Notably, we found that our bioactive hydrogelsenhanced the proliferation of pre-osteoblasts (MC3T3-E1) and gene expression of vascular endothelialgrowth factor (VEGF) from mesenchymal stem cells (MSCs). In summary, our O2- and Ca2+-releasinghydrogels show potential as bioactive hydrogels for vascularized bone tissue regeneration. KCI Citation Count: 0
[Display omitted] Polymeric hydrogels have been extensively utilized as therapeutic vehicles for delivering cells or bioactive molecules to enhance bone tissue regeneration. Among these factors, growing evidence demonstrates that oxygen (O2) and calcium ions (Ca2+) play pivotal roles in bone repair and regeneration, including cell proliferation and vascularization. Herein, we report on gelatin-based bioactive matrices as dual carriers of O2 and Ca2+ for vascularized bone tissue regeneration. Bioactive hydrogels were prepared through a calcium peroxide (CaO2)-mediated crosslinking reaction. We demonstrated that the hydrogels have controllable mechanical properties depending on the composition (G′:300–1700 Pa). We also demonstrated that the hydrogels released Ca2+ in a sustained manner for two days (2.6–2.8 mM) and released O2 (DOmax: G7C0.5, 97.9% pO2; G7C0.25, 82.7% pO2; G7C0.125, 65.5% pO2), providing transient hyperoxic conditions to cells in vitro. Notably, we found that our bioactive hydrogels enhanced the proliferation of pre-osteoblasts (MC3T3-E1) and gene expression of vascular endothelial growth factor (VEGF) from mesenchymal stem cells (MSCs). In summary, our O2- and Ca2+-releasing hydrogels show potential as bioactive hydrogels for vascularized bone tissue regeneration.
Author Park, Kyung Min
Kwon, Il Keun
Heo, Dong Nyoung
An, Jeong Ah
Kim, Jeong Min
Han, Min Ji
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Keywords Gtn
NBCS
Calcium
Bone regeneration
Calcein-AM
G
GtnSH
DO
DS
Angiogenesis
DMEM
MSCs
TCPS
FBS
DOmax
CaO2
EthD-1
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Oxygen
Alpha MEM
HIF
VEGF
qRT-PCR
1H NMR
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ROS
SEM
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Osteogenesis
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Snippet [Display omitted] Polymeric hydrogels have been extensively utilized as therapeutic vehicles for delivering cells or bioactive molecules to enhance bone tissue...
Polymeric hydrogels have been extensively utilized as therapeutic vehicles for delivering cells or bioactivemolecules to enhance bone tissue regeneration....
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SubjectTerms Angiogenesis
Bone regeneration
Calcium
Osteogenesis
Oxygen
Polymeric hydrogels
화학공학
Title Calcium peroxide-mediated bioactive hydrogels for enhanced angiogenic paracrine effect and osteoblast proliferation
URI https://dx.doi.org/10.1016/j.jiec.2022.12.017
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