Studies of Serum Lipids and Blood Coagulation-Fibrinolytic System in Aged Patients with Old Cerebral Thrombosis

• Published in: Nihon Rōnen Igakkai zasshi Vol. 22; no. 4; pp. 340 - 345
• Main Authors: Kobayashi, Yoji, Nakazawa, Yoshihisa, Inaba, Haruki, Hada, Kazumasa, Yoshii, Hitoshi, Terashi, Akiro, Kanekawa, Takuro, Fukuo, Yoshihiro, Kato, Hitoshi, Shibuya, Toshimichi
• Format: Journal Article
• Language: Japanese
• Published: Japan The Japan Geriatrics Society 1985
• Subjects: Aged; atherosclerosis; Blood Coagulation Factors - analysis; coagulation-fibrinolytic system; Fibrinolysis; Humans; Intracranial Embolism and Thrombosis - blood; Lipids - blood; Middle Aged; old cerebral thrombosis in the aged patients; serum lipids; thrombus
• ISSN: 0300-9173
• DOI: 10.3143/geriatrics.22.340

It is well known that abnormality of coagulation-fibrinolytic system and abnormal metabolism of serum lipids play an important role in development of thrombus and atherosclerosis. Blood coagulation-fibrinolytic factors (Fbg, FDP, AT-III, α2-PI, FN, Factor XIII, α1AT, α2-M) and serum lipids (T-C, TRG, β-Lp, HDL-C, Apo AI, AII, Apo AI/AII ratio) were examined in 38 aged patients with old cerebral thrombosis (Ave 72.4 years). i) Serum Apo AI and All levels were significantly lower in patient group than in control group (p<0.01). ii) Fibrinogen levels were significantly higher in patient group (p<0.0005) but α2-PI, FN and Factor XIII levels were significantly lower in patient group (p<0.025). AT-III, FDP, α1-AT and α2-M levels showed no significant change. iii) Correlation with serum lipids and blood coagulation-fibrinolytic factors were as follows, a) Apo AI levels showed positive correlation with α2-PI levels in patient group. b) Apo AI levels showed negative correlation with α2-PI levels in control group. c) β-Lp levels showed positive correlation with FN levels in patient group. iv) FN levels showed positive correlation with α2-PI levels in patient group. These results indicated that the aged patients with old cerebral thrombosis were in the hypercoagulablity state associated with lowering of Apo AI and Apo AII in serum lipids.