A review on multivariate curve resolution applied to spectroscopic and chromatographic data acquired during the real-time monitoring of evolving multi-component processes: From process analytical chemistry (PAC) to process analytical technology (PAT) - Mazivila, Sarmento J.; Santos, João L.M. (TrAC, Trends in analytical chemistry (Regular ed.), 2022)
Keywords: analytical chemistry; biodiesel; chemical reactions; Chromatographically monitored process; chromatography; drugs; Emerging digital manufacturing process; epoxides; Evolving multi-component processes; industry; least squares; Multivariate curve resolution − alternating least-squares (MCR-ALS); Process analytical chemistry (PAC); Process analytical technology (PAT); Quality-by-design (QbD) approach; Real-time process monitoring; Spectroscopically monitored process; spectroscopy; Workflow data acquisition; Process analytical technology (PAT); Emerging digital manufacturing process; Real-time process monitoring; Quality-by-design (QbD) approach; Chromatographically monitored process; Spectroscopically monitored process; Workflow data acquisition; Process analytical chemistry (PAC); Multivariate curve resolution − alternating least-squares (MCR-ALS); Evolving multi-component processes