Modular reorganization of gait in chronic but not in artificial knee joint constraint

• Published in: Journal of neurophysiology Vol. 126; no. 2; pp. 516 - 531
• Main Authors: Cruz-Montecinos, Carlos, Pérez-Alenda, Sofía, Cerda, Mauricio, Maas, Huub
• Format: Journal Article
• Language: English
• Published: United States 01.08.2021
• Subjects: Adult; Biomechanical Phenomena; Gait Analysis; Humans; Knee Joint - physiology; Knee Joint - physiopathology; Knee Prosthesis - adverse effects; Middle Aged; Muscle, Skeletal - physiology; Muscle, Skeletal - physiopathology; Range of Motion, Articular; lower limb kinematics; motor control; muscle synergy; gait analysis; knee joint
• ISSN: 0022-3077; 1522-1598; 1522-1598
• DOI: 10.1152/jn.00418.2020

It is currently unknown if modular reorganization does occur if not the central nervous system, but the musculoskeletal system is affected. This study showed that in the short-term a knee constraint does not affect the modular organization of gait, but in the long-term a knee constraint results in modular reorganization. These results indicate that modular reorganization may also occur when changes in the mechanics of the musculoskeletal system is the primary cause of the motor impairment. It is currently unknown if modular reorganization does occur if not the central nervous system, but the musculoskeletal system is affected. The aims of this study were to investigate 1) the effects of an artificial knee joint constraint on the modular organization of gait in healthy subjects; and 2) the differences in modular organization between healthy subjects with an artificial knee joint constraint and people with a similar but chronic knee joint constraint. Eleven healthy subjects and eight people with a chronic knee joint constraint walked overground at 1 m/s. The healthy subjects also walked with a constraint limiting knee joint movement to 20°. The total variance accounted (tVAF) for one to four synergies and modular organization were assessed using surface electromyography from 11 leg muscles. The distribution of number of synergies were not significantly different between groups. The tVAF and the motor modules were not significantly affected by the artificial knee constraint. A higher tVAF for one and two synergies, as well as merging of motor modules were observed in the chronic knee constraint group. We conclude that in the short-term a knee constraint does not affect the modular organization of gait, but in the long-term a knee constraint results in modular reorganization. These results indicate that merging of motor modules may also occur when changes in the mechanics of the musculoskeletal system is the primary cause of the motor impairment. NEW & NOTEWORTHY It is currently unknown if modular reorganization does occur if not the central nervous system, but the musculoskeletal system is affected. This study showed that in the short-term a knee constraint does not affect the modular organization of gait, but in the long-term a knee constraint results in modular reorganization. These results indicate that modular reorganization may also occur when changes in the mechanics of the musculoskeletal system is the primary cause of the motor impairment.