A study to evaluate the safety, tolerability, and efficacy of brodalumab in subjects with rheumatoid arthritis and an inadequate response to methotrexate - Pavelka, Karel; Chon, Yun; Newmark, Richard; Lin, Shao-Lee; Baumgartner, Scott; Erondu, Ngozi (Journal of rheumatology, 2015)
Keywords: Aged; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - adverse effects; Antibodies, Monoclonal, Humanized - administration & dosage; Antibodies, Monoclonal, Humanized - adverse effects; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - drug therapy; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Maximum Tolerated Dose; Methotrexate - therapeutic use; Middle Aged; Multivariate Analysis; Pain Measurement; Prospective Studies; Retreatment - methods; Risk Assessment; Severity of Illness Index; Treatment Failure; Treatment Outcome; INTERLEUKIN 17; BRODALUMAB; RHEUMATOID ARTHRITIS; RANDOMIZED CONTROLLED TRIAL; PHASE 2