Elevation of markers of endotoxemia in women with polycystic ovary syndrome
Is polycystic ovary syndrome (PCOS) associated with an elevation of markers of endotoxemia? In women with PCOS serum levels of lipopolysaccharides (LPS), the LPS to high-density lipoprotein (HDL) ratio and LPS-binding protein (LBP) are significantly greater than those of normal control subjects. Mon...
Saved in:
Published in | Human reproduction (Oxford) Vol. 35; no. 10; pp. 2303 - 2311 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.10.2020
|
Subjects | |
Online Access | Get full text |
ISSN | 0268-1161 1460-2350 1460-2350 |
DOI | 10.1093/humrep/deaa194 |
Cover
Abstract | Is polycystic ovary syndrome (PCOS) associated with an elevation of markers of endotoxemia?
In women with PCOS serum levels of lipopolysaccharides (LPS), the LPS to high-density lipoprotein (HDL) ratio and LPS-binding protein (LBP) are significantly greater than those of normal control subjects.
Mononuclear cells from women with PCOS respond excessively to LPS by releasing pro-inflammatory cytokines. In rat ovarian theca-interstitial cell cultures LPS stimulates androgen production.
Cross-sectional study comparing markers of endotoxemia in women with PCOS (n = 62), healthy ovulatory women with polycystic ovary morphology (PCOM, n = 39) and a control group of healthy ovulatory women without PCOM [normal (NL), n = 43].
LPS was measured using a chromogenic assay. LBP was measured by ELISA. Total cholesterol and lipids were measured using a homogeneous enzyme colorimetric method. Androgens, gonadotrophins, prolactin, insulin, high-sensitivity C-reactive protein (hs-CRP) and sex hormone-binding globulin were determined by electrochemiluminescence assays. Glucose was measured using an enzymatic reference method with hexokinase.
Women with PCOS, when compared with NL subjects, had a significantly higher mean LPS (P = 0.045), LPS/HDL ratio (P = 0.007) and LBP (P = 0.01). Women with PCOM had intermediate levels of markers of endotoxemia. Comparison among all groups revealed that markers of endotoxemia correlated positively with testosterone level, ovarian volume, number of antral follicles and hirsutism score, but negatively with the number of spontaneous menses per year. In multiple regression analysis, all measures of endotoxemia correlated independently and positively with hs-CRP and with ovarian volume.
This cross-sectional study reveals that markers of endotoxemia are associated with several clinical features observed in women with PCOS. However, responsible mechanisms and causation remain unknown. Steroid quantification was carried out by electrochemiluminescence assays and not by the current gold standard: liquid chromatography-mass spectrometry. Hence, the relationship of endotoxemia with features of PCOS and the extent to which endotoxemia contributes to reproductive and metabolic dysfunction warrants further investigation.
This study reveals the novel observation that markers of endotoxemia are elevated in young and otherwise healthy women with PCOS without significant metabolic dysfunction. Moreover, the association of clinical and endocrine markers of PCOS with those of endotoxemia may represent a pathophysiologic link to reproductive dysfunction as well as metabolic and long-term cardiovascular risks associated with this disorder.
Intramural funding from Poznan University of Medical Sciences. The authors have no conflicts of interest to declare.
N/A. |
---|---|
AbstractList | Is polycystic ovary syndrome (PCOS) associated with an elevation of markers of endotoxemia?
In women with PCOS serum levels of lipopolysaccharides (LPS), the LPS to high-density lipoprotein (HDL) ratio and LPS-binding protein (LBP) are significantly greater than those of normal control subjects.
Mononuclear cells from women with PCOS respond excessively to LPS by releasing pro-inflammatory cytokines. In rat ovarian theca-interstitial cell cultures LPS stimulates androgen production.
Cross-sectional study comparing markers of endotoxemia in women with PCOS (n = 62), healthy ovulatory women with polycystic ovary morphology (PCOM, n = 39) and a control group of healthy ovulatory women without PCOM [normal (NL), n = 43].
LPS was measured using a chromogenic assay. LBP was measured by ELISA. Total cholesterol and lipids were measured using a homogeneous enzyme colorimetric method. Androgens, gonadotrophins, prolactin, insulin, high-sensitivity C-reactive protein (hs-CRP) and sex hormone-binding globulin were determined by electrochemiluminescence assays. Glucose was measured using an enzymatic reference method with hexokinase.
Women with PCOS, when compared with NL subjects, had a significantly higher mean LPS (P = 0.045), LPS/HDL ratio (P = 0.007) and LBP (P = 0.01). Women with PCOM had intermediate levels of markers of endotoxemia. Comparison among all groups revealed that markers of endotoxemia correlated positively with testosterone level, ovarian volume, number of antral follicles and hirsutism score, but negatively with the number of spontaneous menses per year. In multiple regression analysis, all measures of endotoxemia correlated independently and positively with hs-CRP and with ovarian volume.
This cross-sectional study reveals that markers of endotoxemia are associated with several clinical features observed in women with PCOS. However, responsible mechanisms and causation remain unknown. Steroid quantification was carried out by electrochemiluminescence assays and not by the current gold standard: liquid chromatography-mass spectrometry. Hence, the relationship of endotoxemia with features of PCOS and the extent to which endotoxemia contributes to reproductive and metabolic dysfunction warrants further investigation.
This study reveals the novel observation that markers of endotoxemia are elevated in young and otherwise healthy women with PCOS without significant metabolic dysfunction. Moreover, the association of clinical and endocrine markers of PCOS with those of endotoxemia may represent a pathophysiologic link to reproductive dysfunction as well as metabolic and long-term cardiovascular risks associated with this disorder.
Intramural funding from Poznan University of Medical Sciences. The authors have no conflicts of interest to declare.
N/A. Is polycystic ovary syndrome (PCOS) associated with an elevation of markers of endotoxemia?STUDY QUESTIONIs polycystic ovary syndrome (PCOS) associated with an elevation of markers of endotoxemia?In women with PCOS serum levels of lipopolysaccharides (LPS), the LPS to high-density lipoprotein (HDL) ratio and LPS-binding protein (LBP) are significantly greater than those of normal control subjects.SUMMARY ANSWERIn women with PCOS serum levels of lipopolysaccharides (LPS), the LPS to high-density lipoprotein (HDL) ratio and LPS-binding protein (LBP) are significantly greater than those of normal control subjects.Mononuclear cells from women with PCOS respond excessively to LPS by releasing pro-inflammatory cytokines. In rat ovarian theca-interstitial cell cultures LPS stimulates androgen production.WHAT IS KNOWN ALREADYMononuclear cells from women with PCOS respond excessively to LPS by releasing pro-inflammatory cytokines. In rat ovarian theca-interstitial cell cultures LPS stimulates androgen production.Cross-sectional study comparing markers of endotoxemia in women with PCOS (n = 62), healthy ovulatory women with polycystic ovary morphology (PCOM, n = 39) and a control group of healthy ovulatory women without PCOM [normal (NL), n = 43].STUDY DESIGN, SIZE, DURATIONCross-sectional study comparing markers of endotoxemia in women with PCOS (n = 62), healthy ovulatory women with polycystic ovary morphology (PCOM, n = 39) and a control group of healthy ovulatory women without PCOM [normal (NL), n = 43].LPS was measured using a chromogenic assay. LBP was measured by ELISA. Total cholesterol and lipids were measured using a homogeneous enzyme colorimetric method. Androgens, gonadotrophins, prolactin, insulin, high-sensitivity C-reactive protein (hs-CRP) and sex hormone-binding globulin were determined by electrochemiluminescence assays. Glucose was measured using an enzymatic reference method with hexokinase.PARTICIPANTS/MATERIALS, SETTING, METHODSLPS was measured using a chromogenic assay. LBP was measured by ELISA. Total cholesterol and lipids were measured using a homogeneous enzyme colorimetric method. Androgens, gonadotrophins, prolactin, insulin, high-sensitivity C-reactive protein (hs-CRP) and sex hormone-binding globulin were determined by electrochemiluminescence assays. Glucose was measured using an enzymatic reference method with hexokinase.Women with PCOS, when compared with NL subjects, had a significantly higher mean LPS (P = 0.045), LPS/HDL ratio (P = 0.007) and LBP (P = 0.01). Women with PCOM had intermediate levels of markers of endotoxemia. Comparison among all groups revealed that markers of endotoxemia correlated positively with testosterone level, ovarian volume, number of antral follicles and hirsutism score, but negatively with the number of spontaneous menses per year. In multiple regression analysis, all measures of endotoxemia correlated independently and positively with hs-CRP and with ovarian volume.MAIN RESULTS AND THE ROLE OF CHANCEWomen with PCOS, when compared with NL subjects, had a significantly higher mean LPS (P = 0.045), LPS/HDL ratio (P = 0.007) and LBP (P = 0.01). Women with PCOM had intermediate levels of markers of endotoxemia. Comparison among all groups revealed that markers of endotoxemia correlated positively with testosterone level, ovarian volume, number of antral follicles and hirsutism score, but negatively with the number of spontaneous menses per year. In multiple regression analysis, all measures of endotoxemia correlated independently and positively with hs-CRP and with ovarian volume.This cross-sectional study reveals that markers of endotoxemia are associated with several clinical features observed in women with PCOS. However, responsible mechanisms and causation remain unknown. Steroid quantification was carried out by electrochemiluminescence assays and not by the current gold standard: liquid chromatography-mass spectrometry. Hence, the relationship of endotoxemia with features of PCOS and the extent to which endotoxemia contributes to reproductive and metabolic dysfunction warrants further investigation.LIMITATIONS, REASONS FOR CAUTIONThis cross-sectional study reveals that markers of endotoxemia are associated with several clinical features observed in women with PCOS. However, responsible mechanisms and causation remain unknown. Steroid quantification was carried out by electrochemiluminescence assays and not by the current gold standard: liquid chromatography-mass spectrometry. Hence, the relationship of endotoxemia with features of PCOS and the extent to which endotoxemia contributes to reproductive and metabolic dysfunction warrants further investigation.This study reveals the novel observation that markers of endotoxemia are elevated in young and otherwise healthy women with PCOS without significant metabolic dysfunction. Moreover, the association of clinical and endocrine markers of PCOS with those of endotoxemia may represent a pathophysiologic link to reproductive dysfunction as well as metabolic and long-term cardiovascular risks associated with this disorder.WIDER IMPLICATIONS OF THE FINDINGSThis study reveals the novel observation that markers of endotoxemia are elevated in young and otherwise healthy women with PCOS without significant metabolic dysfunction. Moreover, the association of clinical and endocrine markers of PCOS with those of endotoxemia may represent a pathophysiologic link to reproductive dysfunction as well as metabolic and long-term cardiovascular risks associated with this disorder.Intramural funding from Poznan University of Medical Sciences. The authors have no conflicts of interest to declare.STUDY FUNDING/COMPETING INTEREST(S)Intramural funding from Poznan University of Medical Sciences. The authors have no conflicts of interest to declare.N/A.TRIAL REGISTRATION NUMBERN/A. |
Author | Zwozdziak, Barbara Pawelczyk, Leszek Duleba, Antoni J Banaszewska, Beata Spaczynski, Robert Chang, R Jeffrey Siakowska, Martyna Chudzicka-Strugala, Izabela |
Author_xml | – sequence: 1 givenname: Beata surname: Banaszewska fullname: Banaszewska, Beata organization: Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland – sequence: 2 givenname: Martyna surname: Siakowska fullname: Siakowska, Martyna organization: Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland – sequence: 3 givenname: Izabela surname: Chudzicka-Strugala fullname: Chudzicka-Strugala, Izabela organization: Department of Medical Microbiology, Poznan University of Medical Sciences, Poznan, Poland – sequence: 4 givenname: R Jeffrey surname: Chang fullname: Chang, R Jeffrey organization: Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA – sequence: 5 givenname: Leszek surname: Pawelczyk fullname: Pawelczyk, Leszek organization: Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland – sequence: 6 givenname: Barbara surname: Zwozdziak fullname: Zwozdziak, Barbara organization: Department of Medical Microbiology, Poznan University of Medical Sciences, Poznan, Poland – sequence: 7 givenname: Robert surname: Spaczynski fullname: Spaczynski, Robert organization: Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland – sequence: 8 givenname: Antoni J surname: Duleba fullname: Duleba, Antoni J organization: Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32869098$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kDtPwzAUhS1URB-wMqKMLGn9qmuPqCoPUYkFZsuxHdWQxMFOC_n3uLRdkFjOvdI950j3G4NB4xsLwDWCUwQFmW22dbDtzFilkKBnYIQogzkmczgAI4gZzxFiaAjGMb5DmFbOLsCQYM4EFHwEnleV3anO-SbzZVar8GFD3K-2Mb7z37Z2KnNN9uVrm9R1m6z1Va_72Dmd-Z0KfRb7xoR0vwTnpaqivTrOCXi7X70uH_P1y8PT8m6da4JFlyvFOSoxtqxkVJgkC1pQbXChODFQzLEyc00WAiuBUMlJAcsUsKXiwvBCkwm4PfS2wX9ubexk7aK2VaUa67dRYkoEw3TBaLLeHK3borZGtsGlH3t5ApAM9GDQwccYbCm16355dEG5SiIo95zlgbM8ck6x6Z_YqfmfwA9-vIRf |
CitedBy_id | crossref_primary_10_1177_11786469221099214 crossref_primary_10_1210_jendso_bvac128 crossref_primary_10_3390_biomedicines13010177 crossref_primary_10_3389_fendo_2023_1279878 crossref_primary_10_1007_s13273_025_00511_8 crossref_primary_10_1016_j_domaniend_2024_106868 crossref_primary_10_1016_j_smrv_2023_101774 crossref_primary_10_1210_clinem_dgab369 crossref_primary_10_5468_ogs_21185 crossref_primary_10_1186_s12916_024_03434_8 crossref_primary_10_3389_fimmu_2021_685724 crossref_primary_10_1007_s43032_024_01562_3 crossref_primary_10_1016_j_tem_2024_04_004 crossref_primary_10_1021_acsomega_3c00578 crossref_primary_10_1016_j_foodres_2024_114338 crossref_primary_10_3390_diagnostics12122924 crossref_primary_10_3390_metabo14070362 crossref_primary_10_1007_s00404_024_07833_3 crossref_primary_10_3389_fphar_2021_670054 |
Cites_doi | 10.2741/S405 10.2174/1381612822666160720151243 10.2337/db06-1491 10.1210/jc.2016-3863 10.2337/diacare.22.9.1462 10.1097/MD.0000000000012608 10.1210/en.2019-00588 10.1016/j.fertnstert.2018.01.038 10.1210/er.2009-0030 10.1073/pnas.0403249101 10.1093/humrep/des232 10.1016/j.metabol.2017.09.016 10.1177/0022034511413928 10.1371/journal.pone.0108074 10.1016/j.fertnstert.2010.11.036 10.1159/000341683 10.1093/humrep/dew218 10.1189/jlb.3RU0316-151R 10.1016/S0065-2776(08)60502-7 10.1016/j.steroids.2011.12.002 10.1007/s10815-008-9219-0 10.1210/jc.2018-01143 10.1016/j.tem.2014.12.004 10.1210/jc.2006-0178 10.1007/BF00280883 10.3389/fgene.2017.00080 10.1371/journal.pone.0146509 10.1210/jcem-21-11-1440 10.1016/j.resmic.2018.09.002 10.1136/gutjnl-2015-311326 10.1016/j.ijgo.2013.05.005 10.1210/jc.2017-02799 10.5694/mja11.10553 10.1371/journal.pone.0148531 10.1073/pnas.1002601107 10.1016/S0015-0282(00)00501-X 10.1093/ajcn/nqy358 10.1016/j.metabol.2016.12.009 10.12717/DR.2016.20.2.113 10.1093/humrep/dep399 10.1161/01.ATV.0000145979.82184.9f 10.2337/dc10-2197 10.1126/science.aat7164 10.1016/j.steroids.2013.04.009 10.1016/j.ajog.2014.06.044 10.1186/1741-7015-8-41 10.1194/jlr.M800156-JLR200 10.1210/jc.2017-02153 10.1093/humupd/dmr025 10.1016/j.semnephrol.2018.01.008 10.1210/jc.2003-032046 10.2337/dc10-0340 10.1080/14737159.2017.1340833 10.1161/01.ATV.0000147534.69062.dc 10.1007/s11010-013-1911-4 10.1016/j.fertnstert.2010.07.1052 10.1210/jcem.84.10.6079 10.1161/JAHA.117.005784 10.1111/jcpe.12751 10.1210/jc.2005-1329 10.1016/S0026-0495(99)90100-2 10.1161/ATVBAHA.114.304136 10.1007/s11695-007-9243-7 10.1016/j.ajog.2017.04.007 10.1371/journal.pone.0168390 10.2337/db09-0367 |
ContentType | Journal Article |
Copyright | The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
Copyright_xml | – notice: The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
DOI | 10.1093/humrep/deaa194 |
DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1460-2350 |
EndPage | 2311 |
ExternalDocumentID | 32869098 10_1093_humrep_deaa194 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- -E4 .2P .I3 .XZ .ZR 0R~ 1TH 29I 2WC 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 70D AABZA AACZT AAIMJ AAJKP AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AAUAY AAUQX AAVAP AAVLN AAYXX ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABMNT ABNHQ ABNKS ABPQP ABPTD ABQLI ABQNK ABVGC ABWST ABXVV ABXZS ABZBJ ACCCW ACGFS ACPRK ACUFI ACUTJ ACUTO ACYHN ADBBV ADEYI ADEZT ADGKP ADGZP ADHKW ADHZD ADIPN ADNBA ADOCK ADQBN ADRTK ADVEK ADYVW ADZXQ AEGPL AEJOX AEKSI AELWJ AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFGWE AFIYH AFOFC AFXAL AGINJ AGKEF AGORE AGQXC AGSYK AGUTN AHGBF AHMBA AHMMS AHXPO AIJHB AJBYB AJEEA AJNCP AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APWMN ARIXL ATGXG AXUDD AYOIW BAWUL BAYMD BCRHZ BEYMZ BHONS BQDIO BSWAC BTRTY BVRKM C45 CDBKE CITATION CS3 CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS EE~ EMOBN ENERS F5P F9B FECEO FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HW0 HZ~ IOX J21 JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN L7B M-Z MHKGH ML0 N9A NGC NLBLG NOMLY NOYVH NU- O9- OAUYM OAWHX OBOKY OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P PAFKI PEELM PQQKQ Q1. Q5Y R44 RD5 ROL ROX ROZ RUSNO RW1 RXO TCURE TEORI TJX TLC TR2 W8F WH7 WOQ X7H YAYTL YKOAZ YXANX ZKX ~91 CGR CUY CVF ECM EIF NPM 7X8 |
ID | FETCH-LOGICAL-c329t-aa881f22e6f649df6474b4cd2ba83d0952ad5c3792a911f83b0f81fefa89d8bc3 |
ISSN | 0268-1161 1460-2350 |
IngestDate | Sun Sep 28 06:49:11 EDT 2025 Mon Jul 21 05:56:41 EDT 2025 Tue Jul 01 00:55:09 EDT 2025 Thu Apr 24 22:55:41 EDT 2025 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Keywords | lipopolysaccharides lipopolysaccharide binding protein polycystic ovary morphology endotoxemia polycystic ovary syndrome |
Language | English |
License | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c329t-aa881f22e6f649df6474b4cd2ba83d0952ad5c3792a911f83b0f81fefa89d8bc3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 32869098 |
PQID | 2439624764 |
PQPubID | 23479 |
PageCount | 9 |
ParticipantIDs | proquest_miscellaneous_2439624764 pubmed_primary_32869098 crossref_citationtrail_10_1093_humrep_deaa194 crossref_primary_10_1093_humrep_deaa194 |
ProviderPackageCode | CITATION AAYXX |
PublicationCentury | 2000 |
PublicationDate | 2020-10-01 20201001 |
PublicationDateYYYYMMDD | 2020-10-01 |
PublicationDate_xml | – month: 10 year: 2020 text: 2020-10-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Human reproduction (Oxford) |
PublicationTitleAlternate | Hum Reprod |
PublicationYear | 2020 |
References | Insenser (2020092514445630800_deaa194-B30) 2018; 103 Toulis (2020092514445630800_deaa194-B65) 2011; 17 Glaros (2020092514445630800_deaa194-B24) 2013; 5 Lassenius (2020092514445630800_deaa194-B35) 2011; 34 Ding (2020092514445630800_deaa194-B13) 2018; 97 Liu (2020092514445630800_deaa194-B42) 2008; 25 Karjula (2020092514445630800_deaa194-B32) 2017; 102 Shaddox (2020092514445630800_deaa194-B59) 2011; 90 Teede (2020092514445630800_deaa194-B63) 2010; 8 Akcali (2020092514445630800_deaa194-B2) 2014; 9 Chen (2020092514445630800_deaa194-B12) 2019; 109 Cani (2020092514445630800_deaa194-B10) 2007; 56 Matthews (2020092514445630800_deaa194-B47) 1985; 28 (2020092514445630800_deaa194-B1) 2004 Ferriman (2020092514445630800_deaa194-B21) 1961; 21 Torres (2020092514445630800_deaa194-B64) 2018; 103 Vermeulen (2020092514445630800_deaa194-B67) 1999; 84 Lindheim (2020092514445630800_deaa194-B40) 2017; 12 Kolodziejczyk (2020092514445630800_deaa194-B34) 2000; 73 McAllister (2020092514445630800_deaa194-B48) 2015; 26 Dunaif (2020092514445630800_deaa194-B17) 1997; 18 Matsuda (2020092514445630800_deaa194-B46) 1999; 22 Boyle (2020092514445630800_deaa194-B7) 2012; 196 Michelsen (2020092514445630800_deaa194-B50) 2004; 101 Manco (2020092514445630800_deaa194-B44) 2010; 31 Ruiz (2020092514445630800_deaa194-B57) 2007; 17 Wild (2020092514445630800_deaa194-B68) 2012; 77 Macut (2020092514445630800_deaa194-B43) 2013; 40 Gonzalez (2020092514445630800_deaa194-B26) 2019; 104 Zeng (2020092514445630800_deaa194-B72) 2019; 170 Dokras (2020092514445630800_deaa194-B14) 2013; 78 Kelley (2020092514445630800_deaa194-B33) 2016; 11 Munford (2020092514445630800_deaa194-B52) 2016; 100 Zawadski (2020092514445630800_deaa194-B71) 1992 Chan (2020092514445630800_deaa194-B11) 2017; 217 Calderon-Margalit (2020092514445630800_deaa194-B9) 2014; 34 Dursun (2020092514445630800_deaa194-B18) 2011; 95 Li (2020092514445630800_deaa194-B37) 2018; 38 Yoo da (2020092514445630800_deaa194-B70) 2016; 20 Peng (2020092514445630800_deaa194-B55) 2016; 11 Sun (2020092514445630800_deaa194-B62) 2010; 33 Ehrmann (2020092514445630800_deaa194-B19) 2006; 91 Gomes (2020092514445630800_deaa194-B25) 2017; 68 Legro (2020092514445630800_deaa194-B36) 1999; 84 Liljestrand (2020092514445630800_deaa194-B38) 2017; 44 Pussinen (2020092514445630800_deaa194-B56) 2004; 24 Ghoshal (2020092514445630800_deaa194-B23) 2009; 50 Mehta (2020092514445630800_deaa194-B49) 2010; 59 Dominguez-Bello (2020092514445630800_deaa194-B16) 2010; 107 Dokras (2020092514445630800_deaa194-B15) 2018; 109 Spritzer (2020092514445630800_deaa194-B60) 2016; 22 Alexander (2020092514445630800_deaa194-B3) 2001; 7 Fox (2020092514445630800_deaa194-B22) 2019; 160 Liu (2020092514445630800_deaa194-B41) 2017; 8 Yildiz (2020092514445630800_deaa194-B69) 2012; 27 March (2020092514445630800_deaa194-B45) 2010; 25 Ulevitch (2020092514445630800_deaa194-B66) 1993; 53 Jayashree (2020092514445630800_deaa194-B31) 2014; 388 Stoll (2020092514445630800_deaa194-B61) 2004; 24 Gonzalez (2020092514445630800_deaa194-B27) 2014; 211 Anagnostis (2020092514445630800_deaa194-B4) 2018; 86 Escobar-Morreale (2020092514445630800_deaa194-B20) 2011; 95 Azziz (2020092514445630800_deaa194-B5) 2006; 91 Moeller (2020092514445630800_deaa194-B51) 2018; 362 Hacivelioglu (2020092514445630800_deaa194-B29) 2013; 123 Mykhalchenko (2020092514445630800_deaa194-B53) 2017; 17 Bozdag (2020092514445630800_deaa194-B8) 2016; 31 Lim (2020092514445630800_deaa194-B39) 2017; 66 Sandoval-Motta (2020092514445630800_deaa194-B58) 2017; 8 Gonzalez (2020092514445630800_deaa194-B28) 1999; 48 Azziz (2020092514445630800_deaa194-B6) 2004; 89 Pastori (2020092514445630800_deaa194-B54) 2017; 6 |
References_xml | – volume: 5 start-page: 754 year: 2013 ident: 2020092514445630800_deaa194-B24 article-title: Causes and consequences of low grade endotoxemia and inflammatory diseases publication-title: Front Biosci (Schol Ed) doi: 10.2741/S405 – volume: 22 start-page: 5603 year: 2016 ident: 2020092514445630800_deaa194-B60 article-title: Hirsutism in polycystic ovary syndrome: pathophysiology and management publication-title: Curr Pharm Des doi: 10.2174/1381612822666160720151243 – volume: 56 start-page: 1761 year: 2007 ident: 2020092514445630800_deaa194-B10 article-title: Metabolic endotoxemia initiates obesity and insulin resistance publication-title: Diabetes doi: 10.2337/db06-1491 – volume: 102 start-page: 1861 year: 2017 ident: 2020092514445630800_deaa194-B32 article-title: Psychological distress is more prevalent in fertile age and premenopausal women with PCOS symptoms: 15-year follow-up publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2016-3863 – volume: 22 start-page: 1462 year: 1999 ident: 2020092514445630800_deaa194-B46 article-title: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp publication-title: Diabetes Care doi: 10.2337/diacare.22.9.1462 – volume: 97 start-page: e12608 year: 2018 ident: 2020092514445630800_deaa194-B13 article-title: Association between polycystic ovarian syndrome and endometrial, ovarian, and breast cancer: a population-based cohort study in Taiwan publication-title: Medicine doi: 10.1097/MD.0000000000012608 – volume: 8 start-page: 324 year: 2017 ident: 2020092514445630800_deaa194-B41 article-title: Dysbiosis of gut microbiota associated with clinical parameters in polycystic ovary syndrome publication-title: Front Microbiol – volume: 160 start-page: 2946 year: 2019 ident: 2020092514445630800_deaa194-B22 article-title: Inflammatory stimuli trigger increased androgen production and shifts in gene expression in theca-interstitial cells publication-title: Endocrinology doi: 10.1210/en.2019-00588 – start-page: 41 volume-title: Hum Reprod year: 2004 ident: 2020092514445630800_deaa194-B1 article-title: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) – volume: 109 start-page: 888 year: 2018 ident: 2020092514445630800_deaa194-B15 article-title: Androgen Excess- Polycystic Ovary Syndrome Society: position statement on depression, anxiety, quality of life, and eating disorders in polycystic ovary syndrome publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2018.01.038 – volume: 31 start-page: 817 year: 2010 ident: 2020092514445630800_deaa194-B44 article-title: Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk publication-title: Endocr Rev doi: 10.1210/er.2009-0030 – volume: 101 start-page: 10679 year: 2004 ident: 2020092514445630800_deaa194-B50 article-title: Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0403249101 – volume: 27 start-page: 3067 year: 2012 ident: 2020092514445630800_deaa194-B69 article-title: Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria publication-title: Hum Reprod doi: 10.1093/humrep/des232 – volume: 86 start-page: 33 year: 2018 ident: 2020092514445630800_deaa194-B4 article-title: Polycystic ovarian syndrome (PCOS): long-term metabolic consequences publication-title: Metabolism doi: 10.1016/j.metabol.2017.09.016 – volume: 90 start-page: 1140 year: 2011 ident: 2020092514445630800_deaa194-B59 article-title: Local inflammatory markers and systemic endotoxin in aggressive periodontitis publication-title: J Dent Res doi: 10.1177/0022034511413928 – volume: 9 start-page: e108074 year: 2014 ident: 2020092514445630800_deaa194-B2 article-title: Association between polycystic ovary syndrome, oral microbiota and systemic antibody responses publication-title: PLoS one doi: 10.1371/journal.pone.0108074 – volume: 95 start-page: 1048 year: 2011 ident: 2020092514445630800_deaa194-B20 article-title: Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2010.11.036 – volume: 40 start-page: 51 year: 2013 ident: 2020092514445630800_deaa194-B43 article-title: Dyslipidemia and oxidative stress in PCOS publication-title: Front Horm Res doi: 10.1159/000341683 – volume: 31 start-page: 2841 year: 2016 ident: 2020092514445630800_deaa194-B8 article-title: The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis publication-title: Hum Reprod doi: 10.1093/humrep/dew218 – volume: 100 start-page: 687 year: 2016 ident: 2020092514445630800_deaa194-B52 article-title: Endotoxemia-menace, marker, or mistake? publication-title: J Leukoc Biol doi: 10.1189/jlb.3RU0316-151R – volume: 53 start-page: 267 year: 1993 ident: 2020092514445630800_deaa194-B66 article-title: Recognition of bacterial endotoxins by receptor-dependent mechanisms publication-title: Adv Immunol doi: 10.1016/S0065-2776(08)60502-7 – volume: 77 start-page: 295 year: 2012 ident: 2020092514445630800_deaa194-B68 article-title: Dyslipidemia in PCOS publication-title: Steroids doi: 10.1016/j.steroids.2011.12.002 – volume: 25 start-page: 223 year: 2008 ident: 2020092514445630800_deaa194-B42 article-title: The involvement of the Toll-like receptor family in ovulation publication-title: J Assist Reprod Genet doi: 10.1007/s10815-008-9219-0 – volume: 104 start-page: 934 year: 2019 ident: 2020092514445630800_deaa194-B26 article-title: Saturated fat ingestion promotes lipopolysaccharide-mediated inflammation and insulin resistance in polycystic ovary syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2018-01143 – volume: 26 start-page: 118 year: 2015 ident: 2020092514445630800_deaa194-B48 article-title: Functional genomics of PCOS: from GWAS to molecular mechanisms publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2014.12.004 – volume: 91 start-page: 4237 year: 2006 ident: 2020092514445630800_deaa194-B5 article-title: Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-0178 – volume: 28 start-page: 412 year: 1985 ident: 2020092514445630800_deaa194-B47 article-title: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia doi: 10.1007/BF00280883 – volume: 8 start-page: 80 year: 2017 ident: 2020092514445630800_deaa194-B58 article-title: The human microbiome and the missing heritability problem publication-title: Front Genet doi: 10.3389/fgene.2017.00080 – volume: 11 start-page: e0146509 year: 2016 ident: 2020092514445630800_deaa194-B33 article-title: The gut microbiome is altered in a letrozole-induced mouse model of polycystic ovary syndrome publication-title: PLoS One doi: 10.1371/journal.pone.0146509 – volume: 84 start-page: 165 year: 1999 ident: 2020092514445630800_deaa194-B36 article-title: Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women publication-title: J Clin Endocrinol Metab – volume: 21 start-page: 1440 year: 1961 ident: 2020092514445630800_deaa194-B21 article-title: Clinical assessment of body hair growth in women publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-21-11-1440 – volume: 170 start-page: 43 year: 2019 ident: 2020092514445630800_deaa194-B72 article-title: Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study publication-title: Res Microbiol doi: 10.1016/j.resmic.2018.09.002 – volume: 66 start-page: 1031 year: 2017 ident: 2020092514445630800_deaa194-B39 article-title: The effect of heritability and host genetics on the gut microbiota and metabolic syndrome publication-title: Gut doi: 10.1136/gutjnl-2015-311326 – volume: 123 start-page: 33 year: 2013 ident: 2020092514445630800_deaa194-B29 article-title: Acne severity and the Global Acne Grading System in polycystic ovary syndrome publication-title: Int J Gynaecol Obstet doi: 10.1016/j.ijgo.2013.05.005 – volume: 103 start-page: 2552 year: 2018 ident: 2020092514445630800_deaa194-B30 article-title: Gut microbiota and the polycystic ovary syndrome: influence of sex, sex hormones, and obesity publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2017-02799 – volume: 196 start-page: 62 year: 2012 ident: 2020092514445630800_deaa194-B7 article-title: Prevalence of polycystic ovary syndrome in a sample of Indigenous women in Darwin, Australia publication-title: Med J Aust doi: 10.5694/mja11.10553 – volume: 11 start-page: e0148531 year: 2016 ident: 2020092514445630800_deaa194-B55 article-title: Interleukin-6 levels in women with polycystic ovary syndrome: a systematic review and meta-analysis publication-title: PloS one doi: 10.1371/journal.pone.0148531 – volume: 107 start-page: 11971 year: 2010 ident: 2020092514445630800_deaa194-B16 article-title: Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1002601107 – volume: 73 start-page: 11149 year: 2000 ident: 2020092514445630800_deaa194-B34 article-title: Metformin therapy improves hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome publication-title: Fertil Steril doi: 10.1016/S0015-0282(00)00501-X – volume: 109 start-page: 1611 year: 2019 ident: 2020092514445630800_deaa194-B12 article-title: Yogurt improves insulin resistance and liver fat in obese women with nonalcoholic fatty liver disease and metabolic syndrome: a randomized controlled trial publication-title: Am J Clin Nutr doi: 10.1093/ajcn/nqy358 – volume: 68 start-page: 133 year: 2017 ident: 2020092514445630800_deaa194-B25 article-title: Metabolic endotoxemia and diabetes mellitus: a systematic review publication-title: Metabolism doi: 10.1016/j.metabol.2016.12.009 – volume: 20 start-page: 113 year: 2016 ident: 2020092514445630800_deaa194-B70 article-title: Effect of lipopolysaccharide (LPS) exposure on the reproductive organs of immature female rats publication-title: Dev Reprod doi: 10.12717/DR.2016.20.2.113 – volume: 25 start-page: 544 year: 2010 ident: 2020092514445630800_deaa194-B45 article-title: The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria publication-title: Hum Reprod doi: 10.1093/humrep/dep399 – volume: 7 start-page: 167 year: 2001 ident: 2020092514445630800_deaa194-B3 article-title: Bacterial lipopolysaccharides and innate immunity publication-title: J Endotoxin Res – volume: 24 start-page: 2174 year: 2004 ident: 2020092514445630800_deaa194-B56 article-title: Severe periodontitis enhances macrophage activation via increased serum lipopolysaccharide publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000145979.82184.9f – volume: 34 start-page: 1809 year: 2011 ident: 2020092514445630800_deaa194-B35 article-title: Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation publication-title: Diabetes Care doi: 10.2337/dc10-2197 – volume: 362 start-page: 453 year: 2018 ident: 2020092514445630800_deaa194-B51 article-title: Transmission modes of the mammalian gut microbiota publication-title: Science (New York, NY doi: 10.1126/science.aat7164 – volume: 78 start-page: 773 year: 2013 ident: 2020092514445630800_deaa194-B14 article-title: Cardiovascular disease risk in women with PCOS publication-title: Steroids doi: 10.1016/j.steroids.2013.04.009 – volume: 211 start-page: 635.e1–7 year: 2014 ident: 2020092514445630800_deaa194-B27 article-title: Evidence of mononuclear cell preactivation in the fasting state in polycystic ovary syndrome publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2014.06.044 – volume: 8 start-page: 41 year: 2010 ident: 2020092514445630800_deaa194-B63 article-title: Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan publication-title: BMC Med doi: 10.1186/1741-7015-8-41 – volume: 50 start-page: 90 year: 2009 ident: 2020092514445630800_deaa194-B23 article-title: Chylomicrons promote intestinal absorption of lipopolysaccharides publication-title: J Lipid Res doi: 10.1194/jlr.M800156-JLR200 – volume: 103 start-page: 1502 year: 2018 ident: 2020092514445630800_deaa194-B64 article-title: Gut microbial diversity in women with polycystic ovary syndrome correlates with hyperandrogenism publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2017-02153 – volume: 17 start-page: 741 year: 2011 ident: 2020092514445630800_deaa194-B65 article-title: Meta-analysis of cardiovascular disease risk markers in women with polycystic ovary syndrome publication-title: Hum Reprod Update doi: 10.1093/humupd/dmr025 – volume: 38 start-page: 193 year: 2018 ident: 2020092514445630800_deaa194-B37 article-title: Contributory role of gut microbiota and their metabolites toward cardiovascular complications in chronic kidney disease publication-title: Semin Nephrol doi: 10.1016/j.semnephrol.2018.01.008 – volume: 89 start-page: 2745 year: 2004 ident: 2020092514445630800_deaa194-B6 article-title: The prevalence and features of the polycystic ovary syndrome in an unselected population publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-032046 – volume: 33 start-page: 1925 year: 2010 ident: 2020092514445630800_deaa194-B62 article-title: A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese publication-title: Diabetes Care doi: 10.2337/dc10-0340 – volume: 17 start-page: 723 year: 2017 ident: 2020092514445630800_deaa194-B53 article-title: Genetics of polycystic ovary syndrome publication-title: Expert Rev Mol Diagn doi: 10.1080/14737159.2017.1340833 – volume: 24 start-page: 2227 year: 2004 ident: 2020092514445630800_deaa194-B61 article-title: Potential role of endotoxin as a proinflammatory mediator of atherosclerosis publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000147534.69062.dc – volume: 388 start-page: 203 year: 2014 ident: 2020092514445630800_deaa194-B31 article-title: Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes publication-title: Mol Cell Biochem doi: 10.1007/s11010-013-1911-4 – volume: 95 start-page: 320 year: 2011 ident: 2020092514445630800_deaa194-B18 article-title: Periodontal disease in polycystic ovary syndrome publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2010.07.1052 – volume: 84 start-page: 3666 year: 1999 ident: 2020092514445630800_deaa194-B67 article-title: A critical evaluation of simple methods for the estimation of free testosterone in serum publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.84.10.6079 – start-page: 377 volume-title: Current Issues in Endocrinology and Metabolism year: 1992 ident: 2020092514445630800_deaa194-B71 – volume: 6 start-page: e005784 year: 2017 ident: 2020092514445630800_deaa194-B54 article-title: Gut-derived serum lipopolysaccharide is associated with enhanced risk of major adverse cardiovascular events in atrial fibrillation: effect of adherence to Mediterranean diet publication-title: J Am Heart Assoc doi: 10.1161/JAHA.117.005784 – volume: 44 start-page: 784 year: 2017 ident: 2020092514445630800_deaa194-B38 article-title: Lipopolysaccharide, a possible molecular mediator between periodontitis and coronary artery disease publication-title: J Clin Periodontol doi: 10.1111/jcpe.12751 – volume: 91 start-page: 48 year: 2006 ident: 2020092514445630800_deaa194-B19 article-title: Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-1329 – volume: 48 start-page: 437 year: 1999 ident: 2020092514445630800_deaa194-B28 article-title: Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome publication-title: Metabolism doi: 10.1016/S0026-0495(99)90100-2 – volume: 34 start-page: 2688 year: 2014 ident: 2020092514445630800_deaa194-B9 article-title: Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness: the Coronary Artery Risk Development in Young Adults Women's study publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.114.304136 – volume: 17 start-page: 1374 year: 2007 ident: 2020092514445630800_deaa194-B57 article-title: Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis publication-title: Obes Surg doi: 10.1007/s11695-007-9243-7 – volume: 217 start-page: 189 year: 2017 ident: 2020092514445630800_deaa194-B11 article-title: Racial and ethnic differences in the prevalence of metabolic syndrome and its components of metabolic syndrome in women with polycystic ovary syndrome: a regional cross-sectional study publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2017.04.007 – volume: 12 start-page: e0168390 year: 2017 ident: 2020092514445630800_deaa194-B40 article-title: Alterations in gut microbiome composition and barrier function are associated with reproductive and metabolic defects in women with polycystic ovary syndrome (PCOS): a pilot study publication-title: PLoS One doi: 10.1371/journal.pone.0168390 – volume: 18 start-page: 774 year: 1997 ident: 2020092514445630800_deaa194-B17 article-title: Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis publication-title: Endocrine Rev – volume: 59 start-page: 172 year: 2010 ident: 2020092514445630800_deaa194-B49 article-title: Experimental endotoxemia induces adipose inflammation and insulin resistance in humans publication-title: Diabetes doi: 10.2337/db09-0367 |
SSID | ssj0016186 |
Score | 2.4569383 |
Snippet | Is polycystic ovary syndrome (PCOS) associated with an elevation of markers of endotoxemia?
In women with PCOS serum levels of lipopolysaccharides (LPS), the... Is polycystic ovary syndrome (PCOS) associated with an elevation of markers of endotoxemia?STUDY QUESTIONIs polycystic ovary syndrome (PCOS) associated with an... |
SourceID | proquest pubmed crossref |
SourceType | Aggregation Database Index Database Enrichment Source |
StartPage | 2303 |
SubjectTerms | Androgens Cross-Sectional Studies Endotoxemia Female Humans Polycystic Ovary Syndrome - complications |
Title | Elevation of markers of endotoxemia in women with polycystic ovary syndrome |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32869098 https://www.proquest.com/docview/2439624764 |
Volume | 35 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgSNNeEHRcxk1GQuOBhXV2miaPAw1tTEMIddLeohNftKq5VLSdSH89x3acBFgl4CWyEjtR-31xjo_P-Q4hb-RIZAxAB1opFoRGBDOJRjIAoWOdCA1jq7N98SU6vQw_X42uuu0Cm12yzN6L9a15Jf-DKp5DXE2W7D8g294UT2Ab8cUjIozHv8L4JFc3rclXmECb7zYyQ5W41qx-qGIKxp9hVRacx3Ve5bWojTbzu-rGBMzdpljgHPtG7tKqwTqCxC61sOc5-AAlLNY4Sc5c-Wbl0tycw2YKs8pfMVIFddmFBF2v5HoqZhDYMsqQ205nJros73VqHNnffLJZ3z-Bi1Ef6YafFzenhtEwYNzpy_pJ12mUeHIN-1Mot6IHf87tTvfqelXg78eGVABHrkByD-p5YbHmzFTacvWtf9PT9pfukntsjPaWMaTPztudJ1M_oBX35IfucYfNw3bIth_-qx2zYXFijZTJA3K_WV3QY0eVh-SOKgdk97iEZVXUdJ_aeF-7kTIg2xdNWMWA7H91Aub1AZ10-XiLAzuilTavd8l5yzhaadowzjR7jKPTklrGUcM42jGOWsZRz7hH5PLTyeTjadCU4wgEZ8kyAIjjI82YinQUJhIP4zALhWQZxFyiqc4A33w-ThjgF1THPBtqHKA0xImMM8Efk62yKtVTQiOOq-4wUpIlEj8iwigQJWh8KgZmoz3eI4H_c1PRaNWbkil56mImeOpwSRtc9sjbtv_cqbRs7PnaY5XiRGp2x6BU1WqRMjTNIxaOI-zzxIHY3suD_mzjledkpyP_C7KF7496iebqMntl-fUTyjedGA |
linkProvider | Flying Publisher |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Elevation+of+markers+of+endotoxemia+in+women+with+polycystic+ovary+syndrome&rft.jtitle=Human+reproduction+%28Oxford%29&rft.au=Banaszewska%2C+Beata&rft.au=Siakowska%2C+Martyna&rft.au=Chudzicka-Strugala%2C+Izabela&rft.au=Chang%2C+R+Jeffrey&rft.date=2020-10-01&rft.eissn=1460-2350&rft.volume=35&rft.issue=10&rft.spage=2303&rft_id=info:doi/10.1093%2Fhumrep%2Fdeaa194&rft_id=info%3Apmid%2F32869098&rft.externalDocID=32869098 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0268-1161&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0268-1161&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0268-1161&client=summon |