Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it would be updated, based on the availability of new interventions and new evidence to establish their clinical role. The authors continue to endorse the principles used to d...

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Published inDiabetologia Vol. 52; no. 1; pp. 17 - 30
Main Authors Nathan, D. M., Buse, J. B., Davidson, M. B., Ferrannini, E., Holman, R. R., Sherwin, R., Zinman, B.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.01.2009
Springer
Springer Nature B.V
Subjects
Online AccessGet full text
ISSN0012-186X
1432-0428
1432-0428
DOI10.1007/s00125-008-1157-y

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Abstract The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it would be updated, based on the availability of new interventions and new evidence to establish their clinical role. The authors continue to endorse the principles used to develop the algorithm and its major features. We are sensitive to the risks of changing the algorithm cavalierly or too frequently, without compelling new information. An update to the consensus algorithm published in January 2008 specifically addressed safety issues surrounding the thiazolidinediones. In this revision, we focus on the new classes of medications that now have more clinical data and experience.
AbstractList The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it would be updated, based on the availability of new interventions and new evidence to establish their clinical role. The authors continue to endorse the principles used to develop the algorithm and its major features. We are sensitive to the risks of changing the algorithm cavalierly or too frequently, without compelling new information. An update to the consensus algorithm published in January 2008 specifically addressed safety issues surrounding the thiazolidinediones. In this revision, we focus on the new classes of medications that now have more clinical data and experience. [PUBLICATION ABSTRACT]
The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it would be updated, based on the availability of new interventions and new evidence to establish their clinical role. The authors continue to endorse the principles used to develop the algorithm and its major features. We are sensitive to the risks of changing the algorithm cavalierly or too frequently, without compelling new information. An update to the consensus algorithm published in January 2008 specifically addressed safety issues surrounding the thiazolidinediones. In this revision, we focus on the new classes of medications that now have more clinical data and experience.
The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it would be updated, based on the availability of new interventions and new evidence to establish their clinical role. The authors continue to endorse the principles used to develop the algorithm and its major features. We are sensitive to the risks of changing the algorithm cavalierly or too frequently, without compelling new information. An update to the consensus algorithm published in January 2008 specifically addressed safety issues surrounding the thiazolidinediones. In this revision, we focus on the new classes of medications that now have more clinical data and experience.The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it would be updated, based on the availability of new interventions and new evidence to establish their clinical role. The authors continue to endorse the principles used to develop the algorithm and its major features. We are sensitive to the risks of changing the algorithm cavalierly or too frequently, without compelling new information. An update to the consensus algorithm published in January 2008 specifically addressed safety issues surrounding the thiazolidinediones. In this revision, we focus on the new classes of medications that now have more clinical data and experience.
Author Holman, R. R.
Ferrannini, E.
Sherwin, R.
Nathan, D. M.
Davidson, M. B.
Buse, J. B.
Zinman, B.
Author_xml – sequence: 1
  givenname: D. M.
  surname: Nathan
  fullname: Nathan, D. M.
  email: dnathan@partners.org
  organization: Diabetes Center, Massachusetts General Hospital
– sequence: 2
  givenname: J. B.
  surname: Buse
  fullname: Buse, J. B.
  organization: University of North Carolina School of Medicine
– sequence: 3
  givenname: M. B.
  surname: Davidson
  fullname: Davidson, M. B.
  organization: Clinical Center for Research Excellence, Charles R. Drew University
– sequence: 4
  givenname: E.
  surname: Ferrannini
  fullname: Ferrannini, E.
  organization: Department of Internal Medicine, University of Pisa
– sequence: 5
  givenname: R. R.
  surname: Holman
  fullname: Holman, R. R.
  organization: Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University
– sequence: 6
  givenname: R.
  surname: Sherwin
  fullname: Sherwin, R.
  organization: Department of Internal Medicine and Yale Center for Clinical Investigation, Yale University School of Medicine
– sequence: 7
  givenname: B.
  surname: Zinman
  fullname: Zinman, B.
  organization: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto
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https://www.ncbi.nlm.nih.gov/pubmed/18941734$$D View this record in MEDLINE/PubMed
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IsPeerReviewed true
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Issue 1
Keywords HbA1c Level
Glycaemic Control
Lifestyle Intervention
Consensus Algorithm
Metformin
Endocrinopathy
Type 2 diabetes
Metabolic diseases
Hyperglycemia
Association
Language English
License http://www.springer.com/tdm
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PublicationSubtitle Clinical and Experimental Diabetes and Metabolism
PublicationTitle Diabetologia
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References_xml – reference: GenuthSInsulin use in NIDDMDiabetes Care199013124064227630910.2337/diacare.13.12.12401:STN:280:DyaK3M7hsVCqtA%3D%3D
– reference: SchwartzSSieversRStrangePLynessWHHollanderPInsulin 70/30 mix plus metformin versus triple oral therapy in the treatment of type 2 diabetes after failure of two oral drugsDiabetes Care200326223822431288284210.2337/diacare.26.8.22381:CAS:528:DC%2BD3sXmslOktb0%3D
– reference: NathanDMInitial management of glycemia in type 2 diabetes mellitusN Engl J Med2002347134213491239719310.1056/NEJMcp021106
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Snippet The consensus algorithm for the medical management of type 2 diabetes was published in August 2006 with the expectation that it would be updated, based on the...
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SubjectTerms Algorithms
Biological and medical sciences
Consensus Statement Update
Controlled Clinical Trials as Topic
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - psychology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Europe
Human Physiology
Hyperglycemia - drug therapy
Hyperglycemia - prevention & control
Hyperglycemia - psychology
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - therapeutic use
Internal Medicine
Life Style
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Societies, Medical
United States
Subtitle A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
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Title Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy
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